CN111183234A - 在表达pnpla3 i148m变异的患者的肝病治疗中对hsd17b13的抑制 - Google Patents

在表达pnpla3 i148m变异的患者的肝病治疗中对hsd17b13的抑制 Download PDF

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CN111183234A
CN111183234A CN201880065116.XA CN201880065116A CN111183234A CN 111183234 A CN111183234 A CN 111183234A CN 201880065116 A CN201880065116 A CN 201880065116A CN 111183234 A CN111183234 A CN 111183234A
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seq
protein
hsd17b13
nucleic acid
encoding
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辛玉蓉
J·格罗马达
程希平
F·杜威
T·特斯洛维奇·多斯塔尔
C·舒尔曼
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Regeneron Pharmaceuticals Inc
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CN201880065116.XA 2017-10-11 2018-10-11 在表达pnpla3 i148m变异的患者的肝病治疗中对hsd17b13的抑制 Pending CN111183234A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762570985P 2017-10-11 2017-10-11
US62/570,985 2017-10-11
PCT/US2018/055377 WO2019075181A1 (en) 2017-10-11 2018-10-11 INHIBITION OF HSD17B13 IN THE TREATMENT OF HEPATIC DISEASE IN PATIENTS EXPRESSING PNPLA3 I148M VARIATION

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CN111183234A true CN111183234A (zh) 2020-05-19

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US (4) US10961583B2 (enExample)
EP (2) EP3695012B1 (enExample)
JP (2) JP7434151B2 (enExample)
KR (2) KR102694809B1 (enExample)
CN (1) CN111183234A (enExample)
AU (2) AU2018348195B2 (enExample)
CA (1) CA3078883A1 (enExample)
IL (2) IL273550B2 (enExample)
MX (1) MX2020003561A (enExample)
RU (1) RU2020115526A (enExample)
SG (1) SG11202003254SA (enExample)
WO (1) WO2019075181A1 (enExample)

Cited By (2)

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CN112626199A (zh) * 2021-01-04 2021-04-09 杭州艾迪康医学检验中心有限公司 检测慢性肝炎转化为肝硬化的风险预测位点的引物和方法
CN118813778A (zh) * 2024-07-01 2024-10-22 北京泛生子基因科技有限公司 一种试剂盒、使用方法及存储介质

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US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
RU2019126483A (ru) 2017-01-23 2021-02-24 Ридженерон Фармасьютикалз, Инк. Варианты 17-бета-гидроксистероиддегидрогеназы 13 (hsd17b13) и их применение
KR102694809B1 (ko) 2017-10-11 2024-08-16 리제너론 파마슈티칼스 인코포레이티드 Pnpla3 i148m 변이를 발현하는 환자의 간 질환의 치료에서의 hsd17b13의 저해
MX2020009812A (es) 2018-03-21 2021-01-08 Regeneron Pharma COMPOSICIONES DE ARNI DE 17ß-HIDROXIESTEROIDE DESHIDROGENASA TIPO 13 (HSD17B13) Y MÉTODOS DE USO DE LAS MISMAS.
MX2021007503A (es) * 2018-12-21 2021-08-05 Ionis Pharmaceuticals Inc Moduladores de la expresion de hsd17b13.
MA56457A (fr) 2019-07-02 2022-05-11 Regeneron Pharma Modulateurs de hsd17b13 et leurs procédés d'utilisation
WO2021211959A2 (en) * 2020-04-18 2021-10-21 Inipharm, Inc. Methods and compositions for treating drug induced steatohepatitis
WO2021211981A1 (en) * 2020-04-18 2021-10-21 Inipharm, Inc. Substrate selective hsd17b13 inhibitors and uses thereof
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CA3229569A1 (en) 2021-08-20 2023-02-23 Enanta Pharmaceuticals, Inc. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof
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CN114262738B (zh) * 2021-12-31 2023-03-31 吉林大学第一医院 Hsd17b13基因多态性在中重度mafld诊断中的应用
TW202400791A (zh) * 2022-05-06 2024-01-01 大陸商蘇州瑞博生物技術股份有限公司 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途
JP2025533088A (ja) * 2022-10-07 2025-10-03 ファイザー・インク Ｈｓｄ１７ｂ１３阻害薬および／または分解薬
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WO2025012425A1 (en) 2023-07-13 2025-01-16 Enyo Pharma Tromethamine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
WO2025012422A1 (en) 2023-07-13 2025-01-16 Enyo Pharma L-arginine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
WO2025098440A1 (zh) * 2023-11-08 2025-05-15 浙江扬厉医药技术有限公司 抑制PNPLA3表达的双链siRNA以及其缀合物

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