CN110433263A - It is a kind of to prevent and treat a variety of cerebral arteriovenous malformation Chinese medicine compositions and preparation method thereof - Google Patents
It is a kind of to prevent and treat a variety of cerebral arteriovenous malformation Chinese medicine compositions and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment, raw material is composed of the following parts by weight: 60~100 parts of cornu bubali, 50~100 parts of fructus alpiniae oxyphyllae, 5~35 parts of bombyx batryticatus, 5~40 parts of antelope's horn, 40~80 parts of rhizoma nelumbinis, 15~50 parts of rhizoma acori graminei, 25~65 parts of caulis bambusae in taenian leaf, 40~80 parts of cassia seed, 20~65 parts of RADIX SALVIAE MILTIORRHIZAE, 10~50 parts of Radix Paeoniae Alba (stir-fry), 10~50 parts of radix scrophulariae, 5~35 parts of gallbladder star processed.In addition, the present invention also provides a kind of preparation methods for preventing and treating a variety of cerebral arteriovenous malformation Chinese medicine compositions.Chinese medicine composition provided by the invention chooses each bulk pharmaceutical chemicals and its proportion, and compatibility meets " monarch " theory, and compatibility is precise and appropriate, the interpretation of the cause, onset and process of an illness for a variety of cerebral arteriovenous malformations of hitting.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment and its
Preparation method
Background technique
Cerebral arteriosclerosis refers to that cerebral atherosclerosis arteriosclerosis, the ductus arteriosus walls such as hyalinization denaturation etc. are drawn
It rises, Chinese traditional treatment cerebral artery is historied long.Disease incidence of the cerebral arteriovenous malformation in China is disabled, the equal ranking of the death rate
Anteposition and having the tendency that continues to increase.With the basis that modern science and technology and Chinese medicine largely develop, TCM clinical study is obtained
Prominent achievement.Chinese medicine achieves the achievement that attracts people's attention to cerebral arteriovenous malformation.Clinical practice proves Chinese traditional treatment cerebral artery and the heart
Cranial vascular disease curative effect is good.In order to carry forward the essence that the speciality of motherland's Chinese medicine draws Traditional Chinese Medicine therapy, Chinese medicine is to brain
Artery sclerosis and cardiovascular and cerebrovascular classification, which approach, twenties kinds.Each disease divides the different morbidity interpretation of the cause, onset and process of an illness again, so treatment, in advance
It is anti-also just different.The characteristics of highlighting Chinese medicine, characteristic, cardiovascular and cerebrovascular and cerebral arteriovenous malformation are a kind of diseases in close relations.
These diseases have following type:
Arrhythmia cordis, Premature contracfion, rapid heart beat and auricular fibrillation disease, heart sick sinus syndrome, heart failure disease,
Cardiogenic shock, low blood pressure, high blood pressure, pericarditis, expanding myopathy, essential cardiomyopathy, hypertrophic cardiomyopathy are coronal dynamic
Pulse atherosclerosis heart disease, that is, coronary heart disease, rheumatic heart valve myopathy, vital myocarditis, angina pectoris, Acute myocardial stalk
Plug, chronic cor pulmonale, cardiac nerve functional disease, hyperlipidemia, cerebral arteriovenous malformation, acute cerebral infarction, chronic cerebral infarction, brain go out
Blood, acute and chronic cerebral hemorrhage, multiple brain infarct dynamic greatly, cerebral thrombosis, occlusive cerebral artery, Buerger's disease are deep quiet
Arteries and veins thrombosis encephalopathy, cerebral hemorrhage etc., Chinese medicine to all of above disease can early diagnosis and therapy, prevention.This be Chinese medicine most
Big advantage, so Chinese medicine is one of the national treasure in China.
There is giddy in the cause of disease clinical manifestation early stage of cerebral artery, has a headache, tired, drowsiness, absent minded, memory subtracts
It moves back, emotional instability, four limbs are numb, insomnia, and arteriosclerotic is dull-witted, and onset is slow.Male's morbidity is more than two times of women.
