CN109646658A - A kind of jujube compound and preparation method thereof - Google Patents
A kind of jujube compound and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of using classification ultrafiltration, pulverizes the jujube compound of method for combined use preparation, it belongs to traditional Chinese medicine and field of food industry.A kind of jujube compound, it is mainly prepared by following raw materials by the parts by weight: 10-14 parts of jujube, 4-8 parts of fructus lycii, 0.5-1.5 parts of ginger, 0.5-1.5 parts of arillus longan.A kind of fill blood of the invention increases the jujube compound of epidemic disease power, and it is raw material that it, which selects the Chinese medicine of integration of drinking and medicinal herbs, has the function of that enriching the blood and tonifying qi, middle benefit gas dispelling cold, adjusting are immune, can be prepared into series beverage, without any side effects.Preparation method of the invention, it prepares jujube complex composition using classification ultrafiltration, ultramicro grinding joint technology, it destroys raw material cell wall using classification ultrafiltration, ultramicro grinding and effective component in cell is precipitated, effective component structure will not be damaged simultaneously, jujube compound obtained is enable to play curative effect quickly.
Description
Technical field
The present invention relates to a kind of using classification ultrafiltration, pulverizes the jujube compound of method for combined use preparation, it belongs to
In traditional Chinese medicine and field of food industry.
Background technique
Winter master is cold, and cold tending to coagulate and stagnate can make poor blood circulation, while YANG QI being easily injured by cold, human body do not have yang-energy it is warm,
Qi-blood circulating is insufficient, can bring about a series of uncomfortable reaction.Many people are show cold chilly the phenomenon that in winter, in fact greatly
It is mostly the improper sign of human body generated because of qi and blood disorder, the result of insufficiency of vital energy and blood will lead to the decline of viscera function, draw
Play early ageing.If human body is compared to growing plant, gas is exactly sunlight, and blood is exactly rain and dew, and the two collective effect makes in human body
It is grown up strong and sturdy.Once it is comprehensive routed to will lead to function of human body for insufficiency of vital energy and blood.One to winter simultaneously, the variable variation of temperature
It is easy to that people is allowed accidentally just to catch a cold.Everybody reacts the first of flu: wearing few！In fact, chasing after that its root has can
Can because body immunity is not good enough just be easy that flu is allowed to have an opportunity to take advantage of！
Winter is the season for being most suitable for nourishing among 1 year.This when of human body transporting and transforming function of the spleen and stomach ability turns strong, and the winter nourishes
Closely related with Yin Yang balancing, dredging the channel, the regulation of qi and blood, the energy storage that nutriment can be made to convert is in internal, energy quilt
Human body good absorption is built up resistance to strengthen the body resistance to consolidate the constitution, to prevent spring in coming year virus, bacteria attack human body.
In the treatment of doctor trained in Western medicine, there is many drugs for adjusting human immunities, resistance building, such as levamisol, transfer because
Son, core junket, Pidotimod etc..And Chinese medicine fills blood generally by the way of integration of drinking and medicinal herbs help, enhances human immunity, adjusts
Immune function is adjusted at all from inside of human body, improves conditions of human body, abatement to disappearance from root.
Chemical composition of Chinese materia medica is complicated, and traditional is used as medicine mode based on decocting, decoction process along with a large amount of ingredients from lossing,
And medicinal ingredient cannot be precipitated completely, and the process time is long, and energy consumption is high.With modern medicine and pharmacology development in science and technology, with tradition
Experience extractive technique have been unable to meet the needs of prophylactic treatment, and effective component of chinese medicine is typically distributed on cell wall and is wrapped in
Cell interior, the recovery rate of Yao Tigao target product and make full use of resource, need to take effective ways destroy its cell wall and
Effective component in cell is precipitated, while too big destruction will not be caused to effective component structure, it is seen that effective component of chinese medicine
It extracts more and more important.
Summary of the invention
In view of the deficienciess of the prior art, an object of the present invention be to provide it is a kind of fill blood increase epidemic disease power jujube it is multiple
Square composition, it is raw material that it, which selects the Chinese medicine of integration of drinking and medicinal herbs, has the function of that enriching the blood and tonifying qi, middle benefit gas dispelling cold, adjusting are immune, can
It is prepared into series beverage, it is without any side effects.
It is a further object of the present invention to provide the preparation methods of above-mentioned jujube compound, it uses classification ultrafiltration, surpasses
Crushing of Ultrafine destroys raw material cell wall and effective component in cell is precipitated, while will not damage to effective component structure, makes
Jujube compound obtained can play curative effect quickly.
To achieve the above object, the invention provides the following technical scheme:
A kind of jujube compound, it is mainly prepared by following raw materials by the parts by weight: jujube 10-14
Part, 4-8 parts of fructus lycii, 0.5-1.5 parts of ginger, 0.5-1.5 parts of arillus longan.
A kind of above-mentioned jujube compound, it is mainly prepared by following raw materials by the parts by weight: big
12 parts of jujube, 6 parts of fructus lycii, 1 part of ginger, 1 part of arillus longan.
