CN111315749A - 新颖的二氢异噁唑化合物及其在治疗乙型肝炎中的用途 - Google Patents

新颖的二氢异噁唑化合物及其在治疗乙型肝炎中的用途 Download PDF

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Publication number
CN111315749A
CN111315749A CN201880072633.XA CN201880072633A CN111315749A CN 111315749 A CN111315749 A CN 111315749A CN 201880072633 A CN201880072633 A CN 201880072633A CN 111315749 A CN111315749 A CN 111315749A
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China
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methyl
pyridine
carboxamide
dihydroisoxazolo
trifluorophenyl
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Chinese (zh)
Inventor
J·付
M·林德瓦尔
J·R·曼宁
G·麦肯罗
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880072633.XA 2017-11-17 2018-11-16 新颖的二氢异噁唑化合物及其在治疗乙型肝炎中的用途 Pending CN111315749A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762588122P 2017-11-17 2017-11-17
US62/588,122 2017-11-17
US201862727936P 2018-09-06 2018-09-06
US62/727,936 2018-09-06
PCT/IB2018/059059 WO2019097479A1 (en) 2017-11-17 2018-11-16 Novel dihydroisoxazole compounds and their use for the treatment of hepatitis b

Publications (1)

Publication Number Publication Date
CN111315749A true CN111315749A (zh) 2020-06-19

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CN201880072633.XA Pending CN111315749A (zh) 2017-11-17 2018-11-16 新颖的二氢异噁唑化合物及其在治疗乙型肝炎中的用途

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US (1) US20210079015A1 (https=)
EP (1) EP3710455A1 (https=)
JP (1) JP2021503458A (https=)
CN (1) CN111315749A (https=)
WO (1) WO2019097479A1 (https=)

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CN111247131A (zh) * 2017-11-16 2020-06-05 正大天晴药业集团股份有限公司 抗HBV的四氢异噁唑并[4,3-c]吡啶类化合物
CN111511747A (zh) * 2017-12-21 2020-08-07 爱尔兰詹森科学公司 用于治疗与hbv感染相关的疾病的异噁唑化合物
CN114539148A (zh) * 2022-01-25 2022-05-27 北京英飞智药科技有限公司 一种环状n-羟基酰亚胺类化合物及其用途

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WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
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CN111247131B (zh) * 2017-11-16 2022-02-18 正大天晴药业集团股份有限公司 抗HBV的四氢异噁唑并[4,3-c]吡啶类化合物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111247131A (zh) * 2017-11-16 2020-06-05 正大天晴药业集团股份有限公司 抗HBV的四氢异噁唑并[4,3-c]吡啶类化合物
CN111247131B (zh) * 2017-11-16 2022-02-18 正大天晴药业集团股份有限公司 抗HBV的四氢异噁唑并[4,3-c]吡啶类化合物
CN111511747A (zh) * 2017-12-21 2020-08-07 爱尔兰詹森科学公司 用于治疗与hbv感染相关的疾病的异噁唑化合物
CN114539148A (zh) * 2022-01-25 2022-05-27 北京英飞智药科技有限公司 一种环状n-羟基酰亚胺类化合物及其用途

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JP2021503458A (ja) 2021-02-12
WO2019097479A1 (en) 2019-05-23
US20210079015A1 (en) 2021-03-18
EP3710455A1 (en) 2020-09-23

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Application publication date: 20200619