CN110680844A - Medicine for treating insect bite and preparation method thereof - Google Patents

Medicine for treating insect bite and preparation method thereof Download PDF

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Publication number
CN110680844A
CN110680844A CN201911112135.6A CN201911112135A CN110680844A CN 110680844 A CN110680844 A CN 110680844A CN 201911112135 A CN201911112135 A CN 201911112135A CN 110680844 A CN110680844 A CN 110680844A
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Prior art keywords
extract
selfheal
purslane
medicine
menthol
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CN201911112135.6A
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钱英
胡姗姗
黄小容
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Affiliated Hospital of Zunyi Medical University
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Affiliated Hospital of Zunyi Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/02—Ammonia; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Pest Control & Pesticides (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the technical field of medicaments and preparation thereof, and discloses a medicament for treating insect bite and a preparation method thereof, wherein the medicament comprises the following raw materials in parts by weight: 20-35 g/L of menthol, 60-120 ml/L of 7.5-12.5% ammonia water, 30-50 ml/L of purslane extract, 50-70 ml/L of selfheal extract, and the balance of ethanol solution; the preparation process comprises weighing Mentholum according to a certain proportion, dissolving in ethanol solution containing appropriate amount, slowly adding ammonia water, slowly adding herba Portulacae extract and Prunellae Spica extract respectively, stirring, and adding ethanol solution to a designed preparation amount to obtain the medicine for treating insect bite. The medicine for treating insect bite is prepared by mixing the menthol, ammonia water, the purslane extract and the selfheal extract, and has good mosquito and insect repelling effect; meanwhile, the raw materials of the medicinal materials adopt Chinese herbal medicine components, so that the medicinal material has no toxic or side effect, has obvious effects on inflammation, red swelling and itching symptoms caused by biting of mosquito bites, and has quick response on itching relieving effect.