The preparation method of above-mentioned jujube compound, steps are as follows:
(1) jujube for meeting the parts by weight, fructus lycii, ginger, arillus longan are weighed, through co-grinding to 10-40 mesh, is obtained slightly
Medicinal powder is spare；
(2) thick medicinal powder is placed in medicine pot, first time amount of water is 10-20 times of thick medicinal powder weight, and it is small to impregnate 1.5-2.5
When, the pectase of 0.03-0.09 parts by weight is added, uses citric acid-sodium citrate tune pH value for 4.0-6.0, in 40 DEG C -60 DEG C
It digests constant temperature in pot to digest 2-4 hours, after enzymatic hydrolysis, is warming up to 93-97 DEG C of enzyme deactivation；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled decoction 1.5-2.5 hours, is filtered, collect filtrate；Filter residue second
Secondary amount of water is 10-20 times of thick medicinal powder weight, and after boiling, filtrate is collected in slightly boiled decoction 1.5-2.5 hours, filtration；Filter residue
Amount of water is 10-20 times of thick medicinal powder weight three times, and after boiling, filtrate is collected in slightly boiled decoction 1.5-2.5 hours, filtration；
(4) the resulting filtrate three times of step (3) is merged, 4000-6000r/min is centrifuged 10-20min, collects supernatant；
(5) it is super by molecular weight 300K, 100K, 10K doughnut that retention is respectively adopted in the supernatant for collecting step (4)
Filter column carries out ultrafiltration, collects ultrafiltrate；
(6) by step (5) resulting ultrafiltrate, under the conditions of 40-50 DEG C, relative molecular mass 300- is retained using film
600Da carries out nanofiltration concentration, and the volume of the concentrated liquid is the 1/4-3/4 of stoste volume, obtains concentrate；
(7) it to the maltodextrin of 0.1-0.3 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly
After be spray-dried, spray drying condition is as follows: 110-130 DEG C of inlet air temperature, 80-100 DEG C of leaving air temp, atomizing pressure
750-850Pa, hydrojet speed 8-12%, obtains dried powder；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding
The intracorporal mill Jie impacting 5-15min of tank makes the average grain diameter of Ultramicro-powder reach 900-1500nm to get the combination of jujube compound
Object ultra-micro powder.
20 mesh are crushed to after the mixing of above-mentioned steps (1) raw material.
First time amount of water is preferably 15 times of thick medicinal powder weight in above-mentioned steps (2), and soaking time preferably 2 hours, fruit
Glue enzyme additional amount preferably 0.06 parts by weight, pH value is preferably 5.0, preferably 50 DEG C of hydrolysis temperature, enzymolysis time preferably 3 hours, is gone out
Preferably 95 DEG C of enzyme temperature.
Enzymatic hydrolysis decocting time is preferably 2 hours in above-mentioned steps (3), and second of amount of water is preferably the 15 of thick medicinal powder weight
Times, decocting time is preferably 2 hours, and third time amount of water is preferably 15 times of thick medicinal powder weight, and decocting time is preferably 2 small
When.
Centrifugation rate is preferably 5000r/min in above-mentioned steps (4), and centrifugation time is preferably 15min.
Nanofiltration temperature is preferably 45 DEG C in above-mentioned steps (6), and retaining molecular weight is preferably 450Da.
The additive amount of maltodextrin is 0.2 times of concentrate weight in above-mentioned steps (7)；Spray drying EAT is preferred
120 DEG C, preferably 90 DEG C of leaving air temp, the preferred 800Pa of atomizing pressure, hydrojet speed preferably 10%.
Impacting time preferred 10min in above-mentioned steps (8), the average grain diameter of Ultramicro-powder are 1200nm.
Due to the adoption of the above technical scheme, so that compared with prior art, the present invention have following features and the utility model has the advantages that
It is as follows the effect of Chinese medicine material used in the present invention: jujube: Ji Yuan: the dry mature fruit of Rhamnaceae plant jujube.Property
Taste: sweet, warm.Channel tropism: returns spleen, stomach meridian.Major function: tonifying middle-Jiao and Qi, nourishing blood and tranquilization；For spleen eating less, loose stool out of strength, married woman
Hysteria.Fructus lycii: Ji Yuan: the dry mature fruit of Lycium barbarum L. of solanaceae.Nature and flavor: sweet and neutral.Channel tropism: return liver and kidney channel.Function
The major functions: nourishing liver and kidney, benefiting shrewd head；For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision
It is unknown.Ginger: Ji Yuan: rutaceae orange and its dry mature skin of variety.Nature and flavor: bitter, acrid in flavour and warm in nature.Channel tropism: return lung,
The spleen channel.Major function: relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab；For anemofrigid cold, gastrofrigid vomiting, phlegm of trembling with fear
Cough, fish and crab poisoning.Arillus longan: Ji Yuan: the aril of sapindaceous plant longan.Nature and flavor: sweet, warm.Channel tropism: return heart, the spleen channel.
Major function: tonifying heart and spleen, nourishing blood and tranquilization；For insufficiency of vital energy and blood, palpitation and severe palpitation, amnesia insomnia, blood deficiency chlorosis.
