CN116725935A - Essence composition with whitening, anti-allergy and anti-wrinkle functions, and preparation method and application thereof - Google Patents
Essence composition with whitening, anti-allergy and anti-wrinkle functions, and preparation method and application thereof Download PDFInfo
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- CN116725935A CN116725935A CN202310929919.8A CN202310929919A CN116725935A CN 116725935 A CN116725935 A CN 116725935A CN 202310929919 A CN202310929919 A CN 202310929919A CN 116725935 A CN116725935 A CN 116725935A
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- whitening
- raw materials
- skin
- wrinkle
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/34—Alcohols
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The invention provides a whitening, anti-allergic and anti-wrinkle essence composition, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The essence composition is prepared from active substances, emollients, moisturizers, emulsion stabilizers, skin conditioning agents, pH regulators, thickeners, essences, chelating agents and solvents, has the advantages of synergistic effect, good permeability, easy absorption, whitening and skin wrinkle repairing effects, wrinkle regeneration inhibition, skin aging delay, and skin aging relieving and anti-sensitivity effects, can improve facial red blood streaks, reduce skin sensitivity, relieve and repair skin for a long time, and has high stability and good safety.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a whitening, anti-allergic and anti-wrinkle essence composition, and a preparation method and application thereof.
Background
With age, the number of facial skin fibroblasts decreases, collagen and elastin secretion decreases, skin elasticity deteriorates, and wrinkles occur. The aging of facial skin is affected by age factors, and the damage of ultraviolet rays, dust and other factors in the external environment can cause the damage of facial skin, and the aging can also affect the skin after working for a long time after staying at night on computers, smoking, sleeping deficiency, staying in an air conditioning room for a long time, and the like, so that the skin is loose, rough, dull and the like.
Although skin aging is an irreversible physiological phenomenon, its progression can be delayed or slowed down. The main methods for removing wrinkles on the face at present mainly comprise operation wrinkle removal, injection wrinkle removal and anti-wrinkle cosmetics, the treatment cost of the operation wrinkle removal and the injection wrinkle removal is high, the risk is high, not all consumers can bear the cosmetic, and the anti-wrinkle cosmetics are a good choice. The anti-wrinkle cosmetic mainly comprises an anti-wrinkle facial mask, a facial cleanser, an anti-wrinkle toner, a facial cream, an essence and the like. The face cleansing cream has short residence time on the face, has insignificant effect, needs long-term use and is inconvenient in use; the anti-wrinkle toner and the cream have relatively low content of active ingredients, the anti-wrinkle effect is not obvious, and the anti-wrinkle mask or essence contains more nutrient substances and active ingredients than the toner and the cream, and has strong efficacy and obvious anti-wrinkle effect. Therefore, researches on anti-wrinkle essence are attracting attention.
As disclosed in patent CN105250184a, a whitening anti-aging essence is disclosed, which comprises polyethylene glycol, polydimethylsiloxane, sodium polyglutamate, glycerin, hyaluronic acid, xylitol, C20-22 alcohol phosphate/C20-22 alcohol, ginkgo leaf extract, ophiopogon root extract, purslane extract, suberect spatholobus stem extract, milk protein and the like, has good permeability, is easy to absorb, effectively supplements water, moisturizes and whitens skin, repairs skin wrinkles, reduces fine lines and delays skin aging.
As patent CN115400066a discloses a repairing anti-wrinkle essence, which comprises carbomer, humectant, p-hydroxyacetophenone, arginine, skin conditioner, skin activating agent, sodium hyaluronate, purslane extract, umbilical cord extract (animal) ethylhexyl glycerin, solvent and water, wherein the components are used together, so that the skin barrier injury can be quickly repaired, and the repairing anti-wrinkle essence has multiple functions of anti-wrinkle, repairing, moisturizing, whitening, skin tendering, anti-allergy and the like.
Although the research of anti-wrinkle essence has been greatly progressed, the existing anti-wrinkle essence has poor permeability, difficult absorption and the like, and only can realize the basic moisturizing effect, and the effects of anti-wrinkle, whitening and the like are still to be improved.
Disclosure of Invention
In order to overcome the defects of the prior art, the first aim of the invention is to provide an essence composition with the functions of whitening, resisting allergy and wrinkle, which has the advantages of good permeability, easy absorption, whitening and repairing skin wrinkles, inhibiting wrinkle regeneration, delaying skin aging, relieving and resisting allergy, improving facial red blood streak, reducing skin sensitivity, relieving and repairing skin for a long time, high stability and good safety.
The second object of the present invention is to provide a method for preparing the above-mentioned essence composition with whitening, anti-allergic and anti-wrinkle effects.
