CN110612353A - 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 - Google Patents
经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 Download PDFInfo
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- CN110612353A CN110612353A CN201880029395.4A CN201880029395A CN110612353A CN 110612353 A CN110612353 A CN 110612353A CN 201880029395 A CN201880029395 A CN 201880029395A CN 110612353 A CN110612353 A CN 110612353A
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- C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
- C12Y603/05007—Glutaminyl-tRNA synthase (glutamine-hydrolyzing) (6.3.5.7)
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410435171.0A CN118416088A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762466961P | 2017-03-03 | 2017-03-03 | |
| US62/466961 | 2017-03-03 | ||
| US201762551732P | 2017-08-29 | 2017-08-29 | |
| US62/551732 | 2017-08-29 | ||
| PCT/US2018/020762 WO2018161032A1 (en) | 2017-03-03 | 2018-03-02 | RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410435171.0A Division CN118416088A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110612353A true CN110612353A (zh) | 2019-12-24 |
Family
ID=63370240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410435171.0A Pending CN118416088A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| CN201880029395.4A Pending CN110612353A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410435171.0A Pending CN118416088A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US11932856B2 (enExample) |
| EP (1) | EP3589751A4 (enExample) |
| JP (3) | JP2020508685A (enExample) |
| CN (2) | CN118416088A (enExample) |
| GB (1) | GB2574769A (enExample) |
| IL (1) | IL268763A (enExample) |
| WO (1) | WO2018161032A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111326211A (zh) * | 2020-01-07 | 2020-06-23 | 深圳市早知道科技有限公司 | 一种检测地中海贫血基因变异的方法及检测装置 |
| CN114908066A (zh) * | 2022-05-17 | 2022-08-16 | 浙江大学 | 一种正交翻译系统及其在再分配密码子恢复ptc疾病中功能蛋白表达方面的应用 |
| CN115667528A (zh) * | 2020-03-04 | 2023-01-31 | 苏州齐禾生科生物科技有限公司 | 多重基因组编辑方法和系统 |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| WO2016097212A1 (en) * | 2014-12-17 | 2016-06-23 | Proqr Therapeutics Ii B.V. | Targeted rna editing |
| EP3365356B1 (en) | 2015-10-23 | 2023-06-28 | President and Fellows of Harvard College | Nucleobase editors and uses thereof |
| US11932856B2 (en) * | 2017-03-03 | 2024-03-19 | The Regents Of The University Of California | RNA targeting of mutations via suppressor tRNAs and deaminases |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| US20200332272A1 (en) * | 2017-10-23 | 2020-10-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| CN111712248B (zh) | 2017-11-02 | 2024-07-26 | 衣阿华大学研究基金会 | 使用ACE-tRNA经由遗传重分配拯救终止密码子的方法 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3728575A4 (en) * | 2017-12-22 | 2021-11-24 | The Broad Institute, Inc. | CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF DNA BASES |
| CN112752844A (zh) * | 2018-06-29 | 2021-05-04 | 蒂宾根大学 | 用于rna编辑的人工核酸 |
| WO2020033601A1 (en) * | 2018-08-07 | 2020-02-13 | The Broad Institute, Inc. | Novel cas12b enzymes and systems |
| WO2020043750A1 (en) | 2018-08-28 | 2020-03-05 | Roche Innovation Center Copenhagen A/S | Neoantigen engineering using splice modulating compounds |
| AU2019350869A1 (en) * | 2018-09-26 | 2021-05-20 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| US10905778B2 (en) | 2018-09-26 | 2021-02-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| WO2020074001A1 (en) * | 2018-10-12 | 2020-04-16 | Peking University | Methods and Compositions for Editing RNAs |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| EP3887516A1 (en) * | 2018-11-29 | 2021-10-06 | Flagship Pioneering Innovations V, Inc. | Methods of modulating rna |
| US20220048962A1 (en) * | 2019-01-04 | 2022-02-17 | The University Of Chicago | Systems and methods for modulating rna |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
