ES2884107T3 - Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7 - Google Patents
Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7 Download PDFInfo
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- ES2884107T3 ES2884107T3 ES17870529T ES17870529T ES2884107T3 ES 2884107 T3 ES2884107 T3 ES 2884107T3 ES 17870529 T ES17870529 T ES 17870529T ES 17870529 T ES17870529 T ES 17870529T ES 2884107 T3 ES2884107 T3 ES 2884107T3
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- VVWRJUBEIPHGQF-MDZDMXLPSA-N propan-2-yl (ne)-n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)\N=N\C(=O)OC(C)C VVWRJUBEIPHGQF-MDZDMXLPSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- KOUKXHPPRFNWPP-UHFFFAOYSA-N pyrazine-2,5-dicarboxylic acid;hydrate Chemical compound O.OC(=O)C1=CN=C(C(O)=O)C=N1 KOUKXHPPRFNWPP-UHFFFAOYSA-N 0.000 description 1
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- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
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- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid group Chemical group C(CCC(=O)O)(=O)O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- FAGLEPBREOXSAC-UHFFFAOYSA-N tert-butyl isocyanide Chemical compound CC(C)(C)[N+]#[C-] FAGLEPBREOXSAC-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
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- 102000027257 transmembrane receptors Human genes 0.000 description 1
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- 229940066528 trichloroacetate Drugs 0.000 description 1
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- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/126—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662421117P | 2016-11-11 | 2016-11-11 | |
| PCT/CA2017/000244 WO2018085921A1 (en) | 2016-11-11 | 2017-11-10 | CYCLIC PEPTIDES MULTIMERS TARGETING α4β7 INTEGRIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2884107T3 true ES2884107T3 (es) | 2021-12-10 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| ES17870529T Active ES2884107T3 (es) | 2016-11-11 | 2017-11-10 | Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11111273B2 (https=) |
| EP (2) | EP3939989A1 (https=) |
| JP (2) | JP7035044B2 (https=) |
| CN (1) | CN110088121A (https=) |
| CA (1) | CA3042576A1 (https=) |
| DK (1) | DK3538542T3 (https=) |
| ES (1) | ES2884107T3 (https=) |
| WO (1) | WO2018085921A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11111273B2 (en) | 2016-11-11 | 2021-09-07 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha-4-beta-7 integrin |
| KR20230079464A (ko) | 2017-05-10 | 2023-06-07 | 질랜드 파마 에이/에스 | α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드 |
| US20230033021A1 (en) | 2018-06-20 | 2023-02-02 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| US20230117920A1 (en) * | 2019-12-27 | 2023-04-20 | The University Of Tokyo | Library Construction Method, Cyclic Peptide, FXIIa Binder and IFNGR1 Binder |
| JP2021106565A (ja) * | 2019-12-27 | 2021-07-29 | 国立大学法人 東京大学 | ライブラリーの製造方法、環状ペプチド、ＦＸＩＩａ結合剤、及びＩＦＮＧＲ１結合剤 |
| EP4172177A1 (en) * | 2020-06-29 | 2023-05-03 | Zealand Pharma A/S | Compounds targeting alpha4-beta7 integrin |
| US11957761B2 (en) | 2021-12-20 | 2024-04-16 | Zealand Pharma A/S | Compounds having α4β7 integrin inhibition activity |
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| DE3219113A1 (de) | 1982-05-21 | 1983-11-24 | Bayer Ag, 5090 Leverkusen | Verwendung von n-substituierten 2,3-diaminocarbonsaeuren in arzneimitteln und ihre herstellung |
| ZA906188B (en) | 1989-08-10 | 1991-06-26 | Merrell Dow Pharma | Cyclic neurokinin a antagonists |
| US5296604A (en) | 1992-05-15 | 1994-03-22 | Miles Inc. | Proline derivatives and compositions for their use as inhibitors of HIV protease |
| US5705481A (en) | 1992-11-06 | 1998-01-06 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Cyclopeptides |
