CN102247533A - External drug for treating trauma - Google Patents
External drug for treating trauma Download PDFInfo
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- CN102247533A CN102247533A CN 201010191973 CN201010191973A CN102247533A CN 102247533 A CN102247533 A CN 102247533A CN 201010191973 CN201010191973 CN 201010191973 CN 201010191973 A CN201010191973 A CN 201010191973A CN 102247533 A CN102247533 A CN 102247533A
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- emulsifying agent
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- wound
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external drug for treating trauma and a preparation method thereof. The external drug is an external emulsion drug prepared from main raw materials of tea seed soil and immersion liquid of pseudo-ginseng, dragons blood, cattail pollen and bletilla rhizome, and auxiliary raw materials of antiseptic, anti-oxidant, emulsifier and the like. The external drug has the functions of blood stasis dissipation, detumescence, haemostasis, pain relieving, inflammation diminishing, flesh engendering and the like. The external drugs is utilized mainly for treating trauma such as traumatic injury, crush injury, sprain, injury caused by a knife and scald caused by fire or water, and has the characteristics of obvious treatment effects, short wound healing time and convenient use. The preparation method of the external drug has the advantages of simple and convenient operation.
Description
Technical field
The present invention relates to a kind of external used medicine for the treatment of wound and preparation method thereof.Specifically, relate to and a kind ofly (have another name called Oleum Camelliae with Oleum Camelliae, Camellia oil, Camellia oil, Oleum camelliae, camellia seed oil, the seed of Camelliasinensis(L.)Ktzel wet goods), Radix Notoginseng (also claims Radix Notoginseng, Typhonium flagelliforme (Lodd.) Blume etc.), Sanguis Draxonis, Pollen Typhae, Chinese medicine and sterilization antiseptic potassium sorbate such as Pseudobulbus Bletillae (Rhizoma Bletillae), antioxidant BHT, emulsifying agent D-95 molecular distillation glyceryl monostearate, emulsifying agent ZR-1, adjuvants such as ZR-2 are formed has to loose and becomes silted up, detumescence, hemostasis, pain relieving, antiinflammatory, functions such as granulation promoting cure mainly traumatic injury, knife injury, skin trauma, muscle injury, bump is sprained, integumentary musculature swelling due to the burn due to hot liquid or fire, congested, hemorrhage, exterior-applied emulsion medicine etc. wound.
Background technology
The external used medicine of existing treatment wound, have ethanol, iodine tincture, chelated iodine, hydrogen peroxide, the new gill that are used for sterilization go out or the like, the Western medicine preparation that is used for dephlogistication and promoting nuscle growth has sulfa powder, sulfanilamide ointment etc., being used for loosing, silt is stopped blooding and the Chinese medicine oil preparation of energy granulation promoting has WANHUAYOU, Flos Carthami wet goods, and Chinese medicine powder has YUNNAN BAIYAO.These medicines prove that through secular clinical application practice curative effect is in various degree all arranged, feelings due to wound that vary with each individual, have that concrete curative effect has and different.But also have following shortcoming: (1) analgesic effect is obvious inadequately; (2) diffusing silt detumescence effect is not strong; (3) anastalsis is not remarkable; (4) dephlogistication and promoting nuscle growth speed is slow; Wound healing time is long.
The objective of the invention is to overcome above-mentioned defective, external used medicine of a kind of treatment wound with significant curative effects such as diffusing silt, detumescence, hemostasis, pain relieving, antiinflammatory, granulation promotings and preparation method thereof is provided.
Summary of the invention
Test finds that Oleum Camelliae has following characteristic: (1) is rich in oleic acid, linoleic acid, linolenic acid, Palmic acid, stearic acid, aminoacid, protein, vitamins and other nutritious components and ingredient after deliberation; (2) oleic acid and linoleic acid content all are higher than olive oil, Oleum Arachidis hypogaeae semen, Oleum Glycines, Oleum Brassicae campestris, Oleum Gossypii semen and other vegetable oil; (3) have the significant medicinal functions such as silt, detumescence, hemostasis, pain relieving, sterilization, antiinflammatory, granulation promoting that loose; (4) there is stronger permeability to be easy to by skin absorbs.
