CN110327273A - Lightening compositions, Skin whitening care cosmetics and preparation method thereof - Google Patents
Lightening compositions, Skin whitening care cosmetics and preparation method thereof Download PDFInfo
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- CN110327273A CN110327273A CN201910719862.2A CN201910719862A CN110327273A CN 110327273 A CN110327273 A CN 110327273A CN 201910719862 A CN201910719862 A CN 201910719862A CN 110327273 A CN110327273 A CN 110327273A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention discloses a kind of lightening compositions, Skin whitening care cosmetics and preparation method thereof, and wherein lightening compositions, Skin whitening care cosmetics are mainly made of following raw materials: Ramulus et Folium Mussaendae Pubescentis extract, licorice, lecithin, mulberry root bark extract, Turmeric P.E, active dry yeasr element, vitamin C and water.Lightening compositions that the present invention is prepared, Skin whitening care cosmetics use natural herbs extracting solution, active dry yeasr element is added simultaneously, the generation of the melanin in skin can be effectively inhibited, improve the ability of the more raw update of tin cream, it drops hypopigmented precipitating and promotion epidermal cell falls off, skin is made to secure good health the effect of nature whitening.
Description
Technical field
The invention belongs to skin-lightening cosmetic technical field more particularly to a kind of lightening compositions, Skin whitening care cosmetics and its system
Preparation Method.
Background technique
Skin has five basic functions: defencive function, and skin can prevent the infringement of outer bound pair inside of human body: exchange function
Can, skin histology is not the totally enclosed barrier of light, can be swapped with external environment；Sensory function, skin can experience pressure,
Hot and cold, pain.Skin plays an important role to maintenance the constant of body temperature: immunoloregulation function, by synthesizing and secreting water-soluble letter
The factor, such as cell factor are ceased, immunoregulation effect is played；Metabolic function, mainly synthesis of vitamin d.This 5 kinds of functions
In most important function be that human body is protected not encroached on by the external world.Skin, which is one layer, has physical action, biochemical action, immunization
Barrier, mechanical infringement can be resisted, pollution, sunlight neck shoot evil wounded, external substance, such as bacterium, pathogen is prevented to invade people
Internal portion.
The color of normal human skin mainly goes out two factors and determines: (1) in skin all kinds of pigments content and distribution situation,
Mainly including oxyhemoglobin and reduced hemoglobin etc. in melanocyte (excellent melanocyte and pheomelanin), carrotene and blood；(2)
For light in optical considerations such as absorption, the scatterings of skin surface, influence factor includes the thickness of the mutually rough degree of skin surface, epidermis
And it is radiated at the light source etc. of skin surface.Melanocyte is the principal element for determining skin color in all kinds of pigments of skin.Due to black
The links such as tyrosine propylhomoserin enzymatic activity and melanocyte conveying in plain synthesis process are easy by external influence, thus for method spot beauty
The effect link of white active material provides the foundation.Common method spot class is to inhibit network from the main function target spot of active material at present
The links such as propylhomoserin enzymatic activity, the metabolism for influencing melanocyte and transhipment.
With the increase of skin-lightening cosmetic demand, wide market, many famous cosmetics companies and research
Mechanism puts into the exploitation that a large amount of manpower and material resources carry out novel whitening chemicals, the novel beauty to come into operation from chemicals increasingly
It is more.Based on comprehensive consideration to the various factors for influencing skin-whitening, whitening product of new generation should be full effect whitening-from outer
Protection of the portion to ultraviolet light to the internal generation for inhibiting melanin, improves the more raw updating ability of cell, reduction pigment deposition and rush
Into desquamation, until enhancing Skin Cell autoimmunity, raising skin elasticity, moisture content and metabolic function
Deng, using comprehensive formula combination, play more efficacy effects of multicomponent whitening active ingredients, so that skin is secured good health, from
The effect of right whitening.
Summary of the invention
It is various not to there is stability, absorbability, validity, safety etc. based on whitening active ingredients in the prior art
It is highly desirable status, the present invention provides a kind of lightening compositions, Skin whitening care cosmetics and preparation method thereof.
The present invention is achieved through the following technical solutions:
A kind of lightening compositions, including following raw materials: Ramulus et Folium Mussaendae Pubescentis extract, licorice, lecithin, mulberry root skin are extracted
Object, Turmeric P.E, active dry yeasr element, vitamin C and water.
A kind of lightening compositions, the raw material including following weight component: 5-15 parts of Ramulus et Folium Mussaendae Pubescentis extract, 1-10 parts of Radix Glycyrrhizae
Extract, 2-6 parts of lecithin, 10-30 parts of mulberry root bark extract, 35-45 parts of Turmeric P.E, 5-25 parts of active ferment
Female element, 1-3 parts of vitamin C and 80-120 parts of water.
Preferably, the Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, the ginger after being freeze-dried
Huang is subsequently placed in pulverizer and crushes, and is sieved using the sieve of 60-120 mesh, obtains curcuma powder；
Step 3, by curcuma powder using being pulverized in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and digests by step 4, is filtered after the completion of enzymatic hydrolysis using filter membrane, retains
Filtrate；
Filtrate is placed in a centrifuge centrifugation by step 5, retains precipitating, then precipitating is placed in ethanol water, is heated up
To 40-60 DEG C, stirring is dissolved completely in ethanol water to precipitating, is then filtered using ultrafiltration membrane, after obtaining purification
Extracting solution；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, is subsequently placed in spray dryer
In be dried, obtain Turmeric P.E.
It is furthermore preferred that the process that turmeric is specifically freeze-dried after net system in the step 2 are as follows: first set the turmeric after net system
It is refrigerated to -35~-25 DEG C in freeze drier, continues 2-3h, then distils, the temperature of distillation is -15~-5 DEG C, is continued
10-12h finally adjusts the temperature of freeze drier to 40~60 DEG C, continues 20-24h, the ginger after finally obtaining freeze-drying
It is yellow.