It is most to be concentrated mainly on person in middle and old age's stage, after people in middle age, gets weaker physically, liver-kidney deficiency, deficient qi and blood, asthenia of essence and blood, brains
Inanition, brain is through dystrophy, and plus excessive fatigue at an early age, intemperance in sexual life consumes excess of four natures in foods or drugs causing damage of essence, injures liver kidney, angry because being worried, and drinks
It surfeits, eats rich, disease caused by waiting more.
In order to treat because cerebral arteriovenous malformation causes infraction, necrosis, the trouble of caused transient cerebral ischemia and chronic cerebral ischemia
Person requires greatly patient's long-term use, and taking though Western medicine has the drug of the more a variety of cerebral arteriovenous malformations of prevention and treatment at present
Cheng Zhong, patient easily generate drug resistance.Therefore, finding the drug that therapeutic effect is good and toxic side effect is low becomes the area research
Emphasis direction, and traditional Chinese medicine has big advantage in treating such disease, according to traditional Chinese medicine diagnosis and treatment method, from entirety
Start with, by adjusting body yin-yang, achievees the purpose that effect a permanent cure.
Summary of the invention
In order to solve the deficiency in above-mentioned background technique, the object of the invention provides a kind of prevent and treat in a variety of cerebral arteriovenous malformations
Drug composition.
To achieve the above object, the present invention adopts the following technical scheme:
First purpose of the invention is to provide a kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment, and raw material is by following heavy
The group of amount number is grouped as: 60~100 parts of cornu bubali, 50~100 parts of fructus alpiniae oxyphyllae, and 5~35 parts of bombyx batryticatus, 5~40 parts of antelope's horn, lotus root
40~80 parts of section, 15~50 parts of rhizoma acori graminei, 25~65 parts of caulis bambusae in taenian leaf, 40~80 parts of cassia seed, 20~65 parts of RADIX SALVIAE MILTIORRHIZAE, Radix Paeoniae Alba
10~50 parts of (stir-fry), 10~50 parts of radix scrophulariae, 5~35 parts of gallbladder star processed.
Preferably, raw material is composed of the following parts by weight: 80 parts of cornu bubali, 80 parts of fructus alpiniae oxyphyllae, and 20 parts of bombyx batryticatus,
20 parts of antelope's horn, 60 parts of rhizoma nelumbinis, 30 parts of rhizoma acori graminei, 50 parts of caulis bambusae in taenian leaf, 60 parts of cassia seed, 50 parts of RADIX SALVIAE MILTIORRHIZAE, 30 parts of Radix Paeoniae Alba (stir-fry),
30 parts of radix scrophulariae, 20 parts of gallbladder star processed.
Second purpose of the invention is to provide a kind of liquid and preparation method thereof for preventing and treating a variety of cerebral arteriovenous malformation Chinese medicine compositions, wraps
Include following steps:
S1, it weighs respectively according to parts by weight: 60~100 parts of cornu bubali, 50~100 parts of fructus alpiniae oxyphyllae, 5~35 parts of bombyx batryticatus,
5~40 parts of antelope's horn, 40~80 parts of rhizoma nelumbinis, 15~50 parts of rhizoma acori graminei, 25~65 parts of caulis bambusae in taenian leaf, 40~80 parts of cassia seed, red lead
20~65 parts of ginseng, 10~50 portions of Radix Paeoniae Alba (stir-fry) is 10~50 parts of radix scrophulariae, 5~35 parts of gallbladder star processed, spare；
S2, the weighed each raw material of S1 is uniformly mixed, addition is equivalent to the water that 8-12 times of its total weight is measured, and decocts 1.0-
First time filtrate is collected in 2.0h, filtering；Filter residue is added to the water for being equivalent to 6-8 times of its total weight and measuring, decocts 1.0-2.0h, mistake
Second of filtrate is collected in filter, and first time filtrate and second of filtrate are merged, are condensed into thick medicinal extract to get Chinese medicine composition.
The pharmacological action and drug effect of each raw material Chinese medicine in the present invention:
Cornu bubali: major function: heat-clearing, cool blood, removing toxic substances.It controls pyreticosis to have a headache, high fever coma, macula, hematemesis, children are frightened
Wind, sore throat pharynx swelling.Effect to cardiovascular system, the effect to hematological system, calm and anticonvulsant action, to adrenal cortex
Systemic effect promotees the effect of sexual gland sample, other effects.