Technical solution of the present invention is above-mentioned characteristic and the Radix Notoginseng according to Oleum Camelliae, Sanguis Draxonis, Pollen Typhae, the known medicinal function of Chinese medicines such as Pseudobulbus Bletillae (Rhizoma Bletillae), with Oleum Camelliae and contain Radix Notoginseng, Sanguis Draxonis, Pollen Typhae, the middle drug dipping of Pseudobulbus Bletillae (Rhizoma Bletillae) is a primary raw material, with the potassium sorbate is sterilization antiseptic, with the antioxidant BHT is antioxidant and stabilizing agent, with emulsifying agent D-95 molecular distillation glyceryl monostearate, emulsifying agent ZR-1, emulsifying agent ZR-2 etc. wherein the 1-3 kind as emulsifying agent, with water is the leaching solvent of Chinese medicine, filtration washing agent and diluent, with emulsifying agent make Oleum Camelliae emulsifying and with water solublity in the drug dipping mix homogeneously, various active ingredients mutually combine, make and having the silt of loosing, detumescence, pain relieving, hemostasis, antiinflammatory, the exterior-applied emulsion medicine of the treatment wound of significant curative effects such as granulation promoting, according to the ratio range of ingredient, this Emulsion medicine can be made emulsifiable paste shape or emulsion form.
The specific embodiment
The preparation method of the external used medicine of treatment wound of the present invention is as follows:
1, raw material is handled
(1) the Oleum Camelliae fresh Oleum Camelliae produced of milling process preferably is yellowish to golden yellow, limpid transparent, every index symbol should close national edible vegetable oil sanitary standard, the distinctive odor that Oleum Camelliae is arranged if any macroscopic float and precipitate, must be filtered with filter cloth.
(2) raw material is handled and is prepared water and preferably adopts deionized water or distilled water, also can adopt pure water or drinking water (hereinafter to be referred as water).
(3) with the mixed of dry traditional Chinese medicine decoction pieces, be ground into 40～100 purpose Chinese medicine powders by 2～10 parts of Radix Notoginseng, 1～5 part of Sanguis Draxonis, 1～5 part of Pollen Typhae, 1～5 part of Pseudobulbus Bletillae (Rhizoma Bletillae).
(4) Chinese medicine leaches consolidating by the weight of the weight of Chinese medicine powder and water: liquor ratio is 1: 2～1: 4, Chinese medicine powder was put into the normal-temperature water leaching 0.5～2 hour, reheat to 85～95 ℃, be incubated 5～20 minutes, be cooled to about 80 ℃ with filter cloth vacuum filtration or filter pressing, divide 2～3 washings with a small amount of warm boiled water, it is 2～5 times of Chinese medicine powder amount that control filtrate adds the wash water total amount, and filtering residue is deposited in addition, filtrate and wash water merge, and are middle drug dipping.
(5) it is Powdered to have the auxiliary agents such as potassium sorbate, antioxidant BHT of caking to be ground to respectively, so that dissolving.
2, pharmaceutical formulation (percentage ratio of Emulsion medicine total amount)
Oleum Camelliae 30～70%; Middle drug dipping 20～50% (wherein dropping into Radix Notoginseng Tabellae 5～15%, Sanguis Draxonis 2.5～7.5%, Pollen Typhae 2.5～7.5%, Pseudobulbus Bletillae (Rhizoma Bletillae) 2.5～7.5%); Potassium sorbate 0.1～0.5%; Antioxidant BHT 0.1～1.0%; Emulsifying agent D-95 molecular distillation glyceryl monostearate 3～15% or emulsifying agent ZR-1 or ZR-25～20%;
3, processing step
(1) antioxidant BHT with formula ratio adds abundant stirring and dissolving in the Oleum Camelliae;
(2) emulsifying agent of formula ratio is under agitation slowly added contain in the Oleum Camelliae of antioxidant BHT, be heated to 40～60 ℃, fully mixing;
(3) potassium sorbate with formula ratio adds in the middle drug dipping of formula ratio, fully stirring and dissolving;
(4) content there is the middle drug dipping of potassium sorbate slowly add in the mixture of Oleum Camelliae and emulsifying agent, keep 40～60 ℃, continue to stir 0.5～1.5 hour, treat Oleum Camelliae and the middle drug dipping fully emulsified Emulsion that becomes emulsifiable paste shape or emulsion form under the effect of emulsifying agent, stop to stir the bottling of cooling back.
