CN103768464A - Traditional Chinese medicinal composition for treating myelodysplastic syndrome - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal composition for treating myelodysplastic syndrome. The composition is characterized by comprising the following raw medicinal materials by weight: 6-9g of salviae miltiorrhizae, 6-9g of American ginseng, 6-9g of mulberry, 6-9g of frankincense, 6-9g of anisetree bark, 6-9g of circium japonicum charcoal, 3-6g of pangolin, 6-9g of fortune eupatorium herb, 6-9g of gardenia jasminoides ellis, 4.5-6g of folium photiniae, 6-9g of entada phaseoloides, 6-9g of calamus, 6-9g of raspberry, 3-4g of dogwood, 6-9g of rhizoma smilacis glabrae. The traditional Chinese medicine has the beneficial effects of nourishing yin, reducing internal fire, dispelling wind, relieving pain, and strengthening medullary hematopoiesis immunologic balance repairing function. Treatment determination based on syndrome differentiation can be provided clinically according to different symptoms. The traditional Chinese medicine has the advantages of good effect, high cure rate, and small toxic and side effects.

Description

A kind of Chinese medicine composition for the treatment of myelodysplastic syndrome

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of myelodysplastic syndrome.

Background technology

Myelodysplastic syndrome is the one group of heterogeneous medullary system clone property disease that originates from hematopoietic stem cell, feature is myeloid cell differentiation and abnormal development, show as ineffective hematopoiesis, intractable cytopenia, hemopoietic function exhaustion, excessive risk transforms to acute myeloid leukemia (AML).MDS treatment mainly solves two large problems: marrow failure and complication, AML transform.With regard to patient colony, the diversity of MDS patient's natural history and prognosis is very large.Adopt therapy of combining Chinese and Western medicine myeloproliferative disorder, excite bone marrow hematogenesis method.Be with balance human immunity, qi and blood tonifying is basic, by clinical dialectical treating, adopts disease at blood, controls the treatment theory at internal organs, carries out the Synergistic treatment of three-dimensional, many target spots, many internal organs, reaches the object of curing myeloproliferative disorder.

Summary of the invention

Useful effect of Chinese medicine of the present invention is: YIN nourishing, pathogenic fire reducing, wind-expelling pain-stopping, enhancing bone marrow hematogenesis immunologic balance repair function.Often give determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to different disease types clinically.

Technical problem to be solved by this invention is in order to overcome technical deficiency, and a kind of good effect, short treating period are provided, and remission rate is high, and cost is low, a kind of Chinese medicine composition for the treatment of myelodysplastic syndrome having no side effect.

For above-mentioned purpose, treat a Chinese medicine composition for myelodysplastic syndrome, it is characterized in that its raw material medicines in portions by weight is as follows: Radix Salviae Miltiorrhizae 6～9g, Radix Panacis Quinquefolii 6～9g, Fructus Mori 6～9g, Olibanum 6～9g, Cortex Illicii 6～9g, Carbonized Cirsium japonicum 6～9g, Squama Manis 3～6g, Herba Eupatorii 6～9g, SHANZHIZI 6～9g, Folium Photiniae (Folium Photiniae serrulatae) 4.5～6g, Semen Entadae 6～9g, Rhizoma Acori Graminei 6～9g, Fructus Rubi 6～9g, Fructus Corni 3～4g, Rhizoma Smilacis Glabrae 6～9g.

