CN110997724A - 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 - Google Patents

使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 Download PDF

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Publication number
CN110997724A
CN110997724A CN201880051242.XA CN201880051242A CN110997724A CN 110997724 A CN110997724 A CN 110997724A CN 201880051242 A CN201880051242 A CN 201880051242A CN 110997724 A CN110997724 A CN 110997724A
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China
Prior art keywords
btn1a1
molecule
gal
less
antibody
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Chinese (zh)
Inventor
斯蒂芬·成汉·柳
以斯拉·明·哲·钟
奉永植
金龙洙
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Stcube & Co Inc
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Stcube & Co Inc
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Priority to CN202511512743.1A priority Critical patent/CN121609797A/zh
Priority to CN202511334876.4A priority patent/CN121248782A/zh
Publication of CN110997724A publication Critical patent/CN110997724A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201880051242.XA 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 Pending CN110997724A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202511512743.1A CN121609797A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CN202511334876.4A CN121248782A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762516071P 2017-06-06 2017-06-06
US62/516,071 2017-06-06
PCT/US2018/036026 WO2018226671A1 (en) 2017-06-06 2018-06-05 Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands

Related Child Applications (2)

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CN202511334876.4A Division CN121248782A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CN202511512743.1A Division CN121609797A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法

Publications (1)

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CN110997724A true CN110997724A (zh) 2020-04-10

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CN201880051242.XA Pending CN110997724A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CN202511334876.4A Pending CN121248782A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CN202511512743.1A Pending CN121609797A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法

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CN202511334876.4A Pending CN121248782A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CN202511512743.1A Pending CN121609797A (zh) 2017-06-06 2018-06-05 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法

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US (2) US11542331B2 (https=)
EP (1) EP3635007A1 (https=)
JP (2) JP2020522562A (https=)
KR (2) KR20250097991A (https=)
CN (3) CN110997724A (https=)
WO (1) WO2018226671A1 (https=)

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WO2015038832A1 (en) 2013-09-11 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Arrays of accelerating structures and rapid imaging for facilitating rapid radiation therapies
US12215151B2 (en) 2017-05-31 2025-02-04 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1
EP3654976A1 (en) 2017-07-21 2020-05-27 Varian Medical Systems, Inc. Methods of use of ultra-high dose rate radiation and therapeutic agents
US11098093B2 (en) 2019-01-07 2021-08-24 Shattuck Labs, Inc. Heterodimeric proteins for modulating gamma delta T cells
WO2020146393A1 (en) 2019-01-07 2020-07-16 Shattuck Labs. Inc. Heterodimeric proteins for modulating gamma delta t cells
KR102162363B1 (ko) 2020-03-02 2020-10-06 현대건설기계 주식회사 카운터 웨이트 장착 장치 및 이를 포함하는 작업기계
WO2022093841A1 (en) * 2020-10-26 2022-05-05 Puretech Lyt, Inc. Anti-galectin-9 antibodies and uses thereof in the treatment of ocular melanoma
WO2023164689A2 (en) * 2022-02-28 2023-08-31 University Of Massachusetts Targeting neuropilin 2 (nrp2) in lethal prostate cancer
WO2025175166A1 (en) * 2024-02-15 2025-08-21 Stcube & Co., Inc. Combination therapies with btn1a1 binding proteins and chemotherapeutic agents

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CN101754771B (zh) * 2007-05-17 2015-03-04 健泰科生物技术公司 抗神经毡蛋白2抗体对肿瘤转移的抑制
WO2015185875A2 (fr) * 2014-06-06 2015-12-10 Universite Sciences Technologies Lille Anticorps dirigé contre la galectine 9 et inhibiteur de l'activité suppressive des lymphocytes t régulateurs
WO2017172517A1 (en) * 2016-03-29 2017-10-05 Stcube & Co., Inc. Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins
CN108025025A (zh) * 2015-05-22 2018-05-11 斯特库伯株式会社 癌症治疗靶点的筛选方法
WO2018222689A1 (en) * 2017-05-31 2018-12-06 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
CN109415437A (zh) * 2015-12-02 2019-03-01 斯特库伯株式会社 与btn1a1免疫特异性结合的抗体和分子及其治疗用途
CN111051346A (zh) * 2017-05-31 2020-04-21 斯特库伯株式会社 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法
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