JP2020529441A5 - - Google Patents
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- Publication number
- JP2020529441A5 JP2020529441A5 JP2020506159A JP2020506159A JP2020529441A5 JP 2020529441 A5 JP2020529441 A5 JP 2020529441A5 JP 2020506159 A JP2020506159 A JP 2020506159A JP 2020506159 A JP2020506159 A JP 2020506159A JP 2020529441 A5 JP2020529441 A5 JP 2020529441A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo imaging
- nanoemulsion
- biocompatible
- carbon atoms
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 238000011503 in vivo imaging Methods 0.000 claims 16
- 239000002872 contrast media Substances 0.000 claims 10
- 239000007908 nanoemulsion Substances 0.000 claims 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims 9
- 229930195729 fatty acid Natural products 0.000 claims 9
- 239000000194 fatty acid Substances 0.000 claims 9
- 150000004665 fatty acids Chemical class 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 238000002591 computed tomography Methods 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229940039231 contrast media Drugs 0.000 claims 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- -1 sorbitan ester Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17185185.0 | 2017-08-07 | ||
| EP17185185 | 2017-08-07 | ||
| PCT/EP2018/070501 WO2019030024A1 (en) | 2017-08-07 | 2018-07-27 | NANOEMULSION OF IODIZED FATTY ACIDS FOR COMPUTER-ASSISTED TOMOGRAPHY (CT) IMAGING |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529441A JP2020529441A (ja) | 2020-10-08 |
| JP2020529441A5 true JP2020529441A5 (enExample) | 2021-09-02 |
| JP7210542B2 JP7210542B2 (ja) | 2023-01-23 |
Family
ID=59564118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506159A Active JP7210542B2 (ja) | 2017-08-07 | 2018-07-27 | Ｃｔイメージング用のヨウ素化脂肪酸のナノエマルジョン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11654202B2 (enExample) |
| EP (1) | EP3664855A1 (enExample) |
| JP (1) | JP7210542B2 (enExample) |
| CN (1) | CN111194225B (enExample) |
| AU (1) | AU2018314406B2 (enExample) |
| BR (1) | BR112020002619A2 (enExample) |
| CA (1) | CA3072282A1 (enExample) |
| EA (1) | EA202090139A1 (enExample) |
| WO (1) | WO2019030024A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113784734B (zh) * | 2019-02-13 | 2024-09-27 | 日内瓦大学 | 用于恶病质的检测的ct造影剂 |
| JP2023536358A (ja) * | 2020-08-06 | 2023-08-24 | アディポス エスエー | Ｐｅｔ－ｃｔ撮像方法、その撮像方法における使用のための造影剤および医薬組成物 |
| CN112933246A (zh) * | 2020-12-17 | 2021-06-11 | 太阳雨林（厦门）生物医药有限公司 | 一种可显影的油制剂及其制备方法 |
| US20240336552A1 (en) * | 2021-08-02 | 2024-10-10 | Microvention, Inc. | Compounds |
| EP4423211A1 (en) | 2021-10-28 | 2024-09-04 | Adiposs SA | Emulsions, compositions for emulsions, methods for making the same and uses thereof |
| WO2025079088A1 (en) * | 2023-10-11 | 2025-04-17 | Bioroot Exploration India Private Limited | A contrast agent for computed tomography and process of preparation thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258172A (en) * | 1983-12-29 | 1993-11-02 | Rubin Daniel L | Iodinated aliphatic emulsions for X-ray contrast |
| DE3785849T2 (de) | 1987-06-11 | 1993-08-26 | Kabi Pharmacia Ab | Jod enthaltende emulsion. |
| US5861367A (en) | 1993-08-04 | 1999-01-19 | Colgate Palmolive Company | Cleaning and disinfecting composition in microemulsion/liquid crystal form comprising aldehyde and mixture of partially esterified, fully esterified and non-esterified polyhydric alcohols |
| FR2736549B1 (fr) | 1995-07-11 | 1997-10-10 | Louis Jung | Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques |
| DE19936727A1 (de) | 1999-08-06 | 2001-02-08 | Henkel Kgaa | Niotensidbasiertes wäßriges mehrphasiges Reinigungsmittel |
| US20050079131A1 (en) * | 2003-08-08 | 2005-04-14 | Lanza Gregory M. | Emulsion particles for imaging and therapy and methods of use thereof |
| GB0408684D0 (en) | 2004-04-19 | 2004-05-19 | Guy S And St Thomas Hospital N | Diagnostic method |
| SG10201505948VA (en) | 2004-12-13 | 2015-09-29 | Amylin Pharmaceuticals Llc | Pancreatic Polypeptide Family Motifs, Polypeptides And Methods Comprising The Same |
| ATE496881T1 (de) | 2006-02-15 | 2011-02-15 | Ge Healthcare As | Kontrastmittel |
| US20080319315A1 (en) | 2007-06-07 | 2008-12-25 | Beth Israel Deaconess Medical Center | Method of reducing interferences in positron emission tomography |
| US20140065067A1 (en) | 2010-12-17 | 2014-03-06 | Universite De Strasbourg | Radiopaque iodinated products intended for use medical imaging and their methods |
| KR101263733B1 (ko) | 2011-03-22 | 2013-05-14 | 한국과학기술연구원 | 리피오돌을 함유하는 컴퓨터 단층촬영용 혈관 조영제 |
| CN102166365B (zh) | 2011-04-25 | 2012-10-24 | 东南大学 | 一种多模态碘油纳米乳造影剂的制备方法 |
| DE102012204378A1 (de) | 2012-03-20 | 2013-09-26 | Bernd Schwegmann Gmbh & Co. Kg | Reinigungsmittel auf Mikroemulsionsbasis |
| CN105592862B (zh) | 2013-09-30 | 2020-09-29 | 贝朗医疗有限公司 | 肝脏预饱和及其后造影剂的施用 |
| WO2015127347A1 (en) | 2014-02-24 | 2015-08-27 | The Regents Of The University Of California | Therapeutic hyperbranched polyglycerol encapsulated biomolecules |
| US10157462B2 (en) | 2016-06-27 | 2018-12-18 | University Of Central Florida Research Foundation, Inc. | System and method for image-based quantification of white and brown adipose tissue at the whole-body, organ and body-region levels |
-
2018
- 2018-07-27 WO PCT/EP2018/070501 patent/WO2019030024A1/en not_active Ceased
- 2018-07-27 CN CN201880064977.6A patent/CN111194225B/zh active Active
- 2018-07-27 EP EP18743047.5A patent/EP3664855A1/en active Pending
- 2018-07-27 AU AU2018314406A patent/AU2018314406B2/en active Active
- 2018-07-27 US US16/637,366 patent/US11654202B2/en active Active
- 2018-07-27 JP JP2020506159A patent/JP7210542B2/ja active Active
- 2018-07-27 BR BR112020002619-0A patent/BR112020002619A2/pt unknown
- 2018-07-27 EA EA202090139A patent/EA202090139A1/ru unknown
- 2018-07-27 CA CA3072282A patent/CA3072282A1/en active Pending
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