JP7178781B2 - 蛍光合成レチノイド - Google Patents

蛍光合成レチノイド Download PDF

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JP7178781B2
JP7178781B2 JP2017538469A JP2017538469A JP7178781B2 JP 7178781 B2 JP7178781 B2 JP 7178781B2 JP 2017538469 A JP2017538469 A JP 2017538469A JP 2017538469 A JP2017538469 A JP 2017538469A JP 7178781 B2 JP7178781 B2 JP 7178781B2
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hydrogen
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JP2017537140A5 (enExample
JP2017537140A (ja
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アンドリュー ホワイティング
トッド マルダー
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ハイ フォース リサーチ リミテッド
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Priority claimed from GB201419496A external-priority patent/GB201419496D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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JP2017538469A 2014-10-10 2015-10-09 蛍光合成レチノイド Active JP7178781B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1417957.6 2014-10-10
GB201417957A GB201417957D0 (en) 2014-10-10 2014-10-10 Fluorescent synthetic retinoids
GB201419496A GB201419496D0 (en) 2014-10-31 2014-10-31 Fluorescent synthetic retinoids
GB1419496.3 2014-10-31
PCT/GB2015/052956 WO2016055800A2 (en) 2014-10-10 2015-10-09 Fluorescent synthetic retinoids

Publications (3)

Publication Number Publication Date
JP2017537140A JP2017537140A (ja) 2017-12-14
JP2017537140A5 JP2017537140A5 (enExample) 2018-12-27
JP7178781B2 true JP7178781B2 (ja) 2022-11-28

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US (1) US10759762B2 (enExample)
EP (1) EP3204357B1 (enExample)
JP (1) JP7178781B2 (enExample)
CN (1) CN107250112B (enExample)
AU (2) AU2015329798C1 (enExample)
CA (1) CA2962150C (enExample)
DK (1) DK3204357T3 (enExample)
ES (1) ES2909874T3 (enExample)
PL (1) PL3204357T3 (enExample)
PT (1) PT3204357T (enExample)
SI (1) SI3204357T1 (enExample)
WO (1) WO2016055800A2 (enExample)

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CN107176945B (zh) * 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用
EP3496711A1 (en) * 2016-08-09 2019-06-19 University Of Durham Synthetic retinoids (in cell modulation)
GB201910239D0 (en) * 2019-07-17 2019-08-28 Lightox Ltd Fluorescent systems for biological imaging and uses thereof
CN115335367B (zh) * 2019-12-19 2024-08-13 奥弗恩制药公司 用于炎性疾病和雄性避孕的RAR-α化合物
CN112479998B (zh) * 2020-11-16 2022-03-15 广州中医药大学(广州中医药研究院) 一种二氢喹啉类荧光探针及其制备方法与应用

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WO1998007716A2 (en) 1996-08-23 1998-02-26 The Board Of Regents For Oklahoma State University Heteroarotinoids-anticancer agents with receptor specificity and tgase activity
WO2000059861A1 (en) 1999-04-06 2000-10-12 Bristol-Myers Squibb Company Selective retinoic acid analogs
JP2002515025A (ja) 1995-10-06 2002-05-21 リガンド・ファーマシューティカルズ・インコーポレイテッド ダイマー選択的ｒｘｒモジュレーターおよびその使用方法
JP2004507531A (ja) 2000-08-29 2004-03-11 アラーガン、インコーポレイテッド シトクロムｐ４５０ｒａｉ阻害剤としての活性を有する化合物
JP2010503615A (ja) 2006-08-29 2010-02-04 レインナーベート リミテッド レチノイド化合物およびそれらの使用
JP2012533520A (ja) 2009-07-31 2012-12-27 ホールスター イノベーションズ コーポレイション アルコキシクリレン化合物による、レチノイドの光安定化作用
JP2014527083A (ja) 2011-09-15 2014-10-09 アリゾナ ボード オブ リージェンツ， ア ボディー コーポレイト オブ ザ ステート オブ アリゾナ， アクティング フォー アンド オン ビハーフ オブ アリゾナ ステート ユニバーシティー 治療用化合物

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