Present invention conditioning, which fills blood, increases Chinese medicine used in the jujube compound combination of epidemic disease power, selects national integration of drinking and medicinal herbs catalogue
Interior medicinal material is the raw material often selected in raw material, and traditional herbal cuisine.Based on TCM theory, the traditional Chinese medicine preventiveed treatment of disease is adhered to
It says, is that principle carries out prescription by monarch, the proportion of strict control each component has enriching the blood and tonifying qi, middle benefit gas dispelling cold, adjusts and exempt from
The effect of epidemic disease carries out daily conditioning and maintenance to body, complies with winter climate Variation Features and the variation of corresponding body, promotes machine
Body qi-blood circulating, enhancing body material's energy conversion, prevents state of an illness generation and development, achievees the purpose that treating both manifestation and root cause of disease.The present invention
Above-mentioned jujube, fructus lycii, ginger, arillus longan are combined by the dosage, so that each raw material generates synergistic function, compound
In using date polysaccharide in jujube as index ingredient, content improves one times in the more single jujube of content.Huangdi's Internal Classics have
Cloud, when human body will follow the mandate of heaven, i.e., along the variation of five elements' motion and six kinds of natural factors, secret key is to comply with the variation of the gas of YIN YANG in four seasons, and human body is
It can muchly keep fit.In order to receive in the yang-energy that keeps out the cold, metabolism slows down humans during winter months, and nutrient is easy to accumulate, therefore winter
It is the optimal climate and other natural phenomena of a season of nourishing.For jujube compound using jujube as monarch drug in a prescription, being equipped with fructus lycii, ginger, arillus longan is minister adjutant, enhances people
Body transporting and transforming function of the spleen and stomach ability, the energy storage for converting nutriment is in internal, to strengthen the body resistance to consolidate the constitution, builds up resistance.Temperature simultaneously
Warm human body nourishes kidney, promotes qi-blood circulating, and strong function adjusts the variation in organism adaptation severe winter, is also coming year storage
Certain energy.
Present invention application classification ultrafiltration, ultramicro grinding method for combined use prepare jujube compound, and traditional Chinese medicine is extracted
Technique is combined with modern biotechnology technique, retains the extracting mode of traditional water decoction decoction, will using enzymatic hydrolysis pre-treating technology
Protein, cellulose, pectic substance on cell wall etc. hinder the main barrier degradation of effective component dissolution intracellular, to make cell
Wall is loose, ruptures, and reduces diffusion of active ingredient resistance intracellular, improves recovery rate.The present invention is main for raw material sources in composition
To be fruit class, so can effectively hydrolyze the pectic substance ingredient for destroying fruit cell wall using pectase, reduce viscosity, it is higher
Retain to degree the functional components of raw material in compound.Hydrolysis temperature has enzymolysis efficiency and active principle recovery rate important
It influences, to protect polysaccharide component in fruit not to be destroyed, initial temperature is set as 40 DEG C, as hydrolysis temperature gradually rises, enzyme
Solution efficiency and recovery rate quickly increase, when temperature be increased to 60 DEG C it is gradually stable, enzymatic hydrolysis preference temperature be 40 DEG C -60 DEG C, most preferably
Hydrolysis temperature is 50 DEG C, is digested optimum pH slant acidity (4.0-6.0), and the best pH that digests is 5.0.To guarantee enzymatic hydrolysis sufficiently, warp
Enzymolysis time is investigated between 2-4 hours, Best Times are 2 hours.It is broken to the natural barrier of cell when enzyme dosage is less
Bad power is inadequate, when gradually increasing with enzyme dosage, can increase the dissolution of active principle, when position reaches saturation state, selects
When 30000U/g pectin enzyme dosage is within the scope of 0.03-0.09 parts by weight, recovery rate reaches balance.By digesting parameter optimization
Afterwards, date polysaccharide index content is promoted twice compared with traditional extraction process.Using biological hyperfiltration technique removal aqueous extract in starch,
The macromoleculars inert substance such as protein, while loss of effective components is reduced, the filtration water removal of nanofiltration biotechnology is recycled, is enriched with
Ingredient is imitated, while can avoid thermophilic digestion feed liquid in concentrated extracting solution, improves effective component retention rate, reduces heat energy loss.
Obtained Ultramicro-powder is after water dissolves, liquid clear, no residue deposited phenomenon.The present invention is in preparation process simultaneously, not
Organic solvent and chemical reagent are introduced, does not destroy medicinal material internal component structure, protects character of medicinal material, preferably performance health care is treated
Effect.
Present invention conditioning, which fills blood, to be increased the jujube compound of epidemic disease power and can be used for preparing alternative tea.
Present invention application classification ultrafiltration, ultramicro grinding method for combined use prepare jujube compound, super through what is be prepared
Micro mist can be used for preparing jujube compound combined beverage series of products.