It is furthermore preferred that enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1-2% zytase, 1.5-
2.5% cellulase, 0.5-1.5% stabilizer, surplus are water.
It is furthermore preferred that the stabilizer is one of polyvinylpyrrolidone, sodium carboxymethylcellulose or a variety of.
It is furthermore preferred that the stabilizer is the mixture of polyvinylpyrrolidone, sodium carboxymethylcellulose composition, it is described poly-
Vinylpyrrolidone, sodium carboxymethylcellulose mass ratio be (1-2): (1-2).
It is furthermore preferred that the mass fraction of the ethanol water is 40-60%, the ultrafiltration membrane retains relative molecular mass
For 5000-6000Da.
Preferably, the active dry yeasr element is prepared by the following method:
Discarded beer yeast solution 200-400g is chosen, is filtered using the nylon wire of 100-200 mesh, after retaining filtering
Filter residue, then be added 500-800mL distilled water, be stirred 30- under conditions of 30-40 DEG C, 400-500r/min
60min is filtered after the completion of stirring using the nylon wire of 300-400 mesh, is then centrifuged filtrate using centrifuge,
Middle centrifugation rate is 3000-5000r/min, retains centrifugate；It is 0.6- that 80-120mL mass fraction is added in centrifugate
0.8% sodium bicarbonate aqueous solution stirs 60-90min, the protease of 0.05-0.1g is then added, in 40-60 DEG C, 300-
100-120min is stirred under conditions of 400r/min, after the completion of stirring, solution is placed in supersonic cleaning machine and is ultrasonically treated
20-40min, wherein the temperature being ultrasonically treated is 50-60 DEG C, power 200-400w, then enzyme deactivation, in 3000-5000r/min
Under the conditions of be centrifugated, take supernatant, be placed in Rotary Evaporators and be concentrated in vacuo, be concentrated into density be 1.02-1.05kg/L
(20 DEG C), are finally spray-dried, and the active dry yeasr element is obtained.
It is furthermore preferred that the protease is one of ficin, subtilopeptidase A or a variety of.
It is furthermore preferred that the protease is by ficin, subtilopeptidase A with mass ratio (1-2): (1-2) is mixed
It closes.
The present invention also provides a kind of Skin whitening care cosmetics, are prepared using above-mentioned lightening compositions.
The method of a kind of Skin whitening care cosmetics provided by the invention are as follows: after evenly mixing by above-mentioned lightening compositions, carry out spoke
According to processing, the Skin whitening care cosmetics are obtained.
Compared with prior art, the present invention has the advantages that following prominent and effect:
The present invention screens natural herbs, is then specifically matched the natural herbs after screening
Than, while active dry yeasr element is added, cooperate the whitening essence in natural herbs, the melanin in skin can be effectively inhibited
Generation, improve the ability of tin cream more raw update, drop hypopigmented precipitating and promotion epidermal cell falls off, be good for skin
The effect of Kang Ziran whitening.
Specific embodiment
Foregoing invention content of the invention is described in further detail With reference to embodiment, but should not be incited somebody to action
This range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiments.
Each raw material introduction in embodiment:
Ramulus et Folium Mussaendae Pubescentis extract is purchased from Shaanxi Sheng Heng Biotechnology Co., Ltd, specification 10:1, brown ceramic powder.
Licorice is purchased from Shaanxi Sheng Heng Biotechnology Co., Ltd, specification 10:1, yellowish-brown powder.
Lecithin is purchased from Shandong great Xu bioengineering Co., Ltd, food-grade, light brown powder.
Mulberry root bark extract, is purchased from Shaanxi Ang Sheng biological medicine Science and Technology Ltd., and extract part is moraceae plants mulberry
Dry root skin, specification 10:1, brownish-yellow powder.
Vitamin C is purchased from Hebei Yan Ke Biotechnology Co., Ltd, and food-grade, white crystalline powder is acid, has
Stronger reproducibility, heating or oxidizable decomposition in the solution, are easier to be oxidized under alkaline condition, are hexose derivative.
Cellulase is purchased from Guangzhou Long Yuan bioengineering Co., Ltd, food-grade, white solid powder, enzyme activity 10
Ten thousand u/g.
Zytase is purchased from Guangzhou Long Yuan bioengineering Co., Ltd, and food-grade, buff powder, enzyme activity is 100,000
u/g。
Ficin is purchased from Guangdong Yang Hu Biotechnology Co., Ltd, and food-grade, cream coloured powder, enzyme activity is
300000 u/g.
Subtilopeptidase A is purchased from Foochow Teng Yuan Biotechnology Co., Ltd, and food-grade, brown bloom shape, enzyme activity is
100000 u/g.
Polyvinylpyrrolidone, purchased from the beneficial Fine Chemical Co., Ltd in Guangzhou thousand, food-grade, content 99.8%.
Sodium carboxymethylcellulose, purchased from the beneficial Fine Chemical Co., Ltd in Guangzhou thousand, food-grade, content 99%.
The condition of radiation treatment are as follows: use -60 radiation appliance of cobalt, temperature when irradiation is 25 DEG C, relative humidity 80-
90%, irradiation dose 5.5kGy.
Embodiment 1
A kind of lightening compositions, including following raw materials: Ramulus et Folium Mussaendae Pubescentis extract, licorice, lecithin, mulberry root skin are extracted
Object, Turmeric P.E, active dry yeasr element, vitamin C and water.
A kind of Skin whitening care cosmetics are prepared using above-mentioned lightening compositions.
A kind of preparation method of Skin whitening care cosmetics proposes above-mentioned Ramulus et Folium Mussaendae Pubescentis extract, licorice, lecithin, mulberry root skin
It takes object, Turmeric P.E, active dry yeasr element, vitamin C and water after evenly mixing, carries out radiation treatment, obtain the whitening shield
Skin product.
