CN110200830A - A kind of anti-inflammatory Shu Min remediation composition and its preparation method and application - Google Patents
A kind of anti-inflammatory Shu Min remediation composition and its preparation method and application Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a kind of anti-inflammatory Shu Min remediation compositions and its preparation method and application, the composition is made of Radix et Caulis Opuntiae Dillenii extract, oat bran extract, shrubby sophora extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, radix scutellariae root extract, butanediol, pentanediol and water, and preparation method is as follows: 1) preparation of shrubby sophora extract solution；2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, radix scutellariae root extract, butanediol and pentanediol super-high-pressure homogenization, obtain plant extracts mixed liquor；3) mixing of plant extracts mixed liquor and shrubby sophora extract solution, super-high-pressure homogenization and filtering.Anti-inflammatory Shu Min remediation composition of the invention has anti-inflammatory, antiallergic, analgesic effect; skin barrier function can be enhanced; promote the self-protection ability of skin; effectively repair inflammation skin; the skin of dermatitis is especially relied on hormonal, and long-time service will not generate drug resistance, dependence and side effect.
Description
Technical field
The present invention relates to a kind of anti-inflammatory Shu Min remediation compositions and its preparation method and application.
Background technique
When cutaneous anaphylaxis refers to that body is stimulated by certain specific antigens, occur thin with physiological dysfunction or tissue
Abnormal specific immune response based on cellular damage, also referred to as allergy.The symptom of cutaneous anaphylaxis include it is red and swollen,
Itch, drying, furfur etc. not only will affect beauty, but also can make a big impact to daily life.In recent years, skin
The quantity of skin autopath sharply increases, and skin allergy has become the health problem of global concern.Skin allergy may be by more
Aspect factor causes, such as: the anaphylactogens such as skin contact germ, pollen, helminth；The mutation of weather；Human body internal hormone point
Secrete imbalance；Pressure is excessive.
Currently, cosmetics smell is pleasant, appearance is unique, long shelf-life, skin sense are salubrious and other effects in order to assign by businessman, can add
The ingredients such as perfuming, emulsifier, preservative, heavy metal, alcohol, and these ingredients are common anaphylactogen.Meanwhile in order to keep away
Exempt from cosmetics and cause skin allergy, it will usually anti-sensitizer be added.However, common anti-sensitizer is inflammatory factor inhibitor, such as
Antihistaminic anti-sensitizer can only merely cut off allergic reaction, and there is no skin barrier function is repaired, antiallergic effect is general,
And long-time service can also generate dependence and cause some other skin problems；At the same time, most of anti-sensitizers for
The effect of steroid dependent dermatitis is all very poor.
The factor for causing inflammation mainly may be summarized to be following several respects: 1) complement system (connection humoral immunity and cell
Immune reaction system) by bacterium indirect activation: bacterium can activate mast cell and induce anaphylactoid reaction；2) environmental stimuli draws
Play mast cell and discharge histamine: histamine can accelerate blood flow, expansion capillary, the permeability for improving capillary,
And then make rubefaction, and histamine can also activate the other mediators for causing inflammation；3) histamine can activate hyaluronidase, break
Bad surrounding tissue leads to the intrusion of inflammatory cells；4) cosmetics and skin contact and cause inflammation: T- lymphocyte is quick by antigen
Change release inflammation substance, such as lymphokine；5) carragenines causes vascular permeability to increase, and then allergy occurs；6) arachidonic
Acid metabolic causes inflammation cells into prostaglandin.
Therefore, it is necessary to develop a kind of antiallergic effect is excellent, skin barrier function can be enhanced, can inhibit inflammation because
Son, the anti-inflammatory Shu Min remediation composition that can effectively repair steroid dependent dermatitis.
Summary of the invention
The purpose of the present invention is to provide a kind of anti-inflammatory Shu Min remediation compositions and its preparation method and application.
The technical solution used in the present invention is:
A kind of anti-inflammatory Shu Min remediation composition, consists of the following mass percentage components:
Radix et Caulis Opuntiae Dillenii extract: 1%~15%；
Oat bran extract: 1%~5%；
Shrubby sophora extract: 1%~5%；
Radix Ophiopogonis root extract: 1%~5%；
Chinese herbaceous peony root extract: 1%~5%；
Radix scutellariae root extract: 1%~5%；
Butanediol: 25%~50%；
Pentanediol: 2%~10%；
Water: surplus.
