BR112019018723A2 - compostos de imidazo[4,5-c]quinolin-2-ona deuterada e seu uso no tratamento do câncer - Google Patents
compostos de imidazo[4,5-c]quinolin-2-ona deuterada e seu uso no tratamento do câncer Download PDFInfo
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- BR112019018723A2 BR112019018723A2 BR112019018723A BR112019018723A BR112019018723A2 BR 112019018723 A2 BR112019018723 A2 BR 112019018723A2 BR 112019018723 A BR112019018723 A BR 112019018723A BR 112019018723 A BR112019018723 A BR 112019018723A BR 112019018723 A2 BR112019018723 A2 BR 112019018723A2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201762472080P | 2017-03-16 | 2017-03-16 | |
| PCT/EP2018/056516 WO2018167203A1 (en) | 2017-03-16 | 2018-03-15 | Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
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| BR112019018723A2 true BR112019018723A2 (pt) | 2020-04-07 |
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| BR112019018723A BR112019018723A2 (pt) | 2017-03-16 | 2018-03-15 | compostos de imidazo[4,5-c]quinolin-2-ona deuterada e seu uso no tratamento do câncer |
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| LV15575A (lv) * | 2019-12-20 | 2021-06-20 | Latvijas Organiskās Sintēzes Institūts | Selenofēnhromēnu deiterēti analogi, to iegūšana un izmantošana |
| EP4171651A1 (en) | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and atm inhibitor |
| CN116056698B (zh) * | 2020-09-21 | 2024-11-19 | 威尚（上海）生物医药有限公司 | 具有血脑屏障穿透能力的取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮化合物 |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
| WO2022128833A1 (en) | 2020-12-15 | 2022-06-23 | Merck Patent Gmbh | Solid transition metal-ligand complexes |
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| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| KR19990082463A (ko) | 1996-02-13 | 1999-11-25 | 돈 리사 로얄 | 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체 |
| AU719327B2 (en) | 1996-03-05 | 2000-05-04 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US20090082387A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched nvp-bez234 |
| KR101445458B1 (ko) * | 2009-06-04 | 2014-10-07 | 노파르티스 아게 | １Ｈ-이미다조［４,５-ｃ］퀴놀리논 유도체 |
| CN102372711B (zh) * | 2010-08-18 | 2014-09-17 | 山东轩竹医药科技有限公司 | 咪唑并喹啉类PI3K和mTOR双重抑制剂 |
| CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| NO2714752T3 (enExample) * | 2014-05-08 | 2018-04-21 | ||
| RS62082B1 (sr) * | 2015-04-02 | 2021-08-31 | Merck Patent Gmbh | Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze |
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
-
2017
- 2017-06-16 JO JOP/2019/0209A patent/JOP20190209A1/ar unknown
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2018
- 2018-03-15 AU AU2018234985A patent/AU2018234985B2/en not_active Ceased
- 2018-03-15 MA MA049884A patent/MA49884A/fr unknown
- 2018-03-15 SG SG11201908065YA patent/SG11201908065YA/en unknown
- 2018-03-15 WO PCT/EP2018/056516 patent/WO2018167203A1/en not_active Ceased
- 2018-03-15 US US16/493,850 patent/US20200087300A1/en not_active Abandoned
- 2018-03-15 EP EP18713818.5A patent/EP3596076A1/en not_active Withdrawn
- 2018-03-15 UA UAA201910213A patent/UA124554C2/uk unknown
- 2018-03-15 JP JP2019549446A patent/JP2020514344A/ja not_active Ceased
- 2018-03-15 KR KR1020197030079A patent/KR20190129923A/ko not_active Abandoned
- 2018-03-15 CR CR20190429A patent/CR20190429A/es unknown
- 2018-03-15 PE PE2019001872A patent/PE20191486A1/es unknown
- 2018-03-15 BR BR112019018723A patent/BR112019018723A2/pt not_active Application Discontinuation
- 2018-03-15 MX MX2019010898A patent/MX2019010898A/es unknown
- 2018-03-15 CN CN201880017916.4A patent/CN110431139B/zh active Active
- 2018-03-15 CA CA3055258A patent/CA3055258A1/en not_active Abandoned
- 2018-03-15 TW TW107108833A patent/TW201843151A/zh unknown
- 2018-03-15 EA EA201992090A patent/EA038233B1/ru unknown
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2019
- 2019-09-03 CL CL2019002527A patent/CL2019002527A1/es unknown
- 2019-09-06 DO DO2019000228A patent/DOP2019000228A/es unknown
- 2019-09-11 IL IL26927219A patent/IL269272A/en unknown
- 2019-09-12 EC ECSENADI201966134A patent/ECSP19066134A/es unknown
- 2019-09-13 PH PH12019502086A patent/PH12019502086A1/en unknown
- 2019-09-13 NI NI201900094A patent/NI201900094A/es unknown
- 2019-09-16 CO CONC2019/0010029A patent/CO2019010029A2/es unknown
-
2021
- 2021-07-20 US US17/380,323 patent/US20210347775A1/en not_active Abandoned
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| ECSP19066134A (es) | 2019-09-30 |
| EA201992090A1 (ru) | 2020-03-06 |
| EP3596076A1 (en) | 2020-01-22 |
| AU2018234985B2 (en) | 2020-04-02 |
| AU2018234985A1 (en) | 2019-10-24 |
| KR20190129923A (ko) | 2019-11-20 |
| CL2019002527A1 (es) | 2019-11-22 |
| US20200087300A1 (en) | 2020-03-19 |
| NI201900094A (es) | 2020-03-18 |
| TW201843151A (zh) | 2018-12-16 |
| CN110431139A (zh) | 2019-11-08 |
| DOP2019000228A (es) | 2019-09-30 |
| JOP20190209A1 (ar) | 2019-09-12 |
| MA49884A (fr) | 2020-06-24 |
| CR20190429A (es) | 2019-11-12 |
| CN110431139B (zh) | 2022-07-05 |
| UA124554C2 (uk) | 2021-10-05 |
| WO2018167203A1 (en) | 2018-09-20 |
| JP2020514344A (ja) | 2020-05-21 |
| EA038233B1 (ru) | 2021-07-28 |
| CO2019010029A2 (es) | 2019-09-30 |
| SG11201908065YA (en) | 2019-09-27 |
| MX2019010898A (es) | 2019-11-07 |
| PE20191486A1 (es) | 2019-10-18 |
| IL269272A (en) | 2019-11-28 |
| CA3055258A1 (en) | 2018-09-20 |
| PH12019502086A1 (en) | 2020-03-09 |
| US20210347775A1 (en) | 2021-11-11 |
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