Embodiment 2
A kind of lightening compositions, which is characterized in that the raw material including following weight component: 10 parts of Ramulus et Folium Mussaendae Pubescentis extract, 5 parts
Licorice, 3 parts of lecithin, 20 parts of mulberry root bark extract, 40 parts of Turmeric P.E, 15 parts of active dry yeasr
Element, 2 parts of vitamin C and 100 parts of water.
The Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, wherein first by the ginger after net system
Huang, which is placed in freeze drier, is refrigerated to -30 DEG C, continues 2.5h, then distils, and the temperature of distillation is -10 DEG C, continues 10h, most
The temperature of freeze drier is adjusted afterwards to 50 DEG C, is continued for 24 hours, the turmeric after being freeze-dried is subsequently placed in powder in pulverizer
It is broken, it is sieved using the sieve of 100 mesh, obtains curcuma powder；
Step 3, by curcuma powder using ultramicro grinding 10min is carried out in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and carries out enzymatic hydrolysis 12h by step 4, wherein used in the amount of enzymolysis liquid be super
50 times of micro- curcuma powder quality, enzymatic hydrolysis after the completion of using composite fibre filter membrane (be purchased from Haining City Ke Zhun filter plant Co., Ltd,
Precision is 0.22um) filtering, retain filtrate；
Filtrate is placed in a centrifuge centrifugation 5min, centrifugation rate 5000r/min by step 5, retains precipitating, then will
Precipitating is placed in the ethanol water that mass fraction is 60%, and wherein the volume of ethanol water is 30 times of filtrate volume, is risen
To 50 DEG C, stirring to precipitating is dissolved completely in ethanol water temperature, the use of retention relative molecular mass is then 6000Da's
Hollow-fibre membrane is filtered under the conditions of pressure is 0.15MPa, the extracting solution after being purified；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, vacuum degree 0.095MPa, dense
The density of contracting temperature 45 C, the concentrate after concentration is 1.051.06kg/L (20 DEG C), is subsequently placed in spray dryer and carries out
Dry 10min, obtains Turmeric P.E.
Enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1.5% zytase, 2% cellulase, 1%
Stabilizer, surplus are water.
The stabilizer is mixed by polyvinylpyrrolidone, sodium carboxymethylcellulose with mass ratio 1:2.
The active dry yeasr element is prepared by the following method:
Discarded beer yeast solution (offer of Tsingtao beer Co., Ltd) 300g is provided, is carried out using the nylon wire of 200 mesh
Filtering, retains filtered filter residue, and the distilled water of 600mL is then added, is stirred under conditions of 35 DEG C, 500r/min
30min is filtered after the completion of stirring using the nylon wire of 400 mesh, is then centrifuged filtrate using centrifuge, wherein from
Heart rate is 5000r/min, retains centrifugate；It is water-soluble that the sodium bicarbonate that 100mL mass fraction is 0.7% is added in centrifugate
Liquid stirs 60min, and the protease of 0.08g is then added, and 100min is stirred under conditions of 50 DEG C, 400r/min, and stirring is completed
Afterwards, solution is placed in supersonic cleaning machine and carries out ultrasonic treatment 30min, wherein the temperature being ultrasonically treated is 55 DEG C, power is
Then 300w carries out enzyme deactivation under the conditions of temperature is 120 DEG C, is centrifugated under the conditions of 5000r/min, takes supernatant, juxtaposition
It is concentrated in vacuo in Rotary Evaporators, vacuum degree 0.098MPa, 50 DEG C of thickening temperature, being concentrated into density is 1.03kg/L (20
DEG C), spray drying 5min is finally carried out, the active dry yeasr element is obtained.
The protease is mixed by ficin, subtilopeptidase A with mass ratio 1:1.
A kind of Skin whitening care cosmetics are prepared using above-mentioned lightening compositions.
A kind of preparation method of Skin whitening care cosmetics, by the Ramulus et Folium Mussaendae Pubescentis extract of 10 parts by weight, the licorice of 5 parts by weight, 3
The lecithin of parts by weight, the mulberry root bark extract of 20 parts by weight, the Turmeric P.E of 40 parts by weight, 15 parts by weight active dry yeasr
The water of element, the vitamin C of 2 parts by weight and 100 parts by weight after evenly mixing, carries out radiation treatment, obtains the Skin whitening care cosmetics.
Embodiment 3
Substantially the same manner as Example 2, difference is only that:
The Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, wherein first by the ginger after net system
Huang, which is placed in freeze drier, is refrigerated to -30 DEG C, continues 2.5h, then distils, and the temperature of distillation is -10 DEG C, continues 10h, most
The temperature of freeze drier is adjusted afterwards to 50 DEG C, is continued for 24 hours, the turmeric after being freeze-dried is subsequently placed in powder in pulverizer
It is broken, it is sieved using the sieve of 100 mesh, obtains curcuma powder；
Step 3, by curcuma powder using ultramicro grinding 10min is carried out in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and carries out enzymatic hydrolysis 12h by step 4, wherein used in the amount of enzymolysis liquid be super
50 times of micro- curcuma powder quality, enzymatic hydrolysis after the completion of using composite fibre filter membrane (be purchased from Haining City Ke Zhun filter plant Co., Ltd,
Precision is 0.22um) filtering, retain filtrate；
Filtrate is placed in a centrifuge centrifugation 5min, centrifugation rate 5000r/min by step 5, retains precipitating, then will
Precipitating is placed in the ethanol water that mass fraction is 60%, and wherein the volume of ethanol water is 30 times of filtrate volume, is risen
To 50 DEG C, stirring to precipitating is dissolved completely in ethanol water temperature, the use of retention relative molecular mass is then 6000Da's
Hollow-fibre membrane is filtered under the conditions of pressure is 0.15MPa, the extracting solution after being purified；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, vacuum degree 0.095MPa, dense
The density of contracting temperature 45 C, the concentrate after concentration is 1.051.06kg/L (20 DEG C), is subsequently placed in spray dryer and carries out
Dry 10min, obtains Turmeric P.E.
Enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1.5% zytase, 2% cellulase, 1%
Polyvinylpyrrolidone, surplus are water.
Embodiment 4
Substantially the same manner as Example 2, difference is only that:
The Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, wherein first by the ginger after net system
Huang, which is placed in freeze drier, is refrigerated to -30 DEG C, continues 2.5h, then distils, and the temperature of distillation is -10 DEG C, continues 10h, most
The temperature of freeze drier is adjusted afterwards to 50 DEG C, is continued for 24 hours, the turmeric after being freeze-dried is subsequently placed in powder in pulverizer
It is broken, it is sieved using the sieve of 100 mesh, obtains curcuma powder；
Step 3, by curcuma powder using ultramicro grinding 10min is carried out in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and carries out enzymatic hydrolysis 12h by step 4, wherein used in the amount of enzymolysis liquid be super
50 times of micro- curcuma powder quality, enzymatic hydrolysis after the completion of using composite fibre filter membrane (be purchased from Haining City Ke Zhun filter plant Co., Ltd,
Precision is 0.22um) filtering, retain filtrate；
Filtrate is placed in a centrifuge centrifugation 5min, centrifugation rate 5000r/min by step 5, retains precipitating, then will
Precipitating is placed in the ethanol water that mass fraction is 60%, and wherein the volume of ethanol water is 30 times of filtrate volume, is risen
To 50 DEG C, stirring to precipitating is dissolved completely in ethanol water temperature, the use of retention relative molecular mass is then 6000Da's
Hollow-fibre membrane is filtered under the conditions of pressure is 0.15MPa, the extracting solution after being purified；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, vacuum degree 0.095MPa, dense
The density of contracting temperature 45 C, the concentrate after concentration is 1.051.06kg/L (20 DEG C), is subsequently placed in spray dryer and carries out
Dry 10min, obtains Turmeric P.E.
Enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1.5% zytase, 2% cellulase, 1%
Sodium carboxymethylcellulose, surplus are water.
Embodiment 5
Substantially the same manner as Example 2, difference is only that:
The Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, wherein first by the ginger after net system
Huang, which is placed in freeze drier, is refrigerated to -30 DEG C, continues 2.5h, then distils, and the temperature of distillation is -10 DEG C, continues 10h, most
The temperature of freeze drier is adjusted afterwards to 50 DEG C, is continued for 24 hours, the turmeric after being freeze-dried is subsequently placed in powder in pulverizer
It is broken, it is sieved using the sieve of 100 mesh, obtains curcuma powder；
Step 3, by curcuma powder using ultramicro grinding 10min is carried out in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and carries out enzymatic hydrolysis 12h by step 4, wherein used in the amount of enzymolysis liquid be super
50 times of micro- curcuma powder quality, enzymatic hydrolysis after the completion of using composite fibre filter membrane (be purchased from Haining City Ke Zhun filter plant Co., Ltd,
Precision is 0.22um) filtering, retain filtrate；
Filtrate is placed in a centrifuge centrifugation 5min, centrifugation rate 5000r/min by step 5, retains precipitating, then will
Precipitating is placed in the ethanol water that mass fraction is 60%, and wherein the volume of ethanol water is 30 times of filtrate volume, is risen
To 50 DEG C, stirring to precipitating is dissolved completely in ethanol water temperature, the use of retention relative molecular mass is then 6000Da's
Hollow-fibre membrane is filtered under the conditions of pressure is 0.15MPa, the extracting solution after being purified；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, vacuum degree 0.095MPa, dense
The density of contracting temperature 45 C, the concentrate after concentration is 1.051.06kg/L (20 DEG C), is subsequently placed in spray dryer and carries out
Dry 10min, obtains Turmeric P.E.
Enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1.5% zytase, 2% cellulase, 1%
Stabilizer, surplus are water.
The stabilizer is mixed by polyvinylpyrrolidone, sodium carboxymethylcellulose with mass ratio 1:1.
Embodiment 6
Substantially the same manner as Example 2, difference is only that:
The Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, wherein first by the ginger after net system
Huang, which is placed in freeze drier, is refrigerated to -30 DEG C, continues 2.5h, then distils, and the temperature of distillation is -10 DEG C, continues 10h, most
The temperature of freeze drier is adjusted afterwards to 50 DEG C, is continued for 24 hours, the turmeric after being freeze-dried is subsequently placed in powder in pulverizer
It is broken, it is sieved using the sieve of 100 mesh, obtains curcuma powder；
Step 3, by curcuma powder using ultramicro grinding 10min is carried out in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and carries out enzymatic hydrolysis 12h by step 4, wherein used in the amount of enzymolysis liquid be super
50 times of micro- curcuma powder quality, enzymatic hydrolysis after the completion of using composite fibre filter membrane (be purchased from Haining City Ke Zhun filter plant Co., Ltd,
Precision is 0.22um) filtering, retain filtrate；
Filtrate is placed in a centrifuge centrifugation 5min, centrifugation rate 5000r/min by step 5, retains precipitating, then will
Precipitating is placed in the ethanol water that mass fraction is 60%, and wherein the volume of ethanol water is 30 times of filtrate volume, is risen
To 50 DEG C, stirring to precipitating is dissolved completely in ethanol water temperature, the use of retention relative molecular mass is then 6000Da's
Hollow-fibre membrane is filtered under the conditions of pressure is 0.15MPa, the extracting solution after being purified；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, vacuum degree 0.095MPa, dense
The density of contracting temperature 45 C, the concentrate after concentration is 1.051.06kg/L (20 DEG C), is subsequently placed in spray dryer and carries out
Dry 10min, obtains Turmeric P.E.
Enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1.5% zytase, 2% cellulase, 1%
Stabilizer, surplus are water.