Preferably, a kind of anti-inflammatory Shu Min remediation composition, consists of the following mass percentage components:
Radix et Caulis Opuntiae Dillenii extract: 4%~12%；
Oat bran extract: 2%~4%；
Shrubby sophora extract: 2%~4%；
Radix Ophiopogonis root extract: 2%~4%；
Chinese herbaceous peony root extract: 2%~4%；
Radix scutellariae root extract: 2%~4%；
Butanediol: 30%~50%；
Pentanediol: 3%~8%；
Water: surplus.
Preferably, in the Radix et Caulis Opuntiae Dillenii extract polysaccharide content >=70wt%.
Preferably, in the oat bran extract oat alkaloid content >=95wt%.
Preferably, in the shrubby sophora extract matrine content >=95wt%.
Preferably, in the Radix Ophiopogonis root extract polysaccharide content >=70wt%.
Preferably, in the Chinese herbaceous peony root extract Paeoniflorin content >=60wt%.
Preferably, in the radix scutellariae root extract scutelloside content >=90wt%.
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer, carry out homogeneous, and it is mixed to obtain plant extracts
Close liquid；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, the kuh-seng for adding step 1) mentions
Object solution is taken, is mixed well, then is transferred in high pressure Microfluidizer, circulation carries out multiple homogeneous, and filtering obtains anti-inflammatory Shu Min
Remediation composition.
Preferably, the high pressure Microfluidizer use Y shape interactive homogeneous chamber, operating pressure be 1000~
1500bar。
A kind of skin care item, it includes above-mentioned anti-inflammatory Shu Min remediation compositions.
Preferably, additive amount of the anti-inflammatory Shu Min remediation composition in skin care item is 0.5wt%~5wt%.
Preferably, the skin care item are facial mask, moisturizing cream, mildy wash, toner, moisturizing lotion, suncream, BB are white,
One of shampoo, shower cream, skin care gel.
The beneficial effects of the present invention are: anti-inflammatory Shu Min remediation composition of the invention has anti-inflammatory, antiallergic, analgesic effect
Skin barrier function can be enhanced in fruit, promotes the self-protection ability of skin, effectively repairs inflammation skin, especially with sharp
Disposition relies on the skin of dermatitis, and long-time service will not generate drug resistance, dependence and side effect.
1) anti-inflammatory Shu Min remediation composition of the invention has anti-inflammatory, antiallergic, analgesic effect, can alleviate skin exception
State, effect is lasting；
2) anti-inflammatory Shu Min remediation composition of the invention can reduce injury of the inflammatory mediator to normal cell；
3) anti-inflammatory Shu Min remediation composition of the invention can reduce moisture of skin and scatter and disappear, and enhance skin barrier function, mention
The self-protection ability of skin is risen, skin sensitivity degree is reduced；
4) anti-inflammatory Shu Min remediation composition of the invention can remove free radical superfluous in skin, weaken free radical to fertilizer
The antipruritic effect of antiallergic is played in the destruction of maxicell and basocyte cell membrane；
5) anti-inflammatory Shu Min remediation composition of the invention can inhibit inflammatory factor, effectively repair inflammation skin, especially
The skin of dermatitis is relied on hormonal；
6) anti-inflammatory Shu Min remediation composition long-time service of the invention will not generate drug resistance, no dependence, without any
Side effect, it is fool proof reliable；
7) anti-inflammatory Shu Min remediation composition raw material of the invention is natural, and carries out homogeneous by multiple super-voltage micro jet,
Polysaccharide in plant extracts can further be cut into micromolecular polysaccharide, improve bioavilability, and be easier to act on
In skin internal structure；
8) present invention carries out homogenization to material using high pressure Microfluidizer, can make alkaloid and plant glycoside
It is embedded in polysaccharide structures, forms the outstanding powder liquid of polysaccharide mosaic texture, the collaboration that can not only give full play between each component increases
Effect effect, and stability is high, good dispersion；
9) present invention is filtered the outstanding powder liquid of sugared mosaic texture using the filter membrane of 100nm, it is ensured that the grain of composition
Diameter is in 100nm hereinafter, improving transdermal absorption factor；
10) present invention has carried out the screening of qualitative and quantitative to raw material used, it is ensured that anti-inflammatory Shu Min reparation group
The effect of object is closed, and avoids impurity and the synergistic function between each component is impacted.