Description

Medicine for treating insect bite and preparation method thereof
Technical Field
The invention relates to the technical field of medicines and preparation thereof, in particular to a medicine for treating insect bite and a preparation method thereof.
Background
In summer and autumn, particularly in the evening, the peak period of insect activity is when people are most susceptible to the bite of insects, particularly mosquitoes. Once the skin is bitten, the skin is often itchy and intolerant, and the skin becomes red and swollen. If the itching relieving and the bag eliminating can not be timely performed and the patient continues to grasp the skin, the skin is easy to be scratched, infection and ulcer are caused, and scars can be left in severe cases.
The commercially available products for preventing and treating mosquito bites mainly comprise floral water and essential balm. The liquid products are prepared from menthol, ethanol and essence as main components, and comprise anophelifuge, Moschus and calculus bovis due to different varieties. The mosquito repellent is mainly mosquito repellent ester, the component of the mosquito repellent is pesticide, and the mosquito repellent is sprayed on the skin in a large area for a long time, so that the mosquito repellent has no side effect and is a problem which is controversial at present. When sprayed on the skin, the product can generate transient and slight cooling effect, but the main function of the product is to emphasize mosquito repelling, and the product has very limited effects on removing miliaria, relieving itching, eliminating red swelling and rash, and is difficult to effectively control pruritus symptoms.
Disclosure of Invention
Based on the above problems, the present invention provides a medicine for treating insect bites and a preparation method thereof, which has good mosquito and insect repelling effects; meanwhile, the raw materials of the medicinal materials adopt Chinese herbal medicine components, so that the medicinal composition has no toxic or side effect, has obvious effects on inflammation, red swelling and itching symptoms caused by biting of mosquito bites, and has quick response on itching relieving effect.
In order to solve the technical problems, the invention provides a medicine for treating insect bite, which comprises the following raw materials in parts by weight: 20-35 g/L of menthol, 60-120 ml/L of 7.5-12.5% ammonia water, 30-50 ml/L of purslane extract, 50-70 ml/L of selfheal extract, and the balance of ethanol solution.
Further, the concentration of the ethanol solution was 75%.
In order to solve the above technical problems, the present invention also provides a method for preparing a medicine for treating insect bites, comprising the steps of:
the method comprises the following steps: weighing the menthol according to a designed preparation amount and according to a ratio of 20-35 g/L, and dissolving the menthol in a container containing a proper amount of ethanol solution;
step two: after the menthol is completely dissolved, slowly adding 60-120 ml/L7.5-12.5% ammonia water into the container, and then uniformly stirring;
step three: slowly adding 30-50 ml/L of purslane extract and 50-70 ml/L of selfheal extract into the container respectively, and uniformly stirring;
step four: the ethanol solution was added to the vessel to the design preparation.
Further, the extraction method of the purslane extract and the hay extract comprises the following steps:
a1: drying purslane or selfheal at 80-90 ℃ for 8-12 hours, cooling to normal temperature, and then crushing the purslane or selfheal which is dried and cooled into powder;
a2: adding the prepared purslane powder or selfheal powder into deionized water, heating and boiling for 1-2 hours, continuously boiling until a concentrated solution with the density of 1.08-1.10 is obtained, and cooling;
a3: adding 95% ethanol into the cooled concentrated solution according to the volume ratio of 1:1, uniformly stirring, and standing for 12 hours;
a4: taking supernatant of the mixed solution after standing, and drying the supernatant in water bath at the temperature of 75-80 ℃ at constant temperature respectively to obtain brown solid substances, namely the purslane extract and the selfheal extract; then, the brown solid matters of the two are respectively crushed into powder for standby.
Compared with the prior art, the invention has the beneficial effects that: the medicine for treating insect bite is prepared by mixing the menthol, ammonia water, the purslane extract and the selfheal extract, and has good mosquito and insect repelling effect; meanwhile, the raw materials of the medicinal materials adopt Chinese herbal medicine components, so that the medicinal composition has no toxic or side effect, has obvious effects on inflammation, red swelling and itching symptoms caused by biting of mosquito bites, and has quick response on itching relieving effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.
Example 1:
a medicine for treating insect bite comprises the following raw materials and proportions: 20-35 g/L of menthol, 60-120 ml/L of 7.5-12.5% ammonia water, 30-50 ml/L of purslane extract, 50-70 ml/L of selfheal extract, and the balance of ethanol solution.
In the embodiment, the menthol has the effects of cooling and relieving itching on the skin and can also promote the transdermal absorption of the medicine;
because the secretion of acidic substances by mosquito bites is unpleasant to humans. And the ammonia water is alkalescent and can generate neutralization reaction with acidic secretion, thereby being convenient for quickly relieving itching.
The purslane extract is rich in components such as plant polysaccharide, vitamin, amino acid, flavone, alkaloid and the like, wherein the plant polysaccharide and the vitamin can nourish and lubricate the skin, promote the physiological function of epithelial cells to be normal, and reduce the generation of dead skin and cuticle caused by dryness; the amino acid can shrink vascular smooth muscle, and has central and peripheral functions of contraction, and can relieve skin and inhibit skin pruritus caused by dryness; the flavone and alkaloid can resist bacteria and inhibit common pathogenic dermatophytes;
the main active ingredients of the prunella vulgaris extract are triterpenes such as oleanolic acid and the like, and the prunella vulgaris extract has the effects of clearing liver, purging fire, clearing heat, resolving masses and the like, and can achieve the effects of relieving itching, reducing swelling and removing bags.
The preparation method of the medicine for treating insect bite by using the menthol, the ammonia water, the purslane extract and the selfheal extract in a mixing mode has good mosquito and insect repelling effect; meanwhile, the raw materials of the medicinal materials adopt Chinese herbal medicine components, so that the medicinal composition has no toxic or side effect, has obvious effects on inflammation, red swelling and itching symptoms caused by biting of mosquito bites, and has quick response on itching relieving effect.
The concentration of the ethanol solution in this example was 75%.
Example 2:
a method of preparing a medicament for treating insect bites, comprising the steps of:
the method comprises the following steps: weighing the menthol according to a designed preparation amount and according to a ratio of 20-35 g/L, and dissolving the menthol in a container containing a proper amount of ethanol solution;
step two: after the menthol is completely dissolved, slowly adding 60-120 ml/L7.5-12.5% ammonia water into the container, and then uniformly stirring;
step three: slowly adding 30-50 ml/L of purslane extract and 50-70 ml/L of selfheal extract into the container respectively, and uniformly stirring; the extraction method of the purslane extract and the hay extract comprises the following steps:
a1: drying purslane or selfheal at 80-90 ℃ for 8-12 hours, cooling to normal temperature, and then crushing the purslane or selfheal which is dried and cooled into powder;
a2: adding the prepared purslane powder or selfheal powder into deionized water, heating and boiling for 1-2 hours, continuously boiling until a concentrated solution with the density of 1.08-1.10 is obtained, and cooling;
a3: adding 95% ethanol into the cooled concentrated solution according to the volume ratio of 1:1, uniformly stirring, and standing for 12 hours;
a4: taking supernatant of the mixed solution after standing, and drying the supernatant in water bath at the temperature of 75-80 ℃ at constant temperature respectively to obtain brown solid substances, namely the purslane extract and the selfheal extract; then, the brown solid matters of the two are respectively crushed into powder for standby.
Step four: adding ethanol solution into the container to the designed preparation amount.
The above is an embodiment of the present invention. The embodiments and specific parameters in the embodiments are only for the purpose of clearly illustrating the process of verifying the invention and are not intended to limit the scope of the invention, which is defined by the claims, and all the equivalent structural changes made by applying the content of the specification of the invention should be covered by the scope of the invention.