Present invention application classification ultrafiltration, ultramicro grinding method for combined use prepare jujube compound and fill blood in conditioning and increase epidemic disease
Effect in terms of power is preferable, alleviate symptom effect it is obvious, prevention, alleviate because winter it is cold and cool caused by body cold-evil invasion, cold body
Symptoms and its bring other health problems such as cold, weak and sickly, dry skin.Selected materials are all integration of drinking and medicinal herbs Chinese medicine,
Raw material is easy to get, without any side effects, can reduce the body liver kidney burden and financial burden of user.After body is taken, warp
There is the external manifestation that body hair is warm, four limbs are not cool, resists the enhancing of exogeneous cold ability in the Absorption And Metabolism of a period of time, body.Dynamic
In object experiment, after oral administration, the date polysaccharide content in detection of multiple time points blood, internal organs, result of study shows greatly
Haemoconcentration content reach to peak value in jujube polysaccharide 2 hours, and half-life is long, and with absorbing, fast, elimination is slow, bioavilability
High feature.
Preparation method of the invention, medicinal ingredient is precipitated completely in it, and low energy consumption, it is using classification ultrafiltration, ultramicro grinding
It destroys raw material cell wall and effective component in cell is precipitated, while effective component structure will not be damaged, made obtained
Jujube compound can play curative effect quickly.
Specific embodiment
Below with reference to embodiment, the present invention is described further.Following embodiment is only several specific realities of the invention
Example is applied, but the design concept of the present invention is not limited to this, it is all to be made a non-material change to the present invention using this design,
It should belong to the behavior for invading the scope of the present invention.
Method in following embodiments is unless otherwise instructed conventional method.
Percentage composition in following embodiments is unless otherwise instructed mass percentage.
Number in following embodiments is parts by weight.
Embodiment 1
A kind of jujube compound, it is to be prepared by following raw materials by the parts by weight: 10 parts of jujube, fructus lycii
8 parts, 1.5 parts of ginger, 1.5 parts of arillus longan.
The preparation method of jujube compound, its step are as follows:
(1) 10 parts by weight jujubes, 8 parts by weight fructus lyciis, 1.5 parts by weight ginger, 1.5 parts by weight arillus longans are weighed, through mixed powder
10 mesh are broken to, it is spare to obtain thick medicinal powder；
(2) thick medicinal powder is placed in medicine pot, first time amount of water is 10 times of thick medicinal powder weight, is impregnated 1.5 hours, is added
The pectase of 0.03 parts by weight uses citric acid-sodium citrate tune pH value as 4.0, and constant temperature enzymatic hydrolysis 2 is small in 40 DEG C of enzymatic hydrolysis pots
When, after enzymatic hydrolysis, it is warming up to 93 DEG C of enzyme deactivations；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled to decoct 1.5 hours, filtrate is collected in filtration；Filter residue adds for the second time
Water is 10 times of thick medicinal powder weight, slightly boiled to decoct 1.5 hours after boiling, and filtrate is collected in filtration；Filter residue third time amount of water
It is 10 times of thick medicinal powder weight, after boiling, slightly boiled to decoct 1.5 hours, filtrate is collected in filtration；
(4) the resulting filtrate three times of step (3) is merged, 4000r/min is centrifuged 10min, collects supernatant；
(5) it is super by molecular weight 300K, 100K, 10K doughnut that retention is respectively adopted in the supernatant for collecting step (4)
Filter column carries out ultrafiltration, collects ultrafiltrate；
(6) it by step (5) resulting ultrafiltrate, under the conditions of 40 DEG C, is carried out using film retention relative molecular mass 300Da
Nanofiltration concentration, the volume of the concentrated liquid are the 1/4 of stoste volume, obtain concentrate；
(7) it to the maltodextrin of 0.1 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly laggard
Row spray drying, obtains dried powder；Spray drying condition is as follows: 110 DEG C of inlet air temperature, 80 DEG C of leaving air temp, and atomizing pressure
750Pa, hydrojet speed 8%；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding
The intracorporal mill Jie impacting 5min of tank, makes the average grain diameter of Ultramicro-powder reach 900nm to get jujube compound Ultramicro-powder
End.
Embodiment 2
A kind of jujube compound, it is to be prepared by following raw materials by the parts by weight: 11 parts of jujube, fructus lycii
7 parts, 1.2 parts of ginger, 1.2 parts of arillus longan.