The stabilizer is mixed by polyvinylpyrrolidone, sodium carboxymethylcellulose with mass ratio 2:1.
Embodiment 7
Substantially the same manner as Example 2, difference is only that:
The active dry yeasr element is prepared by the following method:
Discarded beer yeast solution (offer of Tsingtao beer Co., Ltd) 300g is provided, is carried out using the nylon wire of 200 mesh
Filtering, retains filtered filter residue, and the distilled water of 600mL is then added, is stirred under conditions of 35 DEG C, 500r/min
30min is filtered after the completion of stirring using the nylon wire of 400 mesh, is then centrifuged filtrate using centrifuge, wherein from
Heart rate is 5000r/min, retains centrifugate；It is water-soluble that the sodium bicarbonate that 100mL mass fraction is 0.7% is added in centrifugate
Liquid stirs 60min, and the ficin of 0.08g is then added, stirs 100min under conditions of 50 DEG C, 400r/min, stirs
After the completion of mixing, solution is placed in supersonic cleaning machine and carries out ultrasonic treatment 30min, wherein the temperature being ultrasonically treated is 55 DEG C, function
Rate is 300w, then carries out enzyme deactivation under the conditions of temperature is 120 DEG C, is centrifugated under the conditions of 5000r/min, takes supernatant,
It is placed in Rotary Evaporators and is concentrated in vacuo, vacuum degree 0.098MPa, 50 DEG C of thickening temperature, being concentrated into density is 1.03kg/L
(20 DEG C), finally carry out spray drying 5min, obtain the active dry yeasr element.
Embodiment 8
Substantially the same manner as Example 2, difference is only that:
The active dry yeasr element is prepared by the following method:
Discarded beer yeast solution (offer of Tsingtao beer Co., Ltd) 300g is provided, is carried out using the nylon wire of 200 mesh
Filtering, retains filtered filter residue, and the distilled water of 600mL is then added, is stirred under conditions of 35 DEG C, 500r/min
30min is filtered after the completion of stirring using the nylon wire of 400 mesh, is then centrifuged filtrate using centrifuge, wherein from
Heart rate is 5000r/min, retains centrifugate；It is water-soluble that the sodium bicarbonate that 100mL mass fraction is 0.7% is added in centrifugate
Liquid stirs 60min, and the subtilopeptidase A of 0.08g is then added, stirs 100min under conditions of 50 DEG C, 400r/min,
After the completion of stirring, solution is placed in supersonic cleaning machine and carries out ultrasonic treatment 30min, wherein the temperature being ultrasonically treated is 55 DEG C,
Power is 300w, then carries out enzyme deactivation under the conditions of temperature is 120 DEG C, is centrifugated under the conditions of 5000r/min, takes supernatant
Liquid is placed in Rotary Evaporators and is concentrated in vacuo, vacuum degree 0.098MPa, and 50 DEG C of thickening temperature, being concentrated into density is 1.03kg/
L (20 DEG C), finally carries out spray drying 5min, obtains the active dry yeasr element.
Embodiment 9
The active dry yeasr element is prepared by the following method:
Discarded beer yeast solution (offer of Tsingtao beer Co., Ltd) 300g is provided, is carried out using the nylon wire of 200 mesh
Filtering, retains filtered filter residue, and the distilled water of 600mL is then added, is stirred under conditions of 35 DEG C, 500r/min
30min is filtered after the completion of stirring using the nylon wire of 400 mesh, is then centrifuged filtrate using centrifuge, wherein from
Heart rate is 5000r/min, retains centrifugate；It is water-soluble that the sodium bicarbonate that 100mL mass fraction is 0.7% is added in centrifugate
Liquid stirs 60min, and the protease of 0.08g is then added, and 100min is stirred under conditions of 50 DEG C, 400r/min, and stirring is completed
Afterwards, solution is placed in supersonic cleaning machine and carries out ultrasonic treatment 30min, wherein the temperature being ultrasonically treated is 55 DEG C, power is
Then 300w carries out enzyme deactivation under the conditions of temperature is 120 DEG C, is centrifugated under the conditions of 5000r/min, takes supernatant, juxtaposition
It is concentrated in vacuo in Rotary Evaporators, vacuum degree 0.098MPa, 50 DEG C of thickening temperature, being concentrated into density is 1.03kg/L (20
DEG C), spray drying 5min is finally carried out, the active dry yeasr element is obtained.
The protease is mixed by ficin, subtilopeptidase A with mass ratio 1:2.
Embodiment 10
The active dry yeasr element is prepared by the following method:
Discarded beer yeast solution (offer of Tsingtao beer Co., Ltd) 300g is provided, is carried out using the nylon wire of 200 mesh
Filtering, retains filtered filter residue, and the distilled water of 600mL is then added, is stirred under conditions of 35 DEG C, 500r/min
30min is filtered after the completion of stirring using the nylon wire of 400 mesh, is then centrifuged filtrate using centrifuge, wherein from
Heart rate is 5000r/min, retains centrifugate；It is water-soluble that the sodium bicarbonate that 100mL mass fraction is 0.7% is added in centrifugate
Liquid stirs 60min, and the protease of 0.08g is then added, and 100min is stirred under conditions of 50 DEG C, 400r/min, and stirring is completed
Afterwards, solution is placed in supersonic cleaning machine and carries out ultrasonic treatment 30min, wherein the temperature being ultrasonically treated is 55 DEG C, power is
Then 300w carries out enzyme deactivation under the conditions of temperature is 120 DEG C, is centrifugated under the conditions of 5000r/min, takes supernatant, juxtaposition
It is concentrated in vacuo in Rotary Evaporators, vacuum degree 0.098MPa, 50 DEG C of thickening temperature, being concentrated into density is 1.03kg/L (20
DEG C), spray drying 5min is finally carried out, the active dry yeasr element is obtained.
The protease is mixed by ficin, subtilopeptidase A with mass ratio 2:1.