Fructus alpiniae oxyphyllae: warm spleen warms up kidney, solid gas, arresting seminal emission.Cold air abdominal pain is controlled, syncope due to pathogenic cold is vomited and diarrhoea, more salivas, spermatorrhea, dribbling urination, night
More urine.
Bombyx batryticatus: dispelling wind and relieving convulsion, reducing phlegm and resolving masses.For convulsion, abscess of throat, pruitus, submandibular lymph nodes is scorching, face
Neural paralysis.Bombyx batryticatus alcohol water-leach liquor has hypnosis, anticonvulsant action to mouse, rabbit；Its extracting solution in vivo, it is outer have compared with
Strong anticoagulation；Bombyx batryticatus powder has preferable hypoglycemic effect；In vitro test has gently staphylococcus aureus, Pseudomonas aeruginosa
The bacteriostasis of degree, alcohol extracting thing can inhibit the breathing of human hepatoma cell in vitro, can be used for the treatment of rectum tumor type polyp.
Antelope's horn: calming the liver to stop the wind, heat-clearing is relieving convulsion, removing toxic substances.It is silent to control pyreticosis coma convulsion, delirious speech is gone mad；Headache and dizziness, frightened epilepsy are jerked
It holds in the hand, conjunctivitis.The effect of Central nervous system, refrigeration function, antihypertensive effect, other effects.
Rhizoma nelumbinis: hemostasis, dispersing blood stasis.For spitting blood, hemoptysis, hematuria, metrorrhagia and metrostaxis.Hemostasis: the rhizoma nelumbinis abdominal cavity hot water extract 1g/kg note
It penetrates, the time of mouse back-end crop bleeding can be shortened.
Rhizoma acori graminei: acrid flavour, bitter, slightly warm in nature.Return heart, liver, the spleen channel.Function dissipating phlegm for resuscitation, wind-dispelling benefit numbness, disappears at dampness elimination promoting the circulation of qi
Swollen analgesic.For pyreticosis coma, coma due to blocking of the respiratory system, amnesia, tinnitus, deafness, abdominal distention, dysentery with vomiting, rheumatic arthralgia." Chongqing hall with
Pen ": rhizoma acori graminei, comfortable gas, the smooth mind, happy mood, invigorating heart will, panacea.Removing summer-heat it is medicinal it, dirty turbid of eliminating the phlegm of relying and defend palace
City, nourish it is medicinal it, so as to declare thought knot and being proficient in the law of natural movement.Modern pharmacology research shows: Rhizoma Acori Graminei extract has obvious
Calmness, cooling, anticonvulsant action, rhizoma acori graminei may improve brain norepinephrine energy, cholinergic nerve function and adjusting
Intracerebral serotonin is horizontal.
Caulis bambusae in taenian leaf: property is sweet, slightly cold.Returns spleen, stomach, gallbladder channel.Function clearing heat and eliminating phlegm relieves restlessness and prevents vomiting.The palpitation with fear of this product energy dysphoria with smothery sensation, stomach
Heat vomit oh, hyperemesis gravidarum." drugization justice ": caulis bambusae in taenian is expelled the excess with mild diaphoretic, cool to reduce phlegm and internal heat, and hardship can be fallen, special heat-clearing phlegm, to allay excitement out
Yu Jiapin.It is dysphagic to cure mainly stomach energy, stomach void is retched, and oh cough is inverse for heat, phlegm heat nausea, wine wound vomiting, sputum sour water, palpitation of palpitating with fear, the heart
Irritated disorderly to doss not peaceful, the disease of this all gallbladder stomach energy phlegm, knowing can prove effective.Internal weakness after " a thousand pieces of gold " manages property, dysphoria with smothery sensation are losed heart, and have Gan Zhuru
Soup；The headache of postpartum dysphoria, loses heart, and bored unrest is not understood, and has henon bamboo to eat soup.Modern pharmacology research shows: caulis bambusae in taenian powder is right on plate
Staphylococcus albus, hay bacillus, Escherichia coli and typhoid bacillus etc. have stronger antibacterial action.
Cassia seed: clearing liver, improving eyesight, Li Shui, defaecation.Control wind-heat cute conjunctivitis, optic atrophy, night blindness, hypertension, hepatitis, cirrhosis abdomen
Water, habitual constipation.