A third object of the present invention is to provide the use of the above-mentioned essence composition having whitening, anti-allergic and anti-wrinkle effects.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
in one aspect, a whitening, anti-allergic and anti-wrinkle essence composition comprises an active substance, an emollient, a humectant, an emulsion stabilizer, a skin conditioner, a pH adjuster, a thickener, an essence, a chelating agent, and a solvent; wherein,,
the active substance comprises cactus extract, radix Ophiopogonis root extract, oat bran extract, radix Paeoniae root extract, radix Scutellariae extract, butanediol and water.
In the invention, the active substances comprise cactus extract, ophiopogon root extract, oat bran extract, paeonia root extract, scutellaria baicalensis root extract, butanediol and water in a mass ratio of 45-55:30-40:5-8:2-5:2-5:1-3:0.5-2.
Preferably, the active substance comprises: 50-52:32-34:6-7:6-7:3-4:3-4:1-2:1-1.5, radix et caulis Opuntiae Dillenii extract, radix Ophiopogonis extract, oat bran extract, radix Paeoniae extract, radix Scutellariae extract, butanediol and water.
In the invention, the skin conditioner comprises a skin conditioner I and a skin conditioner II in a mass ratio of 1-3:0.2-1; the skin conditioner I is allantoin, and the skin conditioner II is a lysate of fermentation products of the two yeasts, butanediol, 1, 2-pentanediol and 1, 2-hexanediol with the mass ratio of 85-88:8-12:1-3:0.5-1.5.
Preferably, the skin conditioner comprises a mass ratio of skin conditioner I to skin conditioner II of 2:0.5; the skin conditioner II is a lysate of fermentation products of the two-split yeast, butanediol, 1, 2-pentanediol and 1, 2-hexanediol in a mass ratio of 87:10:2:1.
In the present invention, the emollient is selected from at least one of tri (ethylhexanoate), methyl propylene glycol, cyclopentadimethicone, dimethicone, cyclotetradimethicone, cyclohexasilicone, trehalose, 1, 2-hexanediol, arginine, 1, 2-pentanediol, sodium chloride, soluble elastin, bis-PEG-18 methyl ether dimethyl silane, polyglycerol-10 dipalmitate, ethylhexyl palmitate, hexyl laurate, and lauryl alcohol.
Preferably, the emollient comprises tri (ethylhexanoate), methyl propylene glycol, cyclopentadimethicone, dimethicone, cyclotetradimethicone, cyclohexasilicone, trehalose, 1, 2-hexanediol, arginine, 1, 2-pentanediol, sodium chloride, soluble elastin, bis-PEG-18 methyl ether dimethyl silane, and polyglycerol-10 dipalmitate.
In the invention, the humectant is at least one selected from polydimethylsiloxane, saccharide isomer, citric acid, sodium citrate, 1, 2-hexanediol, butanediol, p-hydroxyacetophenone, 1, 2-pentanediol, hydroxyphenyl propionamide benzoic acid, betaine, sodium hyaluronate and glycereth-26.
Preferably, the humectant comprises polydimethylsiloxane, saccharide isomers, citric acid, sodium citrate, 1, 2-hexanediol, butylene glycol, p-hydroxyacetophenone, 1, 2-pentanediol, and hydroxyphenyl propionamide benzoic acid.
In the invention, the emulsion stabilizer is at least one selected from acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, polyacrylate-13, polyisobutylene, sorbitan isostearate, polysorbate-20, vitamin E acetate, butylhydroxytoluene, tert-butyl p-methoxyphenol and propyl gallate.
Preferably, the emulsion stabilizer is acrylic acid (ester) or C10-30 alkanol acrylate cross-linked polymer; the said
In the present invention, the pH adjuster is at least one selected from arginine, triethanolamine, citric acid, tartaric acid, and aminomethylpropanol.
Preferably, the pH adjuster is arginine.
In the present invention, the thickener is at least one selected from xanthan gum, carbomer, isopropyl myristate, beeswax, xanthan gum, acrylic polymer, carrageenan, carbomer, pectin and cellulose.
Preferably, the thickener is xanthan gum.
In the invention, the essence is selected from any one or more of cosmetics available essence, including but not limited to lavender essence, lemon essence, jasmine essence, rose essence, camellia essence, kumquat essence, strawberry essence, juicy peach essence and grapefruit essence.
In the present invention, the chelating agent is EDTA-disodium.
In the present invention, the solvent is selected from any one of deionized water, distilled water, ion-exchanged water, double distilled water, high purity water, and purified water.
In the invention, the essence composition with whitening, anti-allergy and anti-wrinkle functions comprises:
phase A raw materials: solvent, bis-PEG-18 methyl ether dimethylsilane, acrylic acid (esters) of C10-30 alkanol acrylate cross-linked polymer, skin conditioner I and EDTA-disodium;
phase B raw materials: methyl propylene glycol and xanthan gum;
c phase raw materials: tri (ethylhexanoate), polydimethylsiloxane and polyglycerol-10 dipalmitate;
d phase raw materials: cyclopentadimethicone, dimethicone, cyclotetradimethicone, and cyclohexasilicone;
e phase raw materials: arginine;
f phase raw materials: solvents, actives, skin conditioning agent II, trehalose, 1, 2-hexanediol, arginine, 1, 2-pentanediol, sodium chloride, soluble elastin, saccharide isomers, citric acid, sodium citrate, butylene glycol, p-hydroxyacetophenone, hydroxyphenylpropionamide benzoic acid, and fragrances.