The preparation method of jujube compound, its step are as follows:
(1) 11 parts by weight jujubes, 7 parts by weight fructus lyciis, 1.2 parts by weight ginger, 1.2 parts by weight arillus longans are weighed, through mixed powder
16 mesh are broken to, it is spare to obtain thick medicinal powder；
(2) thick medicinal powder is placed in medicine pot, first time amount of water is 13 times of thick medicinal powder weight, is impregnated 1.8 hours, is added
The pectase of 0.05 parts by weight uses citric acid-sodium citrate tune pH value as 4.5, and constant temperature enzymatic hydrolysis 2.5 is small in 45 DEG C of enzymatic hydrolysis pots
When, after enzymatic hydrolysis, it is warming up to 94 DEG C of enzyme deactivations；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled to decoct 1.8 hours, filtrate is collected in filtration；Filter residue adds for the second time
Water is 13 times of thick medicinal powder weight, slightly boiled to decoct 1.8 hours after boiling, and filtrate is collected in filtration；Filter residue third time amount of water
It is 13 times of thick medicinal powder weight, after boiling, slightly boiled to decoct 1.8 hours, filtration, merging filtrate；
(4) the resulting filtrate three times of step (3) is merged, 4500r/min is centrifuged 12min, collects supernatant；
(5) it is super by molecular weight 300K, 100K, 10K doughnut that retention is respectively adopted in the supernatant for collecting step (4)
Filter column carries out ultrafiltration, collects ultrafiltrate；
(6) it by step (5) resulting ultrafiltrate, under the conditions of 43 DEG C, is carried out using film retention relative molecular mass 400Da
Nanofiltration concentration, the volume of the concentrated liquid are the 1/4 of stoste volume, obtain concentrate；
(7) it to the maltodextrin of 0.15 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly laggard
Row spray drying, obtains dried powder；Spray drying condition is as follows: 115 DEG C of inlet air temperature, 85 DEG C of leaving air temp, and atomizing pressure
780Pa, hydrojet speed 9%；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding
The intracorporal mill Jie impacting 8min of tank, makes the average grain diameter of Ultramicro-powder reach 1000nm to get jujube compound ultra micro
Powder.
Embodiment 3
A kind of jujube compound, it is to be prepared by following raw materials by the parts by weight: 12 parts of jujube, fructus lycii
6 parts, 1 part of ginger, 1 part of arillus longan.
The preparation method of jujube compound, its step are as follows:
(1) 12 parts by weight jujubes, 6 parts by weight fructus lyciis, 1 parts by weight ginger, 1 parts by weight arillus longan are weighed, extremely through co-grinding
It is spare to obtain thick medicinal powder for 20 mesh；
(2) thick medicinal powder is placed in medicine pot, first time amount of water is 15 times of thick medicinal powder weight, is impregnated 2 hours, is added
The pectase of 0.06 parts by weight uses citric acid-sodium citrate tune pH value as 5.0, and constant temperature enzymatic hydrolysis 3 is small in 50 DEG C of enzymatic hydrolysis pots
When, after enzymatic hydrolysis, it is warming up to 95 DEG C of enzyme deactivations；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled to decoct 2 hours, filtrate is collected in filtration；Filter residue adds water for the second time
Amount is 15 times of thick medicinal powder weight, slightly boiled to decoct 2 hours after boiling, and filtrate is collected in filtration；Filter residue third time amount of water is thick
15 times of medicinal powder weight, slightly boiled to decoct 2 hours after boiling, filtrate is collected in filtration；
(4) the resulting filtrate three times of step (3) is merged, 5000r/min is centrifuged 15min, collects supernatant；
(5) it is super by molecular weight 300K, 100K, 10K doughnut that retention is respectively adopted in the supernatant for collecting step (4)
Filter column carries out ultrafiltration, collects ultrafiltrate；
(6) it by step (5) resulting ultrafiltrate, under the conditions of 45 DEG C, is carried out using film retention relative molecular mass 450Da
Nanofiltration concentration, the volume of the concentrated liquid are the 1/2 of stoste volume, obtain concentrate；
(7) it to the maltodextrin of 0.2 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly laggard
Row spray drying, obtains dried powder；Spray drying condition is as follows: 120 DEG C of inlet air temperature, 90 DEG C of leaving air temp, and atomizing pressure
800Pa, hydrojet speed 10%；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding
The intracorporal mill Jie impacting 10min of tank, makes the average grain diameter of Ultramicro-powder reach 1200nm to get jujube compound ultra micro
Powder.
Embodiment 4
A kind of jujube compound, it is to be prepared by following raw materials by the parts by weight: 13 parts of jujube, fructus lycii
5 parts, 0.8 part of ginger, 0.8 part of arillus longan.
The preparation method of jujube compound, it is characterised in that steps are as follows:
(1) 13 parts by weight jujubes, 5 parts by weight fructus lyciis, 0.8 parts by weight ginger, 0.8 parts by weight arillus longan are weighed, through mixed powder
30 mesh are broken to, it is spare to obtain thick medicinal powder；
(2) thick medicinal powder is placed in medicine pot, first time amount of water is 17 times of thick medicinal powder weight, is impregnated 2.2 hours, is added
The pectase of 0.07 parts by weight uses citric acid-sodium citrate tune pH value as 5.5, and constant temperature enzymatic hydrolysis 3.5 is small in 55 DEG C of enzymatic hydrolysis pots
When, after enzymatic hydrolysis, it is warming up to 96 DEG C of enzyme deactivations；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled to decoct 2.2 hours, filtrate is collected in filtration；Filter residue adds for the second time
Water is 17 times of thick medicinal powder weight, slightly boiled to decoct 2.2 hours after boiling, and filtrate is collected in filtration；Filter residue third time amount of water
It is 17 times of thick medicinal powder weight, after boiling, slightly boiled to decoct 2.2 hours, filtrate is collected in filtration；
(4) the resulting filtrate three times of step (3) is merged into 5500r/min and is centrifuged 17min, collect supernatant；
(5) it is super by molecular weight 300K, 100K, 10K doughnut that retention is respectively adopted in the supernatant for collecting step (4)
Filter column carries out ultrafiltration, collects ultrafiltrate；
(6) it by step (5) resulting ultrafiltrate, under the conditions of 47 DEG C, is carried out using film retention relative molecular mass 500Da
Nanofiltration concentration, the volume of the concentrated liquid are the 3/4 of stoste volume, obtain concentrate；
(7) it to the maltodextrin of 0.25 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly laggard
Row spray drying, obtains dried powder；Spray drying condition is as follows: 125 DEG C of inlet air temperature, 95 DEG C of leaving air temp, and atomizing pressure
830Pa, hydrojet speed 11%；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding
The intracorporal mill Jie impacting 12min of tank, makes the average grain diameter of Ultramicro-powder reach 1300nm to get jujube compound ultra micro
Powder.