RADIX SALVIAE MILTIORRHIZAE: nourishing disney and strengthening bone；Promoting blood circulation for regulating menstruation；Cooling blood and hemostasis.Main lumbago due to the kidney deficiency；Rheumatalgia；It is dizzy；Irregular menstruation；Bitterly
Through；Menostasis；Metrorrhagia and metrostaxis；Hematochezia；It spits blood；Bleeding from five sense organs or subcutaneous tissue；Bruise stasis caused pain；Knife wound bleeding.
Radix Paeoniae Alba: calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For headache and dizziness, hypochondriac pain, abdominal pain, four limbs contraction pain, the deficiency of blood
It is sallow, irregular menstruation, spontaneous perspiration, night sweat.
Radix scrophulariae: warm heresy is joined the army, invaginate pericardium, febrile virulent maculae, the deep red polydipsia of consumption of YIN caused by febrile disease, tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed,
Hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.To cardiovascular effect, effect to blood pressure, antibacterial action, other effects.
Gallbladder star processed: clearing away fire and eliminating phlegm, it is relieving convulsion fixed chronic.Stroke and phlegm confusing heart, infantile convulsion epilepsy are controlled, convulsive seizure due to phlegm-fire asthma is coughed, phlegm-accumulating vertigo.
Above-mentioned each bulk pharmaceutical chemicals compatibility of Chinese medicine composition,
This disease is blood obstruction, and asthenia of qi and blood presss from both sides the stasis of blood, and headache and dizzy is met strain and then sent out.Radix Paeoniae Alba calming the liver and relieving pain in we dissipates strongly fragrant
Dissolving stasis, nourishing blood for regulating menstruation；Rhizoma acori graminei acrid flavour, slightly warm in nature enter the heart, liver, and the spleen channel has one's ideas straightened out, slit phlegm, qi-regulating, promoting blood circulation, relieve heat, dries, therefore
And drawing the two is monarch drug in a prescription.RADIX SALVIAE MILTIORRHIZAE nourishing disney and strengthening bone, promoting blood circulation for regulating menstruation；Caulis bambusae in taenian leaf clearing heat and eliminating phlegm relieves restlessness and prevents vomiting；Bombyx batryticatus dispelling wind and relieving convulsion,
Reducing phlegm and resolving masses makes pain be eased, and is ministerial drug.It is fixed chronic that gallbladder star processed is relieving convulsion, the symptom eliminating twitch, fainting from fear；Radix scrophulariae then spasmolysis
Decompression, cool blood enriching yin, purging fire for removing toxin；Cornu bubali this product is salty-cold, specially enters blood system, it is kind clear away heart-fire liver stomach three through fire and have removing pattogenic heat from the blood and toxic material from the body
Function, for the key medicine for controlling blood-heat and toxin exuberance；Antelope's horn is calming the liver to stop the wind, and heat-clearing is relieving convulsion.Normal solution the former twitch, the toxication of convulsions, avoid
Hyperactivity of yang due to yin deficiency, pharmacology are mutually rushed, and are adjutant.Rhizoma nelumbinis hemostasis dispersing blood stasis；Cassia seed clears liver and improve vision, sharp water defaecation；Fructus alpiniae oxyphyllae temperature spleen warm up kidney,
Solid gas arresting seminal emission.With qi-restoratives gain, reinvigoration is to make medicine.
Compared with prior art, the beneficial effects of the present invention are:
1) present invention is to choose each bulk pharmaceutical chemicals and its proportion under the theory of motherland's medicine and the guidance of clinical experience,
Compatibility meets " monarch " theory, and compatibility is precise and appropriate, the interpretation of the cause, onset and process of an illness for a variety of cerebral arteriovenous malformations of hitting；
2) Chinese medicine composition primary treatment provided by the invention because cerebral arteriovenous malformation cause infraction, necrosis, it is caused of short duration
Property cerebral ischemia and chronic cerebral ischemia patient, based on temperature compensation gain, safety, few side effects, pharmacology reconcile, it is lossless to gastrointestinal tract
Hurt, is small to the stimulation of liver kidney, compared to other prescriptions, the party takes effect compared with block, and curative effect is more preferable.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
Embodiment 1
A kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment, raw material are composed of the following parts by weight: buffalo
80 parts of angle, 80 parts of fructus alpiniae oxyphyllae, 20 parts of bombyx batryticatus, 20 parts of antelope's horn, 60 parts of rhizoma nelumbinis, 30 parts of rhizoma acori graminei, 50 parts of caulis bambusae in taenian leaf, cassia seed 60
Part, 50 parts of RADIX SALVIAE MILTIORRHIZAE, 30 parts of Radix Paeoniae Alba (stir-fry), 30 parts of radix scrophulariae, 20 parts of gallbladder star processed.