(5) Emulsion for preparing by above-mentioned preparation method and processing step is the external used medicine of treatment wound of the present invention.
The external used medicine of treatment wound of the present invention is compared with the external used medicine of existing treatment wound, has the following advantages:
(1) relieving pain, pain relieving at once after wound is coated medicine of the present invention;
(2) the silt detumescence effect of loosing is strong, but hinders eliminating stagnated blood to disperse swelling in the lighter 3 hours, but severely injured person can be in 24 hours eliminating stagnated blood to disperse swelling;
(3) anastalsis is obvious, and capillary hemorrhage can stop blooding about 5 minutes behind the coating, and is hemorrhage for medium and small vein blood vessel, and coating is also wrapped up and can be stopped blooding in back about 10 minutes;
(4) traumatic injury, wound, the lighter can heal in 5～6 days, and heavy person can heal in 8～12 days;
(5) dephlogistication and promoting nuscle growth speed is fast, and wound healing time is short, promptly can heal in 3～5 days to little knife injury, can heal in 7～10 days to big knife injury, to glycosuria patient's also healing easily of wound;
(6) easy to use.
Embodiment
Below in conjunction with embodiment external used medicine of treatment wound of the present invention and preparation method thereof is further described, but is not limitation of the invention.
One, production instance
Present embodiment once drops into fresh milling process Oleum Camelliae 53kg, Radix Notoginseng powder 8kg, Sanguis Draxonis powder 4kg, Pollen Typhae powder 4kg, Rhizoma Bletillae powder 4kg, potassium sorbate 0.3kg, antioxidant BHT 0.5kg, emulsifying agent D-95 molecular distillation glyceryl monostearate 5.2kg.Prepare by following processing step:
1, raw material is handled
(1) the fresh milling process Oleum Camelliae that adopts of this embodiment is glassy yellow, and is limpid, abnormal smells from the patient is pure, does not have macroscopic float, precipitate, pretreatment such as filters, and it is standby directly to take by weighing 53kg.
(2) take by weighing dry prepared slices of Chinese crude drugs Radix Notoginseng Tabellae 8kg, Sanguis Draxonis 4kg, Pollen Typhae 4kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 4kg and be crushed to 40～100 order mixings in pulverizer, it is standby to make the 20kg Chinese medicine powder altogether.
(3) the 20kg Chinese medicine powder is added in 50 liters of normal-temperature water, leaching 1 hour, reheat to 85～95 ℃, be incubated 10 minutes, be cooled to about 80 ℃ with 250 order filter cloth press filtrations, with three washings of 10 liters of 50～60 ℃ of eliminating cold for resuscitation moisture, it is 40 liters that control filtrate adds the wash water total amount, filtering residue is deposited in addition, and filtrate and wash water are merged into middle drug dipping, and be standby.
(4) it is Powdered to have the auxiliary agents such as potassium sorbate, antioxidant BHT of caking to be ground to respectively, so that dissolving.
2, pharmaceutical formulation (percentage ratio of Emulsion medicine total amount)
The medicine total amount of present embodiment is 100kg, fills a prescription to be Oleum Camelliae: 53%; Middle drug dipping 41%; Potassium sorbate 0.3%; Antioxidant BHT 0.5%; Emulsifying agent D-95 molecular distillation glyceryl monostearate 5.2%;
3, processing step
(1) abundant stirring and dissolving in the Oleum Camelliae with 0.5kg antioxidant BHT adding 53kg;
(2) 5.2kg emulsifying agent D-95 molecular distillation glyceryl monostearate is under agitation slowly added 53.5kg and contain in the Oleum Camelliae of antioxidant BHT, be heated to 40～60 ℃, continue to stir 10 minutes;
(3) with in the drug dipping among the 0.3kg potassium sorbate adding 41kg, abundant stirring and dissolving;
(4) the middle drug dipping that will contain potassium sorbate under agitation slowly adds in the mixture of emulsifying agent and Oleum Camelliae, keep 40～60 ℃, continue to stir 50 minutes, treat Oleum Camelliae and the middle drug dipping fully emulsified Emulsion that becomes emulsifiable paste shape or emulsion form under the effect of emulsifying agent, stop to stir the bottling of cooling back.
(5) be the external used medicine of treatment wound of the present invention by the Emulsion of the preparation method of present embodiment and processing step preparation.
Two, clinical experiment
The external used medicine of treatment wound of the present invention has successively carried out the clinical treatment experiment to 116 traumatic patients, 35 of the persons that wherein has the skin abrasion, and 29 of cutter the wounded, muscle injury has 31 of hematoma persons, and head is by 21 of the bump persons that has the lump.Wound is successively healing in 4 days to 10 days, 2 blood glucose patients wherein, because of many places skin such as traumatic injury head, hands, knee by motorcycle and flesh wound hemorrhage, wound reaches 0.6 centimetre deeply, reach 2.5 centimetres, be not respectively under 8.94 and 10.45 situations carrying out wound suture and fasting glucose, all heal at the 8th day and the 10th day wound respectively.Clinical trial certificate, the external used medicine of treatment wound of the present invention has functions such as diffusing silt, detumescence, hemostasis, pain relieving, antiinflammatory, granulation promoting really, be applicable to that treatment traumatic injury, bump are sprained, the skin due to the skin trauma, muscle injury, soft tissue injury, knife injury etc., muscle swelling, hyperemia, wound such as hemorrhage, and evident in efficacy.
Claims (8)
1. treat external used medicine of wound and preparation method thereof for one kind, it comprises adopts Oleum Camelliae and contains Radix Notoginseng, Sanguis Draxonis, Pollen Typhae, the middle drug dipping of Pseudobulbus Bletillae (Rhizoma Bletillae) is a primary raw material, add the sterilization antiseptic potassium sorbate, antioxidant BHT, with emulsifying agent D-95 molecular distillation glyceryl monostearate, emulsifying agent ZR-1, the emulsifiable paste shape that emulsifying agent ZR-2 etc. form or the exterior-applied emulsion medicine of emulsion form, having looses becomes silted up, detumescence, hemostasis, pain relieving, antiinflammatory, functions such as granulation promoting cure mainly traumatic injury, bump is sprained, knife injury, skin abrasion, wound, muscle injury, wound such as soft tissue injury and burn due to hot liquid or fire.It is characterized in that this external used medicine is is primary raw material with Oleum Camelliae or the middle drug dipping that contains Radix Notoginseng, add D-95 molecular distillation glyceryl monostearate, emulsifying agent ZR-1, emulsifying agent ZR-2 etc. are wherein a kind of as emulsifying agent.
2. a kind of external used medicine for the treatment of wound according to claim 1 and preparation method thereof is characterized in that with the Oleum Camelliae being primary raw material.
3. a kind of external used medicine for the treatment of wound according to claim 2 and preparation method thereof, the addition that it is characterized in that Oleum Camelliae are 30～70% of this external used medicine total amounts.
4. a kind of external used medicine for the treatment of wound according to claim 1 and preparation method thereof is characterized in that with the middle drug dipping that contains Radix Notoginseng be primary raw material.
