CN110088121A - 靶向α4β7整联蛋白的环肽多聚体 - Google Patents
靶向α4β7整联蛋白的环肽多聚体 Download PDFInfo
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/126—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662421117P | 2016-11-11 | 2016-11-11 | |
| US62/421,117 | 2016-11-11 | ||
| PCT/CA2017/000244 WO2018085921A1 (en) | 2016-11-11 | 2017-11-10 | CYCLIC PEPTIDES MULTIMERS TARGETING α4β7 INTEGRIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110088121A true CN110088121A (zh) | 2019-08-02 |
Family
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Family Applications (1)
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| CN201780076105.7A Pending CN110088121A (zh) | 2016-11-11 | 2017-11-10 | 靶向α4β7整联蛋白的环肽多聚体 |
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| EP (2) | EP3939989A1 (https=) |
| JP (2) | JP7035044B2 (https=) |
| CN (1) | CN110088121A (https=) |
| CA (1) | CA3042576A1 (https=) |
| DK (1) | DK3538542T3 (https=) |
| ES (1) | ES2884107T3 (https=) |
| WO (1) | WO2018085921A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111273B2 (en) | 2016-11-11 | 2021-09-07 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha-4-beta-7 integrin |
| KR20230079464A (ko) | 2017-05-10 | 2023-06-07 | 질랜드 파마 에이/에스 | α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드 |
| US20230033021A1 (en) | 2018-06-20 | 2023-02-02 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| US20230117920A1 (en) * | 2019-12-27 | 2023-04-20 | The University Of Tokyo | Library Construction Method, Cyclic Peptide, FXIIa Binder and IFNGR1 Binder |
| JP2021106565A (ja) * | 2019-12-27 | 2021-07-29 | 国立大学法人 東京大学 | ライブラリーの製造方法、環状ペプチド、ＦＸＩＩａ結合剤、及びＩＦＮＧＲ１結合剤 |
| EP4172177A1 (en) * | 2020-06-29 | 2023-05-03 | Zealand Pharma A/S | Compounds targeting alpha4-beta7 integrin |
| US11957761B2 (en) | 2021-12-20 | 2024-04-16 | Zealand Pharma A/S | Compounds having α4β7 integrin inhibition activity |
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| CN104144706A (zh) * | 2012-01-27 | 2014-11-12 | 弗·哈夫曼-拉罗切有限公司 | 靶向递送至表达α-V-β-3的细胞的整联蛋白拮抗剂结合物 |
| CN105102470A (zh) * | 2012-10-11 | 2015-11-25 | 领导医疗有限公司 | 新型α4β7肽二聚体拮抗剂 |
| WO2016054445A1 (en) * | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
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| DE3219113A1 (de) | 1982-05-21 | 1983-11-24 | Bayer Ag, 5090 Leverkusen | Verwendung von n-substituierten 2,3-diaminocarbonsaeuren in arzneimitteln und ihre herstellung |
| ZA906188B (en) | 1989-08-10 | 1991-06-26 | Merrell Dow Pharma | Cyclic neurokinin a antagonists |
| US5296604A (en) | 1992-05-15 | 1994-03-22 | Miles Inc. | Proline derivatives and compositions for their use as inhibitors of HIV protease |
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| US5693325A (en) | 1994-03-15 | 1997-12-02 | Molecumetics, Ltd. | Peptide vaccines and methods relating thereto |
| DE4415310A1 (de) | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
| WO1996000581A1 (en) | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
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-
2017
- 2017-11-10 US US16/348,103 patent/US11111273B2/en active Active
- 2017-11-10 WO PCT/CA2017/000244 patent/WO2018085921A1/en not_active Ceased
- 2017-11-10 CA CA3042576A patent/CA3042576A1/en active Pending
- 2017-11-10 EP EP21167845.3A patent/EP3939989A1/en active Pending
- 2017-11-10 EP EP17870529.9A patent/EP3538542B1/en active Active
- 2017-11-10 DK DK17870529.9T patent/DK3538542T3/da active
- 2017-11-10 ES ES17870529T patent/ES2884107T3/es active Active
- 2017-11-10 JP JP2019524203A patent/JP7035044B2/ja active Active
- 2017-11-10 CN CN201780076105.7A patent/CN110088121A/zh active Pending
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2021
- 2021-04-19 US US17/234,488 patent/US11713338B2/en active Active
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2022
- 2022-03-02 JP JP2022032190A patent/JP7429726B2/ja active Active
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2023
- 2023-06-08 US US18/207,268 patent/US12077611B2/en active Active
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| Publication number | Publication date |
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| ES2884107T3 (es) | 2021-12-10 |
| DK3538542T3 (da) | 2021-10-11 |
| JP2020504080A (ja) | 2020-02-06 |
| EP3538542A4 (en) | 2020-08-26 |
| CA3042576A1 (en) | 2018-05-17 |
| JP2022078188A (ja) | 2022-05-24 |
| US11713338B2 (en) | 2023-08-01 |
| US20200216501A1 (en) | 2020-07-09 |
| JP7429726B2 (ja) | 2024-02-08 |
| US11111273B2 (en) | 2021-09-07 |
| EP3939989A1 (en) | 2022-01-19 |
| EP3538542A1 (en) | 2019-09-18 |
| WO2018085921A1 (en) | 2018-05-17 |
| US20230406884A1 (en) | 2023-12-21 |
| US12077611B2 (en) | 2024-09-03 |
| US20210324007A1 (en) | 2021-10-21 |
| JP7035044B2 (ja) | 2022-03-14 |
| EP3538542B1 (en) | 2021-08-04 |
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