Comparative example 1
A kind of lightening compositions, which is characterized in that the raw material including following weight component: 10 parts of Ramulus et Folium Mussaendae Pubescentis extract, 5 parts
Licorice, 3 parts of lecithin, 20 parts of mulberry root bark extract, 40 parts of Turmeric P.E (purchased from Xi'an Rayleigh biology
Science and Technology Ltd., purity 99%, yellow powder, main component are cyclohexadione compounds), the element (purchase of 15 parts of active dry yeasr
From Shaanxi Heng Ling natural biological Products Co., Ltd, brownish-yellow powder, specification 10:1), 2 parts of vitamin C and 100 parts
Water.
A kind of Skin whitening care cosmetics are prepared using above-mentioned lightening compositions.
A kind of preparation method of Skin whitening care cosmetics, by the Ramulus et Folium Mussaendae Pubescentis extract of 10 parts by weight, the licorice of 5 parts by weight, 3
The lecithin of parts by weight, the mulberry root bark extract of 20 parts by weight, 40 parts by weight Turmeric P.E (be purchased from Xi'an Rayleigh biology section
Skill Co., Ltd, purity 99%, yellow powder, main component are cyclohexadione compounds), the active dry yeasrs of 15 parts by weight element
The vitamin C of (be purchased from Shaanxi Heng Ling natural biological Products Co., Ltd, brownish-yellow powder, specification 10:1), 2 parts by weight and
The water of 100 parts by weight after evenly mixing, carries out radiation treatment, obtains the Skin whitening care cosmetics.
Comparative example 2
A kind of lightening compositions, which is characterized in that the raw material including following weight component: 10 parts of Ramulus et Folium Mussaendae Pubescentis extract, 5 parts
Licorice, 3 parts of lecithin, 20 parts of mulberry root bark extract, 40 parts of Turmeric P.E (purchased from Xi'an Rayleigh biology
Science and Technology Ltd., purity 99%, yellow powder, main component are cyclohexadione compounds), 15 parts of active dry yeasr element, 2 parts
Vitamin C and 100 parts of water.
A kind of Skin whitening care cosmetics are prepared using above-mentioned lightening compositions.
A kind of preparation method of Skin whitening care cosmetics, by the Ramulus et Folium Mussaendae Pubescentis extract of 10 parts by weight, the licorice of 5 parts by weight, 3
The lecithin of parts by weight, the mulberry root bark extract of 20 parts by weight, 40 parts by weight Turmeric P.E (be purchased from Xi'an Rayleigh biology section
Skill Co., Ltd, purity 99%, yellow powder, main component are cyclohexadione compounds), the active dry yeasrs of 15 parts by weight element, 2
The vitamin C of parts by weight and the water of 100 parts by weight after evenly mixing, carry out radiation treatment, obtain the Skin whitening care cosmetics.
The active dry yeasr element is prepared by the following method:
Discarded beer yeast solution (offer of Tsingtao beer Co., Ltd) 300g is provided, is carried out using the nylon wire of 200 mesh
Filtering, retains filtered filter residue, and the distilled water of 600mL is then added, is stirred under conditions of 35 DEG C, 500r/min
30min is filtered after the completion of stirring using the nylon wire of 400 mesh, is then centrifuged filtrate using centrifuge, wherein from
Heart rate is 5000r/min, retains centrifugate；It is water-soluble that the sodium bicarbonate that 100mL mass fraction is 0.7% is added in centrifugate
Liquid stirs 60min, and the protease of 0.08g is then added, and 100min is stirred under conditions of 50 DEG C, 400r/min, and stirring is completed
Afterwards, solution is placed in supersonic cleaning machine and carries out ultrasonic treatment 30min, wherein the temperature being ultrasonically treated is 55 DEG C, power is
Then 300w carries out enzyme deactivation under the conditions of temperature is 120 DEG C, is centrifugated under the conditions of 5000r/min, takes supernatant, juxtaposition
It is concentrated in vacuo in Rotary Evaporators, vacuum degree 0.098MPa, 50 DEG C of thickening temperature, being concentrated into density is 1.03kg/L (20
DEG C), spray drying 5min is finally carried out, the active dry yeasr element is obtained.
The protease is mixed by ficin, subtilopeptidase A with mass ratio 1:1.
Comparative example 3
A kind of lightening compositions, which is characterized in that the raw material including following weight component: 10 parts of Ramulus et Folium Mussaendae Pubescentis extract, 5 parts
Licorice, 3 parts of lecithin, 20 parts of mulberry root bark extract, 40 parts of Turmeric P.E, 15 parts active dry yeasr element
(be purchased from Shaanxi Heng Ling natural biological Products Co., Ltd, brownish-yellow powder, specification 10:1), 2 parts of vitamin C and 100 parts
Water.
A kind of Skin whitening care cosmetics are prepared using above-mentioned lightening compositions.
A kind of preparation method of Skin whitening care cosmetics, by the Ramulus et Folium Mussaendae Pubescentis extract of 10 parts by weight, the licorice of 5 parts by weight, 3
The lecithin of parts by weight, the mulberry root bark extract of 20 parts by weight, the Turmeric P.E of 40 parts by weight, 15 parts by weight active dry yeasr
Element (be purchased from Shaanxi Heng Ling natural biological Products Co., Ltd, brownish-yellow powder, specification 10:1), 2 parts by weight vitamin C and
The water of 100 parts by weight after evenly mixing, carries out radiation treatment, obtains the Skin whitening care cosmetics.
