CN110123702A - A kind of toothpaste and preparation method thereof containing hyaluronic acid and trehalose - Google Patents
A kind of toothpaste and preparation method thereof containing hyaluronic acid and trehalose Download PDFInfo
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- CN110123702A CN110123702A CN201910521063.4A CN201910521063A CN110123702A CN 110123702 A CN110123702 A CN 110123702A CN 201910521063 A CN201910521063 A CN 201910521063A CN 110123702 A CN110123702 A CN 110123702A
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- hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention relates to a kind of toothpaste and preparation method thereof containing hyaluronic acid and trehalose, the toothpaste include following parts by weight of component: component A: deionized water, and 10-15 parts；B component: sweetener, 0.2-0.5 parts；Acid-base buffer agent, 0.2-0.5 parts；Deionized water, 1-5 parts；Trehalose, 2-5 parts；Component C: anionic surfactant, 1-2.5 parts；D component: moisturizer a, 55-60 part；Glycerol, 5 parts；Component E: moisturizer b, 3-5 part；F component: thickener, 0.3-0.7 parts；Preservative, 0.01-0.1 parts；Hyaluronic acid, 0.05-0.5 parts；G component: rubbing agent, 16-20 parts；Essence, 0.5-1 parts.The present invention adds hyaluronic acid and trehalose active constituent, provides wet environment for oral cavity, is effectively improved dry, and inflammatory factor is inhibited to generate, and each component cooperates, and reaches and keeps the wet shield gum effect in oral cavity.
Description
Technical field
The invention belongs to oral-cavity article fields, and in particular to a kind of toothpaste and its preparation side containing hyaluronic acid and trehalose
Method.
Background technique
Toothpaste is made of the mixing of other additives such as rubbing agent, moisturizer, thickener, foaming agent, aromatic and water
Pasty masses can help the plaque for removing dental surface, and soft dirt and swill are without damaging enamel and dentine, tool
There are good cleaning tooth, protection oral cavity.However, with the increasingly raising of our people's living standard, eating habit
Also huge change occurs, the illness rate of mouth disease and disease incidence are also higher and higher per capita, and it is main to have become China
One of public health problem.Wherein dry, gingivitis are common oral problems.Want to solve current oral problem, it is necessary to
An effective oral care product is selected, toothpaste is presently the most convenient solution.Toothpaste currently on the market is most
Based on cleaning, other protect oral cavities such as: anti-caries, antiallergy, anti-cold acid, prevent canker sore and gum from going out at protection gum
The toothpaste of blood etc., actually active fruit it is very few, be often lack of pertinence.Since everyone constitution is different, somebody holds
Easily there is xerostomia, gingivitis problem, it is therefore necessary to develop a kind of toothpaste of moisturizing shield gum.
Summary of the invention
To comply with the market demand, in view of the deficiencies of the prior art, the present invention provides a kind of containing hyaluronic acid and trehalose
Toothpaste and preparation method thereof.Formulation of tooth-paste provided by the invention containing hyaluronic acid and trehalose is reasonable, ingredient safety, and addition is saturating
Bright matter acid and trehalose active constituent, have good water holding capacity, provide wet environment for oral cavity, are effectively improved dry, inhibit
Oral cavity germ inhibits inflammatory factor to generate, while can reduce the irritation of surfactant, reduces stimulant to oral cavity tissue
Injury can repair impaired gingival cell.
The present invention to achieve the above object, adopts the following technical scheme that a kind of toothpaste containing hyaluronic acid and trehalose, presses
Parts by weight meter comprising following components:
Component A: deionized water, 10-15 parts；
B component: sweetener, 0.2-0.5 parts；Acid-base buffer agent, 0.2-0.5 parts；Deionized water, 1-5 parts；Trehalose, 2-5 parts；
Component C: anionic surfactant, 1-2.5 parts；
D component: moisturizer a, 55-60 part；Glycerol, 5 parts；
Component E: moisturizer b, 3-5 part；
F component: thickener, 0.3-0.7 parts；Preservative, 0.01-0.1 parts；Hyaluronic acid, 0.05-0.5 parts；
G component: rubbing agent, 16-20 parts；Essence, 0.5-1 parts.
Preferably, the sweetener is qualities of stevia extract；The acid-base buffer agent is tetrasodium pyrophosphate；Trehalose is to live
Property ingredient；The anionic surfactant is sodium lauroyl sarcosine；The moisturizer a is sorbierite；The moisturizer b is
Polyethylene glycol -12；The thickener is cellulose gum；The preservative is methyl hydroxybenzoate；Hyaluronic acid is active constituent；It is described
Rubbing agent is silica；The essence is edible essence (material).