Embodiment 5
A kind of jujube compound, it is to be prepared by following raw materials by the parts by weight: 14 parts of jujube, fructus lycii
4 parts, 0.5 part of ginger, 0.5 part of arillus longan.
The preparation method of jujube compound, its step are as follows:
(1) 14 parts by weight jujubes, 4 parts by weight fructus lyciis, 0.5 parts by weight ginger, 0.5 parts by weight arillus longan are weighed, through mixed powder
40 mesh are broken to, it is spare to obtain thick medicinal powder；
(2) thick medicinal powder is placed in medicine pot, first time amount of water is 20 times of thick medicinal powder weight, is impregnated 2.5 hours, is added
The pectase of 0.09 parts by weight uses citric acid-sodium citrate tune pH value as 6.0, and constant temperature enzymatic hydrolysis 4 is small in 60 DEG C of enzymatic hydrolysis pots
When, after enzymatic hydrolysis, it is warming up to 97 DEG C of enzyme deactivations；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled to decoct 2.5 hours, filtrate is collected in filtration；Filter residue adds for the second time
Water is 20 times of thick medicinal powder weight, slightly boiled to decoct 2.5 hours after boiling, and filtrate is collected in filtration；Filter residue third time amount of water
It is 20 times of thick medicinal powder weight, after boiling, slightly boiled to decoct 2.5 hours, filtrate is collected in filtration；
(4) the resulting filtrate three times of step (3) is merged, 6000r/min is centrifuged 20min, collects supernatant；
(5) it is super by molecular weight 300K, 100K, 10K doughnut that retention is respectively adopted in the supernatant for collecting step (4)
Filter column carries out ultrafiltration, collects ultrafiltrate；
(6) it by step (5) resulting ultrafiltrate, under the conditions of 50 DEG C, is carried out using film retention relative molecular mass 600Da
Nanofiltration concentration, the volume of the concentrated liquid are the 3/4 of stoste volume, obtain concentrate；
(7) it to the maltodextrin of 0.3 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly laggard
Row spray drying, obtains dried powder；Spray drying condition is as follows: 130 DEG C of inlet air temperature, 100 DEG C of leaving air temp, and atomizing pressure
850Pa, hydrojet speed 12%；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding
The intracorporal mill Jie impacting 15min of tank, makes the average grain diameter of Ultramicro-powder reach 1500nm to get jujube compound ultra micro
Powder.
Thick medicinal powder obtained by step (1) can be applied to prepare jujube compound alternative tea in embodiment 1,2,3,4,5.
Jujube compound obtained by step (8) can be used for jujube compound combined beverage series in embodiment 1,2,3,4,5
Product.
Test example 1
The detection of the jujube compound ingredient of 1,2,3,4,5 method of embodiment of the present invention preparation and content analysis method
And result is as follows:
(1) prepared by reference substance solution: precision weighs that glucose control product are appropriate, and it is the molten of 0.2mg/mL that concentration, which is made, with water
Liquid is to get glucose control product solution.
(2) drafting of standard curve: precision draws dextrose standard sample solution 0,0.5,1.0,1.5,2.0,2.5,3.0ml
To 10mL measuring bottle, it is diluted to scale with distilled water, is shaken up, it is accurate respectively to draw 1mL, it sets in 10mL tool plug test tube, 5% benzene is added
Phenol solution 1.0mL, shakes up, and the 5.0mL concentrated sulfuric acid is added, shakes up immediately, is placed at room temperature for 40min, and absorbance value is surveyed at 490nm
(A).Using its absorbance value as abscissa, concentration (C) is ordinate, draws standard curve.
(3) prepared by test solution: it is each that precision weighs jujube compound made from 1,2,3,4,5 method of embodiment
1.0g is respectively placed in stuffed conical flask, is added 80% ethyl alcohol 100mL, at 40-50 DEG C, ultrasonic 30min, to the second in residue
After alcohol volatilizes, add water 100mL, at 40-50 DEG C, ultrasonic extraction 3 times, each 30min, filtration, merging filtrate is settled to 100mL.
