CN102716193A - Pharmaceutical composition and preparation method thereof - Google Patents
Pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN102716193A CN102716193A CN2012102305096A CN201210230509A CN102716193A CN 102716193 A CN102716193 A CN 102716193A CN 2012102305096 A CN2012102305096 A CN 2012102305096A CN 201210230509 A CN201210230509 A CN 201210230509A CN 102716193 A CN102716193 A CN 102716193A
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- fructus piperis
- piperis longi
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Abstract
The invention relates to a pharmaceutical composition, which consists of clove oil, cinnamon oil and fructus piperis longi. The pharmaceutical composition has the functions of tonifying spleen and warming middle-jiao and removing coldness and relieving diarrhea, can be used for children dyspepsia, abdominal distension, diarrhea and diarrhea and can also be used for uterine coldness and abdominal distension during women menstruation, abdominal pain, uterine bleeding and straining, nonstop drop and peculiar smell during menstruation. The invention also relates to a preparation method for a patch of the pharmaceutical composition.
Description
Technical field:
The present invention relates to a kind of pharmaceutical composition; Form by Oleum Caryophylli, Oleum Cinnamomi and Fructus Piperis Longi, but the spleen invigorating warming middle-JIAO, cold expelling antidiarrheal; Be used for infantile dyspepsia, abdominal distention, diarrhoea, stomachache, also can be used for gynecologic menstrual cold womb abdominal distention, stomachache, metrorrhagia tenesmus, more than and unpleasant abnormal flavour arranged through the row drop.The invention still further relates to the patch method for preparing of this pharmaceutical composition.
Background technology:
Flos Caryophylli is the dry flower of plant clove of myrtaceae (Eugenia caryo-phyllataThumb); Mainly contain eugenol (eugenol); Eugenol acetate (acetyl eugenol); Caryophyllene (β-caryophyllene), flavones ingredients such as methyl n-heptyl ketone volatile ingredients such as (n-Heptylmethyl ketone) and nimbecetin, Fructus rhamni (Rhamnus davurica Pall.) element, oleanolic acid.Fourth osmanthus sporadically appears in " surgery pass firewood collection ", and by Flos Caryophylli three money, Cortex Cinnamomi one or two is formed, and is used for temperature and reduces phlegm wetly, and dispersing cold for relieving pain cures mainly headache and invisible cold-damp.Flos Caryophylli sporadically appears in " Chinese umbilicus treatment great achievement ", by Flos Caryophylli, Cortex Cinnamomi, very light blue, each is an amount of for Rhizoma Zingiberis Recens, smashes into mud cream, spreads on umbilical part.The fourth osmanthus stomach warming of the accurate word Z32021009 of traditional Chinese medicines looses and is made up of Flos Caryophylli 500g, Cortex Cinnamomi 500g, but warming stomach for dispelling cold, promoting the circulation of QI to relieve pain.Be used for cold gastralgia and abdominal pain due to cold.Contain Flos Caryophylli and cinnamomic prescription multiple reports such as the mongolian medicine Cortex Cinnamomi five tastes diffusing treatment dyspepsia and incense drug rheumatalgia relieving plaster treatment pain are still arranged.Wherein one Chinese patent application numbers 93104666.1; Name is called " control infantile diarrhea, apositia-plaster and preparation method thereof ", application number 200810102544.3; Name is called " a kind of treatment infantile anorexia, dyspeptic Chinese medicine plaster and preparation method thereof "; Application number 200810102543.9, name are called " a kind of Chinese medicine plaster of treating dysmenorrhea " three patent applications, and to disclose Flos Caryophylli, Cortex Cinnamomi and Fructus Piperis Longi prescription ratio respectively be to be used to treat the patch and the method for making thereof of infantile diarrhea and dysmenorrhea in 1: 0.5～1.5: 0.01.
But below all be preliminary study and the application to its prescription and medicament, clinical use bolus volume is big, and complex chemical composition, residual dermal drug are prone to the set-off medicated clothing; Taste is strong in the drug use process; Stimulate nasal cavity, and the injection volume and the weight of direct contacting skin are big, the adhesive tape sticking performance injures the tender skin of child too by force easily; The adhesive tape sticking performance is then peeled off skin by the volume and weight of medicine itself a little less than too easily; Feasible one side does not have the effect of drug absorption, and the part of plaster is pasted leakage on the other hand, makes child's urine import in the plaster through diaper easily again; Thereby urine is held the umbilical part in the child for a long time through the umbilicus subsides, very easily cause corrosion inflammation of umbilical part uric acid and MOI.
The present invention has carried out research to traditional patch formulation and technology and has improved; Find through a large amount of literature research and test; Flos Caryophylli, Cortex Cinnamomi in patch main acting be volatile oil, so be used as medicine, thereby reduced the volume and weight of medicine greatly with Oleum Caryophylli and Oleum Cinnamomi replacement Flos Caryophylli and Cortex Cinnamomi medical material; Save numerous and diverse water soluble ingredient and prepared process; And improved the stable and controllable property of medicine to a great extent, greatly facilitate manufacturing, storage, transportation and clinical use, and significantly improve clinical effectiveness.