Detailed description of the invention
Fig. 1 is the formation mechenism figure of the outstanding powder liquid with polysaccharide mosaic texture.
Fig. 2 is guinea pig skin itch test result caused by histamine phosphate.
Fig. 3 is hyaluronidase body outer suppressioning test test result.
Fig. 4 is skin irritatin repairing effect test result.
Fig. 5 is anticomplementary action test result.
Fig. 6 is the test result for inhibiting carragenines to induce inflammation.
Fig. 7 is the test result for inhibiting arachidonic acid to induce inflammation.
Fig. 8 is the antiallergic measure of merit result of moisturiser.
Fig. 9 is the antiallergic measure of merit result of toner.
Specific embodiment
The present invention will be further explained combined with specific embodiments below and explanation.
Embodiment 1:
A kind of anti-inflammatory Shu Min remediation composition, raw material composition are as shown in the table:
A kind of raw material of the anti-inflammatory Shu Min remediation composition of table 1 forms table
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer (operating pressure 1200bar), carry out homogeneous,
Obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, is heated to 50 DEG C, adds step
1) shrubby sophora extract solution, mixes well, then is transferred in high pressure Microfluidizer (operating pressure 1500bar), recycle into
3 homogeneous of row, then filtered with the supermicro filtration membrane of aperture 100nm, obtaining anti-inflammatory Shu Min remediation composition (has polysaccharide mosaic texture
Outstanding powder liquid, formation mechenism figure is as shown in Figure 1).
Embodiment 2:
A kind of anti-inflammatory Shu Min remediation composition, raw material composition are as shown in the table:
A kind of raw material of the anti-inflammatory Shu Min remediation composition of table 2 forms table
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer (operating pressure 1200bar), carry out homogeneous,
Obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, is heated to 50 DEG C, adds step
1) shrubby sophora extract solution, mixes well, then is transferred in high pressure Microfluidizer (operating pressure 1500bar), recycle into
3 homogeneous of row, then filtered with the supermicro filtration membrane of aperture 100nm, obtaining anti-inflammatory Shu Min remediation composition (has polysaccharide mosaic texture
Outstanding powder liquid, formation mechenism figure is as shown in Figure 1).
Embodiment 3:
A kind of anti-inflammatory Shu Min remediation composition, raw material composition are as shown in the table:
A kind of raw material of the anti-inflammatory Shu Min remediation composition of table 3 forms table
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer (operating pressure 1400bar), carry out homogeneous,
Obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, is heated to 50 DEG C, adds step
1) shrubby sophora extract solution, mixes well, then is transferred in high pressure Microfluidizer (operating pressure 1500bar), recycle into
3 homogeneous of row, then filtered with the supermicro filtration membrane of aperture 100nm, obtaining anti-inflammatory Shu Min remediation composition (has polysaccharide mosaic texture
Outstanding powder liquid, formation mechenism figure is as shown in Figure 1).
Embodiment 4:
A kind of anti-inflammatory Shu Min remediation composition, raw material composition are as shown in the table:
A kind of raw material of the anti-inflammatory Shu Min remediation composition of table 4 forms table
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer (operating pressure 1200bar), carry out homogeneous,
Obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, is heated to 50 DEG C, adds step
1) shrubby sophora extract solution, mixes well, then is transferred in high pressure Microfluidizer (operating pressure 1500bar), recycle into
3 homogeneous of row, then filtered with the supermicro filtration membrane of aperture 100nm, obtaining anti-inflammatory Shu Min remediation composition (has polysaccharide mosaic texture
Outstanding powder liquid, formation mechenism figure is as shown in Figure 1).
Embodiment 5:
A kind of anti-inflammatory Shu Min remediation composition, raw material composition are as shown in the table:
A kind of raw material of the anti-inflammatory Shu Min remediation composition of table 5 forms table
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer (operating pressure 1200bar), carry out homogeneous,
Obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, is heated to 50 DEG C, adds step
1) shrubby sophora extract solution, mixes well, then is transferred in high pressure Microfluidizer (pressure 1500bar), carries out homogeneous, follows
Then ring homogeneous three times is filtered with the supermicro filtration membrane of aperture 100nm again, obtaining anti-inflammatory Shu Min remediation composition (has polysaccharide edge
The outstanding powder liquid of embedding structure, formation mechenism figure are as shown in Figure 1).