Take appropriate volume constant volume into 10mL measuring bottle.By standard curve method " take 1.0mL in 10mL colorimetric cylinder ..., it is cold with ice water
But to room temperature ", as test solution.
The preparation of jujube simple: precision weighs jujube, extracts by 3 extracting method of embodiment, by test solution method system
For to get jujube single drug solns.
Traditional water decoction agent group sample preparation: in 3 step of embodiment (1) ratio weigh 12 parts of jujube, 6 parts of fructus lycii, 1 part of ginger,
It 1 part of arillus longan, carries out being crushed to 20 mesh after mixing.First time amount of water is 15 times of medicinal material amount, is impregnated 2 hours, slightly boiled to decoct 2
Hour, filtrate is collected in filtration；Second of amount of water of filter residue is 15 times of medicinal material amount, slightly boiled to decoct 2 hours after boiling, filtration,
Collect filtrate；Filter residue third time amount of water is 15 times of medicinal material amount, slightly boiled to decoct 2 hours after boiling, and filtrate is collected in filtration.It closes
And filtrate, moisture volatilize three times.Precision weighs 1.0g medicinal extract, prepares by test solution method to get traditional water decoction agent group sample
Product solution.
(5) experimental result
Table 1 draws standard curve
| Concentration of glucose mg/mL | 0.01 | 0.02 | 0.03 | 0.04 | 0.05 | 0.06 |
| Light absorption value | 0.097 | 0.223 | 0.336 | 0.428 | 0.591 | 0.700 |
Calibration curve equation is A=12.031C-0.0253, coefficient R=0.9979
The comparison of 2 polysaccharide component assay of table
| Grouping | Polyoses content % |
| Example 1 group | 15.21 |
| 2 groups of embodiment | 15.92 |
| 3 groups of embodiment | 17.45 |
| 4 groups of embodiment | 16.84 |
| 5 groups of embodiment | 16.41 |
| Jujube simple group | 8.14 |
| Traditional water decoction agent group | 5.67 |
The comparison of 3 nutrient component determining of table
Test example 2
The jujube compound of 1,2,3,4,5 method of embodiment of the present invention preparation is used for deficiency in both Qi and blood immunosuppressant animal
Model test.
(1) Animal Model
Selection healthy rat 120, female, weight 250g randomly selects 90, respectively at experiment the 1st, 3,5,7,9 day,
Tail portion bloodletting 0.1g/20g, in the 2nd day intraperitoneal injection of cyclophosphamide normal saline solution 40mg/kg, in the 4th, 6,8,10,12 day
Intraperitoneal injection of cyclophosphamide normal saline solution 20mg/kg, causes deficiency in both Qi and blood model.
(2) animal packet and administration
By 110 deficiency in both Qi and blood rat models, it is randomly divided into 9 groups, respectively blank control group, model control group, implementation
1,2,3,4,5 group of example, jujube simple group, traditional water decoction agent group, every group 10.1,2,3,4,5 group of embodiment, jujube simple
Group and traditional water decoction agent group dosage are 235.58mg/kg, and administration capacity is 10mL/kg.Blank control group only fills same volume
Physiological saline.It is administered once daily, continuous 14 days.
(3) observation index
It is tested by Mouse whole blood cell and ATP enzyme, observes jujube compound to mouse deficiency in both Qi and blood mould
The influence of type.
(4) experimental result
Comparison of 4 each group of table to deficiency in both Qi and blood immunosuppression model rat whole blood cell
Note: compared with blank group,#P < 0.05,##P<0.01
Compared with model group, P < 0.01 * P < 0.05, * *
Compared with jujube simple group,ΔP < 0.05,△△P<0.01
Compared with traditional water decoction agent group,▲P < 0.05,▲▲P<0.01
5 each group of table generates the comparison of Phos amount to deficiency in both Qi and blood immunosuppression model Rat Erythrocytes ATP enzyme
Note: compared with blank group,#P < 0.05,##P<0.01
Compared with model group,*P < 0.05,**P<0.01
Compared with jujube simple group,△P < 0.05,△△P<0.01
Compared with traditional water decoction agent group,▲P < 0.05,▲▲P<0.01
As shown in Table 4, blank control group, 1,2,3,4,5 group of embodiment, jujube simple group, traditional water decoction agent group rat
Red blood cell count, white blood cell count(WBC), platelet count and content of hemoglobin, hence it is evident that be higher than model group, wherein embodiment 3
Effect is best, and each embodiment group effect of jujube compound is better than jujube simple group and traditional water decoction agent group.
Table 5 is it is found that pass through the Na in red blood cell+-K+ATP enzyme, Ca2+-Mg2+ATP enzyme decomposes 1 × 10 per hour7It is a red
Cell generate Phos amount it was found that, each embodiment group of jujube compound, jujube simple group and traditional water decoction
Agent group has raising atpase activity in varying degrees, and wherein the effect of embodiment 3 is best, and jujube compound is imitated
Fruit is better than jujube simple and traditional water decoction agent.
