CN1107678C - 高亲脂性喜树碱衍生物，其制备方法及其用途 - Google Patents

高亲脂性喜树碱衍生物，其制备方法及其用途 Download PDF

Info

Publication number
CN1107678C
CN1107678C CN97197194A CN97197194A CN1107678C CN 1107678 C CN1107678 C CN 1107678C CN 97197194 A CN97197194 A CN 97197194A CN 97197194 A CN97197194 A CN 97197194A CN 1107678 C CN1107678 C CN 1107678C
Authority
CN
China
Prior art keywords
camptothecine
compound
group
alkyl
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN97197194A
Other languages
English (en)
Chinese (zh)
Other versions
CN1227559A (zh
Inventor
F·H·赫施尔
K·哈里达斯
P·斯特哈拉穆鲁
D·穆拉里
D·G·勒迪
S·姚
P·彼特路鲁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioNumerik Pharmaceuticals Inc
Original Assignee
BioNumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNumerik Pharmaceuticals Inc filed Critical BioNumerik Pharmaceuticals Inc
Publication of CN1227559A publication Critical patent/CN1227559A/zh
Application granted granted Critical
Publication of CN1107678C publication Critical patent/CN1107678C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
CN97197194A 1996-08-19 1997-08-15 高亲脂性喜树碱衍生物，其制备方法及其用途 Expired - Lifetime CN1107678C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2417196P 1996-08-19 1996-08-19
US60/024,171 1996-08-19

Publications (2)

Publication Number Publication Date
CN1227559A CN1227559A (zh) 1999-09-01
CN1107678C true CN1107678C (zh) 2003-05-07

Family

ID=21819224

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97197194A Expired - Lifetime CN1107678C (zh) 1996-08-19 1997-08-15 高亲脂性喜树碱衍生物，其制备方法及其用途

Country Status (17)

Country Link
US (3) US5910491A (enExample)
EP (1) EP0925301B1 (enExample)
JP (1) JP4364305B2 (enExample)
KR (1) KR100516593B1 (enExample)
CN (1) CN1107678C (enExample)
AT (1) ATE261974T1 (enExample)
AU (1) AU718799C (enExample)
BR (1) BR9711319B1 (enExample)
CA (1) CA2262745C (enExample)
DE (1) DE69728152T2 (enExample)
DK (1) DK0925301T3 (enExample)
ES (1) ES2214634T3 (enExample)
IL (1) IL127800A (enExample)
NZ (1) NZ334240A (enExample)
PT (1) PT925301E (enExample)
WO (1) WO1998007727A1 (enExample)
ZA (1) ZA977437B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743917B2 (en) 1993-06-30 2004-06-01 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6136978A (en) * 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6150343A (en) 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6407118B1 (en) * 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
EP0925301B1 (en) * 1996-08-19 2004-03-17 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6169080B1 (en) * 1997-02-13 2001-01-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6057303A (en) * 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
DE69901379T2 (de) * 1999-03-09 2002-11-07 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori, Mailand/Milano Camptothecin-Derivate mit Antitumor-Wirkung
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
AU4822500A (en) * 1999-05-04 2000-11-17 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7332550B2 (en) * 2000-10-06 2008-02-19 Carnegie Mellon University Stabilization of transition metal complexes for catalysis in diverse environments
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
WO2003101406A1 (en) * 2002-06-03 2003-12-11 California Pacific Medical Center Homo-camptothecin derivatives
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US6723849B1 (en) * 2002-10-25 2004-04-20 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ZA200604758B (en) * 2003-12-17 2007-10-31 Bionumerik Pharmaceuticals Inc Process for making camptothecin derivatives
DK1694242T3 (da) * 2003-12-17 2014-06-30 Bionumerik Pharmaceuticals Inc Fremgangsmåde til fremstilling af farmaceutiske 7-(2-trimethylsilylethyl)camptothecinpræparater
US7030243B1 (en) 2004-10-28 2006-04-18 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US20060094692A1 (en) * 2004-10-28 2006-05-04 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CA2648895C (en) * 2006-04-19 2015-02-10 Bionumerik Pharmaceuticals, Inc. Camptothecin-analog with a novel, "flipped" lactone-stable, e-ring and methods for making and using same
US20110028536A1 (en) * 2006-08-18 2011-02-03 Gjerset Ruth A Methods and compositions for topoisomerase i modulated tumor suppression
JP2010511427A (ja) * 2006-12-01 2010-04-15 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ コラーゲン阻害剤を含む医療デバイス
US7687497B2 (en) 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
CA2700904C (en) * 2007-10-16 2014-10-14 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
CA2700905C (en) * 2007-10-16 2015-02-10 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
US7687496B2 (en) 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
US20140073793A1 (en) * 2012-09-07 2014-03-13 BioNumeric Pharmaceuticals, Inc. Germanium-containing camptothecin analogues
CN110590796B (zh) * 2018-06-12 2022-07-15 青岛海洋生物医药研究院股份有限公司 喜树碱衍生物及其制备方法和应用
WO2025077767A1 (zh) * 2023-10-10 2025-04-17 上海翊维康医药有限责任公司 新的i型拓扑异构酶抑制剂及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2150234A1 (de) * 1971-10-08 1973-04-12 Basf Ag Verfahren zur herstellung von camptothecin und camptothecin-derivaten
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
DE2534601C2 (de) * 1975-08-02 1987-01-22 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Camptothecin und Camptothecin-Derivaten
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US5405963A (en) * 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
EP0925301B1 (en) * 1996-08-19 2004-03-17 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same