The Turmeric P.E is prepared from the following steps:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric table
Face moisture, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, wherein first by the ginger after net system
Huang, which is placed in freeze drier, is refrigerated to -30 DEG C, continues 2.5h, then distils, and the temperature of distillation is -10 DEG C, continues 10h, most
The temperature of freeze drier is adjusted afterwards to 50 DEG C, is continued for 24 hours, the turmeric after being freeze-dried is subsequently placed in powder in pulverizer
It is broken, it is sieved using the sieve of 100 mesh, obtains curcuma powder；
Step 3, by curcuma powder using ultramicro grinding 10min is carried out in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and carries out enzymatic hydrolysis 12h by step 4, wherein used in the amount of enzymolysis liquid be super
50 times of micro- curcuma powder quality, enzymatic hydrolysis after the completion of using composite fibre filter membrane (be purchased from Haining City Ke Zhun filter plant Co., Ltd,
Precision is 0.22um) filtering, retain filtrate；
Filtrate is placed in a centrifuge centrifugation 5min, centrifugation rate 5000r/min by step 5, retains precipitating, then will
Precipitating is placed in the ethanol water that mass fraction is 60%, and wherein the volume of ethanol water is 30 times of filtrate volume, is risen
To 50 DEG C, stirring to precipitating is dissolved completely in ethanol water temperature, the use of retention relative molecular mass is then 6000Da's
Hollow-fibre membrane is filtered under the conditions of pressure is 0.15MPa, the extracting solution after being purified；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, vacuum degree 0.095MPa, dense
The density of contracting temperature 45 C, the concentrate after concentration is 1.051.06kg/L (20 DEG C), is subsequently placed in spray dryer and carries out
Dry 10min, obtains Turmeric P.E.
Enzymolysis liquid includes the raw material of following mass fraction in the step 4: 1.5% zytase, 2% cellulase, 1%
Stabilizer, surplus are water.
The stabilizer is mixed by polyvinylpyrrolidone, sodium carboxymethylcellulose with mass ratio 1:2.
Test case 1
Stability test is carried out to the Skin whitening care cosmetics being prepared in embodiment 2-10 and comparative example 1-3.
Referring to related request in " moisturizing creams " QB/T1857-2013, using this method accelerated stability test
(1) heat resistant test and low temperature resistant test
The Skin whitening care cosmetics sample 5mL for taking this research to prepare is placed in (40 ± 1) DEG C insulating box and (- 15 ± 2) DEG C refrigerator
It takes out afterwards for 24 hours, after recovery room temperature compared with the control group, the color appearance of sample.
(2) the heat-resisting alternating that resists cold is tested
Take the sample for finishing heat resistant test (low temperature resistant test) in (1), continue low temperature resistant test (heat resistant test), be repeated as
This cold cycling until phenomena such as grease layering, discoloration occurs in sample, and records cycle-index.
(3) centrifugal test
The Skin whitening care cosmetics prepared are packed at the 2/3 of 15mL centrifuge tube, keep the temperature 1h in 37 DEG C of insulating boxs, then with
The speed of 2000r/min is centrifuged 30min, takes out observation, while measuring centrifugation index KE, KEIt is worth smaller, system is more stable.
(4) pH value measures
The Skin whitening care cosmetics sample of preparation is pre-processed using the dilution process that the pH value for being suitable for cosmetics measures.
Each 1 part of gel, face cream is taken respectively, is added and is free of CO210 parts of deionized water, be heated to 40 DEG C, after mixing evenly, be cooled to room
Temperature detects the pH value of solution.
1 stability test of table
| Serial number | Color appearance | Cycle-index | KEValue | PH value |
| Embodiment 2 | Nearly colour of skin exquisiteness is uniform | 11 | 0.12 | 6.71 |
| Embodiment 3 | Nearly colour of skin exquisiteness is uniform | 8 | 0.15 | 6.13 |
| Embodiment 4 | Nearly colour of skin exquisiteness is uniform | 7 | 0.17 | 6.35 |
| Embodiment 5 | Nearly colour of skin exquisiteness is uniform | 9 | 0.15 | 6.79 |
| Embodiment 6 | Nearly colour of skin exquisiteness is uniform | 8 | 0.13 | 6.51 |
| Embodiment 7 | Nearly colour of skin exquisiteness is uniform | 7 | 0.16 | 6.35 |
| Embodiment 8 | Nearly colour of skin exquisiteness is uniform | 7 | 0.19 | 6.64 |
| Embodiment 9 | Nearly colour of skin exquisiteness is uniform | 6 | 0.20 | 6.81 |
| Embodiment 10 | Nearly colour of skin exquisiteness is uniform | 5 | 0.17 | 6.72 |
| Comparative example 1 | Nearly colour of skin exquisiteness is uniform | 4 | 0.18 | 6.34 |
| Comparative example 2 | Nearly colour of skin exquisiteness is uniform | 5 | 0.21 | 6.54 |
| Comparative example 3 | Nearly colour of skin exquisiteness is uniform | 5 | 0.19 | 6.78 |
Test case 2
Microbiologic inhibition tests, detection are carried out to the Skin whitening care cosmetics being prepared in embodiment 2-10 and comparative example 1-3
Method is according to 2007 editions " cosmetics health specification ".
(1) preparation of samples
Skin whitening care cosmetics 10g is weighed, is added in the triangular flask containing 90mL sterile saline, fullys shake, is stood
15min.It is configured to the liquid to be checked of 1:10.
(2) measurement of total plate count
The liquid 2mL to be checked of above-mentioned 1:10 is taken, is injected in aseptic flat board, infusion volume 1mL.In addition 1mL sample is drawn to be added
9mL sterile saline is configured to 1:100mL liquid to be checked.
1:100mL liquid 2mL to be checked is drawn, is injected in plate, infusion volume 1mL.It can continue to be diluted to 1 as needed:
1000,1:10000 ... etc..45~50 DEG C of lecithin tween 80 nutrient agar culture medium of preparation is poured into plate,
About 15mL, sample are mixed well with culture medium, after solidification, are placed in 37 DEG C of constant incubator culture 48h.Blank control group is to be not added
The lecithin tween 80 nutrient agar culture medium of sample.
