JP2017537140A5 - - Google Patents
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- Publication number
- JP2017537140A5 JP2017537140A5 JP2017538469A JP2017538469A JP2017537140A5 JP 2017537140 A5 JP2017537140 A5 JP 2017537140A5 JP 2017538469 A JP2017538469 A JP 2017538469A JP 2017538469 A JP2017538469 A JP 2017538469A JP 2017537140 A5 JP2017537140 A5 JP 2017537140A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- hydrogen
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 230000006907 apoptotic process Effects 0.000 claims 3
- 230000024245 cell differentiation Effects 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- VTQODUPVJJIRNL-UHFFFAOYSA-N COC(=O)C=CC1=CC=C(C=C1)C1=CC2=C(C=C1)N(C)CCC2(C)C Chemical compound COC(=O)C=CC1=CC=C(C=C1)C1=CC2=C(C=C1)N(C)CCC2(C)C VTQODUPVJJIRNL-UHFFFAOYSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940124443 chemopreventive agent Drugs 0.000 claims 2
- 239000012627 chemopreventive agent Substances 0.000 claims 2
- 230000000973 chemotherapeutic effect Effects 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000018109 developmental process Effects 0.000 claims 2
- IOLNBCWVYOJDQM-UHFFFAOYSA-N methyl 6-(1,4,4-trimethyl-2,3-dihydroquinolin-6-yl)naphthalene-2-carboxylate Chemical compound COC(=O)C1=CC2=CC=C(C=C2C=C1)C1=CC2=C(C=C1)N(C)CCC2(C)C IOLNBCWVYOJDQM-UHFFFAOYSA-N 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 238000001069 Raman spectroscopy Methods 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000000515 tooth Anatomy 0.000 claims 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1417957.6 | 2014-10-10 | ||
| GB201417957A GB201417957D0 (en) | 2014-10-10 | 2014-10-10 | Fluorescent synthetic retinoids |
| GB201419496A GB201419496D0 (en) | 2014-10-31 | 2014-10-31 | Fluorescent synthetic retinoids |
| GB1419496.3 | 2014-10-31 | ||
| PCT/GB2015/052956 WO2016055800A2 (en) | 2014-10-10 | 2015-10-09 | Fluorescent synthetic retinoids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537140A JP2017537140A (ja) | 2017-12-14 |
| JP2017537140A5 true JP2017537140A5 (enExample) | 2018-12-27 |
| JP7178781B2 JP7178781B2 (ja) | 2022-11-28 |
Family
ID=54697607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538469A Active JP7178781B2 (ja) | 2014-10-10 | 2015-10-09 | 蛍光合成レチノイド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10759762B2 (enExample) |
| EP (1) | EP3204357B1 (enExample) |
| JP (1) | JP7178781B2 (enExample) |
| CN (1) | CN107250112B (enExample) |
| AU (2) | AU2015329798C1 (enExample) |
| CA (1) | CA2962150C (enExample) |
| DK (1) | DK3204357T3 (enExample) |
| ES (1) | ES2909874T3 (enExample) |
| PL (1) | PL3204357T3 (enExample) |
| PT (1) | PT3204357T (enExample) |
| SI (1) | SI3204357T1 (enExample) |
| WO (1) | WO2016055800A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107176945B (zh) * | 2016-03-11 | 2021-06-08 | 中国科学院上海有机化学研究所 | 一种视黄酸类化合物、其制备方法、中间体及应用 |
| WO2018029473A1 (en) | 2016-08-09 | 2018-02-15 | University Of Durham | Synthetic retinoids (in cell modulation) |
| GB201910239D0 (en) | 2019-07-17 | 2019-08-28 | Lightox Ltd | Fluorescent systems for biological imaging and uses thereof |
| CN115335367B (zh) * | 2019-12-19 | 2024-08-13 | 奥弗恩制药公司 | 用于炎性疾病和雄性避孕的RAR-α化合物 |
| CN112479998B (zh) * | 2020-11-16 | 2022-03-15 | 广州中医药大学(广州中医药研究院) | 一种二氢喹啉类荧光探针及其制备方法与应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH651034A5 (de) * | 1982-05-12 | 1985-08-30 | Hoffmann La Roche | Chroman-, thiochroman- oder 1,2,3,4-tetrahydrochinolinderivate und ihre verwendung als arzneimittel-wirkstoffe. |
| EP0130795B1 (en) * | 1983-07-05 | 1988-11-23 | Pfizer Inc. | Carboxylic acid derivatives useful for inhibiting the degradation of cartilage |
| US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
| US4810804A (en) | 1987-03-26 | 1989-03-07 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity |
| US5023341A (en) | 1989-09-19 | 1991-06-11 | Allergan, Inc. | Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity |
| US4980369A (en) | 1989-09-19 | 1990-12-25 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity |
| US5324840A (en) * | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
| JPH08505852A (ja) * | 1993-01-11 | 1996-06-25 | リガンド・ファーマシューティカルズ・インコーポレーテッド | レチノイドｘレセプターに対する選択性を有する化合物 |
| WO1997012853A1 (en) | 1995-10-06 | 1997-04-10 | Ligand Pharmaceuticals Incorporated | Dimer-selective rxr modulators and methods for their use |
| AU4080597A (en) | 1996-08-23 | 1998-03-06 | Board Of Regents For Oklahoma State University, The | Heteroarotinoids-anticancer agents with receptor specificity and tgase activity |
| AU3770600A (en) | 1999-04-06 | 2000-10-23 | Bristol-Myers Squibb Company | Selective retinoic acid analogs |
| US6906057B1 (en) * | 1999-06-11 | 2005-06-14 | Allergan, Inc. | Methods for modulating FXR receptor activity |
| US6127382A (en) * | 1999-08-16 | 2000-10-03 | Allergan Sales, Inc. | Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
| JP2004505519A (ja) | 2000-07-13 | 2004-02-19 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Ｍｐｅｇ−４符号器及び斯様な符号器の出力符号化信号 |
| DE60116642T2 (de) | 2000-08-29 | 2006-11-09 | Allergan, Inc., Irvine | Verbindungen mit cytochrom p450ra1 hemmenden aktivität |
| US6387951B1 (en) * | 2000-08-29 | 2002-05-14 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
| US20030083357A1 (en) * | 2001-08-17 | 2003-05-01 | Magnus Pfahl | Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia |
| WO2005017185A2 (en) * | 2003-07-16 | 2005-02-24 | Ligand Pharmceuticals Incorporated | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS |
| CA2550010A1 (en) * | 2003-12-17 | 2005-06-30 | Allergan, Inc. | Methods for treating retinoid responsive disorders using selective inhibitors of cyp26a and cyp26b |
| JP2006063064A (ja) * | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| JP2009512637A (ja) * | 2005-09-30 | 2009-03-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 異常脂血症、高コレステロール血症及び糖尿病の処置のためのｒｘｒアゴニストとしてのジヒドロ−［１ｈ］−キノリン−２−オン誘導体 |
| US20100247679A1 (en) * | 2006-04-24 | 2010-09-30 | Alltech, Inc. | Methods and compositions for altering cell function |
| CA2662218A1 (en) | 2006-08-29 | 2008-03-06 | Reinnervate Limited | Retinoid compounds and their use |
| US8070989B2 (en) | 2007-08-09 | 2011-12-06 | Hallstar Innovations Corp. | Photostabilization of retinoids with alkoxycrylene compounds |
| CA2816753A1 (en) * | 2010-11-08 | 2012-05-18 | Lycera Corporation | N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of rory activity and the treatment of diseases |
| WO2012104782A1 (en) * | 2011-02-03 | 2012-08-09 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
| EP2755942A2 (en) | 2011-09-15 | 2014-07-23 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | Therapeutic compounds |
| TW201414704A (zh) * | 2012-07-02 | 2014-04-16 | Biogen Idec Inc | 作爲ＲＯＲ－γ受體之反向促效劑之含聯芳化合物 |
-
2015
- 2015-10-09 SI SI201531818T patent/SI3204357T1/sl unknown
- 2015-10-09 US US15/514,923 patent/US10759762B2/en active Active
- 2015-10-09 DK DK15798539.1T patent/DK3204357T3/da active
- 2015-10-09 AU AU2015329798A patent/AU2015329798C1/en active Active
- 2015-10-09 CA CA2962150A patent/CA2962150C/en active Active
- 2015-10-09 ES ES15798539T patent/ES2909874T3/es active Active
- 2015-10-09 PT PT157985391T patent/PT3204357T/pt unknown
- 2015-10-09 WO PCT/GB2015/052956 patent/WO2016055800A2/en not_active Ceased
- 2015-10-09 EP EP15798539.1A patent/EP3204357B1/en active Active
- 2015-10-09 CN CN201580067667.6A patent/CN107250112B/zh active Active
- 2015-10-09 PL PL15798539T patent/PL3204357T3/pl unknown
- 2015-10-09 JP JP2017538469A patent/JP7178781B2/ja active Active
-
2019
- 2019-05-28 AU AU2019203709A patent/AU2019203709B2/en active Active
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