The preparation method of above-mentioned Chinese medicine composition the following steps are included:
S1, bulk pharmaceutical chemicals are weighed according to above-mentioned parts by weight, it is spare；Wherein, suitable wheat is first added in Radix Paeoniae Alba before decoction
Wheat bran enters a pot frying together, waits in pots and to remove wheat bran after Radix Paeoniae Alba stir-bake to yellowish and obtain stir-baked RADIX PAEONIAE ALBA；
S2, by the weighed cornu bubali of S1, antelope's horn, fructus alpiniae oxyphyllae, bombyx batryticatus, rhizoma nelumbinis, rhizoma acori graminei, caulis bambusae in taenian leaf, cassia seed, red lead
Ginseng, Radix Paeoniae Alba (stir-fry), radix scrophulariae, gallbladder star processed are uniformly mixed, and the water for being equivalent to 8 times of its total weight amounts is added, and decoct 1.0h, are filtered, and are received
Collect first time filtrate；Filter residue is added to the water for being equivalent to 6 times of its total weight amounts, decocts 1.0h, second of filtrate is collected in filtering,
First time filtrate and second of filtrate are merged, are condensed into thick medicinal extract to get Chinese medicine composition.
Embodiment 2
A kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment, raw material are composed of the following parts by weight: buffalo
60 parts of angle, 50 parts of fructus alpiniae oxyphyllae, 5 parts of bombyx batryticatus, 5 parts of antelope's horn, 40 parts of rhizoma nelumbinis, 15 parts of rhizoma acori graminei, 25 parts of caulis bambusae in taenian leaf, cassia seed 40
Part, 20 parts of RADIX SALVIAE MILTIORRHIZAE, 10 parts of Radix Paeoniae Alba (stir-fry), 10 parts of radix scrophulariae, 5 parts of gallbladder star processed.
The preparation method of above-mentioned Chinese medicine composition the following steps are included:
S1, bulk pharmaceutical chemicals are weighed according to above-mentioned parts by weight, it is spare；Wherein, suitable wheat is first added in Radix Paeoniae Alba before decoction
Wheat bran enters a pot frying together, waits in pots and to remove wheat bran after Radix Paeoniae Alba stir-bake to yellowish and obtain stir-baked RADIX PAEONIAE ALBA；
S2, by the weighed cornu bubali of S1, antelope's horn, fructus alpiniae oxyphyllae, bombyx batryticatus, rhizoma nelumbinis, rhizoma acori graminei, caulis bambusae in taenian leaf, cassia seed, red lead
Ginseng, Radix Paeoniae Alba (stir-fry), radix scrophulariae, gallbladder star processed are uniformly mixed, and the water for being equivalent to 12 times of its total weight amounts is added, and decoct 2.0h, are filtered, and are received
Collect first time filtrate；Filter residue is added to the water for being equivalent to 8 times of its total weight amounts, decocts 2.0h, second of filtrate is collected in filtering,
First time filtrate and second of filtrate are merged, are condensed into thick medicinal extract to get Chinese medicine composition.
Embodiment 3
A kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment, raw material are composed of the following parts by weight: buffalo
100 parts of angle, 100 parts of fructus alpiniae oxyphyllae, 35 parts of bombyx batryticatus, 40 parts of antelope's horn, 80 parts of rhizoma nelumbinis, 50 parts of rhizoma acori graminei, 65 parts of caulis bambusae in taenian leaf, cassia seed
80 parts, 65 parts of RADIX SALVIAE MILTIORRHIZAE, 50 parts of Radix Paeoniae Alba (stir-fry), 50 parts of radix scrophulariae, 35 parts of gallbladder star processed.