Claims (4)

1. The medicine for treating insect bite is characterized by comprising the following raw materials in parts by weight: 20-35 g/L of menthol, 60-120 ml/L of 7.5-12.5% ammonia water, 30-50 ml/L of purslane extract, 50-70 ml/L of selfheal extract, and the balance of ethanol solution.
2. The medicine for treating insect bites as set forth in claim 1, wherein: the concentration of the ethanol solution is 75%.
3. A method for preparing a medicine for treating insect bites according to any one of claims 1 to 2 and a method for preparing the same, comprising the steps of:
the method comprises the following steps: weighing the menthol according to a designed preparation amount and according to a ratio of 20-35 g/L, and dissolving the menthol in a container containing a proper amount of ethanol solution;
step two: after the menthol is completely dissolved, slowly adding 60-120 ml/L7.5-12.5% ammonia water into the container, and then uniformly stirring;
step three: slowly adding 30-50 ml/L of purslane extract and 50-70 ml/L of selfheal extract into the container respectively, and uniformly stirring;
step four: the ethanol solution was added to the vessel to the design preparation.
4. The method of preparing a medicine for treating insect bites according to claim 3, wherein the purslane extract and the hay extract are extracted by:
a1: drying purslane or selfheal at 80-90 ℃ for 8-12 hours, cooling to normal temperature, and then crushing the purslane or selfheal which is dried and cooled into powder;
a2: adding the prepared purslane powder or selfheal powder into deionized water, heating and boiling for 1-2 hours, continuously boiling until a concentrated solution with the density of 1.08-1.10 is obtained, and cooling;
a3: adding 95% ethanol into the cooled concentrated solution according to the volume ratio of 1:1, uniformly stirring, and standing for 12 hours;
a4: taking supernatant of the mixed solution after standing, and drying the supernatant in water bath at the temperature of 75-80 ℃ at constant temperature respectively to obtain brown solid substances, namely the purslane extract and the selfheal extract; then, the brown solid matters of the two are respectively crushed into powder for standby.
CN201911112135.6A 2019-11-14 2019-11-14 Medicine for treating insect bite and preparation method thereof Pending CN110680844A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1759861A (en) * 2004-10-15 2006-04-19 孙民富 Recipe of drop pills of compound selfheal spike, and preparation method
CN103463188A (en) * 2013-09-27 2013-12-25 江门市新时代外用制剂有限公司 Relieving itching condensation and preparing method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1759861A (en) * 2004-10-15 2006-04-19 孙民富 Recipe of drop pills of compound selfheal spike, and preparation method
CN103463188A (en) * 2013-09-27 2013-12-25 江门市新时代外用制剂有限公司 Relieving itching condensation and preparing method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李兰夏等: "马齿苋加芒硝外敷治疗骨折部位红肿热痛", 《河北中医》 *
王凤魁等: "苍耳子酊和虫咬水的配制与临床应用", 《中医外治杂志》 *

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