Embodiment 6:
A kind of anti-inflammatory Shu Min remediation composition, raw material composition are as shown in the table:
A kind of raw material of the anti-inflammatory Shu Min remediation composition of table 6 forms table
The preparation method of above-mentioned anti-inflammatory Shu Min remediation composition, comprising the following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, scutellariae,radix are extracted
Object, butanediol and pentanediol mix well, then are transferred in high pressure Microfluidizer (operating pressure 1200bar), carry out homogeneous,
Obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, is heated to 50 DEG C, adds step
1) shrubby sophora extract solution, mixes well, then is transferred in high pressure Microfluidizer (operating pressure 1500bar), recycle into
Then 3 homogeneous of row are filtered again with the supermicro filtration membrane of aperture 100nm, obtain anti-inflammatory Shu Min remediation composition and (inlay with polysaccharide
The outstanding powder liquid of structure, formation mechenism figure are as shown in Figure 1).
Comparative example 1:
Certain commercially available anti-sensitizer, main component include: Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea
Leaf extract, glycyrrhiza glabra root extract, german chamomile flower extract and rosemary leaf extract.
Comparative example 2:
Certain commercially available anti-sensitizer, main component include: gorgonian extract.
Comparative example 3:
Certain commercially available anti-sensitizer, main component include: bisabolol and ginger-root extract.
Test case:
1, guinea pig skin itch caused by histamine phosphate is tested:
Cavy 100 are taken, male and female have, and are divided into 10 groups at random, and instep shaving behind the cavy right side is distinguished at shaving position
Radix et Caulis Opuntiae Dillenii extract, shrubby sophora extract, ophiopogon japonicus extract, Radix Paeoniae Alba that 0.5g active matter total content is 100mg/kg is smeared to extract
Object, oat alkaloid, Baical Skullcap root P.E, embodiment 1 anti-inflammatory Shu Min remediation composition and comparative example 1~3 anti-sensitizer, after 1h
The skin at shaving is gently abraded with coarse sandpaper, scratch region area is about 1cm2, by above-mentioned grouping and dosage in scratch site
Respectively coating 1 time again, after 10min scratch region every 3min be gradually added dropwise increasing concen-trations (0.01%, 0.02%, 0.03%,
0.04%, histamine phosphate 0.05% ...), each 0.05mL/, until cavy occurs later licking right metapedes, finally to occur
Cavy turns one's head the histamine phosphate total amount given when licking right metapedes as itch-threshold, and test results are shown in figure 2.
As shown in Figure 2: 6 Plant Extracts, embodiment 1 anti-inflammatory Shu Min remediation composition and comparative example 1~3 antiallergic
Agent has certain inhibiting effect to guinea pig skin itch caused by histamine phosphate, wherein shrubby sophora extract, oat alkaloid, implementation
The anti-inflammatory Shu Min remediation composition of example 1 and the anti-sensitizer of comparative example 1~3 itch reaction with apparent to the cause of cavy histamine phosphate
Inhibiting effect, and the inhibiting effect of the anti-inflammatory Shu Min remediation composition of embodiment 1 is most strong, antiallergic itching-relieving efficacies are best.
2, hyaluronidase body outer suppressioning test:
1) test group is divided into totally 4 groups of A, B, C, D, to A group and component C not Jia Ru 0.5mL hyaluronidase (500U/
ML), B group and D group are separately added into the acetate buffer solution (pH value 5.6) of 0.5mL, then are separately added into the CaCl of 0.1mL2Solution
It is placed on after (2.5mol/L) in 37 DEG C of thermostat water bath and keeps the temperature 20min；
2) it takes out A group and sample solution is not added for B component, C group and D group are separately added into distilled water, then in 37 DEG C of constant temperature
20min is kept the temperature in water-bath；
3) take out A group and component C not Jia Ru 0.5mL sodium hyaluronate solution (0.5mg/mL), B group and D group add respectively
The acetum (pH value 5.6) for entering 0.5mL, then keeps the temperature 30min in 37 DEG C of thermostat water baths；
4) take out A~D group, place 5min at room temperature, then every group of NaOH solution (0.5mol/L) for being separately added into 0.5mL and
The acetylacetone,2,4-pentanedione solution (sodium carbonate liquor of 3.5mL acetylacetone,2,4-pentanedione+50mL concentration 1.0mol/L) of 0.5mL, then boiling water bath
15min, ice-water bath 5min, it is placed at room temperature for 10min, (0.8g is to Dimethylaminobenzene first for every group of Ehrlich's reagent for being added 1mL
Aldehyde+15mL concentrated hydrochloric acid+15mL dehydrated alcohol), it sufficiently vibrates, then be separately added into the dehydrated alcohol of 3mL and be diluted, is placed at room temperature for
20min colour developing, measures its absorbance value, substitutes into following formula and calculates inhibiting rate:
Hyaluronic acid enzyme inhibition rate (%)=[(C-D)-(A-B)]/(C-D) × 100%,
In formula: A is the absorbance value of given the test agent solution, and B is the absorbance value of blank reagent solution, and C is contrast solution
Absorbance value, D be placebo solution absorbance value.