Fourth cassia oil umbilicus of the present invention pastes as a traditional patch dosage form and improves, and the clinical medicine use amount is near one of original percentage, and preparation and the use of whole medicine all produced tremendous influence, and comparing with the existing medicine of tradition has essential difference.Consult patent database, not seeing has compositions and the method for preparing similar with the present invention.
Summary of the invention:
But one of the object of the invention provides a kind of warming middle-JIAO of spleen invigorating safely and effectively, and cold expelling antidiarrheal is used for the pharmaceutical composition of infantile dyspepsia, abdominal distention, diarrhoea, stomachache.The invention still further relates to the patch method for preparing of this pharmaceutical composition.
One of the object of the invention provide this pharmaceutical composition be used for gynecologic menstrual cold womb abdominal distention, stomachache, metrorrhagia tenesmus, more than and unpleasant abnormal flavour arranged through the row drop.
Other a kind of purpose of the present invention provides this preparation of drug combination method.
Pharmaceutical composition of the present invention is made up of active ingredient or active ingredient and pharmaceutically acceptable carrier, and the raw material that wherein prepares said active ingredient is:
Oleum Caryophylli 25-75 weight portion, Oleum Cinnamomi 10-40 weight portion, Fructus Piperis Longi 15-35 weight portion.
The raw material of the said active ingredient of preparation of the present invention is preferably:
Oleum Caryophylli 40-65 weight portion, Oleum Cinnamomi 15-30 weight portion, Fructus Piperis Longi 20-30 weight portion.
The raw material of the said active ingredient of preparation of the present invention is more preferably:
Oleum Caryophylli 50 weight portions, Oleum Cinnamomi 25 weight portions, Fructus Piperis Longi 25 weight portions.
Pharmaceutical composition of the present invention, wherein said active ingredient prepare process and may further comprise the steps:
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described Fructus Piperis Longi is sneaked in Oleum Cinnamomi and the Oleum Caryophylli, after putting the high-speed homogenization machine and stirring, the pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, there is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Above-mentioned active ingredient can be processed various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient, and like granule, suspensoid, wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.
Pharmaceutical composition of the present invention is used to prepare the application of the medicine of preventing/treating infantile diarrhea.
Pharmaceutical composition of the present invention is used to prepare the application of the medicine of preventing/treating dysmenorrhea.
The specific embodiment:
The preparation of medicine
Embodiment 1
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia prepare from the Cortex Cinnamomi raw material distillation of passing through.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 350 gram Fructus Piperis Longi are sneaked in 100 gram Oleum Cinnamomi and the 750 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 50 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 2
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 150 gram Fructus Piperis Longi are sneaked in 400 gram Oleum Cinnamomi and the 250 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 50 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 3
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 300 gram Fructus Piperis Longi are sneaked in 150 gram Oleum Cinnamomi and the 400 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 50 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 4
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia prepare from the Cortex Cinnamomi raw material distillation of passing through.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 350 gram Fructus Piperis Longi are sneaked in 100 gram Oleum Cinnamomi and the 750 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 20 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 5
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 150 gram Fructus Piperis Longi are sneaked in 400 gram Oleum Cinnamomi and the 250 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 20 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 6
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 300 gram Fructus Piperis Longi are sneaked in 150 gram Oleum Cinnamomi and the 400 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 20 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 7
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia prepare from the Cortex Cinnamomi raw material distillation of passing through.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 250 gram Fructus Piperis Longi are sneaked in 250 gram Oleum Cinnamomi and the 500 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 50 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 8
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 250 gram Fructus Piperis Longi are sneaked in 250 gram Oleum Cinnamomi and the 500 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 20 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Embodiment 9
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described 250 gram Fructus Piperis Longi are sneaked in 250 gram Oleum Cinnamomi and the 500 gram Oleum Caryophyllis; After putting the high-speed homogenization machine and stirring; The pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, make 30 milligrams on every adsorptive pads absorption ointment; There is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
Clinical observation on the therapeutic effect
1. treat the light disease the spleen and stomach in children diarrhea due to deficiency and coldness of 60 examples, disease is seen stomachache, diarrhoea, poor appetite, Mental fatigue etc.
Get in the foregoing description the 20 milligrams/specification plaster that pastes or 30 milligrams/paste, unpack, remove the leakproof plastic film of ointment bilateral, be affixed on children's's SHENQUE acupoint (umbilicus), cling adhesive tape.Change dressings every day once, 3 days is a course of treatment, observes 60 examples altogether.The result has 55 examples diarrhoea situation in 3 days to be clearly better, and stomachache, poor appetite, Mental fatigue phenomenon are obviously improved, and 49 examples diarrhoea situation in 2 days is clearly better; Stomachache, poor appetite, Mental fatigue phenomenon are obviously improved; 33 examples diarrhoea situation in 1 day is clearly better, and stomachache, Mental fatigue phenomenon are improved, and 3 examples patch midway come off and do not count; 2 example diarrhoea are comparatively serious and with cough, go to hospitalize and do not follow up and go and find out what's going on.Wherein embodiment 9 said plaster curative effects are best, and 12 routine infants of observation all took an evident turn for the better in 1 day; Embodiment 8 said plaster curative effects are inferior good, have 10 examples in 1 day, all to take an evident turn for the better in the 12 routine infants of observation, and 2 examples all took an evident turn for the better in 2 days; Embodiment 6 and 4 said plaster curative effects once more, embodiment 5 said plaster curative effects come the last of plaster effect, but still in 3 days, have 10 examples to play tangible curative effect.
