AU2015329798C1 - Fluorescent synthetic retinoids - Google Patents

Fluorescent synthetic retinoids Download PDF

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Publication number
AU2015329798C1
AU2015329798C1 AU2015329798A AU2015329798A AU2015329798C1 AU 2015329798 C1 AU2015329798 C1 AU 2015329798C1 AU 2015329798 A AU2015329798 A AU 2015329798A AU 2015329798 A AU2015329798 A AU 2015329798A AU 2015329798 C1 AU2015329798 C1 AU 2015329798C1
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compound
cell
formula
stem cell
differentiation
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AU2015329798B2 (en
AU2015329798A1 (en
Inventor
Todd Marder
Andrew Whiting
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HIGH FORCE RESEARCH Ltd
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High Force Res Ltd
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Priority claimed from GB201417957A external-priority patent/GB201417957D0/en
Priority claimed from GB201419496A external-priority patent/GB201419496D0/en
Application filed by High Force Res Ltd filed Critical High Force Res Ltd
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Priority to AU2019203709A priority Critical patent/AU2019203709B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0693—Tumour cells; Cancer cells
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N21/643—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
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AU2015329798A 2014-10-10 2015-10-09 Fluorescent synthetic retinoids Active AU2015329798C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019203709A AU2019203709B2 (en) 2014-10-10 2019-05-28 Fluorescent synthetic retinoids

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1417957.6 2014-10-10
GB201417957A GB201417957D0 (en) 2014-10-10 2014-10-10 Fluorescent synthetic retinoids
GB201419496A GB201419496D0 (en) 2014-10-31 2014-10-31 Fluorescent synthetic retinoids
GB1419496.3 2014-10-31
PCT/GB2015/052956 WO2016055800A2 (en) 2014-10-10 2015-10-09 Fluorescent synthetic retinoids

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AU2019203709A Division AU2019203709B2 (en) 2014-10-10 2019-05-28 Fluorescent synthetic retinoids

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AU2015329798A1 AU2015329798A1 (en) 2017-05-11
AU2015329798B2 AU2015329798B2 (en) 2019-07-11
AU2015329798C1 true AU2015329798C1 (en) 2019-10-24

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US (1) US10759762B2 (enExample)
EP (1) EP3204357B1 (enExample)
JP (1) JP7178781B2 (enExample)
CN (1) CN107250112B (enExample)
AU (2) AU2015329798C1 (enExample)
CA (1) CA2962150C (enExample)
DK (1) DK3204357T3 (enExample)
ES (1) ES2909874T3 (enExample)
PL (1) PL3204357T3 (enExample)
PT (1) PT3204357T (enExample)
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CN107176945B (zh) * 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用
EP3496711A1 (en) * 2016-08-09 2019-06-19 University Of Durham Synthetic retinoids (in cell modulation)
GB201910239D0 (en) * 2019-07-17 2019-08-28 Lightox Ltd Fluorescent systems for biological imaging and uses thereof
CN115335367B (zh) * 2019-12-19 2024-08-13 奥弗恩制药公司 用于炎性疾病和雄性避孕的RAR-α化合物
CN112479998B (zh) * 2020-11-16 2022-03-15 广州中医药大学(广州中医药研究院) 一种二氢喹啉类荧光探针及其制备方法与应用

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US4678793A (en) * 1982-05-12 1987-07-07 Hoffmann-La Roche Inc. Heterocyclic compounds
US5324840A (en) * 1992-06-11 1994-06-28 Allergan, Inc. Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
WO2002018361A2 (en) * 2000-08-29 2002-03-07 Allergan, Inc. Compounds having activity as inhibitors of cytochrome p450rai

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US5264578A (en) 1987-03-20 1993-11-23 Allergan, Inc. Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US4810804A (en) * 1987-03-26 1989-03-07 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity
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