Based on the above technical solution, the invention also discloses a kind of systems of toothpaste containing hyaluronic acid and trehalose
Preparation Method, comprising the following steps:
1) component A is put into metering hair jelly pot；
2) B component is first dissolved in 80 DEG C of hot water, is put into hair jelly pot after filtering；
3) component C is put into hair jelly pot, impregnates 15min, starts hair jelly pot agitating paddle, controls mixing speed 20-40r/min；
4) in meter metering D component investment hair jelly pot；
5) component E is put into premix pot, then puts into F component, opened quickly stirring 10min, make it dissolve and be uniformly dispersed, until
It without conglomeration, is then placed in hair jelly pot, first crawl stirring continuously stirs circulation 15min, then by glue after glue thickening
It send to basin, stands storage 5-8h；
6) it starts cream pot vacuum pump processed and controls cream pot vacuum degree processed in 0.02Mpa into glue, open scraper plate stirring；
7) it controls cream pot vacuum degree processed and puts into rubbing agent in G component in 0.03Mpa, after rubbing agent enters in cream pot processed, protect
Hold quickly stirring 5min；When vacuum degree rises to 0.08Mpa, essence of offering incense in a temple, into complete essence after simultaneously start quickly stirring 20min, when
When vacuum degree reaches 0.096Mpa or more, stop quickly stirring, homogeneous continues, and scraper plate is kept to stir at least 10min.
Compared with prior art, the invention has the following advantages that
1) hyaluronic acid that the present invention adds is a kind of natural bioactive moisturizer, maintenance agent and bacteriostatic agent efficiently, safe,
Gingivitis can be quickly and effectively controlled, including the symptom generally mitigated: gum is itched, and uncomfortable, distending pain, halitosis mitigates bleeding gums, is promoted
Into periodontium wound healing, repair, effective prevention of gingivitis, periodontosis.Hyaluronic acid has special water retention, is mesh
The good substance of moisture retention in the nature of preceding discovery can be alleviated since xerostomia and the scorching hot bring of mucous membrane are uncomfortable, improve dry
Problem.
2) present invention addition trehalose, the lotion of the toothpaste containing trehalose has on the water lock performance of keeping humidity of lotion centainly to be mentioned
It rises, so that lotion is kept wet for a longer period of time, be not easy stiff；Trehalose can protect living tissue to resist adverse circumstances
The damage of (dry, cold) to cell protein, replaces water to provide moisturizing, goes drying, prevent albuminous degeneration, press down under syneresis
The effect of bacterium processed, using can enhance after lotion and keep mouth-moistening degree.
3) toothpaste component safety of the present invention, compatibility is reasonable, and lotion is stablized, and has good prevention and treatment bleeding gums, periodontitis, gum
The effect of swelling and pain, can significantly improve dry problem, have great market prospects and economic value.
4) preparation process of the invention is simple, and each component successively stringent addition in order is uniformly mixed various raw materials, in oral cavity
Various composition complements each other during clean, gives full play to it and keeps the wet protection gum effect in oral cavity.
Specific embodiment
In order to make the objectives, technical solutions and advantages of the present invention clearer, below by embodiment, to the present invention into
Row is further described.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
In limiting the scope of the invention.
Unless otherwise defined, all technical terms and scientific terms used herein are led with technology of the invention is belonged to
The normally understood meaning of the technical staff in domain is identical, and term as used herein in the specification of the present invention is intended merely to retouch
State the purpose of specific embodiment, it is not intended that in the limitation present invention.
Embodiment 1
A kind of toothpaste containing hyaluronic acid and trehalose, by weight, the toothpaste includes following components:
Component A: deionized water, 10 parts.
B component: qualities of stevia extract, 0.3 part；Tetrasodium pyrophosphate, 0.3 part；Deionized water, 5 parts；Trehalose, 3 parts.
Component C: sodium lauroyl sarcosine, 1.8 parts.
D component: sorbierite, 55 parts；Glycerol, 5 parts.
Component E: polyethylene glycol -12,5 part.
F component: cellulose gum, 0.5 part；Methyl hydroxybenzoate, 0.05 part；Hyaluronic acid, 0.1 part.
G component: silica, 18 parts；Edible essence, 0.6 part.
