CN111194350A - 一种基因编辑t细胞及其用途 - Google Patents

一种基因编辑t细胞及其用途 Download PDF

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CN111194350A
CN111194350A CN201880060667.7A CN201880060667A CN111194350A CN 111194350 A CN111194350 A CN 111194350A CN 201880060667 A CN201880060667 A CN 201880060667A CN 111194350 A CN111194350 A CN 111194350A
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cell
sgrna
cells
car
tcr
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袁鹏飞
王飞
于玲玲
董曦
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Edigene Biotechnology Inc
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Edigene Beijing Biotechnology Co ltd
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Abstract

提供了一种通用型T细胞及其制备方法。所述通用型T细胞包括CAR‑T和TCR‑T细胞，是通过CRISPR/Cas9基因编辑技术敲除了T细胞的TCR和/或HLA和/或PD‑1蛋白获得的，其中通用型CAR‑T可在体内、体外持续杀伤靶细胞。

Description

PCT国内申请，说明书已公开。

Claims (37)

  1. PCT国内申请，权利要求书已公开。
CN201880060667.7A 2017-09-18 2018-09-18 一种基因编辑t细胞及其用途 Pending CN111194350A (zh)

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CN201710841323 2017-09-18
CN2017108413237 2017-09-18
CN201710842264 2017-09-18
CN2017108422645 2017-09-18
PCT/CN2018/106237 WO2019052577A1 (zh) 2017-09-18 2018-09-18 一种基因编辑t细胞及其用途

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CN201811088292.3A Pending CN109517796A (zh) 2017-09-18 2018-09-18 一种基因编辑t细胞及其用途

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US (1) US20200216805A1 (zh)
EP (1) EP3686275A4 (zh)
JP (1) JP7190096B2 (zh)
CN (2) CN111194350A (zh)
TW (1) TW201920661A (zh)
WO (1) WO2019052577A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112980800A (zh) * 2021-03-08 2021-06-18 河北森朗生物科技有限公司 Car-t细胞、其构建方法及其应用
CN114929866A (zh) * 2020-02-28 2022-08-19 大塚制药株式会社 基因改造巨核细胞、改造血小板和它们的制造方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112239769B (zh) * 2019-07-19 2023-11-07 上海邦耀生物科技有限公司 一种引导PD1基因切割实现外源序列高效整合的sgRNA
EP4026910A1 (en) * 2019-09-04 2022-07-13 Edigene Inc. Method for evaluating gene editing therapy based on off-target assessment
CN113122503B (zh) * 2019-12-30 2022-10-11 博雅缉因（北京）生物科技有限公司 一种靶向t细胞淋巴瘤细胞的通用型car-t及其制备方法和应用
US20230054266A1 (en) * 2019-12-30 2023-02-23 Edigene Biotechnology Inc. Method for purifying ucart cell and use thereof
CN114901813A (zh) * 2019-12-30 2022-08-12 博雅缉因（北京）生物科技有限公司 一种靶向t细胞淋巴瘤细胞的通用型car-t及其制备方法和应用
CN113122504A (zh) * 2019-12-30 2021-07-16 博雅辑因（北京）生物科技有限公司 一种纯化ucart细胞的方法与应用
CN110951695A (zh) * 2019-12-31 2020-04-03 深圳市茵冠生物科技有限公司 通用型car-t细胞、其制备方法及其应用
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