Further, the essence composition with whitening, anti-allergy and anti-wrinkle functions comprises the following components in percentage by weight:
phase A raw materials: 50-60% of solvent, 1.5-4% of bis-PEG-18 methyl ether dimethyl silane, 0.1-0.5% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.1-0.3% of allantoin and 0.02-0.08% of EDTA-disodium;
phase B raw materials: 3-6% of methyl propylene glycol and 0.1-0.3% of xanthan gum;
c phase raw materials: 8-15% of triglyceride (ethyl caproic acid), 0.8-3% of polydimethylsiloxane and 0.5-1% of polyglycerol-10 dipalmitate;
d phase raw materials: the mass ratio of the cyclopentadimethicone to the polydimethylsiloxane to the cyclotetradimethicone is 85-88:8-12:1-3:0.5-1.5, and the total mass ratio of the cyclopentadimethicone to the cyclohexasiloxane is 3-8%;
e phase raw materials: arginine 0.1-0.6%;
f phase raw materials: 4-12% of solvent, 1.5-4% of active substance, 0.02-0.1% of skin conditioning agent II, 0.2-0.5% of trehalose, 0.25-0.43% of 1, 2-hexanediol, 0.1-0.6% of arginine, 0.2-0.6% of 1, 2-pentanediol, 0.012-0.03% of sodium chloride, 0.004-0.01% of soluble elastin, 0.4-1% of saccharide isomer, 0.004-0.01% of citric acid, 0.004-0.01% of sodium citrate, 0.44-0.67% of butanediol, 0.075-0.15% of p-hydroxyacetophenone, 0.02-0.075% of hydroxyphenyl propionamide benzoic acid and 0.02-0.1% of essence.
Preferably, the essence composition with whitening, anti-allergic and anti-wrinkle effects comprises the following components in percentage by weight:
phase A raw materials: 53-55% of solvent, 3% of bis-PEG-18 methyl ether dimethyl silane, 0.35% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.15% of allantoin and 0.04% of EDTA-disodium;
phase B raw materials: 5% of methyl propylene glycol and 0.24% of xanthan gum;
c phase raw materials: 12% of glycerol tri (ethylhexanoate), 2.2% of polydimethylsiloxane and 0.8% of polyglycerol-10 dipalmitate;
d phase raw materials: cyclopentamethylsiloxane, polydimethylsiloxane, cyclotetradimethylsiloxane and cyclohexasiloxane in a mass ratio of 87:10:2:1, totaling 4.7%;
e phase raw materials: arginine 0.3%;
f phase raw materials: 10% of solvent, 3.5% of active substance, 0.08% of skin conditioning agent II, 0.38% of trehalose, 0.3% of 1, 2-hexanediol, 0.5% of arginine, 0.42% of 1, 2-pentanediol, 0.024% of sodium chloride, 0.01% of soluble elastin, 0.9% of saccharide isomer, 0.008% of citric acid, 0.008% of sodium citrate, 0.6% of butanediol, 0.11% of p-hydroxyacetophenone, 0.06% of hydroxyphenyl propionamide benzoic acid and 0.05-0.06% of essence.
On the other hand, the preparation method of the essence composition with the functions of whitening, resisting allergy and resisting wrinkles comprises the following steps of:
(1) Uniformly mixing the phase A raw material and the phase B raw material to obtain a water phase mixed solution;
(2) Uniformly mixing the C-phase raw material and the D-phase raw material to obtain an oil phase mixed solution;
(3) Mixing the water phase mixed solution obtained in the step (1) and the oil phase mixed solution, homogenizing and emulsifying, cooling to 60-65 ℃, adding the E phase raw material, uniformly mixing, adding the F phase raw material, uniformly mixing, discharging and standing to obtain the water phase emulsion.
Further, in the step (1), during the mixing process of the phase A raw material and the phase B raw material, the temperature is 75-80 ℃, and the stirring speed is 550-700rpm; preferably, the temperature is 80℃and the stirring rate is 600rpm.
Further, in the step (2), the heating temperature is 70-75 ℃, and the stirring speed is 400-600rpm. Preferably, the heating temperature is 70℃and the stirring rate is 500rpm.
Further, in the step (3), in the homogenizing and emulsifying process: the temperature is 70-75 ℃, the stirring speed is 500-700r/min, and the time is 8-15min; preferably, in the homogenizing emulsification process: the temperature is 75 ℃, the stirring speed is 600r/min, and the time is 10min.
In still another aspect, the use of the above-described essence composition with whitening, antiallergic and anti-wrinkle effects in the preparation of cosmetics.