| CN111793627A (zh) * | 2019-04-08 | 2020-10-20 | 中国科学院上海生命科学研究院 | 利用人工构建rna编辑酶进行rna定点编辑及相关应用 |
| WO2020208169A1 (en) * | 2019-04-11 | 2020-10-15 | Universität Hamburg | Synthetic transfer rna with extended anticodon loop |
| LU101182B1 (en) * | 2019-04-11 | 2020-10-12 | Univ Hamburg | Synthetic transfer RNA with extended anticodon loop |
| CR20210572A (es) | 2019-04-15 | 2022-04-07 | Univ Beijing | Métodos y composiciones para editar ácido ribonucleicos (arn) |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| MX2022000497A (es) * | 2019-07-12 | 2022-02-03 | Univ Beijing | Edicion de acido ribonucleico (arn) dirigido aprovechando la adenosina desaminasa que actua sobre acido ribonucleico endogeno (adar) utilizando acidos ribonucleicos (arn) modificados geneticamente. |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021072201A1 (en) * | 2019-10-11 | 2021-04-15 | University Of Massachusetts | Raav-mediated in vivo delivery of suppressor trnas |
| AU2020395113A1 (en) | 2019-12-02 | 2022-06-09 | Shape Therapeutics Inc. | Therapeutic editing |
| WO2021113390A1 (en) * | 2019-12-02 | 2021-06-10 | Shape Therapeutics Inc. | Compositions for treatment of diseases |
| CN115397983A (zh) * | 2019-12-02 | 2022-11-25 | 西普治疗公司 | 用于治疗疾病的靶向转移rna |
| WO2021142343A1 (en) * | 2020-01-09 | 2021-07-15 | The Regents Of The University Of California | Targeting transfer rna for the suppression of nonsense mutations in messenger rna |
| US20240247258A1 (en) * | 2020-03-12 | 2024-07-25 | Frest Inc. | Oligonucleotide and target rna site-specific editing method |
| BR112022020780A2 (pt) | 2020-04-14 | 2022-11-29 | Flagship Pioneering Innovations Vi Llc | Composições de trem e usos das mesmas |
| WO2021231680A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2) |
| WO2022003684A1 (en) * | 2020-06-29 | 2022-01-06 | Bar-Ilan University | Composition and methods for identifying antisense guide rna for rna editing |
| WO2022078569A1 (en) * | 2020-10-12 | 2022-04-21 | Eberhard Karls Universität Tübingen | Artificial nucleic acids for rna editing |
| US20240150754A1 (en) | 2020-12-25 | 2024-05-09 | Astellas Pharma Inc. | Guide rna for editing polyadenylation signal sequence of target rna |
| JP2024504608A (ja) * | 2021-01-12 | 2024-02-01 | 北京大学 | 遺伝子操作rnaを使用した内因性adarの活用による標的化rnaの編集 |
| JP2024523877A (ja) * | 2021-06-15 | 2024-07-02 | マサチューセッツ インスティテュート オブ テクノロジー | デアミナーゼベースのrnaセンサー |
| MX2024002647A (es) | 2021-09-03 | 2024-05-10 | Tacit Therapeutics Inc | Edición de arn a través del reclutamiento de componentes de espliceosomas. |
| IL316014A (en) * | 2022-03-30 | 2024-11-01 | Univ Pittsburgh Commonwealth Sys Higher Education | Adeno-associated virus vectors for delivering nucleic acids to retinal cells |
| TW202405173A (zh) | 2022-04-18 | 2024-02-01 | 美商維泰克斯製藥公司 | 用於增強aav療法及降低aav向肝臟之趨性的組合物及方法 |
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| CN111326211A (zh) * | 2020-01-07 | 2020-06-23 | 深圳市早知道科技有限公司 | 一种检测地中海贫血基因变异的方法及检测装置 |
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| CN115667528A (zh) * | 2020-03-04 | 2023-01-31 | 苏州齐禾生科生物科技有限公司 | 多重基因组编辑方法和系统 |
| CN115667528B (zh) * | 2020-03-04 | 2024-10-01 | 苏州齐禾生科生物科技有限公司 | 多重基因组编辑方法和系统 |
| CN114908066A (zh) * | 2022-05-17 | 2022-08-16 | 浙江大学 | 一种正交翻译系统及其在再分配密码子恢复ptc疾病中功能蛋白表达方面的应用 |
| CN114908066B (zh) * | 2022-05-17 | 2024-01-23 | 杭州嵌化合生医药科技有限公司 | 一种正交翻译系统及其在再分配密码子恢复ptc疾病中功能蛋白表达方面的应用 |
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| JP2025066771A (ja) | 2025-04-23 |
| EP3589751A4 (en) | 2021-11-17 |
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| WO2018161032A1 (en) | 2018-09-07 |
| US20200277607A1 (en) | 2020-09-03 |
| US20200263180A1 (en) | 2020-08-20 |
| US20220186226A1 (en) | 2022-06-16 |
| IL268763A (en) | 2019-10-31 |
| GB201913819D0 (en) | 2019-11-06 |
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