CN110072866A - 作为bet蛋白降解剂的稠合的1,4-二氮杂* - Google Patents

作为bet蛋白降解剂的稠合的1,4-二氮杂* Download PDF

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Publication number
CN110072866A
CN110072866A CN201780069335.0A CN201780069335A CN110072866A CN 110072866 A CN110072866 A CN 110072866A CN 201780069335 A CN201780069335 A CN 201780069335A CN 110072866 A CN110072866 A CN 110072866A
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pharmaceutically acceptable
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acceptable salt
cancer
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王绍梦
胡杨
秦冲
徐福明
胡建涛
向卫国
周冰
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University of Michigan System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201780069335.0A 2016-09-13 2017-09-13 作为bet蛋白降解剂的稠合的1,4-二氮杂* Pending CN110072866A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393923P 2016-09-13 2016-09-13
US62/393,923 2016-09-13
PCT/US2017/051286 WO2018052949A1 (en) 2016-09-13 2017-09-13 Fused 1,4-diazepines as bet protein degraders

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CN110072866A true CN110072866A (zh) 2019-07-30

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CN201780069335.0A Pending CN110072866A (zh) 2016-09-13 2017-09-13 作为bet蛋白降解剂的稠合的1,4-二氮杂*

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US (2) US10975093B2 (https=)
EP (2) EP3858837A1 (https=)
JP (1) JP7035027B2 (https=)
CN (1) CN110072866A (https=)
AU (1) AU2017326175B2 (https=)
CA (1) CA3036841A1 (https=)
ES (1) ES2857743T3 (https=)
WO (1) WO2018052949A1 (https=)

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WO2022156764A1 (zh) * 2021-01-22 2022-07-28 泰比棣医药科技(石家庄)有限公司 一种降解脱氧核糖核酸(dna)聚合酶的化合物及其用途
CN116585322A (zh) * 2023-01-16 2023-08-15 中山大学中山眼科中心 Bet蛋白降解剂在预防和治疗视网膜退行性改变相关疾病中的应用
WO2025011624A1 (en) * 2023-07-11 2025-01-16 Etern Biopharma (Shanghai) Co., Ltd. Bifunctional compounds for androgen receptor degradation and methods of use

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CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
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US11173211B2 (en) 2016-12-23 2021-11-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
WO2018144789A1 (en) * 2017-02-03 2018-08-09 The Regents Of The University Of Michigan Fused 1,4-diazepines as bet bromodomain inhibitors
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WO2021023233A1 (zh) 2019-08-05 2021-02-11 上海科技大学 Egfr蛋白降解剂及其抗肿瘤应用
CN115397821B (zh) 2019-10-17 2024-09-03 阿尔维纳斯运营股份有限公司 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子
JP2023508891A (ja) * 2019-12-17 2023-03-06 オリオニス バイオサイエンシズ，インコーポレイテッド タンパク質の動員および／または分解のための二機能性剤
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KR20240035820A (ko) 2021-07-09 2024-03-18 플렉시움 인코포레이티드 Ikzf2를 조절하는 아릴 화합물 및 약학 조성물
CN115611881B (zh) * 2021-07-13 2024-09-20 复旦大学 一种合成新型vhl配体4-f-vh032的方法
WO2023074780A1 (ja) * 2021-10-27 2023-05-04 国立大学法人愛媛大学 治療薬組成物
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Cited By (6)

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WO2022156764A1 (zh) * 2021-01-22 2022-07-28 泰比棣医药科技(石家庄)有限公司 一种降解脱氧核糖核酸(dna)聚合酶的化合物及其用途
CN116802180A (zh) * 2021-01-22 2023-09-22 泰比棣医药科技(石家庄)有限公司 一种降解脱氧核糖核酸(dna)聚合酶的化合物及其用途
CN116802180B (zh) * 2021-01-22 2024-05-28 泰比棣医药科技(石家庄)有限公司 一种降解脱氧核糖核酸(dna)聚合酶的化合物及其用途
CN116585322A (zh) * 2023-01-16 2023-08-15 中山大学中山眼科中心 Bet蛋白降解剂在预防和治疗视网膜退行性改变相关疾病中的应用
CN116585322B (zh) * 2023-01-16 2023-10-13 中山大学中山眼科中心 Bet蛋白降解剂在预防和治疗视网膜退行性改变相关疾病中的应用
WO2025011624A1 (en) * 2023-07-11 2025-01-16 Etern Biopharma (Shanghai) Co., Ltd. Bifunctional compounds for androgen receptor degradation and methods of use

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EP3512853A1 (en) 2019-07-24
ES2857743T3 (es) 2021-09-29
AU2017326175A1 (en) 2019-04-04
JP7035027B2 (ja) 2022-03-14
US10975093B2 (en) 2021-04-13
AU2017326175B2 (en) 2022-01-27
EP3512853B1 (en) 2020-12-23
WO2018052949A1 (en) 2018-03-22
JP2019526616A (ja) 2019-09-19
US20190263827A1 (en) 2019-08-29
CA3036841A1 (en) 2018-03-22
US20220356192A1 (en) 2022-11-10
EP3858837A1 (en) 2021-08-04

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Application publication date: 20190730