Compared with the prior art, the invention has the following beneficial effects:
(1) The essence composition with the functions of whitening, resisting allergy and wrinkle resistance is safe and stable, good in permeability and easy to absorb, has the effects of whitening and repairing skin wrinkles, inhibits the regeneration of wrinkles, delays skin aging, has the effects of relieving and resisting allergy, can improve facial red blood streaks, reduces skin sensitivity, and can relieve and repair skin for a long time, and the stability and safety are high, and the skin care composition is mild and has no stimulation.
(2) The active ingredients of the essence composition with whitening, anti-allergy and anti-wrinkle effects comprise cactus extract, dwarf lilyturf tuber extract, oat bran extract, paeonia lactiflora root extract and baical skullcap root extract, and through reasonable proportion, the extracts are synergistic mutually, so that the skin metabolism can be promoted, fine lines and wrinkles can be effectively reduced, the skin aging is slowed down, the skin relaxation sagging is improved, the skin brightness is improved, and the anti-allergy effect is also improved.
(3) The essence composition with the functions of whitening, resisting allergy and resisting wrinkle is added with allantoin, the lysate of the fermentation product of the two-split yeast, butanediol, 1, 2-pentanediol and 1, 2-hexanediol as skin conditioning agents, so that the sensitivity of skin can be reduced, the skin can be eased, the skin sensitive to dryness can be conditioned, the penetration of the essence into the skin can be further promoted, the efficacy of the essence can be improved, and in addition, the stability of the product can be improved.
Detailed Description
The following non-limiting examples will enable those of ordinary skill in the art to more fully understand the invention and are not intended to limit the invention in any way. The following is merely exemplary of the scope of the invention as claimed and many variations and modifications of the invention will be apparent to those skilled in the art in light of the disclosure, which are intended to be within the scope of the invention as claimed.
The invention is further illustrated by means of the following specific examples. In the invention, the essence is purchased from Xiamen one Meiya essence perfume limited company, saccharide isomer is purchased from Disman nutrition products limited company, soluble elastin is purchased from Guangdong graphene biotechnology Co., ltd., cactus (OPUNTIA DILLENII) extract, radix Ophiopogonis (OPHIOPOGON JAPONICUS) root extract, oat (AVENA SATIVA) bran extract, radix Paeoniae (PAEONIA ALBIFLORA) root extract and radix Scutellariae (SCUTELLARIA BAICALENSIS) root extract are purchased from Magnolia officinalis (Guangzhou) technology development limited company. Various other chemical reagents, unless otherwise specified, are commercially available in conventional fashion.
Examples 1 to 3, comparative examples 1 and 2
Raw materials and proportions of the essence compositions with whitening, anti-allergic and anti-wrinkle of examples 1 to 3 and comparative examples 1 and 2 are shown in the following table 1 (in weight percent):
TABLE 1
Wherein, in the embodiment 1, the active substances comprise cactus extract, dwarf lilyturf tuber extract, oat bran extract, paeonia root extract, baical skullcap root extract, butanediol and water according to the mass ratio of 45:40:8:2:2:1:2; skin conditioner II comprises a split yeast fermentation product lysate, butylene glycol, 1, 2-pentanediol, and 1, 2-hexanediol in a mass ratio of 85:12:2:1.
In example 2, the active substance comprises cactus extract, radix Ophiopogonis root extract, oat bran extract, radix Paeoniae root extract, radix Scutellariae root extract, butanediol and water in a mass ratio of 50:34:7:3:3:2:1; skin conditioner II contained a split yeast fermentation product lysate, butylene glycol, 1, 2-pentanediol, and 1, 2-hexanediol in a mass ratio of 87:10:2:1.
In example 3, the active substance comprises cactus extract, radix Ophiopogonis root extract, oat bran extract, radix Paeoniae root extract, radix Scutellariae extract, butanediol and water in a mass ratio of 55:30:5:5:2:2.5:0.5; skin conditioner II comprises a split yeast fermentation product lysate, butylene glycol, 1, 2-pentanediol, and 1, 2-hexanediol in a mass ratio of 88:8:3:1.
The preparation method of the essence composition with whitening, anti-allergic and anti-wrinkle effects of examples 1-3 and comparative examples 1 and 2 comprises the following steps:
(1) Mixing the A phase raw material and the B phase raw material, and uniformly stirring and mixing at 80 ℃ and 600r/min to obtain a water phase mixed solution;
(2) Mixing the C phase raw material and the D phase raw material, and uniformly stirring and mixing at 70 ℃ and 500r/min to obtain an oil phase mixed solution;
(3) Mixing the water phase mixed solution and the oil phase mixed solution, homogenizing and emulsifying for 10min at 70 ℃ and 600r/min, cooling to 60 ℃, adding the E phase raw material, mixing uniformly, adding the F phase raw material, mixing uniformly, discharging and standing to obtain the water phase emulsion.
Comparative example 3
The difference from example 2 is that the active substance comprises cactus extract, radix Ophiopogonis root extract, oat bran extract, radix Paeoniae root extract, radix Scutellariae extract, butanediol and water in a mass ratio of 42:45:10:1:1:0.5:0.5.
Comparative example 4
The difference from example 2 is that the active substance comprises cactus extract, radix Ophiopogonis root extract, oat bran extract, radix Paeoniae root extract, radix Scutellariae extract, butanediol and water in a mass ratio of 58:28:3:1:7:0.5:2.5.
Comparative example 5
The difference from example 2 is that the mass ratio of skin conditioner I to skin conditioner II is 0.5:2.
Comparative example 6
The difference from example 2 is that the mass ratio of skin conditioner I to skin conditioner II is 4:0.1.
Comparative example 7
The difference from example 2 is that there is no lysate of the fermentation product of Saccharomyces cerevisiae in skin conditioner II.
Comparative example 8
The difference from example 2 is that there is no skin conditioner I allantoin.
Comparative example 9
The difference from example 2 is that no skin conditioner II was present.
Experimental example 1
Safety evaluation
The experimental object: women 110 aged 20-50 were randomly selected and randomized into 11 groups, 10 each, with a healthy skin with no history of dermatological allergies;
the experimental method comprises the following steps: (Patch method) in a closed Patch test, about 0.02 to 0.03mL of the essence composition obtained in examples 1 to 4 and comparative examples 1 to 7 of the present invention was added to a patch tester, and the test article was removed after 24 hours by applying a special adhesive tape to the back of the subject, and the skin reactions were observed at 0.5, 6, 12, 24 and 48 hours after the removal, and the results were recorded according to the skin reaction classification standard in the cosmetic hygiene Specification.
Experimental results: after the essence compositions obtained in the examples 1-3 and the comparative examples 1-9 are used, skin irritation reactions such as erythema, edema, pimple, stinging and the like do not appear in each group of subjects within 48 hours, which proves that the essence composition provided by the invention is safe to use.
Experimental example 2
Efficacy evaluation
Human skin fibroblast HSF proliferation assay
Taking human skin fibroblast in logarithmic growth phase1×10 5 Inoculating 90 μL of the culture medium to each well, inoculating 5% CO at 37 ℃ in each well, and culturing 2 Culturing for 24h, taking out, and then respectively arranging an experimental group, a negative control group (containing equivalent cell heavy suspension) and a blank control group (containing equivalent DMEM culture solution), wherein 10 mu L/hole of the essence composition is added into the experimental group, the negative control group is added into equivalent DMEM culture solution, culturing is continued in a standard incubator for 48h, taking out, adding 20 mu L of MTT into each hole, culturing for 4h, adding 150 mu L/hole of dimethyl sulfoxide, shaking uniformly, measuring the absorbance value (OD) of each hole at the position with the wavelength of 490nm of an enzyme-labeled instrument, and calculating the cell proliferation rate (%) = (OD of the experimental group-OD of the blank control group)/(OD of the negative control group-OD) of the blank control group) ×100%. The results are shown in Table 2 below.
TABLE 2
| Group of | Cell proliferation rate (%) | Group of | Cell proliferation rate (%) |
| Example 1 | 338.1±25.7 | Comparative example 5 | 328.6±26.3 |
| Example 2 | 358.5±22.4 | Comparative example 6 | 317.5±24.6 |
| Example 3 | 330.5±28.2 | Comparative example 7 | 325.5±28.2 |
| Comparative example 1 | 255.8±20.6 | Comparative example 8 | 330.6±25.5 |
| Comparative example 2 | 282.6±23.1 | Comparative example 9 | 315.4±22.1 |
| Comparative example 3 | 162.7±20.7 | Negative control group | 125.6±17.7 |
| Comparative example 4 | 194.5±22.1 | —— | —— |
The human skin fibroblast can secrete extracellular matrixes such as procollagen, fibronectin, collagenase and the like, and can migrate to a wound for proliferation in the wound healing process, so that the proliferation of the human skin fibroblast is beneficial to the update and repair of aged skin. From the data in the table, the essence composition obtained in examples 1-3 has obvious proliferation effect on human skin fibroblasts, the cell proliferation rate in comparative examples 3 and 4 is obviously lower than that in examples, and the proportion of the active substances has great effect on proliferation of human skin fibroblasts, and the proliferation of human skin fibroblasts can be further promoted by reasonable proportion of each component in the active substances, so that the anti-wrinkle effect is improved.
(II) wrinkle-removing efficacy experiment
Selecting 35-55 volunteers with similar facial wrinkles, and dividing female volunteers without skin disease allergy history into 5 groups of 20 people each; after the face of a subject is cleaned, the essence composition is uniformly smeared on the face and gently massaged until the essence composition is absorbed, and the essence composition is continuously used for one month in the morning and evening. The experimental evaluation results are shown in table 3 below.