Radix Salviae Miltiorrhizae bitter in the mouth in Chinese medicine of the present invention, cold nature effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind." book on Chinese herbal medicine converges and says ": Radix Salviae Miltiorrhizae, be apt to control blood system, remove stagnant tissue regeneration promoting, regulating menstruation is along feeling pulse medicine also.Modern study, has antibacterial, to improve microcirculation, promotion tissue reparation and regeneration.Radix Panacis Quinquefolii regulates nervus centralis, protection cardiovascular system, improves immunity antitumor.Fructus Mori sweet in the mouth, acid, cold in nature.GUIXIN, liver, kidney channel.Function with cure mainly: the YIN nourishing of enriching blood, promote the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Herba Eupatorii acrid in the mouth, property is flat.Return spleen, stomach, lung meridian.Removing dampness by means of aromatics, the appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouthful, halitosis, sialism, heat-damp in summer exterior syndrome, hygropyrexia is from the beginning of, heating asthenia, uncomfortable in chestly do not relax.Rhizoma Smilacis Glabrae feeble QI, lightly seasoned, astringent taste is sweet, light property is flat.Poisonous.Return liver, stomach, kidney spleen channel.Opening loose falling lets out.Sweet mung bean soup damp eliminating heat, removing toxic substances removing heat from blood.Folium Photiniae (Folium Photiniae serrulatae) acrid in the mouth, hardship, levelling.Dispel the wind, dredging collateral, kidney tonifying.For rheumatic arthralgia, aching pain in waist and back, the foot and knee being feeble, migraine.Olibanum acrid in the mouth, hardship, warm in nature.Enter the heart, liver, spleen channel.Function cures mainly: invigorates blood circulation, and circulation of qi promoting, pain relieving." not Lu ": treat edema due to wind pathogen poison swollen, remove bad odor.Treat urticaria itch poison and " detailed outline ": all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, the analgesic therapy of invigorating blood circulation, stretches muscle.Carbonized Cirsium japonicum sweet in the mouth, hardship, cool in nature.GUIXIN, Liver Channel.Function with cure mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, to spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Semen Entadae mildly bitter flavor is cool.Enter liver, spleen, stomach, kidney channel.Function with cure mainly: QI invigorating is enriched blood, invigorating the stomach and promoting digestion, except wind pain relieving, strong muscle os osseum.For water insufficiency of blood, pale complexion, myasthenia of limbs, epigastric pain, indigestion and loss of appetite lack of appetite; The soft pain of rheumatism limbs joint flaccidity, hyposexuality.Rhizoma Acori Graminei Herb has fragrance, pungent, bitter, temperature.GUIXIN, stomach warp.Function with cure mainly: the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, removing dampness appetizing.For god.Confused epilepsy, forgetful insomnia, Hiccough and deaf, gastral cavity painful abdominal mass is not hungry, mouthful dysentery of keeping silent.Ancients think that Rhizoma Acori Graminei has the effect of Fructus Alpiniae Oxyphyllae the chest stuffiness relieving, clear-headed and clear-sighted, the removing toxic substances of drying, thereby are seen as the thing of controlling heresy.Herba Centellae bitter in the mouth, pungent, cold in nature.Return liver,spleen,kidney warp.Effect: heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Be Asians's long-lived medicine, can refresh oneself by beneficial brain.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.It blood purification and immunity is had to activation, because can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviates mental fatigue; Also can blood pressure lowering, treatment hepatopathy etc.Fructus Rubi. " explaining abstruseness of the canon of materia medica ": Fructus Rubi, sweet normal person kidney, plays a sun and controls repeatly, controlling nocturnal emission with astringent drugs is taken the photograph excessive, kidney tonifying and without scorching partially, controlling nocturnal emission with astringent drugs and without coagulating puckery evil, the product of gold and jade are also.Fructus Corni sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Function with cure mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.Interior-heat is quenched one's thirst.There is in vitro the effect of killing ascites cells. also there is the effect of anti-experimental character hepatic injury. to the leukopenia causing because of chemotherapy and X-ray therapy, there is the effect that makes its rising.Cornin toxicity is very low, not haemolysis, but have the weak parasympathetic effect of excitement. above medicine matches, and brings out the best in each other.

The present invention follows the prescription principle of the traditional Chinese medical science, the use that is decocted in water for oral dose, and through clinical application for many years checking, total effective rate is 91.8%, and remission rate 83.8%, has no side effect.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1: a kind of Chinese medicine composition for the treatment of myelodysplastic syndrome, is characterized in that its raw material medicines in portions by weight is as follows: Radix Salviae Miltiorrhizae 6～9g, Radix Panacis Quinquefolii 6～9g, Fructus Mori 6～9g, Olibanum 6～9g, Cortex Illicii 6～9g, Carbonized Cirsium japonicum 6～9g, Squama Manis 3～6g, Herba Eupatorii 6～9g, SHANZHIZI 6～9g, Folium Photiniae (Folium Photiniae serrulatae) 4.5～6g, Semen Entadae 6～9g, Rhizoma Acori Graminei 6～9g, Fructus Rubi 6～9g, Fructus Corni 3～4g, Rhizoma Smilacis Glabrae 6～9g.

Embodiment 2: a kind of Chinese medicine composition for the treatment of myelodysplastic syndrome, is characterized in that its raw material medicines in portions by weight is as follows: Radix Salviae Miltiorrhizae 9g, Radix Panacis Quinquefolii 6g, Fructus Mori 9g, Olibanum 6g, Cortex Illicii 6g, Carbonized Cirsium japonicum 9g, Squama Manis 6g, Herba Eupatorii 6g, SHANZHIZI 9g, Folium Photiniae (Folium Photiniae serrulatae) 6g, Semen Entadae 6g, Rhizoma Acori Graminei 6g, Fructus Rubi 6g, Fructus Corni 4g, Rhizoma Smilacis Glabrae 9g.