The preparation method of above-mentioned Chinese medicine composition the following steps are included:
S1, bulk pharmaceutical chemicals are weighed according to above-mentioned parts by weight, it is spare；Wherein, suitable wheat is first added in Radix Paeoniae Alba before decoction
Wheat bran enters a pot frying together, waits in pots and to remove wheat bran after Radix Paeoniae Alba stir-bake to yellowish and obtain stir-baked RADIX PAEONIAE ALBA；
S2, by the weighed cornu bubali of S1, antelope's horn, fructus alpiniae oxyphyllae, bombyx batryticatus, rhizoma nelumbinis, rhizoma acori graminei, caulis bambusae in taenian leaf, cassia seed, red lead
Ginseng, Radix Paeoniae Alba (stir-fry), radix scrophulariae, gallbladder star processed are uniformly mixed, and the water for being equivalent to 10 times of its total weight amounts is added, and decoct 1.5h, are filtered, and are received
Collect first time filtrate；Filter residue is added to the water for being equivalent to 7 times of its total weight amounts, decocts 1.5h, second of filtrate is collected in filtering,
First time filtrate and second of filtrate are merged, are condensed into thick medicinal extract to get Chinese medicine composition.
What Examples 1 to 3 was provided which is used to prevent and treat a variety of cerebral arteriovenous malformation Chinese medicine compositions, and since Examples 1 to 3 mentions
The traditional Chinese medicine composition for treating effect of confession is substantially parallel, therefore for the Chinese medicine composition prepared below only with embodiment 1, right
Effect of the invention is illustrated.
Further effect of the invention is illustrated using clinical test below.
Clinical test
1, clinical data
1.1 general information
Accept a variety of cerebral arteriovenous malformation patients of outpatient service totally 120 for medical treatment from 2012.Wherein male 60, women 60,
Age 20-60 years old, average age 55.26 years old；The course of disease less than 5 years person 30,5-10 person 40,10-15 person 50.
More than 1.2 kinds of cerebral arteriovenous malformation tcm diagnosis standards
Essential resistance of turbid phlegm, qi depression to blood stasis, deficiency of kidney-essence.Main disease includes that patient body's fertilizer moves less, drowsiness, morning open in it is sticky
Dull, pale tongue is fat or light dark, while there is indentation, whitish tongue is greasy, deep-slow pulse or cunning.Irritability is vexed usually, when feel the swollen bored discomfort of sternal rib, when
Or it is dizzy, dark tongue quality or there is ecchymosis, sublingual vein is tortuous, veins string or puckery.Dizziness is had a headache, insomnia, failure of memory, waist and knee acid
It is soft, it sends out de- tooth and shakes, deafness and tinnitus, slow movement, spirit is stayed blunt, and tongue fur is thin white, and pale tongue is dark, and arteries and veins is thin.
2, treatment method
The grouping of 2.1 cases
120 a variety of cerebral arteriovenous malformation patients are divided into treatment group according to random digits table and control group intervene and ground
Study carefully；
Treatment group: 60 patients, wherein male patient 30, female patient 30, person 20 below 5-year courses, 5-10
Year person 20,10-15 person 20；
Control group: 60 patients, wherein male patient 30, female patient 30, person 20 below 5-year courses, 5-10
Year person 20,10-15 person 20.
2.2 treatment method
Treatment group: the drug of the offer of the embodiment of the present invention 1, one dose per day, 15 days courses for the treatment of are taken；
Control group: acupuncture therapy selects Shenmen, Sanyinjiao, Sishengcong, Baihui, Hsinshu (acupoint), Zusanli；Slight stimulation, the next day
Once, 5~7 times it is as a treatment course, rest 3 after 1 course for the treatment of, then carry out next course for the treatment of.
3, curative effect determinate standard
(1) effective most of symptom all disappears, and main Index for examination result is normal；
(2) effectively various symptoms take a favorable turn, and main Index for examination result has improvement；
(3) invalid various symptoms and Index for examination result are without improvement.
4, clinical test results are shown in Table 1.