2 microorganism detection of table
Claims (10)
1. a kind of lightening compositions, which is characterized in that including following raw materials: Ramulus et Folium Mussaendae Pubescentis extract, licorice, lecithin, mulberry
Root bark extract, Turmeric P.E, active dry yeasr element, vitamin C and water.
2. a kind of lightening compositions according to claim 1, which is characterized in that the raw material including following weight component: 5-
15 parts of Ramulus et Folium Mussaendae Pubescentis extract, 1-10 parts of licorice, 2-6 parts of lecithin, 10-30 parts of mulberry root bark extract, 35-45
The Turmeric P.E of part, 5-25 parts of active dry yeasr element, 1-3 parts of vitamin C and 80-120 parts of water.
3. a kind of lightening compositions according to claim 2, which is characterized in that the Turmeric P.E is by following steps system
It is standby to form:
Turmeric is removed impurity, and is cleaned up using water by step 1, until ejected wash water without obvious muddiness, drains turmeric surface water
Point, the turmeric after obtaining net system；
Turmeric after net system is placed in vacuum freeze drier and is freeze-dried by step 2, the turmeric after being freeze-dried, so
It is placed in pulverizer and crushes, be sieved using the sieve of 60-120 mesh, obtain curcuma powder；
Step 3, by curcuma powder using being pulverized in micronizer, obtain ultra micro curcuma powder；
Ultra micro curcuma powder is placed in enzymolysis liquid and digests by step 4, is filtered after the completion of enzymatic hydrolysis using filter membrane, retains filtrate；
Filtrate is placed in a centrifuge centrifugation by step 5, retains precipitating, then precipitating is placed in ethanol water, is warming up to
40-60 DEG C, stirring is dissolved completely in ethanol water to precipitating, is then filtered using ultrafiltration membrane, after being purified
Extracting solution；
Extracting solution after purification is placed in Rotary Evaporators and is concentrated in vacuo by step 6, be subsequently placed in spray dryer into
Row drying, obtains Turmeric P.E.
4. a kind of lightening compositions according to claim 3, which is characterized in that turmeric is specific after net system in the step 2
The process of freeze-drying are as follows: first the turmeric after net system is placed in freeze drier and is refrigerated to -35~-25 DEG C, continues 2-3h, so
After distil, the temperature of distillation is -15~-5 DEG C, continues 10-12h, finally adjusts the temperature of freeze drier to 40~60 DEG C, holds
Continuous 20-24h, the turmeric after finally obtaining freeze-drying.
5. a kind of lightening compositions according to claim 3, which is characterized in that enzymolysis liquid includes following in the step 4
The raw material of mass fraction: 1-2% zytase, 1.5-2.5% cellulase, 0.5-1.5% stabilizer, surplus are water.
6. a kind of lightening compositions according to claim 5, which is characterized in that the stabilizer is polyvinylpyrrolidine
One of ketone, sodium carboxymethylcellulose are a variety of.
7. a kind of lightening compositions according to claim 3, which is characterized in that the mass fraction of the ethanol water is
40-60%, the ultrafiltration membrane retention relative molecular mass is 5000-6000Da.
8. a kind of lightening compositions according to claim 2, which is characterized in that the active dry yeasr element is by following methods system
It is standby to form:
Discarded beer yeast solution is chosen, filtering retains filter residue, distilled water is then added, filters after mixing evenly, then will filter
Liquid is centrifuged using centrifuge, retains centrifugate；Sodium bicarbonate aqueous solution is added in centrifugate, stirs, egg is then added
Solution, is then placed in supersonic cleaning machine and is ultrasonically treated by white enzyme, stirring, enzyme deactivation, and centrifuge separation takes supernatant, juxtaposition
It is concentrated in vacuo in Rotary Evaporators, is finally spray-dried, obtain the active dry yeasr element.
9. a kind of Skin whitening care cosmetics, which is characterized in that using lightening compositions of any of claims 1-8 preparation
At.
10. a kind of method for preparing Skin whitening care cosmetics as claimed in claim 9, which is characterized in that the lightening compositions are equal
After even mixing, radiation treatment is carried out, the Skin whitening care cosmetics are obtained.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726387A (en) * | 2016-02-17 | 2016-07-06 | 佛山市芊茹化妆品有限公司 | Skin whitening microemulsion |
| CN106821780A (en) * | 2017-03-31 | 2017-06-13 | 佳木斯大学 | One kind promotees whitening, antiplaque Essence and preparation method thereof |
| CN107410668A (en) * | 2017-06-10 | 2017-12-01 | 威海温喜生物科技有限公司 | A kind of method that yeast polypeptides chelated copper is prepared using beer waste yeast |
| CN108485816A (en) * | 2018-06-01 | 2018-09-04 | 成都众宜坊农业开发有限公司 | A kind of extracting method of turmeric essential oil |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
-
2019
- 2019-08-06 CN CN201910719862.2A patent/CN110327273B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726387A (en) * | 2016-02-17 | 2016-07-06 | 佛山市芊茹化妆品有限公司 | Skin whitening microemulsion |
| CN106821780A (en) * | 2017-03-31 | 2017-06-13 | 佳木斯大学 | One kind promotees whitening, antiplaque Essence and preparation method thereof |
| CN107410668A (en) * | 2017-06-10 | 2017-12-01 | 威海温喜生物科技有限公司 | A kind of method that yeast polypeptides chelated copper is prepared using beer waste yeast |
| CN108485816A (en) * | 2018-06-01 | 2018-09-04 | 成都众宜坊农业开发有限公司 | A kind of extracting method of turmeric essential oil |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
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Effective date of registration: 20220126 Address after: 510000 3 gangpu 3rd road, Taihe Nanling, Baiyun District, Guangzhou City, Guangdong Province Applicant after: Guangzhou Mingzhuang Cosmetics Manufacturing Co.,Ltd. Address before: 431701 No. 4, hulujiawan (West), jingling office, Tianmen City, Hubei Province Applicant before: Su Gege |
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