CN111194225B - 用于ct成像的碘化脂肪酸的纳米乳剂 - Google Patents

用于ct成像的碘化脂肪酸的纳米乳剂 Download PDF

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Publication number
CN111194225B
CN111194225B CN201880064977.6A CN201880064977A CN111194225B CN 111194225 B CN111194225 B CN 111194225B CN 201880064977 A CN201880064977 A CN 201880064977A CN 111194225 B CN111194225 B CN 111194225B
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contrast agent
nanoemulsion
biocompatible
iodinated
fatty acids
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Chinese (zh)
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CN111194225A (zh
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劳伦特·维纳特
安德烈·巴比克
埃里克·艾利曼
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Universite de Geneve
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Universite de Geneve
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461Dispersions, colloids, emulsions or suspensions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicinal Preparation (AREA)
CN201880064977.6A 2017-08-07 2018-07-27 用于ct成像的碘化脂肪酸的纳米乳剂 Active CN111194225B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17185185.0 2017-08-07
EP17185185 2017-08-07
PCT/EP2018/070501 WO2019030024A1 (en) 2017-08-07 2018-07-27 NANOEMULSION OF IODIZED FATTY ACIDS FOR COMPUTER-ASSISTED TOMOGRAPHY (CT) IMAGING

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CN111194225A CN111194225A (zh) 2020-05-22
CN111194225B true CN111194225B (zh) 2023-01-13

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US (1) US11654202B2 (enExample)
EP (1) EP3664855A1 (enExample)
JP (1) JP7210542B2 (enExample)
CN (1) CN111194225B (enExample)
AU (1) AU2018314406B2 (enExample)
BR (1) BR112020002619A2 (enExample)
CA (1) CA3072282A1 (enExample)
EA (1) EA202090139A1 (enExample)
WO (1) WO2019030024A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113784734B (zh) * 2019-02-13 2024-09-27 日内瓦大学 用于恶病质的检测的ct造影剂
JP2023536358A (ja) * 2020-08-06 2023-08-24 アディポス エスエー Pet-ct撮像方法、その撮像方法における使用のための造影剤および医薬組成物
CN112933246A (zh) * 2020-12-17 2021-06-11 太阳雨林(厦门)生物医药有限公司 一种可显影的油制剂及其制备方法
US20240336552A1 (en) * 2021-08-02 2024-10-10 Microvention, Inc. Compounds
EP4423211A1 (en) 2021-10-28 2024-09-04 Adiposs SA Emulsions, compositions for emulsions, methods for making the same and uses thereof
WO2025079088A1 (en) * 2023-10-11 2025-04-17 Bioroot Exploration India Private Limited A contrast agent for computed tomography and process of preparation thereof

Citations (5)

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FR2736549A1 (fr) * 1995-07-11 1997-01-17 Louis Jung Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
CN101379023A (zh) * 2006-02-15 2009-03-04 通用电气医疗集团股份有限公司 造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
WO2015127347A1 (en) * 2014-02-24 2015-08-27 The Regents Of The University Of California Therapeutic hyperbranched polyglycerol encapsulated biomolecules
CN105592862A (zh) * 2013-09-30 2016-05-18 贝朗医疗有限公司 肝脏预饱和及其后造影剂的施用

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US5258172A (en) * 1983-12-29 1993-11-02 Rubin Daniel L Iodinated aliphatic emulsions for X-ray contrast
DE3785849T2 (de) 1987-06-11 1993-08-26 Kabi Pharmacia Ab Jod enthaltende emulsion.
US5861367A (en) 1993-08-04 1999-01-19 Colgate Palmolive Company Cleaning and disinfecting composition in microemulsion/liquid crystal form comprising aldehyde and mixture of partially esterified, fully esterified and non-esterified polyhydric alcohols
DE19936727A1 (de) 1999-08-06 2001-02-08 Henkel Kgaa Niotensidbasiertes wäßriges mehrphasiges Reinigungsmittel
US20050079131A1 (en) * 2003-08-08 2005-04-14 Lanza Gregory M. Emulsion particles for imaging and therapy and methods of use thereof
GB0408684D0 (en) 2004-04-19 2004-05-19 Guy S And St Thomas Hospital N Diagnostic method
SG10201505948VA (en) 2004-12-13 2015-09-29 Amylin Pharmaceuticals Llc Pancreatic Polypeptide Family Motifs, Polypeptides And Methods Comprising The Same
US20080319315A1 (en) 2007-06-07 2008-12-25 Beth Israel Deaconess Medical Center Method of reducing interferences in positron emission tomography
US20140065067A1 (en) 2010-12-17 2014-03-06 Universite De Strasbourg Radiopaque iodinated products intended for use medical imaging and their methods
KR101263733B1 (ko) 2011-03-22 2013-05-14 한국과학기술연구원 리피오돌을 함유하는 컴퓨터 단층촬영용 혈관 조영제
DE102012204378A1 (de) 2012-03-20 2013-09-26 Bernd Schwegmann Gmbh & Co. Kg Reinigungsmittel auf Mikroemulsionsbasis
US10157462B2 (en) 2016-06-27 2018-12-18 University Of Central Florida Research Foundation, Inc. System and method for image-based quantification of white and brown adipose tissue at the whole-body, organ and body-region levels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736549A1 (fr) * 1995-07-11 1997-01-17 Louis Jung Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
CN101379023A (zh) * 2006-02-15 2009-03-04 通用电气医疗集团股份有限公司 造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN105592862A (zh) * 2013-09-30 2016-05-18 贝朗医疗有限公司 肝脏预饱和及其后造影剂的施用
WO2015127347A1 (en) * 2014-02-24 2015-08-27 The Regents Of The University Of California Therapeutic hyperbranched polyglycerol encapsulated biomolecules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
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平阳霉素碘油乳剂栓塞肺减容术的初步研究;王万胜等;《介入放射学杂志》;20060130(第01期);全文 *
经皮穿刺瘤内注射碘油化疗药乳剂在外生型肝癌介入治疗中的应用;张儒焱等;《当代医学》;20091015(第29期);全文 *

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JP2020529441A (ja) 2020-10-08
EP3664855A1 (en) 2020-06-17
EA202090139A1 (ru) 2020-08-06
AU2018314406A1 (en) 2020-02-20
WO2019030024A1 (en) 2019-02-14
CA3072282A1 (en) 2019-02-14
CN111194225A (zh) 2020-05-22
JP7210542B2 (ja) 2023-01-23
AU2018314406B2 (en) 2024-08-15
BR112020002619A2 (pt) 2020-07-28
US11654202B2 (en) 2023-05-23
US20210330820A1 (en) 2021-10-28

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