TABLE 3 Table 3
The results show that the essence composition of the embodiment 2 is widely loved and accepted by subjects, and the subjects show that the whitening anti-aging essence has good permeability and is easy to absorb, fine lines are effectively smoothed, wrinkles are reduced, and the skin is recovered to be compact and elastic. The level fine lines, wrinkle reducing effect of the essence compositions of comparative examples 1-4 was not as good as that of example 2, and the subjects were not satisfied. The invention shows that the components are mutually cooperated, so that the wrinkle-removing effect can be better exerted. In addition, all subjects did not develop adverse reactions during one month of use of the concentrate composition of the present invention.
(III) whitening efficacy experiment
Women with relatively dark facial complexion aged 23-50 years are selected, randomly divided into 8 groups, 10 groups are used for collecting, analyzing and testing melanin and color difference data of facial skin before sampling, and the change of skin color is measured by a color system (Lab color system) regulated by International Commission on illumination (CIE), and the data are used as skin background values. The essence composition is used by a subject once in the morning and evening for 4 weeks, and the change of the whiteness (brightness) and the melanin content of the skin before and after the cosmetic is used by the subject is tested and evaluated again after the completion of the use; wherein,,
Δmi=tn—t0; wherein Tn is the time-varying value of the tested area; t0 is the test area start value;
Δl=tn-T0; wherein Tn is the time-varying value of the tested area; t0 is the test area start value.
The experimental results are shown in table 4 below.
TABLE 4 Table 4
| Group of | Skin melanin delta MI | Skin brightness Δl |
| Example 2 | -22.65 | 1.81 |
| Comparative example 1 | -18.14 | 1.63 |
| Comparative example 2 | -19.83 | 1.67 |
| Comparative example 3 | -17.56 | 1.52 |
| Comparative example 4 | --18.03 | 1.67 |
| Comparative example 5 | -20.65 | 1.70 |
| Comparative example 6 | -21.11 | 1.72 |
| Comparative example 7 | -20.85 | 1.64 |
| Comparative example 8 | -20.92 | 1.60 |
| Comparative example 9 | -19.33 | 1.71 |
The results show that after the subject uses the essence composition of the embodiment 2, the MI value of skin melanin is obviously reduced, and the brightness of the skin is improved, so that the essence composition has the effects of reducing the skin melanin and improving the whiteness of the skin; the skin melanin MI value reduction amplitude of the essence composition obtained in the comparative example, namely the delta MI value is lower than that of the example, and it is seen that the proportion of the active substances and the components of the skin conditioner influence the whitening efficacy of the essence composition.
(IV) anti-allergy relief test
Selecting 40 volunteers with reddening faces, and equally dividing the volunteers into 8 groups; after the face of the subject is cleaned, the essence composition of the invention is uniformly smeared on the face and gently massaged to be absorbed, and the composition is continuously used for 7 days in the morning and at night, and the condition of red blood streak of the face of the subject is analyzed by a VISIA-CR face image analyzer. The results are shown in Table 5 below.
TABLE 5
| Group of | Skin red area a rate of change (%) | Skin red area ratio change rate (%) |
| Example 2 | -5.18 | -26.88 |
| Comparative example 1 | -3.62 | -22.15 |
| Comparative example 2 | -4.17 | -20.86 |
| Comparative example 5 | -3.22 | -19.07 |
| Comparative example 6 | -3.68 | -21.51 |
| Comparative example 7 | -3.47 | -20.88 |
| Comparative example 8 | -2.14 | -17.63 |
| Comparative example 9 | -2.55 | -18.11 |
The results show that: after the subject uses the essence composition of the embodiment 2 of the invention for 7 days, the face Pi Fufan is improved, which indicates that the essence composition of the invention can play a good role in relieving the problems of facial inflammation, redness and the like; the improvement of facial redness of comparative examples 5 to 9, and particularly comparative examples 8 and 9, is not as good as that of example 2, and it can be seen that the skin conditioner has a large influence on the effects of reducing the sensitivity of the skin and soothing the skin.
Experimental example 3
Stability test
The heat and cold resistance experiments were performed with reference to standard QB/T2660-2004 as follows:
heat resistance experiment: maintaining the essence composition at 40+/-1 ℃ for 24 hours, and after the essence composition is recovered to room temperature, observing whether layering and oil slick exist or not, and whether the color and luster change or not;
cold resistance experiment: maintaining the essence composition at 5+/-1 ℃ for 24 hours, and after the essence composition is recovered to room temperature, observing whether layering and oil slick exist or not, and whether the color and luster change or not;
cold and hot cycle experiment: the essence composition of the invention is kept for 24 hours at 40+/-1 ℃, stored for 24 hours at room temperature and kept for 24 hours at 5+/-1 ℃; and (3) circulating for 3 times in turn, and observing whether layering and oil slick exist or not and whether the color changes or not.
The results are shown in Table 6.