By above-mentioned test method, testing active matter total content is the Radix et Caulis Opuntiae Dillenii extract of 10mg/mL, kuh-seng extraction
Object, ophiopogon japonicus extract, radix paeoniae alba extraction, oat alkaloid, Baical Skullcap root P.E, embodiment 1 anti-inflammatory Shu Min remediation composition and
The anti-sensitizer of comparative example 1~3 is to the extracorporeal inhibiting rate of hyaluronidase, and test results are shown in figure 3.
As shown in Figure 3: 6 Plant Extracts all have the function of inhibiting hyaluronidase activity, and embodiment 1 is anti-inflammatory
Shu Min remediation composition reaches 95% or more to the inhibiting rate of hyaluronidase, and the effect than the anti-sensitizer of comparative example 1~3 is good.
3, skin irritatin repairing effect is tested:
1) 10 people of volunteer is collected, gender is random, using on the inside of the left and right arm of volunteer as recipient site, chooses 2cm
The square region of × 2cm is tested region；
2) tested region is cleaned with clear water, uses Germany's CK Multi-functional skin tester measurement skin red after waiting for 10min quietly
Value, then stimulates tested region with the capsaicine aqueous solution (about 0.01mL) of mass fraction 50%, persistently stimulate 15min with
After 30min, data acquisition is carried out；
3) test sample (active matter total content is 10mg/mL) of 0.05mL, 15min, 30min are smeared in tested region
With progress data acquisition after 45min, 0.05mL pure water, the number that statistics volunteer's experiment position measures every time are smeared in blank control
Value, analyzes the variation of red value.
The variation reflection of skin red value is that the tested general red Time Change of area skin, value are got within test period
Greatly, heat flush degree is bigger.
Skin red value change rate (%)=(T-TBlank value)/TBlank value× 100%.
Using above-mentioned test method, testing active matter total content is the Radix et Caulis Opuntiae Dillenii extract of 10mg/mL, kuh-seng extraction
Object, ophiopogon japonicus extract, radix paeoniae alba extraction, oat alkaloid, Baical Skullcap root P.E, embodiment 2 anti-inflammatory Shu Min remediation composition and
The anti-sensitizer of comparative example 1~3 is to skin irritatin repairing effect, and test results are shown in figure 4.
As shown in Figure 4: 6 Plant Extracts have a degree of reparation function to the post-stimulatory skin of capsaicine aqueous solution
Effect, wherein after smearing 45min, red value change rate drops to 2%, skin to skin repair effect most preferably ophiopogon japonicus extract
Return to normal, the anti-inflammatory Shu Min remediation composition of embodiment 2 compared to comparative example 1~3 anti-sensitizer, after skin irritatin
Repairing effect it is more significant, can quickly repair impaired skin.
4, anticomplementary action is tested:
Test philosophy: complement system can be activated by antigen-antibody complex, cause hemolytic reaction, and hemoglobin is caused to escape
Out；It can be by measuring the absorbance value of hemoglobin, inhibition with the height discriminating test sample of absorbance value to role of complement
Rate.The calculation formula of inhibiting rate is as follows: inhibiting rate (%)=(A-ABlank)/AFull haemolysis× 100%.
Antigen-antibody complex and test sample are injected into sheeps blood erythrocyte suspension, full haemolysis and blank pair are set
According to 32 DEG C of incubation 30min constantly rock, then be centrifuged 10min, supernatant is taken to survey its absorbance with spectrophotometer (560nm)
Value.Anticomplement activation assesses the inhibiting rate of haemocylolysis by extract.
