TW201843151A - 氘化咪唑并[4,5-c]喹啉-2-酮化合物及其於治療癌症之用途 - Google Patents
氘化咪唑并[4,5-c]喹啉-2-酮化合物及其於治療癌症之用途 Download PDFInfo
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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Landscapes
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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| CN116194109A (zh) | 2020-06-24 | 2023-05-30 | 阿斯利康(英国)有限公司 | 抗体-药物缀合物和atm抑制剂的组合 |
| CN116056698B (zh) * | 2020-09-21 | 2024-11-19 | 威尚（上海）生物医药有限公司 | 具有血脑屏障穿透能力的取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮化合物 |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
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| CN118434736A (zh) * | 2022-01-26 | 2024-08-02 | 正大天晴药业集团股份有限公司 | 含有肼基的化合物 |
| WO2026120558A1 (en) | 2024-12-06 | 2026-06-11 | Sun Pharma Advanced Research Company Limited | Macrocyclic compounds as atm inhibitors |
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| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
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| MA33332B1 (fr) * | 2009-06-04 | 2012-06-01 | Novartis Ag | Dérivés de la 1h-imidazo[4,5-c]quinolinone |
| CN102372711B (zh) * | 2010-08-18 | 2014-09-17 | 山东轩竹医药科技有限公司 | 咪唑并喹啉类PI3K和mTOR双重抑制剂 |
| CN102399218A (zh) | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
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| PL3277681T3 (pl) * | 2015-04-02 | 2019-10-31 | Merck Patent Gmbh | Imidazolonylochinoliny i ich zastosowanie jako inhibitorów kinazy atm |
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
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| AU2018234985A1 (en) | 2019-10-24 |
| CA3055258A1 (en) | 2018-09-20 |
| CN110431139A (zh) | 2019-11-08 |
| CL2019002527A1 (es) | 2019-11-22 |
| SG11201908065YA (en) | 2019-09-27 |
| EA201992090A1 (ru) | 2020-03-06 |
| EA038233B1 (ru) | 2021-07-28 |
| CO2019010029A2 (es) | 2019-09-30 |
| US20200087300A1 (en) | 2020-03-19 |
| WO2018167203A1 (en) | 2018-09-20 |
| KR20190129923A (ko) | 2019-11-20 |
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| PE20191486A1 (es) | 2019-10-18 |
| UA124554C2 (uk) | 2021-10-05 |
| AU2018234985B2 (en) | 2020-04-02 |
| CN110431139B (zh) | 2022-07-05 |
| CR20190429A (es) | 2019-11-12 |
| EP3596076A1 (en) | 2020-01-22 |
| MX2019010898A (es) | 2019-11-07 |
| BR112019018723A2 (pt) | 2020-04-07 |
| JOP20190209A1 (ar) | 2019-09-12 |
| IL269272A (en) | 2019-11-28 |
| NI201900094A (es) | 2020-03-18 |
| MA49884A (fr) | 2020-06-24 |
| US20210347775A1 (en) | 2021-11-11 |
| JP2020514344A (ja) | 2020-05-21 |
| DOP2019000228A (es) | 2019-09-30 |
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