| IL109615A (en) | 1993-05-17 | 2000-12-06 | Fujisawa Pharmaceutical Co | Cyclic polypeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5693325A (en) | 1994-03-15 | 1997-12-02 | Molecumetics, Ltd. | Peptide vaccines and methods relating thereto |
| DE4415310A1 (de) | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
| WO1996000581A1 (en) | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| AU6311996A (en) | 1995-07-06 | 1997-02-05 | Zeneca Limited | Peptide inhibitors of fibronectine |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| US5696084A (en) | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
| US6492553B1 (en) | 1998-01-29 | 2002-12-10 | Aventis Pharamaceuticals Inc. | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| DE10107707A1 (de) | 2001-02-19 | 2002-08-29 | Wilex Biotechnology Gmbh | Antagonisten für alpha¶4¶beta¶7¶-Integrin |
| US6667407B2 (en) | 2002-05-03 | 2003-12-23 | Bayer Polymers Llc | Process of making polyaziridines |
| WO2005105827A2 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for proteasome enzyme inhibition |
| US8143375B2 (en) | 2006-10-20 | 2012-03-27 | The Governing Council Of The University Of Toronto | Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation |
| EP1961759A1 (en) | 2007-02-21 | 2008-08-27 | Universita'degli Studi Di Milano | Integrin targeted cyclopeptide ligands, their preparation and use |
| EP2291390B1 (en) | 2008-05-22 | 2014-11-05 | Centre National de la Recherche Scientifique (CNRS) | New optically pure compounds for improved therapeutic efficiency |
| AU2010225426B2 (en) * | 2009-03-16 | 2015-09-03 | The Governing Council Of The University Of Toronto | Cyclic amino acid molecules and methods of preparing the same |
| US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
| EP2556060A1 (en) | 2010-04-08 | 2013-02-13 | Ah Usa 42 Llc | Substituted 3,5- diphenyl-isoxazoline derivatives as insecticides and acaricides |
| WO2012113803A1 (en) | 2011-02-22 | 2012-08-30 | Leo Pharma A/S | A cyclic peptide and conjugate thereof for binding to keratinocytes |
| BR112014016736A8 (pt) * | 2012-01-27 | 2017-07-04 | Hoffmann La Roche | composto, composição farmacêutica, método para tratamento, uso de um composto e invenção |
| JP6152093B2 (ja) * | 2012-04-24 | 2017-06-21 | Ｅａファーマ株式会社 | スルホンアミド誘導体及びその医薬用途 |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| PT3143037T (pt) | 2014-05-16 | 2021-09-24 | Protagonist Therapeutics Inc | Antagonistas peptídicos tioéter de integrina alfa4beta7 |
| KR20170108936A (ko) * | 2014-10-01 | 2017-09-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 신규한 α4β7 펩타이드 단량체 및 이량체 길항제 |
| EP3201217A4 (en) * | 2014-10-01 | 2018-07-18 | Protagonist Therapeutics Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| US11046695B2 (en) | 2015-11-11 | 2021-06-29 | Zealand Pharma A/S | Fragment synthesis of substituted cyclic peptides |
| US11111273B2 (en) * | 2016-11-11 | 2021-09-07 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha-4-beta-7 integrin |
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- 2017-11-10 WO PCT/CA2017/000244 patent/WO2018085921A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| DK3538542T3 (da) | 2021-10-11 |
| JP2020504080A (ja) | 2020-02-06 |
| CN110088121A (zh) | 2019-08-02 |
| EP3538542A4 (en) | 2020-08-26 |
| CA3042576A1 (en) | 2018-05-17 |
| JP2022078188A (ja) | 2022-05-24 |
| US11713338B2 (en) | 2023-08-01 |
| US20200216501A1 (en) | 2020-07-09 |
| JP7429726B2 (ja) | 2024-02-08 |
| US11111273B2 (en) | 2021-09-07 |
| EP3939989A1 (en) | 2022-01-19 |
| EP3538542A1 (en) | 2019-09-18 |
| WO2018085921A1 (en) | 2018-05-17 |
| US20230406884A1 (en) | 2023-12-21 |
| US12077611B2 (en) | 2024-09-03 |
| US20210324007A1 (en) | 2021-10-21 |
| JP7035044B2 (ja) | 2022-03-14 |
| EP3538542B1 (en) | 2021-08-04 |
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