AU2018234985B2 - Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer - Google Patents

Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer Download PDF

Info

Publication number
AU2018234985B2
AU2018234985B2 AU2018234985A AU2018234985A AU2018234985B2 AU 2018234985 B2 AU2018234985 B2 AU 2018234985B2 AU 2018234985 A AU2018234985 A AU 2018234985A AU 2018234985 A AU2018234985 A AU 2018234985A AU 2018234985 B2 AU2018234985 B2 AU 2018234985B2
Authority
AU
Australia
Prior art keywords
cancer
compound
formula
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2018234985A
Other languages
English (en)
Other versions
AU2018234985A1 (en
Inventor
Bernard Christophe Barlaam
Kurt Gordon Pike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2018234985A1 publication Critical patent/AU2018234985A1/en
Application granted granted Critical
Publication of AU2018234985B2 publication Critical patent/AU2018234985B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018234985A 2017-03-16 2018-03-15 Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer Ceased AU2018234985B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762472080P 2017-03-16 2017-03-16
US62/472,080 2017-03-16
PCT/EP2018/056516 WO2018167203A1 (en) 2017-03-16 2018-03-15 Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

Publications (2)

Publication Number Publication Date
AU2018234985A1 AU2018234985A1 (en) 2019-10-24
AU2018234985B2 true AU2018234985B2 (en) 2020-04-02

Family

ID=61801891

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018234985A Ceased AU2018234985B2 (en) 2017-03-16 2018-03-15 Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

Country Status (25)

Country Link
US (2) US20200087300A1 (enExample)
EP (1) EP3596076A1 (enExample)
JP (1) JP2020514344A (enExample)
KR (1) KR20190129923A (enExample)
CN (1) CN110431139B (enExample)
AU (1) AU2018234985B2 (enExample)
BR (1) BR112019018723A2 (enExample)
CA (1) CA3055258A1 (enExample)
CL (1) CL2019002527A1 (enExample)
CO (1) CO2019010029A2 (enExample)
CR (1) CR20190429A (enExample)
DO (1) DOP2019000228A (enExample)
EA (1) EA038233B1 (enExample)
EC (1) ECSP19066134A (enExample)
IL (1) IL269272A (enExample)
JO (1) JOP20190209A1 (enExample)
MA (1) MA49884A (enExample)
MX (1) MX2019010898A (enExample)
NI (1) NI201900094A (enExample)
PE (1) PE20191486A1 (enExample)
PH (1) PH12019502086A1 (enExample)
SG (1) SG11201908065YA (enExample)
TW (1) TW201843151A (enExample)
UA (1) UA124554C2 (enExample)
WO (1) WO2018167203A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV15575A (lv) * 2019-12-20 2021-06-20 Latvijas Organiskās Sintēzes Institūts Selenofēnhromēnu deiterēti analogi, to iegūšana un izmantošana
CN116194109A (zh) 2020-06-24 2023-05-30 阿斯利康(英国)有限公司 抗体-药物缀合物和atm抑制剂的组合
CN116056698B (zh) * 2020-09-21 2024-11-19 威尚（上海）生物医药有限公司 具有血脑屏障穿透能力的取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮化合物
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
WO2022128833A1 (en) 2020-12-15 2022-06-23 Merck Patent Gmbh Solid transition metal-ligand complexes
CN118434736A (zh) * 2022-01-26 2024-08-02 正大天晴药业集团股份有限公司 含有肼基的化合物
WO2026120558A1 (en) 2024-12-06 2026-06-11 Sun Pharma Advanced Research Company Limited Macrocyclic compounds as atm inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102372711A (zh) * 2010-08-18 2012-03-14 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
WO2015170081A1 (en) * 2014-05-08 2015-11-12 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2017046216A1 (en) * 2015-09-17 2017-03-23 Astrazeneca Ab 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US20090082387A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched nvp-bez234
MA33332B1 (fr) * 2009-06-04 2012-06-01 Novartis Ag Dérivés de la 1h-imidazo[4,5-c]quinolinone
PL3277681T3 (pl) * 2015-04-02 2019-10-31 Merck Patent Gmbh Imidazolonylochinoliny i ich zastosowanie jako inhibitorów kinazy atm

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102372711A (zh) * 2010-08-18 2012-03-14 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
WO2015170081A1 (en) * 2014-05-08 2015-11-12 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2017046216A1 (en) * 2015-09-17 2017-03-23 Astrazeneca Ab 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer

Also Published As

Publication number Publication date
ECSP19066134A (es) 2019-09-30
AU2018234985A1 (en) 2019-10-24
CA3055258A1 (en) 2018-09-20
CN110431139A (zh) 2019-11-08
CL2019002527A1 (es) 2019-11-22
SG11201908065YA (en) 2019-09-27
EA201992090A1 (ru) 2020-03-06
EA038233B1 (ru) 2021-07-28
CO2019010029A2 (es) 2019-09-30
US20200087300A1 (en) 2020-03-19
WO2018167203A1 (en) 2018-09-20
TW201843151A (zh) 2018-12-16
KR20190129923A (ko) 2019-11-20
PH12019502086A1 (en) 2020-03-09
PE20191486A1 (es) 2019-10-18
UA124554C2 (uk) 2021-10-05
CN110431139B (zh) 2022-07-05
CR20190429A (es) 2019-11-12
EP3596076A1 (en) 2020-01-22
MX2019010898A (es) 2019-11-07
BR112019018723A2 (pt) 2020-04-07
JOP20190209A1 (ar) 2019-09-12
IL269272A (en) 2019-11-28
NI201900094A (es) 2020-03-18
MA49884A (fr) 2020-06-24
US20210347775A1 (en) 2021-11-11
JP2020514344A (ja) 2020-05-21
DOP2019000228A (es) 2019-09-30

Similar Documents

Publication Publication Date Title
US20230286981A1 (en) Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer
DK3140303T3 (en) IMIDAZO [4,5-C] QUINOLIN-2 COMPOUNDS AND ITS USE IN TREATMENT OF CANCER
US20210347775A1 (en) Deuterated Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer
US20180318287A1 (en) Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer
WO2017194632A1 (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2017153578A1 (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2019057757A1 (en) 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER
CA3015953A1 (en) N,n-dimethyl-3-[[5-(3-methyl-2-oxo-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine oxide as atm (ataxia telangiectasia mutated) kinase modulator for treating cancer
HK40016607A (en) Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
HK1257413B (en) 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer
HK1232528A1 (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
HK1232528B (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
BR112016025153B1 (pt) "compostos de imidazo[4,5-c]quinolin-2-ona, composição farmaceutica e seu uso no tratamento de câncer

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired