CN110291200B - 对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体 - Google Patents
对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体 Download PDFInfo
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| US201662433183P | 2016-12-12 | 2016-12-12 | |
| US62/433,183 | 2016-12-12 | ||
| PCT/US2017/065597 WO2018111763A1 (en) | 2016-12-12 | 2017-12-11 | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
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| CN110291200A CN110291200A (zh) | 2019-09-27 |
| CN110291200B true CN110291200B (zh) | 2024-05-14 |
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| CN201780086283.8A Active CN110291200B (zh) | 2016-12-12 | 2017-12-11 | 对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体 |
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| JP (2) | JP7091357B2 (enExample) |
| CN (1) | CN110291200B (enExample) |
| AU (1) | AU2017375630B2 (enExample) |
| CA (1) | CA3045665A1 (enExample) |
| MX (1) | MX2019006631A (enExample) |
| WO (1) | WO2018111763A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| SG11201608393TA (en) * | 2014-04-10 | 2016-11-29 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Transgene genetic tags and methods of use |
| US11458167B2 (en) | 2015-08-07 | 2022-10-04 | Seattle Children's Hospital | Bispecific CAR T-cells for solid tumor targeting |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| CN110291200B (zh) * | 2016-12-12 | 2024-05-14 | 西雅图儿童医院(Dba西雅图儿童研究所) | 对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体 |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| US10561686B2 (en) | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) * | 2018-02-06 | 2020-11-13 | 西雅图儿童医院(Dba西雅图儿童研究所) | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| KR20210025525A (ko) | 2018-06-22 | 2021-03-09 | 카이트 파마 인코포레이티드 | 키메라 막횡단 단백질 및 그의 용도 |
| JP2021530217A (ja) * | 2018-07-10 | 2021-11-11 | プレシゲン,インコーポレイテッド | Ror−1特異的キメラ抗原受容体およびその使用 |
| EP3845564A4 (en) * | 2018-08-28 | 2022-05-18 | Immunotech Biopharm Co., Ltd. | ENHANCED THERAPEUTIC T LYMPHOCYTE |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| EP3912992A4 (en) | 2019-02-04 | 2022-11-23 | National University Corporation Ehime University | Car library and production method for scfv |
| CN113543792A (zh) | 2019-03-08 | 2021-10-22 | 奥托路斯有限公司 | 包含工程化嵌合抗原受体和car调节剂的组合物和方法 |
| EP3937975A4 (en) * | 2019-03-13 | 2023-06-21 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | FLUORESCEIN SODIUM AS AN INVERSION AGENT FOR ANTI-FLUORESCEIN CAR-T CELLS AND FLUORESCEIN-PHOSPHOLIPID ETHERS OR PHOSPHOLIPID-PHOSPHOLIPID ETHERS |
| WO2020219425A1 (en) * | 2019-04-25 | 2020-10-29 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Combinatorial car t cell and hematopoeitic stem cell genetic engineering for specific immunotherapy of myeloid leukemias |
| BR112021025735A2 (pt) * | 2019-06-21 | 2022-03-08 | Kite Pharma Inc | Receptores de tgf-ss e métodos de uso |
| CN115087466A (zh) * | 2019-12-12 | 2022-09-20 | 森迪生物科学公司 | 用于细胞的调控装甲的方法和组合物 |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| EP4149966A4 (en) * | 2020-05-14 | 2024-08-07 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | DOUBLE PROMOTOR SYSTEMS |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| IL298779A (en) * | 2020-06-08 | 2023-02-01 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Anti-cd171 chimeric antigen receptors |
| CN111848819A (zh) * | 2020-07-31 | 2020-10-30 | 广东昭泰体内生物医药科技有限公司 | 一种靶向msln的嵌合抗原受体及其应用 |
| JP2023545071A (ja) * | 2020-10-09 | 2023-10-26 | シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) | Pd1キメラポリペプチドを含む方法および組成物 |
| AU2021397206A1 (en) * | 2020-12-08 | 2023-07-27 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-egfr chimeric antigen receptors |
| WO2022174035A2 (en) * | 2021-02-12 | 2022-08-18 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Activity-inducible fusion proteins having a heat shock protein 90 binding domain |
| WO2022221592A2 (en) * | 2021-04-15 | 2022-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for producing and using cell-based immunotherapies to target tumors |
| WO2022241289A2 (en) * | 2021-05-14 | 2022-11-17 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Activity-inducible fusion proteins having a transcription factor and a heat shock protein 90 binding domain |
| CN116444671B (zh) * | 2021-12-29 | 2024-02-23 | 华道(上海)生物医药有限公司 | 一种抗IL13Ra2的纳米抗体及其应用 |
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| AU2017375630A1 (en) | 2019-06-13 |
| MX2019006631A (es) | 2019-11-12 |
| JP2020500563A (ja) | 2020-01-16 |
| EP3551197A1 (en) | 2019-10-16 |
| US20200181624A1 (en) | 2020-06-11 |
| CA3045665A1 (en) | 2018-06-21 |
| US20220411805A1 (en) | 2022-12-29 |
| JP2022130485A (ja) | 2022-09-06 |
| JP7091357B2 (ja) | 2022-06-27 |
| EP3551197A4 (en) | 2020-10-28 |
| EP3551197B1 (en) | 2023-11-22 |
| WO2018111763A1 (en) | 2018-06-21 |
| US11408005B2 (en) | 2022-08-09 |
| AU2017375630B2 (en) | 2023-12-21 |
| WO2018111763A9 (en) | 2018-07-19 |
| JP7392043B2 (ja) | 2023-12-05 |
| CN110291200A (zh) | 2019-09-27 |
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