Claims (10)
1. a kind of jujube compound, it is characterised in that it is mainly prepared by following raw materials by the parts by weight:
10-14 parts of jujube, 4-8 parts of fructus lycii, 0.5-1.5 parts of ginger, 0.5-1.5 parts of arillus longan.
2. a kind of jujube compound according to claim 1, it is characterised in that it mainly presses institute by following raw materials
It states parts by weight to be prepared: 12 parts of jujube, 6 parts of fructus lycii, 1 part of ginger, 1 part of arillus longan.
3. a kind of preparation method of jujube compound of any of claims 1 or 2, it is characterised in that steps are as follows:
(1) jujube for meeting the parts by weight, fructus lycii, ginger, arillus longan are weighed, through co-grinding to 10-40 mesh, obtains thick medicinal powder
It is spare；
(2) thick medicinal powder being placed in medicine pot, first time amount of water is 10-20 times of thick medicinal powder weight, it impregnates 1.5-2.5 hours,
The pectase of 0.03-0.09 parts by weight is added, uses citric acid-sodium citrate tune pH value for 4.0-6.0, in 40 DEG C of -60 DEG C of enzymes
It solves constant temperature in pot to digest 2-4 hours, after enzymatic hydrolysis, is warming up to 93-97 DEG C of enzyme deactivation；
(3) after enzyme deactivation, enzymatic treatment system is boiled, slightly boiled decoction 1.5-2.5 hours, is filtered, collect filtrate；Filter residue adds for the second time
Water is 10-20 times of thick medicinal powder weight, and after boiling, filtrate is collected in slightly boiled decoction 1.5-2.5 hours, filtration；Filter residue third time
Amount of water is 10-20 times of thick medicinal powder weight, and after boiling, filtrate is collected in slightly boiled decoction 1.5-2.5 hours, filtration；
(4) the resulting filtrate three times of step (3) is merged, 4000-6000r/min is centrifuged 10-20min, collects supernatant；
(5) retention is respectively adopted by molecular weight 300K, 100K, 10K Hollow Fiber Ultrafiltration column in the supernatant for collecting step (4)
Ultrafiltration is carried out, ultrafiltrate is collected；
(6) by step (5) resulting ultrafiltrate, under the conditions of 40-50 DEG C, relative molecular mass 300-600Da is retained using film
Nanofiltration concentration is carried out, the volume of the concentrated liquid is the 1/4-3/4 of stoste volume, obtains concentrate；
(7) it to the maltodextrin of 0.1-0.3 times of concentrate weight of addition in step (6) resulting concentrate, stirs evenly laggard
Row spray drying, spray drying condition are as follows: 110-130 DEG C of inlet air temperature, 80-100 DEG C of leaving air temp, and atomizing pressure 750-
850Pa, hydrojet speed 8-12%, obtains dried powder；
(8) dried powder obtained by step (7) is put into micronizer to pulverize, passes through high energy nanometer impact grinding tank body
Interior mill Jie impacting 5-15min makes the average grain diameter of Ultramicro-powder reach 900-1500nm super to get jujube compound
Micropowder.
4. the preparation method of jujube compound according to claim 3, which is characterized in that the mixing of step (1) raw material
After be crushed to 20 mesh.
5. the preparation method of jujube compound according to claim 3, which is characterized in that in step (2) for the first time
Amount of water is 15 times of thick medicinal powder weight, and soaking time is 2 hours, and pectase additional amount is 0.06 parts by weight, pH value 5.0,
Hydrolysis temperature is 50 DEG C, and enzymolysis time is 3 hours, and enzyme-removal temperature is 95 DEG C.
6. the preparation method of jujube compound according to claim 3, which is characterized in that enzymatic hydrolysis is decocted in step (3)
Boiling the time is 2 hours, and second of amount of water is 15 times of thick medicinal powder weight, and decocting time is 2 hours, and third time amount of water is thick
15 times of medicinal powder weight, decocting time are 2 hours.
7. the preparation method of jujube compound according to claim 3, which is characterized in that centrifugation speed in step (4)
Rate is 5000r/min, centrifugation time 15min.
8. the preparation method of jujube compound according to claim 3, which is characterized in that nanofiltration temperature in step (6)
Degree is 45 DEG C, retaining molecular weight 450Da.
9. the preparation method of jujube compound according to claim 3, which is characterized in that maltodextrin in step (7)
Additive amount be 0.2 times of concentrate weight；Spray drying condition is as follows: 120 DEG C of inlet air temperature, 90 DEG C of leaving air temp, and atomization
Pressure 800Pa, hydrojet speed 10%.
10. the preparation method of jujube compound according to claim 3, which is characterized in that hit and grind in step (8)
Time consuming is 10min, and the average grain diameter of Ultramicro-powder is 1200nm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112715940A (en) * | 2021-01-20 | 2021-04-30 | 中科优术(黑龙江)科技产业有限公司 | Black fungus composition with effects of benefiting qi, nourishing blood and resisting radiation and preparation method and application thereof |
| CN112890065A (en) * | 2021-02-26 | 2021-06-04 | 福建省诏安四海食品有限公司 | Instant salted-golden jujube granules and preparation method thereof |
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