CN110431139B - 氘代的咪唑并[4,5-c]喹啉-2-酮化合物及其在治疗癌症中的用途 - Google Patents

氘代的咪唑并[4,5-c]喹啉-2-酮化合物及其在治疗癌症中的用途 Download PDF

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Publication number
CN110431139B
CN110431139B CN201880017916.4A CN201880017916A CN110431139B CN 110431139 B CN110431139 B CN 110431139B CN 201880017916 A CN201880017916 A CN 201880017916A CN 110431139 B CN110431139 B CN 110431139B
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compound
cancer
formula
pharmaceutically acceptable
acceptable salt
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CN110431139A (zh
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K.G.派克
B.C.巴拉姆
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880017916.4A 2017-03-16 2018-03-15 氘代的咪唑并[4,5-c]喹啉-2-酮化合物及其在治疗癌症中的用途 Active CN110431139B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762472080P 2017-03-16 2017-03-16
US62/472080 2017-03-16
PCT/EP2018/056516 WO2018167203A1 (en) 2017-03-16 2018-03-15 Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

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CN110431139A CN110431139A (zh) 2019-11-08
CN110431139B true CN110431139B (zh) 2022-07-05

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US (2) US20200087300A1 (enExample)
EP (1) EP3596076A1 (enExample)
JP (1) JP2020514344A (enExample)
KR (1) KR20190129923A (enExample)
CN (1) CN110431139B (enExample)
AU (1) AU2018234985B2 (enExample)
BR (1) BR112019018723A2 (enExample)
CA (1) CA3055258A1 (enExample)
CL (1) CL2019002527A1 (enExample)
CO (1) CO2019010029A2 (enExample)
CR (1) CR20190429A (enExample)
DO (1) DOP2019000228A (enExample)
EA (1) EA038233B1 (enExample)
EC (1) ECSP19066134A (enExample)
IL (1) IL269272A (enExample)
JO (1) JOP20190209A1 (enExample)
MA (1) MA49884A (enExample)
MX (1) MX2019010898A (enExample)
NI (1) NI201900094A (enExample)
PE (1) PE20191486A1 (enExample)
PH (1) PH12019502086A1 (enExample)
SG (1) SG11201908065YA (enExample)
TW (1) TW201843151A (enExample)
UA (1) UA124554C2 (enExample)
WO (1) WO2018167203A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV15575A (lv) * 2019-12-20 2021-06-20 Latvijas Organiskās Sintēzes Institūts Selenofēnhromēnu deiterēti analogi, to iegūšana un izmantošana
EP4171651A1 (en) 2020-06-24 2023-05-03 AstraZeneca UK Limited Combination of antibody-drug conjugate and atm inhibitor
CN116056698B (zh) * 2020-09-21 2024-11-19 威尚（上海）生物医药有限公司 具有血脑屏障穿透能力的取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮化合物
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
WO2022128833A1 (en) 2020-12-15 2022-06-23 Merck Patent Gmbh Solid transition metal-ligand complexes

Citations (4)

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CN102372711A (zh) * 2010-08-18 2012-03-14 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
CN106255692A (zh) * 2014-05-08 2016-12-21 阿斯利康(瑞典)有限公司 咪唑并[4,5‑c]喹啉‑2‑酮化合物以及它们在治疗癌症中的用途
WO2017046216A1 (en) * 2015-09-17 2017-03-23 Astrazeneca Ab 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer

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US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
KR19990082463A (ko) 1996-02-13 1999-11-25 돈 리사 로얄 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
AU719327B2 (en) 1996-03-05 2000-05-04 Astrazeneca Ab 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US20090082387A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched nvp-bez234
KR101445458B1 (ko) * 2009-06-04 2014-10-07 노파르티스 아게 １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체
RS62082B1 (sr) * 2015-04-02 2021-08-31 Merck Patent Gmbh Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN102372711A (zh) * 2010-08-18 2012-03-14 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
CN106255692A (zh) * 2014-05-08 2016-12-21 阿斯利康(瑞典)有限公司 咪唑并[4,5‑c]喹啉‑2‑酮化合物以及它们在治疗癌症中的用途
WO2017046216A1 (en) * 2015-09-17 2017-03-23 Astrazeneca Ab 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer

Non-Patent Citations (1)

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ECSP19066134A (es) 2019-09-30
EA201992090A1 (ru) 2020-03-06
EP3596076A1 (en) 2020-01-22
AU2018234985B2 (en) 2020-04-02
AU2018234985A1 (en) 2019-10-24
KR20190129923A (ko) 2019-11-20
CL2019002527A1 (es) 2019-11-22
US20200087300A1 (en) 2020-03-19
NI201900094A (es) 2020-03-18
TW201843151A (zh) 2018-12-16
CN110431139A (zh) 2019-11-08
BR112019018723A2 (pt) 2020-04-07
DOP2019000228A (es) 2019-09-30
JOP20190209A1 (ar) 2019-09-12
MA49884A (fr) 2020-06-24
CR20190429A (es) 2019-11-12
UA124554C2 (uk) 2021-10-05
WO2018167203A1 (en) 2018-09-20
JP2020514344A (ja) 2020-05-21
EA038233B1 (ru) 2021-07-28
CO2019010029A2 (es) 2019-09-30
SG11201908065YA (en) 2019-09-27
MX2019010898A (es) 2019-11-07
PE20191486A1 (es) 2019-10-18
IL269272A (en) 2019-11-28
CA3055258A1 (en) 2018-09-20
PH12019502086A1 (en) 2020-03-09
US20210347775A1 (en) 2021-11-11

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