JP2020508685A - サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング - Google Patents

サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング Download PDF

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JP2020508685A
JP2020508685A JP2019547704A JP2019547704A JP2020508685A JP 2020508685 A JP2020508685 A JP 2020508685A JP 2019547704 A JP2019547704 A JP 2019547704A JP 2019547704 A JP2019547704 A JP 2019547704A JP 2020508685 A JP2020508685 A JP 2020508685A
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rna
adar
trna
protein
vector
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JP2020508685A5 (enExample
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マリ，プラシャント
カトレカール，ドゥルヴァ
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University of California
University of California Berkeley
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University of California San Diego UCSD
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Priority to JP2023023308A priority Critical patent/JP2023075118A/ja
Priority to JP2025008232A priority patent/JP2025066771A/ja
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05007—Glutaminyl-tRNA synthase (glutamine-hydrolyzing) (6.3.5.7)
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2019547704A 2017-03-03 2018-03-02 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング Pending JP2020508685A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023023308A JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2025008232A JP2025066771A (ja) 2017-03-03 2025-01-21 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762466961P 2017-03-03 2017-03-03
US62/466,961 2017-03-03
US201762551732P 2017-08-29 2017-08-29
US62/551,732 2017-08-29
PCT/US2018/020762 WO2018161032A1 (en) 2017-03-03 2018-03-02 RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES

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JP2023023308A Division JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

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JP2020508685A true JP2020508685A (ja) 2020-03-26
JP2020508685A5 JP2020508685A5 (enExample) 2021-07-26

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JP2019547704A Pending JP2020508685A (ja) 2017-03-03 2018-03-02 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2023023308A Pending JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2025008232A Pending JP2025066771A (ja) 2017-03-03 2025-01-21 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

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JP2023023308A Pending JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2025008232A Pending JP2025066771A (ja) 2017-03-03 2025-01-21 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

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US (8) US11932856B2 (enExample)
EP (1) EP3589751A4 (enExample)
JP (3) JP2020508685A (enExample)
CN (2) CN118416088A (enExample)
GB (1) GB2574769A (enExample)
IL (1) IL268763A (enExample)
WO (1) WO2018161032A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2023075118A (ja) * 2017-03-03 2023-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2023552037A (ja) * 2020-10-12 2023-12-14 エバーハルト カール ウニヴェルジテート テュービンゲン Ｒｎａ編集のための人工核酸
JP2024504608A (ja) * 2021-01-12 2024-02-01 北京大学 遺伝子操作ｒｎａを使用した内因性ａｄａｒの活用による標的化ｒｎａの編集

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US12043852B2 (en) 2015-10-23 2024-07-23 President And Fellows Of Harvard College Evolved Cas9 proteins for gene editing
EP3592381A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Cancer vaccine
KR20190127797A (ko) 2017-03-10 2019-11-13 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 시토신에서 구아닌으로의 염기 편집제
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
EP3701042A4 (en) * 2017-10-23 2021-08-11 The Broad Institute, Inc. NUCLEIC ACID TARGETED EDITING SYSTEMS, METHODS AND COMPOSITIONS
IL274396B2 (en) * 2017-11-02 2025-10-01 Wistar Inst Methods for rescuing stop codons through genetic rearrangement with ACE–tRNA
EP3724214A4 (en) 2017-12-15 2021-09-01 The Broad Institute Inc. SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
US20230193242A1 (en) * 2017-12-22 2023-06-22 The Broad Institute, Inc. Cas12b systems, methods, and compositions for targeted dna base editing
US20220073915A1 (en) * 2018-06-29 2022-03-10 Eberhard-Karls-Universität-Tübingen Artificial nucleic acids for rna editing
EP3833761A1 (en) * 2018-08-07 2021-06-16 The Broad Institute, Inc. Novel cas12b enzymes and systems
EP3844274A1 (en) 2018-08-28 2021-07-07 Roche Innovation Center Copenhagen A/S Neoantigen engineering using splice modulating compounds
WO2020069194A1 (en) * 2018-09-26 2020-04-02 Case Western Reserve University Methods and compositions for treating a premature stop codon-mediated disorder
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CA3115864A1 (en) * 2018-10-12 2020-04-16 Peking University Methods and compositions for editing rnas
US12281338B2 (en) 2018-10-29 2025-04-22 The Broad Institute, Inc. Nucleobase editors comprising GeoCas9 and uses thereof
WO2020113135A1 (en) * 2018-11-29 2020-06-04 Flagship Pioneering Innovations V, Inc. Methods of modulating rna
JP2022516919A (ja) * 2019-01-04 2022-03-03 ザ・ユニバーシティ・オブ・シカゴ Ｒｎａをモジュレートするためのシステムおよび方法
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
DE112020001306T5 (de) 2019-03-19 2022-01-27 Massachusetts Institute Of Technology Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen
CN111793627A (zh) * 2019-04-08 2020-10-20 中国科学院上海生命科学研究院 利用人工构建rna编辑酶进行rna定点编辑及相关应用
WO2020208169A1 (en) * 2019-04-11 2020-10-15 Universität Hamburg Synthetic transfer rna with extended anticodon loop
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CA3163514A1 (en) * 2019-12-02 2021-06-10 David HUSS Targeted transfer rnas for treatment of diseases
CN111326211B (zh) * 2020-01-07 2023-12-19 深圳市早知道科技有限公司 一种检测地中海贫血基因变异的方法及检测装置
WO2021142343A1 (en) * 2020-01-09 2021-07-15 The Regents Of The University Of California Targeting transfer rna for the suppression of nonsense mutations in messenger rna
WO2021175289A1 (zh) * 2020-03-04 2021-09-10 中国科学院遗传与发育生物学研究所 多重基因组编辑方法和系统
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