Also Published As

Publication number Publication date
PT925301E (pt) 2004-08-31
WO1998007727A1 (en) 1998-02-26
IL127800A (en) 2005-11-20
CN1227559A (zh) 1999-09-01
JP4364305B2 (ja) 2009-11-18
EP0925301B1 (en) 2004-03-17
CA2262745A1 (en) 1998-02-26
ATE261974T1 (de) 2004-04-15
BR9711319A (pt) 2000-01-18
KR20000068135A (ko) 2000-11-25
BR9711319B1 (pt) 2009-08-11
AU4020497A (en) 1998-03-06
ES2214634T3 (es) 2004-09-16
NZ334240A (en) 2000-01-28
AU718799B2 (en) 2000-04-20
IL127800A0 (en) 1999-10-28
CA2262745C (en) 2006-04-04
AU718799C (en) 2004-02-12
DE69728152D1 (en) 2004-04-22
EP0925301A1 (en) 1999-06-30
US6028078A (en) 2000-02-22
DE69728152T2 (de) 2004-08-05
KR100516593B1 (ko) 2005-09-22
DK0925301T3 (da) 2004-07-12
ZA977437B (en) 1999-02-19
US6194579B1 (en) 2001-02-27
US5910491A (en) 1999-06-08
JP2000516933A (ja) 2000-12-19

Similar Documents

Publication Publication Date Title
CN1107678C (zh) 高亲脂性喜树碱衍生物，其制备方法及其用途
EP1362855B1 (en) Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US8658837B2 (en) Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
TWI720803B (zh) 製備ｐｄｅ４抑制劑之方法
PL186446B1 (pl) Związki pośrednie do wytwarzania pochodnych kamptotecyny (CPT-11) oraz sposóby wytwarzania tych związków
CN111620903A (zh) C-核苷类似物以及用于合成瑞德西韦合成的含腈c-核苷类化合物的制备方法及其应用
EP2132179B1 (en) Process for preparing isomers of carmoterol
KR20000070756A (ko) 동맥경화증 및 지단백질과잉혈증 치료에 사용되는 2-아미노 치환된 피리딘
CN1117754C (zh) 吲哚并吗啡喃衍生物及其组合物
WO2008077305A1 (en) Quinoline compounds, intermediates, prepartion methods and uses thereof
CA2591397A1 (en) 4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments
CN1228341C (zh) 喜树碱的制备方法
CN104507948A (zh) 含氮杂环n-氧化物化合物的制造方法
CN113493430B (zh) 一种贝前列素及其盐的中间体及其制备方法
CN1310920C (zh) 消旋和光活胡桐素a及其类似物的制备方法
CN1122669C (zh) 8H－噻吩并[2，3－b]吡咯嗪－8－酮化合物，其制备方法以及含有它们的药物组合物
CN1318054A (zh) 新化合物
CN1273480C (zh) 一类17－α－羟基甾体内酯、合成方法及其用途
KR100396431B1 (ko) 2-술포닐피리딘 유도체 및 2-[((2-피리딜)메틸)티오]-1ｈ-벤즈이
JP4887503B2 (ja) ９−置換−１９−ノルビタミンｄ誘導体
JP2001122870A (ja) イソクマリン誘導体およびそれらの製造方法
JP3857353B2 (ja) ピロロキノリン誘導体
HK40068745A (en) Process for the preparation of a pde4 inhibitor
TW202440544A (zh) 具有sting抑制作用的含肟化合物及其藥物組合物和用途
JP2009132650A (ja) イソオキサゾリジン化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1050053

Country of ref document: HK

CX01 Expiry of patent term

Granted publication date: 20030507

CX01 Expiry of patent term