CN110545850A - 可释放的缀合物 - Google Patents

可释放的缀合物 Download PDF

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Publication number
CN110545850A
CN110545850A CN201880014422.0A CN201880014422A CN110545850A CN 110545850 A CN110545850 A CN 110545850A CN 201880014422 A CN201880014422 A CN 201880014422A CN 110545850 A CN110545850 A CN 110545850A
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China
Prior art keywords
compound
formula
group
hydrochloride
optionally substituted
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Pending
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CN201880014422.0A
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English (en)
Chinese (zh)
Inventor
M·克维亚特科夫斯基
C·松德
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QuiaPEG Pharmaceuticals AB
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QuiaPEG Pharmaceuticals AB
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Publication of CN110545850A publication Critical patent/CN110545850A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201880014422.0A 2017-03-10 2018-03-10 可释放的缀合物 Pending CN110545850A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762469989P 2017-03-10 2017-03-10
US62/469,989 2017-03-10
US201762564820P 2017-09-28 2017-09-28
US62/564,820 2017-09-28
PCT/IB2018/051579 WO2018163131A1 (en) 2017-03-10 2018-03-10 Releasable conjugates

Publications (1)

Publication Number Publication Date
CN110545850A true CN110545850A (zh) 2019-12-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880014422.0A Pending CN110545850A (zh) 2017-03-10 2018-03-10 可释放的缀合物

Country Status (11)

Country Link
US (2) US11786599B2 (enExample)
EP (2) EP4011396A1 (enExample)
JP (2) JP7152408B2 (enExample)
KR (1) KR20190125310A (enExample)
CN (1) CN110545850A (enExample)
AU (2) AU2018231832A1 (enExample)
BR (1) BR112019017103A2 (enExample)
CA (1) CA3051173A1 (enExample)
DK (1) DK3592393T3 (enExample)
SI (1) SI3592393T1 (enExample)
WO (1) WO2018163131A1 (enExample)

Cited By (18)

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CN110946844A (zh) * 2019-12-11 2020-04-03 正大制药（青岛）有限公司 一种含有艾地骨化醇的复方控释制剂
CN111175387A (zh) * 2018-11-13 2020-05-19 成都康弘药业集团股份有限公司 一种米那普仑异构体的检测方法
CN112168820A (zh) * 2019-07-05 2021-01-05 中国科学院生物物理研究所 SRCAP ATPase抑制剂在结直肠癌治疗中的应用
CN112316156A (zh) * 2020-10-27 2021-02-05 四川大学 具抗氧化和抗菌性的胶原蛋白修复膜、其制备方法及应用
CN112402620A (zh) * 2020-12-07 2021-02-26 南开大学 肿瘤微环境还原响应性的纳米药物及其制备方法
CN112457383A (zh) * 2020-12-16 2021-03-09 南京盖斯夫医药科技有限公司 一种多肽、制备方法及其医药用途
CN112516285A (zh) * 2020-12-18 2021-03-19 中南大学 一种预防或治疗缺血/再灌注损伤的药物组合物及应用
CN112574272A (zh) * 2020-12-25 2021-03-30 中国医学科学院药用植物研究所 一种灵芝酸a衍生物的制备及其应用
CN112955216A (zh) * 2018-09-12 2021-06-11 奎亚培格制药公司 可释放glp-1缀合物
CN113456824A (zh) * 2020-03-31 2021-10-01 四川大学华西医院 一种抗肿瘤载药纳米复合材料
CN114516921A (zh) * 2021-02-05 2022-05-20 华南理工大学 基于单链抗体片段的融合蛋白、纳米组装体及其制备方法和应用
CN114617876A (zh) * 2022-01-28 2022-06-14 四川大学华西医院 一种抗肿瘤联合用药物
CN114886817A (zh) * 2022-06-02 2022-08-12 杭州配方师科技有限公司 一种弗来歇氏柳叶菜和酵母菌锌发酵复合物、制备方法及应用
CN116287048A (zh) * 2023-01-09 2023-06-23 海南师范大学 一种药用红树来源真菌中联苯醚类化合物及其制备方法与应用
CN118324849A (zh) * 2022-12-22 2024-07-12 四川大学华西医院 一种抗菌肽及其制备方法和用途
CN119613558A (zh) * 2024-12-12 2025-03-14 东北农业大学 一种抗磺胺嘧啶纳米抗体及其应用
CN119709677A (zh) * 2024-10-28 2025-03-28 皖西学院 一种糖基转移酶及其在制备金线莲苷中的应用
CN120531651A (zh) * 2025-07-29 2025-08-26 清枫链食苏打饮品(吉林)有限公司 人参提取物、制备方法及其在美白嫩肤祛皱产品中的应用

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CN110545850A (zh) 2017-03-10 2019-12-06 奎亚培格制药公司 可释放的缀合物
BR112020015071A2 (pt) 2018-03-09 2021-01-05 Quiapeg Pharmaceuticals Ab Conjugados de anticorpos liberáveis
US10768173B1 (en) 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
KR102398574B1 (ko) 2019-10-10 2022-05-13 주식회사 엘지에너지솔루션 전지 모듈 및 이를 포함하는 전지 팩
WO2021155427A1 (en) * 2020-02-03 2021-08-12 Snoretox Pty Ltd Composition and method
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CN112138170B (zh) * 2020-09-28 2022-05-20 广东药科大学 一种预防顺铂药源性聋的缀合物及其制备方法和应用
CN112999196B (zh) * 2021-03-03 2023-04-28 西安医学院 用于长效稳定释放的吗替麦考酚酯纳米制剂及其制备方法
CN113133989B (zh) * 2021-03-09 2023-04-25 西安医学院 一种用于抗结核药物利福平的长效制剂及制备方法
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CN119331240B (zh) * 2023-07-19 2026-01-02 南京大学 一种苯并环辛炔-聚乙二醇修饰的常山酮及其制备方法和应用
KR102623104B1 (ko) * 2023-08-23 2024-01-11 에프아이씨씨주식회사 보툴리눔톡신 결합체와 줄기세포 엑소좀 복합체를 유효성분으로 함유하는 피부 재생 및 주름 개선용 화장료 조성물 및 그의 제조 방법
WO2025043547A1 (zh) 2023-08-30 2025-03-06 杭州高田生物医药有限公司 T细胞导向免疫脂质体及其用途
WO2025257419A1 (en) * 2024-06-13 2025-12-18 4Moving Biotech Glp-1 receptor agonist compounds for treating a proliferative synovial disorder
CN118415977B (zh) * 2024-07-03 2024-08-23 山东新时代药业有限公司 一种米力农注射剂及其用途

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