CN118416088A - 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 - Google Patents
经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 Download PDFInfo
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- CN118416088A CN118416088A CN202410435171.0A CN202410435171A CN118416088A CN 118416088 A CN118416088 A CN 118416088A CN 202410435171 A CN202410435171 A CN 202410435171A CN 118416088 A CN118416088 A CN 118416088A
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- trna
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- adar
- protein
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
- C12Y603/05007—Glutaminyl-tRNA synthase (glutamine-hydrolyzing) (6.3.5.7)
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Plant Pathology (AREA)
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- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762466961P | 2017-03-03 | 2017-03-03 | |
| US62/466,961 | 2017-03-03 | ||
| US201762551732P | 2017-08-29 | 2017-08-29 | |
| US62/551,732 | 2017-08-29 | ||
| PCT/US2018/020762 WO2018161032A1 (en) | 2017-03-03 | 2018-03-02 | RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES |
| CN201880029395.4A CN110612353A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880029395.4A Division CN110612353A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118416088A true CN118416088A (zh) | 2024-08-02 |
Family
ID=63370240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880029395.4A Pending CN110612353A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| CN202410435171.0A Pending CN118416088A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880029395.4A Pending CN110612353A (zh) | 2017-03-03 | 2018-03-02 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US11932856B2 (enExample) |
| EP (1) | EP3589751A4 (enExample) |
| JP (3) | JP2020508685A (enExample) |
| CN (2) | CN110612353A (enExample) |
| GB (1) | GB2574769A (enExample) |
| IL (1) | IL268763A (enExample) |
| WO (1) | WO2018161032A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| EP3712269A1 (en) * | 2014-12-17 | 2020-09-23 | ProQR Therapeutics II B.V. | Targeted rna editing |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| CN110612353A (zh) * | 2017-03-03 | 2019-12-24 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物 |
| WO2019084063A1 (en) * | 2017-10-23 | 2019-05-02 | The Broad Institute, Inc. | SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION |
| EP3703701A4 (en) * | 2017-11-02 | 2022-02-09 | University of Iowa Research Foundation | Methods of rescuing stop codons via genetic reassignment with ace-trna |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US20230193242A1 (en) * | 2017-12-22 | 2023-06-22 | The Broad Institute, Inc. | Cas12b systems, methods, and compositions for targeted dna base editing |
| US20220073915A1 (en) * | 2018-06-29 | 2022-03-10 | Eberhard-Karls-Universität-Tübingen | Artificial nucleic acids for rna editing |
| EP3833761A1 (en) * | 2018-08-07 | 2021-06-16 | The Broad Institute, Inc. | Novel cas12b enzymes and systems |
| JP2021536239A (ja) | 2018-08-28 | 2021-12-27 | ロシュ イノベーション センター コペンハーゲン エーエス | スプライス調節化合物を使用したネオアンチゲン操作 |
| AU2019350869A1 (en) * | 2018-09-26 | 2021-05-20 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| US10905778B2 (en) | 2018-09-26 | 2021-02-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
| CN116042611A (zh) * | 2018-10-12 | 2023-05-02 | 北京大学 | 编辑rna的方法和组合物 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US20220024999A1 (en) * | 2018-11-29 | 2022-01-27 | Flagship Pioneering Innovations V, Inc. | Methods of modulating rna |
| US20220048962A1 (en) * | 2019-01-04 | 2022-02-17 | The University Of Chicago | Systems and methods for modulating rna |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| AU2020240109A1 (en) | 2019-03-19 | 2021-09-30 | President And Fellows Of Harvard College | Methods and compositions for editing nucleotide sequences |
| CN111793627A (zh) * | 2019-04-08 | 2020-10-20 | 中国科学院上海生命科学研究院 | 利用人工构建rna编辑酶进行rna定点编辑及相关应用 |
| WO2020208169A1 (en) * | 2019-04-11 | 2020-10-15 | Universität Hamburg | Synthetic transfer rna with extended anticodon loop |
| LU101182B1 (en) * | 2019-04-11 | 2020-10-12 | Univ Hamburg | Synthetic transfer RNA with extended anticodon loop |
| TW202043249A (zh) | 2019-04-15 | 2020-12-01 | 大陸商博雅輯因(北京)生物科技有限公司 | 編輯rna的方法和組合物 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20220243194A1 (en) | 2019-07-12 | 2022-08-04 | Peking University | Targeted rna editing by leveraging endogenous adar using engineered rnas |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021072201A1 (en) * | 2019-10-11 | 2021-04-15 | University Of Massachusetts | Raav-mediated in vivo delivery of suppressor trnas |
| WO2021113390A1 (en) * | 2019-12-02 | 2021-06-10 | Shape Therapeutics Inc. | Compositions for treatment of diseases |
| WO2021113218A1 (en) * | 2019-12-02 | 2021-06-10 | Shape Therapeutics Inc. | Targeted transfer rnas for treatment of diseases |
| CN115038789A (zh) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | 治疗性编辑 |
| CN111326211B (zh) * | 2020-01-07 | 2023-12-19 | 深圳市早知道科技有限公司 | 一种检测地中海贫血基因变异的方法及检测装置 |
| WO2021142343A1 (en) * | 2020-01-09 | 2021-07-15 | The Regents Of The University Of California | Targeting transfer rna for the suppression of nonsense mutations in messenger rna |
| WO2021175289A1 (zh) * | 2020-03-04 | 2021-09-10 | 中国科学院遗传与发育生物学研究所 | 多重基因组编辑方法和系统 |
| WO2021182474A1 (ja) * | 2020-03-12 | 2021-09-16 | 株式会社Frest | オリゴヌクレオチド及び標的rnaの部位特異的編集方法 |
| MX2022012955A (es) | 2020-04-14 | 2023-02-23 | Flagship Pioneering Innovations Vi Llc | Composiciones de trem y usos de las mismas. |
| WO2021231680A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2) |
| EP4172336A4 (en) * | 2020-06-29 | 2024-07-24 | Bar Ilan University | Composition and methods for identifying antisense guide rna for rna editing |
| WO2022078569A1 (en) * | 2020-10-12 | 2022-04-21 | Eberhard Karls Universität Tübingen | Artificial nucleic acids for rna editing |
| US20240150754A1 (en) | 2020-12-25 | 2024-05-09 | Astellas Pharma Inc. | Guide rna for editing polyadenylation signal sequence of target rna |
| CN117015605A (zh) * | 2021-01-12 | 2023-11-07 | 北京大学 | 使用工程化rna通过利用内源性adar进行靶向rna编辑 |
| US12195734B2 (en) * | 2021-06-15 | 2025-01-14 | Massachusetts Institute Of Technology | Deaminase-based RNA sensors |
| WO2023034582A1 (en) | 2021-09-03 | 2023-03-09 | Tacit Therapeutics, Inc. | Rna editing via recruitment of spliceosome components |
| KR20250006360A (ko) * | 2022-03-30 | 2025-01-10 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 망막 세포에 핵산을 전달하기 위한 아데노 관련 바이러스 벡터 |
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