It is raw using above method test Radix et Caulis Opuntiae Dillenii extract, shrubby sophora extract, ophiopogon japonicus extract, radix paeoniae alba extraction, oat
Alkaloids, Baical Skullcap root P.E, the anti-inflammatory Shu Min remediation composition of embodiment 2 and comparative example 1~3 anti-sensitizer anticomplementary action,
Test results are shown in figure 5.
As shown in Figure 5: relative to the anti-sensitizer of single plant extracts and comparative example 1~3, the anti-inflammatory of embodiment 2 relaxes
Quick remediation composition almost inhibits anticomplementary action, and effect is very excellent.
5, carragenines is inhibited to induce the test of inflammation:
The sole thickness of 6 weeks big ICR female mouse is measured, then applies the test sample of 25mg (active matter total content is
Its right crus of diaphragm bottom 10mg/g) is arrived, left foot primary coat is smeared 25mg physiological saline, applied again after for 24 hours 1 time, applies again 1 time after crossing 1h, crosses 1h
Apply again afterwards 25 μ L containing 2% λ-carragenines physiological saline arrive mouse two soles, later measurement two soles thickness,
Measurement is primary per hour, continues 4h, and the difference before and after measurement swab calculates inhibiting rate compared with blank control group.
Oedema inhibiting rate (%)=(Z-ZRight initial value)/(ZBlank value-ZLeft initial value) × 100%.
Test Radix et Caulis Opuntiae Dillenii extract, shrubby sophora extract, ophiopogon japonicus extract, radix paeoniae alba extraction, oat alkaloid, radix scutellariae extraction
Work of the anti-sensitizer of object, the anti-inflammatory Shu Min remediation composition of embodiment 3 and comparative example 1~3 to the inflammation for inhibiting carragenines to induce
With test results are shown in figure 6.
As shown in Figure 6: compared to the anti-sensitizer of single plant extracts and comparative example 1~3, the anti-inflammatory of embodiment 3 relaxes
Quick remediation composition plays the role of the inflammation that extraordinary inhibition carragenines induces, and with the growth better effect of time.
6, arachidonic acid is inhibited to induce the test of inflammation:
1) 30 cavys are taken, are divided into ten groups, with p-phenylenediamine-olive oil mixture (quality of p-phenylenediamine, olive oil
Than smearing cavy two sides ear for 4:1), 0.1mL is applied daily, continues 3 days；
2) after 5 days, the test sample of 20mg is smeared 3 times on the ear of side, wipes survey after the 1h that last time is smeared
Test agent, and coat 20 μ L p-phenylenediamine-olive oil mixture (p-phenylenediamine, olive oil mass ratio be 4:1), after 17h
Smear test sample twice again, test sample wiped after 19h, for 24 hours after to cut with puncher 5mm respectively on the ear of two sides straight
The part of diameter measures, and measurement is led to using the ear and the difference of the weight for the ear for not using test sample of test sample
It crosses compared with referring to sample and calculates inhibiting rate.
Radix et Caulis Opuntiae Dillenii extract, shrubby sophora extract, ophiopogon japonicus extract, radix paeoniae alba extraction, oat alkaloid, radix scutellariae are extracted
The anti-sensitizer of object, the anti-inflammatory Shu Min remediation composition of embodiment 3 and comparative example 1~3 is mixed with hydrophilic vaseline respectively to be survived
Property object total content be 10% test sample, tested according still further to the above method, test results are shown in figure 7.
As shown in Figure 7: can inhibit before arachidonic acid induces inflammation using the anti-inflammatory Shu Min remediation composition of embodiment 3
Oedema more than 60%, effect are more preferable than the anti-sensitizer of single plant extracts and 1~3.
7, a kind of moisturiser, it includes the anti-inflammatory Shu Min remediation compositions of the embodiment 4 of 0.5wt%.
Performance test:
1 volunteer (women, 30 years old age) is chosen, first smears the test section on its arm repeatedly with histamine stimulation liquid
Domain 6min causes test zone allergic reaction (gargalesthesia and tingling sensation are obvious) occur, then smears above-mentioned moisturiser, is smearing respectively
It takes pictures when moisturiser 0min, 30min and 45min, and observes the skin of test zone, test results are shown in figure 8.