TABLE 6
| Group of | Heat resistance test | Cold resistance experiment | Experiment of cold and hot circulation |
| Example 1 | No obvious change | No obvious change | No obvious change |
| Example 2 | No obvious change | No obvious change | No obvious change |
| Example 3 | No obvious change | No obvious change | No obvious change |
| Comparative example 1 | No obvious change | No obvious change | Delamination occurs |
| Comparative example 2 | No obvious change | No obvious change | No obvious change |
| Comparative example 3 | Delamination occurs | No obvious change | Delamination occurs |
| Comparative example 4 | No obvious change | No obvious change | Delamination occurs |
| Comparative example 5 | No obvious change | No obvious change | Delamination occurs |
| Comparative example 6 | Layering and darkening of color | No obvious change | Layering and oil slick and deep color |
| Comparative example 7 | Darkening of color | Darkening of color | Layering and darkening of color |
| Comparative example 8 | Layering and darkening of color | No obvious change | Layering and oil slick and deep color |
| Comparative example 9 | Layering and darkening of color | Delamination occurs | Layering and oil slick and deep color |
The results show that the essence composition obtained by the embodiment of the invention has no obvious change in shape, no layering and no oil slick and has changed color after heat resistance experiments, cold resistance experiments and cold and heat cycle experiments. The essence compositions obtained in comparative examples 1 to 9 exhibited delamination, oil slick, darkening, and the like, and were significantly inferior in stability to the examples.
The previous description of the embodiments is provided to facilitate a person of ordinary skill in the art in order to make and use the present invention. It will be apparent to those skilled in the art that various modifications can be readily made to these embodiments and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above-described embodiments, and those skilled in the art, based on the present disclosure, should make improvements and modifications without departing from the scope of the present invention.
Claims (15)
1. An essence composition with whitening, anti-allergic and anti-wrinkle effects is characterized by comprising an active substance, an emollient, a humectant, an emulsion stabilizer, a skin conditioner, a pH regulator, a thickener, an essence, a chelating agent and a solvent; wherein,,
the active substance comprises cactus extract, radix Ophiopogonis root extract, oat bran extract, radix Paeoniae root extract, radix Scutellariae extract, butanediol and water.
2. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 1, wherein the active substance comprises cactus extract, ophiopogon root extract, oat bran extract, paeonia lactiflora root extract, scutellaria baicalensis root extract, butylene glycol and water in a mass ratio of 45-55:30-40:5-8:2-5:2-5:1-3:0.5-2.
3. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 2, wherein the active substance comprises cactus extract, radix ophiopogonis extract, oat bran extract, paeonia lactiflora extract, scutellaria baicalensis extract, butanediol and water in a mass ratio of 50-52:32-34:6-7:6-7:3-4:3-4:1-2:1-1.5.
4. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 1, wherein the skin conditioner comprises a skin conditioner I and a skin conditioner II in a mass ratio of 1-3:0.2-1; the skin conditioner I is allantoin, and the skin conditioner II is a lysate of fermentation products of the two yeasts, butanediol, 1, 2-pentanediol and 1, 2-hexanediol with the mass ratio of 85-88:8-12:1-3:0.5-1.5.
5. The essence composition with whitening, anti-allergic and anti-wrinkle properties according to claim 4, characterized in that preferably the skin conditioner comprises a mass ratio of skin conditioner I to skin conditioner II of 2:0.5; the skin conditioner II is a lysate of fermentation products of the two-split yeast, butanediol, 1, 2-pentanediol and 1, 2-hexanediol in a mass ratio of 87:10:2:1.
6. The anti-allergic anti-wrinkle essence composition according to claim 1, wherein the emollient is at least one selected from the group consisting of tri (ethylhexanoate), methyl propylene glycol, cyclopentadimethicone, dimethicone, cyclotetradimethicone, cyclohexasiloxane, trehalose, 1, 2-hexanediol, arginine, 1, 2-pentanediol, sodium chloride, soluble elastin, bis-PEG-18 methyl ether dimethyl silane, polyglycerol-10 dipalmitate, ethylhexyl palmitate, hexyl laurate, and lauryl alcohol.
7. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 1, wherein the humectant is at least one selected from the group consisting of polydimethylsiloxane, saccharide isomers, citric acid, sodium citrate, 1, 2-hexanediol, butylene glycol, p-hydroxyacetophenone, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid, betaine, sodium hyaluronate and glycereth-26.
8. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 1, wherein the emulsion stabilizer is at least one selected from the group consisting of acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer, polyacrylate-13, polyisobutylene, sorbitan isostearate, polysorbate-20, vitamin E acetate, butylated hydroxytoluene, t-butyl-p-methoxyphenol and propyl gallate.
9. The essence composition with whitening, anti-allergic and anti-wrinkle properties according to claim 1, wherein the pH adjuster is at least one selected from arginine, triethanolamine, citric acid, tartaric acid and aminomethylpropanol.
10. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 1, wherein the thickener is at least one selected from xanthan gum, carbomer, isopropyl myristate, beeswax, xanthan gum, acrylic polymer, carrageenan, carbomer, pectin and cellulose.
11. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to any one of claims 1 to 10, characterized by comprising:
phase A raw materials: solvent, bis-PEG-18 methyl ether dimethylsilane, acrylic acid (esters) of C10-30 alkanol acrylate cross-linked polymer, skin conditioner I and EDTA-disodium;
phase B raw materials: methyl propylene glycol and xanthan gum;
c phase raw materials: tri (ethylhexanoate), polydimethylsiloxane and polyglycerol-10 dipalmitate;
d phase raw materials: cyclopentadimethicone, dimethicone, cyclotetradimethicone, and cyclohexasilicone;
e phase raw materials: arginine;
f phase raw materials: solvents, actives, skin conditioning agent II, trehalose, 1, 2-hexanediol, arginine, 1, 2-pentanediol, sodium chloride, soluble elastin, saccharide isomers, citric acid, sodium citrate, butylene glycol, p-hydroxyacetophenone, hydroxyphenylpropionamide benzoic acid, and fragrances.
12. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 11, characterized by comprising, in weight percent:
phase A raw materials: 50-60% of solvent, 1.5-4% of bis-PEG-18 methyl ether dimethyl silane, 0.1-0.5% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.1-0.3% of allantoin and 0.02-0.08% of EDTA-disodium;
phase B raw materials: 3-6% of methyl propylene glycol and 0.1-0.3% of xanthan gum;
c phase raw materials: 8-15% of triglyceride (ethyl caproic acid), 0.8-3% of polydimethylsiloxane and 0.5-1% of polyglycerol-10 dipalmitate;
d phase raw materials: the mass ratio of the cyclopentadimethicone to the polydimethylsiloxane to the cyclotetradimethicone is 85-88:8-12:1-3:0.5-1.5, and the total mass ratio of the cyclopentadimethicone to the cyclohexasiloxane is 3-8%;
e phase raw materials: arginine 0.1-0.6%;
f phase raw materials: 4-12% of solvent, 1.5-4% of active substance, 0.02-0.1% of skin conditioning agent II, 0.2-0.5% of trehalose, 0.25-0.43% of 1, 2-hexanediol, 0.1-0.6% of arginine, 0.2-0.6% of 1, 2-pentanediol, 0.012-0.03% of sodium chloride, 0.004-0.01% of soluble elastin, 0.4-1% of saccharide isomer, 0.004-0.01% of citric acid, 0.004-0.01% of sodium citrate, 0.44-0.67% of butanediol, 0.075-0.15% of p-hydroxyacetophenone, 0.02-0.075% of hydroxyphenyl propionamide benzoic acid and 0.02-0.1% of essence.
13. The essence composition with whitening, anti-allergic and anti-wrinkle effects according to claim 12, characterized by comprising, in weight percent:
phase A raw materials: 53-55% of solvent, 3% of bis-PEG-18 methyl ether dimethyl silane, 0.35% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.15% of allantoin and 0.04% of EDTA-disodium;
phase B raw materials: 5% of methyl propylene glycol and 0.24% of xanthan gum;
c phase raw materials: 12% of glycerol tri (ethylhexanoate), 2.2% of polydimethylsiloxane and 0.8% of polyglycerol-10 dipalmitate;
d phase raw materials: cyclopentamethylsiloxane, polydimethylsiloxane, cyclotetradimethylsiloxane and cyclohexasiloxane in a mass ratio of 87:10:2:1, totaling 4.7%;
e phase raw materials: arginine 0.3%;
f phase raw materials: 10% of solvent, 3.5% of active substance, 0.08% of skin conditioning agent II, 0.38% of trehalose, 0.3% of 1, 2-hexanediol, 0.5% of arginine, 0.42% of 1, 2-pentanediol, 0.024% of sodium chloride, 0.01% of soluble elastin, 0.9% of saccharide isomer, 0.008% of citric acid, 0.008% of sodium citrate, 0.6% of butanediol, 0.11% of p-hydroxyacetophenone, 0.06% of hydroxyphenyl propionamide benzoic acid and 0.05-0.06% of essence.
14. The method for preparing the essence composition with whitening, anti-allergic and anti-wrinkle effects according to any one of claims 1 to 13, comprising the following steps:
(1) Uniformly mixing the phase A raw material and the phase B raw material to obtain a water phase mixed solution;
(2) Uniformly mixing the C-phase raw material and the D-phase raw material to obtain an oil phase mixed solution;
(3) Mixing the water phase mixed solution obtained in the step (1) and the oil phase mixed solution, homogenizing and emulsifying, cooling to 60-65 ℃, adding the E phase raw material, uniformly mixing, adding the F phase raw material, uniformly mixing, discharging and standing to obtain the water phase emulsion.
15. Use of the essence composition with whitening, antiallergic and anti-wrinkle effects according to any one of claims 1 to 13 for the preparation of cosmetics.
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