CN110167926B - 聚-adp核糖聚合酶（parp）抑制剂 - Google Patents

聚-adp核糖聚合酶（parp）抑制剂 Download PDF

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CN110167926B
CN110167926B CN201780082024.8A CN201780082024A CN110167926B CN 110167926 B CN110167926 B CN 110167926B CN 201780082024 A CN201780082024 A CN 201780082024A CN 110167926 B CN110167926 B CN 110167926B
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alkyl
optionally substituted
disease
oxo
methyl
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CN110167926A (zh
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高桥泰辅
A·克鲁格
B·拉古
嵇楠
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Astellas Engineered Small Molecules US Inc
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Mitobridge Inc
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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CN201780082024.8A 2016-12-30 2017-12-28 聚-adp核糖聚合酶（parp）抑制剂 Active CN110167926B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662440581P 2016-12-30 2016-12-30
US62/440,581 2016-12-30
PCT/US2017/068636 WO2018125961A1 (en) 2016-12-30 2017-12-28 Poly-adp ribose polymerase (parp) inhibitors

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CN110167926A CN110167926A (zh) 2019-08-23
CN110167926B true CN110167926B (zh) 2022-09-13

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