5. a kind of external used medicine for the treatment of wound according to claim 4 and preparation method thereof, the addition of drug dipping is 20～50% of this external used medicine total amount in it is characterized in that.
6. a kind of external used medicine for the treatment of wound according to claim 1 and preparation method thereof, it is characterized in that adopting emulsifying agent D-95 molecular distillation glyceryl monostearate, wherein a kind of emulsifying Oleum Camelliae such as emulsifying agent ZR-1, emulsifying agent ZR-2, Oleum Camelliae can fully be mixed with middle drug dipping, be uniformly dispersed.
7. a kind of external used medicine for the treatment of wound according to claim 6 and preparation method thereof is characterized in that the addition of emulsifying agent D-95 molecular distillation glyceryl monostearate is 3～15% of this external used medicine total amount.
8. a kind of external used medicine for the treatment of wound according to claim 6 and preparation method thereof, the addition that it is characterized in that emulsifying agent ZR-1 or ZR-2 are 5～20% of this external used medicine total amounts.
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| CN 201010191973 CN102247533B (en) | 2010-05-19 | 2010-05-19 | External drug for treating trauma and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010191973 CN102247533B (en) | 2010-05-19 | 2010-05-19 | External drug for treating trauma and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102247533A true CN102247533A (en) | 2011-11-23 |
| CN102247533B CN102247533B (en) | 2013-04-10 |
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| CN 201010191973 Expired - Fee Related CN102247533B (en) | 2010-05-19 | 2010-05-19 | External drug for treating trauma and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074870A (en) * | 2016-08-03 | 2016-11-09 | 浦北五皇山农业科技有限公司 | A kind of ointment treating burn and preparation method thereof |
| CN106361628A (en) * | 2016-08-31 | 2017-02-01 | 贵州苗侗古方民族医药开发有限公司 | Moisturizing skincare cooling oil |
| CN107951987A (en) * | 2017-12-22 | 2018-04-24 | 何煌元 | It is a kind of to dredge glandular tube, detumescenceization knot, promoting menstruationization stagnant external application medicine oil and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101607040A (en) * | 2009-07-31 | 2009-12-23 | 孟庆华 | A kind of weapons for the treatment of are hindered the traumatic injury medicine of skin ulcer and preparation method thereof that festers |
| CN101632803A (en) * | 2009-08-25 | 2010-01-27 | 肖云 | Stancher and preparation method thereof |
-
2010
- 2010-05-19 CN CN 201010191973 patent/CN102247533B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101607040A (en) * | 2009-07-31 | 2009-12-23 | 孟庆华 | A kind of weapons for the treatment of are hindered the traumatic injury medicine of skin ulcer and preparation method thereof that festers |
| CN101632803A (en) * | 2009-08-25 | 2010-01-27 | 肖云 | Stancher and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中国民间疗法》 19960531 黄立雄 中医_洗伤_疗法治疗外伤74例 18-19 1-8 , 第5期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074870A (en) * | 2016-08-03 | 2016-11-09 | 浦北五皇山农业科技有限公司 | A kind of ointment treating burn and preparation method thereof |
| CN106361628A (en) * | 2016-08-31 | 2017-02-01 | 贵州苗侗古方民族医药开发有限公司 | Moisturizing skincare cooling oil |
| CN107951987A (en) * | 2017-12-22 | 2018-04-24 | 何煌元 | It is a kind of to dredge glandular tube, detumescenceization knot, promoting menstruationization stagnant external application medicine oil and its preparation method |
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| Publication number | Publication date |
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| CN102247533B (en) | 2013-04-10 |
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Effective date of registration: 20201111 Address after: No.59-5, Jingyi Road, Chengbei Park, Jingjiang Economic Development Zone, Taizhou City, Jiangsu Province, 214500 Patentee after: JIANGSU OPT BARCODE LABEL Co.,Ltd. Address before: 413516, Hunan County, Anhua Province town of Li Li village old house Patentee before: Chen Huisheng Patentee before: Sun Shifan |
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