2. treat 180 routine women's cold womb stagnation of QIs, passages through which vital energy circulates deficiency and coldness, the dysmenorrhea that the unable grade of fortuneization is caused.
Get the specification plaster of 50 milligrams/subsides in the foregoing description, unpack, remove the leakproof plastic film of ointment bilateral, be affixed on women's Guanyuan acupoint (public region), cling adhesive tape.Keep a close eye on and observe Guanyuan acupoint local skin situation, then can take off, then can stick continuously 4-6 days like no dermathemia like rubescent hyperemia; Pasted, and before each dysmenorrhea occurs, sticked in 2-4 days in every month shared 2 with 1 subsides in per 2 days; Treatment is 3 months continuously, observes 180 examples altogether.Acetonideexample 7 said plaster curative effects are best, and total effective rate reaches 93%; Embodiment 1 and 3 said plaster curative effects are inferior good, and total effective rate reaches 89%; Embodiment 2 said plaster curative effects come the last of plaster effect, and total effective rate is 85%.
Claims (7)
1. pharmaceutical composition, it is characterized in that: the raw material that wherein prepares said active ingredient is:
Oleum Caryophylli 25-75 weight portion, Oleum Cinnamomi 10-40 weight portion, Fructus Piperis Longi 15-35 weight portion.
2. pharmaceutical composition according to claim 1 is characterized in that: the raw material that wherein prepares said active ingredient is:
Oleum Caryophylli 40-65 weight portion, Oleum Cinnamomi 15-30 weight portion, Fructus Piperis Longi 20-30 weight portion.
3. pharmaceutical composition according to claim 1 is characterized in that: the raw material that wherein prepares said active ingredient is:
Oleum Caryophylli 50 weight portions, Oleum Cinnamomi 25 weight portions, Fructus Piperis Longi 25 weight portions.
4. pharmaceutical composition according to claim 1 is characterized in that: wherein said active ingredient prepares process and may further comprise the steps:
Oleum Cinnamomi: according to " 2010 editions first one 378 pages described " Oleum Cinnamomi " standard-requireds of Chinese pharmacopoeia are buied or the Cortex Cinnamomi raw material distillation of passing through certainly prepares.
Oleum Caryophylli: according to " 2010 editions first one 4 pages described " Flos Caryophylli " standard-requireds of Chinese pharmacopoeia are buied after the conventional way of distillation makes volatile oil, promptly get.
Fructus Piperis Longi: will " after Chinese pharmacopoeia 2010 editions first one 219 pages described " Fructus Piperis Longi " buys, be crushed to 100 order fine powders, and promptly get according to the breaking method of routine.
Described Fructus Piperis Longi is sneaked in Oleum Cinnamomi and the Oleum Caryophylli, after putting the high-speed homogenization machine and stirring, the pasty state ointment, this pasty state ointment is inclined on the adsorptive pads of getting ready, there is the leakproof plastic film below of said adsorptive pads, and the soft circle of leakproof is arranged on every side.After clinging the leakproof plastic film above the ointment, be covered with Medical adhesive plaster again, the leakproof plastic film of the feasible adsorptive pads below that tapes on; Behind the plastic film below the adsorptive pads with Medical adhesive plaster to sticking one deck harder hard plastic film relatively; Cut adhesive tape and hard plastic film as required, packing promptly gets.
5. pharmaceutical composition according to claim 1; It is characterized in that: said active ingredient can be processed various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient; Like granule, suspensoid, wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.
6. pharmaceutical composition as claimed in claim 1 is used to prepare the application of the medicine of preventing/treating infantile diarrhea.
7. pharmaceutical composition as claimed in claim 1 is used to prepare the application of the medicine of preventing/treating dysmenorrhea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102305096A CN102716193A (en) | 2012-07-05 | 2012-07-05 | Pharmaceutical composition and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102305096A CN102716193A (en) | 2012-07-05 | 2012-07-05 | Pharmaceutical composition and preparation method thereof |
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| CN102716193A true CN102716193A (en) | 2012-10-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138233A (en) * | 2016-07-27 | 2016-11-23 | 南京正宽医药科技有限公司 | A kind of infantile diarrhea patch and its preparation method and application |
-
2012
- 2012-07-05 CN CN2012102305096A patent/CN102716193A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138233A (en) * | 2016-07-27 | 2016-11-23 | 南京正宽医药科技有限公司 | A kind of infantile diarrhea patch and its preparation method and application |
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