As shown in Figure 8: after allergic reaction occurs in the test zone on volunteer's arm, smearing anti-inflammatory easypro containing 0.5wt%
The moisturiser of quick remediation composition can obtain good antiallergic effect.
8, a kind of toner, it includes the anti-inflammatory Shu Min remediation compositions for the embodiment 5 for having 5wt%.
1 hormone-dependent type volunteer (women, 30 years old age) is chosen, smears above-mentioned toner in its face, daily one
It is secondary, it continuous 14 days, takes pictures when 0day, 7day and 14day, and observe the skin of face, test result such as Fig. 9 institute
Show.
As shown in Figure 9: after volunteer's face smears toner 14 days of the anti-inflammatory Shu Min remediation composition containing 5wt%,
The allergic conditions of face are clearly better.
9, chick chorioallantoic membrane vascular stimulation test (CAMVA):
Experimental principle: a certain amount of tested material is directly contacted with chick chorioallantoic membrane, by observing after effect a period of time
Chorioallantoic membrane injury of blood vessel (such as ghost blood vessel, capillary injection or bleeding) degree, to different injury of blood vessel degree into
Row scoring, to judge the irritation size of tested material.
Evaluation criterion:
0 < NC≤2, show as stress sexual stimulus, i.e., non-invasi stimulate, capillary does not have bleeding lesions at this time；
2 < NC≤3 show as minimal irritation, i.e., have generated slight damage sexual stimulus at this time, and capillary occurs light at this time
Micro- property bleeding lesions；
3 < NC≤5 show as moderate stimulation, i.e., have generated more serious destructive stimulus at this time, at this time capillary
There are more serious bleeding lesions, may be irreversible damage；
NC > 5, show as seriously stimulating, i.e., have generated extremely serious destructive stimulus at this time, at this time the big face of capillary
Product bleeding, and amount of bleeding is larger, is irreversible damage.
The SLS (sldium lauryl sulfate) that 0.01mol/L is first added in same facial mask base-material is chosen, is further divided into 5 groups, 1 group is stayed
Make blank (SLS facial mask), in addition the anti-inflammatory Shu Min remediation composition and comparative example of 4 groups of experimental examples 6 for being separately added into 0.5wt% again
1~3 anti-sensitizer obtains facial mask 1~4, then carries out CAMVA test, and test result is as follows shown in table:
7 CAMVA test result of table
As shown in Table 7: the facial mask containing SLS has relatively high irritation, and joined can be obvious after anti-sensitizer
The irritation of stimulus contained by facial mask is reduced, and the facial mask effect of the anti-inflammatory Shu Min remediation composition containing embodiment 6 is more preferable, it is several
The irritation of stimulus can be completely eliminated.
10, stability test:
Same toner base-material is chosen, adds anti-inflammatory Shu Min remediation composition and the comparison of the embodiment 1 of 5wt% respectively
The anti-sensitizer of example 1~3 obtains toner 1~4, and blank control group is arranged, and places for 24 hours in -18 DEG C of environment of constant temperature, then restore
Room temperature is subsequently placed into 48 DEG C of environment of constant temperature for 24 hours, persistently carries out a month loop test, then respectively in 48 DEG C of constant temperature and -18
It is placed respectively one month in DEG C environment, the stability of finally observation test toner, test result is as follows shown in table:
8 toner stability test result of table
| Name of product | Test result |
| Blank toner | It is as clear as crystal, it is without exception |
| Toner 1 | It is as clear as crystal, it is without exception |
| Toner 2 | There is floccule in bottom |
| Toner 3 | Clarity reduces |
| Toner 4 | Occur muddy |
As shown in Table 8: the anti-inflammatory Shu Min remediation composition of embodiment 1 is after the resistance to Thermal test that extremely resists cold, stability
Than most commercial commodity stabilization, under polysaccharide mosaic texture, aqueous solution is more as clear as crystal, more stable.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of anti-inflammatory Shu Min remediation composition, it is characterised in that: consist of the following mass percentage components:
Radix et Caulis Opuntiae Dillenii extract: 1%~15%；
Oat bran extract: 1%~5%；
Shrubby sophora extract: 1%~5%；
Radix Ophiopogonis root extract: 1%~5%；
Chinese herbaceous peony root extract: 1%~5%；
Radix scutellariae root extract: 1%~5%；
Butanediol: 25%~50%；
Pentanediol: 2%~10%；
Water: surplus.