Clinical efficacy is summed up:

One, physical data: Chinese medicine of the present invention is extensive in clinical practice for many years, treatment male patient 58 examples, women's 16 examples, the age is at 51～76 years old, and average 65.2 years old, all to make a definite diagnosis through hospital above county level, curative effect is frequently good.

Two, diagnostic criteria: medical history: chemotherapy/lonizing radiation, chemical toxicant contact history; MDS/AML family history and other medical histories.Health check-up: anemia, hemorrhage, infection sign, the enlargement of part spleen.Continue (>=June) lab testing: one is or polyphyly cytopenia: DH: in bone marrow smear erythron, neutrophil series, megakaryocytic series, arbitrary system at least reaches 10%; Ring-type sideroblast occupies nucleated red blood cell ratio >=15%; Germinal cell: reach 5～19% in bone marrow smear; Chromosomal abnormality.

Three, method of administration: decoct 200ml 1 dose, every dose of the every day of being decocted in water for oral dose, being grown up, early, late sub-service, every 10 days was 1 course for the treatment of.

Four, curative effect judging standard

Alleviate: clinical symptoms is improved more than 80%, laboratory checking index improves.

Take a turn for the better: clinical symptoms is improved and reduced 50%.

Invalid: clinical symptoms is unchanged or increase the weight of.

Five, therapeutic effect: the present invention is for many years in clinical practice, and treatment 62 routine patients, alleviate 52 examples 83.8%, and 5 examples that take a turn for the better, are 8%; Invalid 1 example.Total effective rate is 91.8%, remission rate 83.8%.

Six, model case

1, Rhizoma Zingiberis Recens XX, man, 56 years old.In May, 2010 take dizzy, weak, gingival hemorrhage as cardinal symptom is in hospital, and with nasal bleeding.Blood routine examination after being admitted to hospital: HB68G/L, PIT7 × 109/L.Bone marrow cytomorphologic examination: hypertrophy is still active, M/E=0.88: lymphocytosis, account for 59.5%, myeloid tissue is almost replaced by fatty tissue, and rarely seen few hematopoietic cell of being permitted, has no megalokaryocyte.AD: low hypertrophy MDS-RA.Can, give the treatments such as auspicious white, sharp XUEBAO, poor effect through giving peace hero, stanozolol, field therebetween.Patient requires to take 20 doses, Chinese medicine of the present invention, and clinical symptoms disappears completely, after half a year, does not follow up a case by regular visits to and does not recur.

2, Lee XX, man, 62 years old, it was that cardinal symptom is in hospital that, pale complexion weak in May, 2011, skin have petechia, and with gingiva and nasal bleeding.Blood routine examination after being admitted to hospital: HB68G/L, PIT7 × 109/L.Bone marrow cytomorphologic examination: hypertrophy is still active, and myeloid tissue is almost replaced by fatty tissue, rarely seen few hematopoietic cell of being permitted, has no megalokaryocyte.AD: low hypertrophy MDS-RA.Stop and the treatment such as hormone, poor effect through giving low dose of reaction therebetween.Patient requires to take 20 doses, Chinese medicine of the present invention, and drug withdrawal continues to take 15 doses, Chinese medicine for two days.Clinical symptoms disappears completely, after half a year, does not follow up a case by regular visits to and does not recur.

3, high X, female, 41 years old, have in August, 2012 take weak, pale complexion, skin petechia as cardinal symptom be in hospital.Blood routine examination after being admitted to hospital: HB68G/L, WBC3.8 × 109/L, PIT7 × 90/L.Bone marrow cytomorphologic examination: hypertrophy is still active, M/E=0.88: 1, lymphocytosis, accounts for 59.5%, and the rarely seen few hematopoietic cell of being permitted of myeloid tissue, has no megalokaryocyte.AD: low hypertrophy MDS-RA.Therebetween through giving the treatments such as peace hero, stanozolol, sharp XUEBAO, poor effect.Patient requires to take 30 doses, Chinese medicine of the present invention, and clinical symptoms disappears completely, after half a year, does not follow up a case by regular visits to and does not recur.

Claims (1)

1. treat a Chinese medicine composition for myelodysplastic syndrome, it is characterized in that its raw material medicines in portions by weight is as follows: Radix Salviae Miltiorrhizae 6～9g, Radix Panacis Quinquefolii 6～9g, Fructus Mori 6～9g, Olibanum 6～9g, Cortex Illicii 6～9g, Carbonized Cirsium japonicum 6～9g, Squama Manis 3～6g, Herba Eupatorii 6～9g, SHANZHIZI 6～9g, Folium Photiniae (Folium Photiniae serrulatae) 4.5～6g, Semen Entadae 6～9g, Rhizoma Acori Graminei 6～9g, Fructus Rubi 6～9g, Fructus Corni 3～4g, Rhizoma Smilacis Glabrae 6～9g.