1 clinical test results of table
| Group | Number of cases | It is effective | Effectively | In vain | Clinical obvious effective rate (%) | Total effective rate (%) |
| Treatment group | 60 | 35 | 15 | 10 | 58.3% | 83.3% |
| Control group | 60 | 27 | 13 | 20 | 45% | 66.7% |
As it can be seen from table 1 two groups of clinic obvious effective rates and total effective rate curative effect compare, there is significant difference in equal P < 0.05,
The Chinese medicine composition that the embodiment of the present invention 1 provides, clinical test results show that total effective rate is up to 83.3%, and obvious effective rate is up to
58.3%, and control group total effective rate is 66.7%, obvious effective rate 45%, this shows the anti-Zhiduo County of oral traditional Chinese medicine composition of the present invention
The curative effect of kind cerebral arteriovenous malformation is better than conventional treatments.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, since the step method of use is identical as embodiment,
It repeating in order to prevent, the present invention describes preferred embodiment, although preferred embodiments of the present invention have been described, but this field
Interior technical staff once knows basic creative concept, then additional changes and modifications may be made to these embodiments.Institute
With it includes preferred embodiment and all change and modification for falling into the scope of the invention that the following claims are intended to be interpreted as.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (3)
1. a kind of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment, which is characterized in that be made of the component of following parts by weight: water
60~100 parts of ox horn, 50~100 parts of fructus alpiniae oxyphyllae, 5~35 parts of bombyx batryticatus, 5~40 parts of antelope's horn, 40~80 parts of rhizoma nelumbinis, rhizoma acori graminei 15
~50 parts, 25~65 parts of caulis bambusae in taenian leaf, 40~80 parts of cassia seed, 20~65 parts of RADIX SALVIAE MILTIORRHIZAE, 10~50 parts of Radix Paeoniae Alba (stir-fry), radix scrophulariae 10~
50 parts, 5~35 parts of gallbladder star processed.
2. a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment according to claim 1, which is characterized in that by following parts by weight
Several components are made: 80 parts of cornu bubali, 80 parts of fructus alpiniae oxyphyllae, and 20 parts of bombyx batryticatus, 20 parts of antelope's horn, 60 parts of rhizoma nelumbinis, 30 parts of rhizoma acori graminei, bamboo
Eat 50 parts of leaf, 60 parts of cassia seed, 50 parts of RADIX SALVIAE MILTIORRHIZAE, 30 parts of Radix Paeoniae Alba (stir-fry), 30 parts of radix scrophulariae, 20 parts of gallbladder star processed.
3. a kind of preparation method of a variety of cerebral arteriovenous malformation Chinese medicine compositions of prevention and treatment described in claim 1, which is characterized in that packet
Include following steps:
S1, it weighs respectively according to parts by weight: 60~100 parts of cornu bubali, 50~100 parts of fructus alpiniae oxyphyllae, 5~35 parts of bombyx batryticatus, antelope
5~40 parts of angle, 40~80 parts of rhizoma nelumbinis, 15~50 parts of rhizoma acori graminei, 25~65 parts of caulis bambusae in taenian leaf, 40~80 parts of cassia seed, RADIX SALVIAE MILTIORRHIZAE 20
~65 parts, 10~50 portions of Radix Paeoniae Alba (stir-fry) is 10~50 parts of radix scrophulariae, 5~35 parts of gallbladder star processed, spare；
S2, the weighed each raw material of S1 being uniformly mixed, addition is equivalent to the water that 8-12 times of its total weight is measured, 1.0-2.0h is decocted,
First time filtrate is collected in filtering；Filter residue is added to the water for being equivalent to 6-8 times of its total weight and measuring, decocts 1.0-2.0h, is filtered, is received
Collect second of filtrate, first time filtrate and second of filtrate are merged, are condensed into thick medicinal extract to get Chinese medicine composition.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9421181B2 (en) * | 2013-05-06 | 2016-08-23 | Changzhou Hi-Tech District Multiple Dimension Industry Technology Institute Co., Ltd | Antihypoxic pharmaceutical composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9421181B2 (en) * | 2013-05-06 | 2016-08-23 | Changzhou Hi-Tech District Multiple Dimension Industry Technology Institute Co., Ltd | Antihypoxic pharmaceutical composition and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王志强: "HPLC法测定参麻通络胶囊中阿魏酸的含量", 《河北医药》 * |
| 隋继成 等: "溶栓牵正胶囊质量标准的制定", 《光明中医》 * |
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Application publication date: 20191112 |