CN110891600B - 表达寨卡病毒蛋白的重组麻疹病毒及其应用 - Google Patents

表达寨卡病毒蛋白的重组麻疹病毒及其应用 Download PDF

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CN110891600B
CN110891600B CN201880047044.6A CN201880047044A CN110891600B CN 110891600 B CN110891600 B CN 110891600B CN 201880047044 A CN201880047044 A CN 201880047044A CN 110891600 B CN110891600 B CN 110891600B
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zikv
protein
seq
gly
leu
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CN110891600A (zh
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F·坦吉
E·西蒙-洛列里
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Centre National de la Recherche Scientifique
Institut Pasteur
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Institut Pasteur
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CN201880047044.6A 2017-06-07 2018-06-06 表达寨卡病毒蛋白的重组麻疹病毒及其应用 Expired - Fee Related CN110891600B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305676.3 2017-06-07
EP17305676.3A EP3412307A1 (en) 2017-06-07 2017-06-07 Recombinant measles virus expressing zika virus proteins and their applications
PCT/EP2018/064943 WO2018224573A1 (en) 2017-06-07 2018-06-06 Recombinant measles virus expressing zika virus proteins and their applications

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CN110891600A CN110891600A (zh) 2020-03-17
CN110891600B true CN110891600B (zh) 2024-04-02

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US (1) US11857616B2 (enExample)
EP (2) EP3412307A1 (enExample)
JP (2) JP2020524496A (enExample)
CN (1) CN110891600B (enExample)
AU (1) AU2018281889B2 (enExample)
BR (1) BR112019025310A2 (enExample)
CA (1) CA3064322A1 (enExample)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3031923A1 (en) * 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
KR20190003471A (ko) * 2016-02-25 2019-01-09 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 지카 바이러스에 대항하는 신규한 백신
EP3412307A1 (en) * 2017-06-07 2018-12-12 Institut Pasteur Recombinant measles virus expressing zika virus proteins and their applications
KR101966841B1 (ko) * 2018-12-12 2019-04-08 대한민국 지카바이러스 e 단백질 유래의 재조합 항원 및 이의 용도
AU2020273263A1 (en) * 2019-04-10 2021-12-02 Katholieke Universiteit Leuven Chimeric Zika-Japanese encephalitis virus
CN113999823B (zh) * 2021-12-30 2022-04-26 北京赛尔富森生物科技有限公司 D8基因型嵌合麻疹病毒减毒株和制备方法及用途
WO2023164441A1 (en) * 2022-02-22 2023-08-31 Vyro Bio Inc. Nucleic acid compositions for delivering exogenous polynucleotides and methods of use
AU2023362558A1 (en) * 2022-10-21 2025-05-08 Theravectys Polynucleotides and lentiviral vectors expressing non-structural antigens of a flavivirus selected from the group of denv, zikv and yfv, inducing protective cd8+ t-cell immunity in a host

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104918952A (zh) * 2012-09-27 2015-09-16 巴斯德研究院 表达屈曲病毒多肽的重组麻疹病毒及其应用
WO2016199936A1 (ja) * 2015-06-12 2016-12-15 国立大学法人三重大学 ヒトパラインフルエンザ2型ウイルスベクター及びワクチン
WO2016210127A1 (en) * 2015-06-25 2016-12-29 Technovax, Inc. Flavivirus and alphavirus virus-like particles (vlps)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1375512B1 (en) 2002-06-20 2009-07-22 Institut Pasteur Infectious cDNA of an approved vaccine strain of measles virus. Use for immunogenic compositions
DK1939214T3 (da) 2006-12-22 2013-10-14 Pasteur Institut Celler og metodik til at generere ikke-segmenterede negativstrengede RNA-vira
EP3184119A1 (en) * 2015-12-23 2017-06-28 Themis Bioscience GmbH Chromatography based purification strategies for measles scaffold based viruses
EP3412307A1 (en) * 2017-06-07 2018-12-12 Institut Pasteur Recombinant measles virus expressing zika virus proteins and their applications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104918952A (zh) * 2012-09-27 2015-09-16 巴斯德研究院 表达屈曲病毒多肽的重组麻疹病毒及其应用
WO2016199936A1 (ja) * 2015-06-12 2016-12-15 国立大学法人三重大学 ヒトパラインフルエンザ2型ウイルスベクター及びワクチン
WO2016210127A1 (en) * 2015-06-25 2016-12-29 Technovax, Inc. Flavivirus and alphavirus virus-like particles (vlps)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Role of a ZIKV CHIM in vaccine evaluation;Anna Durbin;《Johns Hopkins Bloomberg School of Public Health WHO Zika Workshop》;20170602;第22页表格 *
寨卡病毒研究进展;谌章舟等;《中国病毒病杂志》;20160920(第05期);第394页第1栏倒数第1段 *

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MX2019014674A (es) 2020-09-07
EP3634482A1 (en) 2020-04-15
US11857616B2 (en) 2024-01-02
JP2020524496A (ja) 2020-08-20
JP2023107780A (ja) 2023-08-03
WO2018224573A8 (en) 2019-07-25
US20200237893A1 (en) 2020-07-30
CA3064322A1 (en) 2018-12-13
BR112019025310A2 (pt) 2020-06-23
AU2018281889B2 (en) 2022-03-03
CN110891600A (zh) 2020-03-17
EP3412307A1 (en) 2018-12-12
WO2018224573A1 (en) 2018-12-13
AU2018281889A1 (en) 2019-12-19

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