Steps are as follows for above-mentioned toothpaste preparation manipulation:
1) component A is put into metering hair jelly pot；
2) B component is first dissolved in 80 DEG C of hot water, is put into hair jelly pot after filtering；
3) component C is put into hair jelly pot, impregnates 15min, starts hair jelly pot agitating paddle, controls mixing speed 20-40r/min；
4) in meter metering D component investment hair jelly pot；
5) component E is put into premix pot, then puts into F component, opened quickly stirring 10min, make it dissolve and be uniformly dispersed, until
It without conglomeration, is then placed in hair jelly pot, first crawl stirring continuously stirs circulation 15min, then by glue after glue thickening
It send to basin, stands storage 5-8h；
6) it starts cream pot vacuum pump processed and controls cream pot vacuum degree processed in 0.02Mpa into glue, open scraper plate stirring；
7) it controls cream pot vacuum degree processed and puts into rubbing agent in G component in 0.03Mpa, after rubbing agent enters in cream pot processed, protect
Hold quickly stirring 5min；When vacuum degree rises to 0.08Mpa, essence of offering incense in a temple, into complete essence after simultaneously start quickly stirring 20min, when
When vacuum degree reaches 0.096Mpa or more, stop quickly stirring, homogeneous continues, and scraper plate is kept to stir at least 10min.
Embodiment 2
A kind of toothpaste containing hyaluronic acid and trehalose, by weight, the toothpaste includes following components:
Component A: deionized water, 15 parts.
B component: qualities of stevia extract, 0.5 part；Tetrasodium pyrophosphate, 0.5 part；Deionized water, 5 parts；Trehalose, 4 parts.
Component C: sodium lauroyl sarcosine, 2.5 parts.
D component: sorbierite, 58 parts；Glycerol, 5 parts.
Component E: polyethylene glycol -12；3 parts.
F component: cellulose gum, 0.7 part；Methyl hydroxybenzoate, 0.08 part；Hyaluronic acid, 0.28 part.
G component: silica, 20 parts；Edible essence, 1 part.
2 preparation manipulation step of embodiment is same as Example 1, and details are not described herein.
Embodiment 3
A kind of toothpaste containing hyaluronic acid and trehalose, by weight, the toothpaste includes following components,
Component A: deionized water, 12 parts.
B component: qualities of stevia extract, 0.2 part；Tetrasodium pyrophosphate, 0.2 part；Deionized water, 3 parts；Trehalose, 2.5 parts.
Component C: sodium lauroyl sarcosine, 1 part.
D component: sorbierite, 56 parts；Glycerol, 5 parts.
Component E: polyethylene glycol -12,4 part.
F component: cellulose gum, 0.3 part；Methyl hydroxybenzoate, 0.03 part；Hyaluronic acid, 0.4 part.
G component: silica, 16 parts；Edible essence, 0.5 part.
3 preparation manipulation step of embodiment is same as Example 1, and details are not described herein.
Toothpaste containing hyaluronic acid and trehalose made from above-described embodiment is detected, specific testing result such as following table
Shown in 1.
A kind of toothpaste performance detection containing hyaluronic acid and trehalose of table 1
Analytical table 1 is appearance, odor type, cold-resistant and resistance to it is found that a kind of toothpaste containing hyaluronic acid and trehalose of the invention
Hot property is qualified, is centrifuged without exception.
By the toothpaste in embodiment 1-3 to subject (each 50 people, the men and women for thering is dry problem and gum to be easy to appear problem
It is fifty-fifty, three groups) it is tested, subject is brushed teeth using the toothpaste in embodiment 1-3, and twice daily, each 3min is used 10 days
Afterwards, 90% subject indicates that dry problem is improved；After the subject that gum is easy to appear problem uses 2 months, gum
It does not go wrong.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (9)
1. a kind of toothpaste containing hyaluronic acid and trehalose, which is characterized in that by weight, the toothpaste includes with the following group
Point:
Component A: deionized water, 10-15 parts；
B component: sweetener, 0.2-0.5 parts；Acid-base buffer agent, 0.2-0.5 parts；Deionized water, 1-5 parts；Trehalose, 2-5 parts；
Component C: anionic surfactant, 1-2.5 parts；
D component: moisturizer a, 55-60 part；Glycerol, 5 parts；
Component E: moisturizer b, 3-5 part；
F component: thickener, 0.3-0.7 parts；Preservative, 0.01-0.1 parts；Hyaluronic acid, 0.05-0.5 parts；
G component: rubbing agent, 16-20 parts；Essence, 0.5-1 parts.
2. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the sweetener is
Qualities of stevia extract.
3. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the soda acid buffering
Agent is tetrasodium pyrophosphate；Trehalose is active constituent.
4. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the anion table
Face activating agent is sodium lauroyl sarcosine.
5. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the moisturizer a
For sorbierite.
6. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the moisturizer b
For polyethylene glycol -12.
7. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the thickener is
Cellulose gum；The preservative is methyl hydroxybenzoate；Hyaluronic acid is active constituent.
8. a kind of toothpaste containing hyaluronic acid and trehalose according to claim 1, which is characterized in that the rubbing agent is
Silica；The essence is edible essence (material).
9. a kind of preparation method of the toothpaste containing hyaluronic acid and trehalose as described in claim 1-8 is any, which is characterized in that
The following steps are included:
1) component A is put into metering hair jelly pot；
2) B component is first dissolved in 80 DEG C of hot water, is put into hair jelly pot after filtering；
3) component C is put into hair jelly pot, impregnates 15min, starts hair jelly pot agitating paddle, controls mixing speed 20-40r/min；
4) in meter metering D component investment hair jelly pot；
5) component E is put into premix pot, then puts into F component, opened quickly stirring 10min, make it dissolve and be uniformly dispersed, until
It without conglomeration, is then placed in hair jelly pot, first crawl stirring continuously stirs circulation 15min, then by glue after glue thickening
It send to basin, stands storage 5-8h；
6) it starts cream pot vacuum pump processed and controls cream pot vacuum degree processed in 0.02Mpa into glue, open scraper plate stirring；
7) it controls cream pot vacuum degree processed and puts into rubbing agent in G component in 0.03Mpa, after rubbing agent enters in cream pot processed, protect
Hold quickly stirring 5min；When vacuum degree rises to 0.08Mpa, essence of offering incense in a temple, into complete essence after simultaneously start quickly stirring 20min, when
When vacuum degree reaches 0.096Mpa or more, stop quickly stirring, homogeneous continues, and scraper plate is kept to stir at least 10min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910521063.4A CN110123702A (en) | 2019-06-17 | 2019-06-17 | A kind of toothpaste and preparation method thereof containing hyaluronic acid and trehalose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910521063.4A CN110123702A (en) | 2019-06-17 | 2019-06-17 | A kind of toothpaste and preparation method thereof containing hyaluronic acid and trehalose |
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| CN110123702A true CN110123702A (en) | 2019-08-16 |
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| CN201910521063.4A Pending CN110123702A (en) | 2019-06-17 | 2019-06-17 | A kind of toothpaste and preparation method thereof containing hyaluronic acid and trehalose |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020249042A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| CN113350222A (en) * | 2021-07-16 | 2021-09-07 | 邓家能 | Toothpaste and preparation method thereof |
| CN113712831A (en) * | 2021-08-27 | 2021-11-30 | 广东南方洁灵科技实业有限公司 | Breath-freshening toothpaste and preparation method thereof |
| US11883520B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883368B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11904041B2 (en) | 2019-06-14 | 2024-02-20 | The Procter & Gamble Company | Leave-on oral care compositions |
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| CN105434315A (en) * | 2016-01-08 | 2016-03-30 | 青岛康尔生物工程有限公司 | Gum-protecting whitening toothpaste and preparation method thereof |
| CN108670931A (en) * | 2018-07-24 | 2018-10-19 | 冯绍良 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
| CN109431857A (en) * | 2019-01-02 | 2019-03-08 | 华熙福瑞达生物医药有限公司 | A kind of toothpaste and preparation method thereof containing hyaluronic acid |
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2019
- 2019-06-17 CN CN201910521063.4A patent/CN110123702A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434315A (en) * | 2016-01-08 | 2016-03-30 | 青岛康尔生物工程有限公司 | Gum-protecting whitening toothpaste and preparation method thereof |
| CN108670931A (en) * | 2018-07-24 | 2018-10-19 | 冯绍良 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
| CN109431857A (en) * | 2019-01-02 | 2019-03-08 | 华熙福瑞达生物医药有限公司 | A kind of toothpaste and preparation method thereof containing hyaluronic acid |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020249042A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883520B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883368B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11904041B2 (en) | 2019-06-14 | 2024-02-20 | The Procter & Gamble Company | Leave-on oral care compositions |
| CN113350222A (en) * | 2021-07-16 | 2021-09-07 | 邓家能 | Toothpaste and preparation method thereof |
| CN113712831A (en) * | 2021-08-27 | 2021-11-30 | 广东南方洁灵科技实业有限公司 | Breath-freshening toothpaste and preparation method thereof |
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