2. anti-inflammatory Shu Min remediation composition according to claim 1, it is characterised in that: by the component of following mass percent
Composition:
Radix et Caulis Opuntiae Dillenii extract: 4%~12%；
Oat bran extract: 2%~4%；
Shrubby sophora extract: 2%~4%；
Radix Ophiopogonis root extract: 2%~4%；
Chinese herbaceous peony root extract: 2%~4%；
Radix scutellariae root extract: 2%~4%；
Butanediol: 30%~50%；
Pentanediol: 3%~8%；
Water: surplus.
3. anti-inflammatory Shu Min remediation composition according to claim 1 or 2, it is characterised in that: in the Radix et Caulis Opuntiae Dillenii extract
Content >=70wt% of polysaccharide；Content >=95wt% of oat alkaloid in the oat bran extract.
4. anti-inflammatory Shu Min remediation composition according to claim 1 or 2, it is characterised in that: bitter in the shrubby sophora extract
Join content >=95wt% of alkali；Content >=70wt% of polysaccharide in the Radix Ophiopogonis root extract.
5. anti-inflammatory Shu Min remediation composition according to claim 1 or 2, it is characterised in that: in the Chinese herbaceous peony root extract
Content >=60wt% of Paeoniflorin；Content >=90wt% of scutelloside in the radix scutellariae root extract.
6. the preparation method of anti-inflammatory Shu Min remediation composition described in any one of Claims 1 to 5, it is characterised in that: packet
Include following steps:
1) shrubby sophora extract and water are mixed well, obtains shrubby sophora extract solution；
2) by Radix et Caulis Opuntiae Dillenii extract, oat bran extract, Radix Ophiopogonis root extract, Chinese herbaceous peony root extract, radix scutellariae root extract, fourth
Two pure and mild pentanediols mix well, then are transferred in high pressure Microfluidizer, carry out homogeneous, obtain plant extracts mixed liquor；
3) blender is added in the plant extracts mixed liquor of step 2), opens stirring, adds the shrubby sophora extract of step 1)
Solution mixes well, then is transferred in high pressure Microfluidizer, and circulation carries out multiple homogeneous, and filtering obtains anti-inflammatory Shu Min and repairs
Composition.
7. preparation method according to claim 6, it is characterised in that: the high pressure Microfluidizer is using Y shape interaction
Type homogeneous chamber, operating pressure are 1000~1500bar.
8. anti-inflammatory Shu Min remediation composition described in any one of Claims 1 to 5 is preparing the application in skin care item.
9. application according to claim 8, it is characterised in that: anti-inflammatory Shu Min remediation composition the adding in skin care item
Dosage is 0.5wt%~5wt%.
10. application according to claim 8 or claim 9, it is characterised in that: the skin care item are facial mask, moisturizing cream, face cleaning
One of cream, toner, moisturizing lotion, suncream, BB frost, shampoo, shower cream, skin care gel.
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| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 510440 first floor, No. 45, Kexing Road, Guangzhou Private Science Park, No. 1633, Beitai Road, Baiyun District, Guangzhou, Guangdong Patentee after: Guangzhou Costman Biotechnology Co.,Ltd. Patentee after: Zhongke Houpu (Guangzhou) Technology Development Co.,Ltd. Address before: 510440 Workshop on the first floor of building A8, No. 9, Pingsha Dashan Road, JUNHE street, Baiyun District, Guangzhou City, Guangdong Province Patentee before: Guangzhou Costman Biotechnology Co.,Ltd. Patentee before: Zhongke Houpu (Guangzhou) Technology Development Co.,Ltd. |
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| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 510405 No. 1205, 12 / F, building 1, agile science and innovation center, No. 1627, Beitai Road, Guangzhou private science and Technology Park, Baiyun District, Guangzhou, Guangdong Province Patentee after: Zhongke Houpu (Guangzhou) Technology Development Co.,Ltd. Patentee after: Guangzhou Costman Biotechnology Co.,Ltd. Address before: 510440 first floor, No. 45, Kexing Road, Guangzhou Private Science Park, No. 1633, Beitai Road, Baiyun District, Guangzhou, Guangdong Patentee before: Guangzhou Costman Biotechnology Co.,Ltd. Patentee before: Zhongke Houpu (Guangzhou) Technology Development Co.,Ltd. |