CN110051876B - 疏水性组织粘着剂 - Google Patents

疏水性组织粘着剂 Download PDF

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Publication number
CN110051876B
CN110051876B CN201811299270.1A CN201811299270A CN110051876B CN 110051876 B CN110051876 B CN 110051876B CN 201811299270 A CN201811299270 A CN 201811299270A CN 110051876 B CN110051876 B CN 110051876B
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China
Prior art keywords
prepolymer
tissue
patch
polymer
groups
Prior art date
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CN201811299270.1A
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English (en)
Chinese (zh)
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CN110051876A (zh
Inventor
J·M·卡普
P·德尔尼多
N·朗
R·S·兰格
M·J·M·N·佩雷拉
Y·李
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The Brigham and Women's Hospital Inc
Boston Children's Hospital
Massachusetts Institute of Technology
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The Brigham and Women's Hospital Inc
Boston Children's Hospital
Massachusetts Institute of Technology
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Publication of CN110051876A publication Critical patent/CN110051876A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/46—Polyesters chemically modified by esterification
    • C08G63/47—Polyesters chemically modified by esterification by unsaturated monocarboxylic acids or unsaturated monohydric alcohols or reactive derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/106—Esters of polycondensation macromers
    • C08F222/1061—Esters of polycondensation macromers of alcohol terminated polyesters or polycarbonates, e.g. polyester (meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Biological Depolymerization Polymers (AREA)
CN201811299270.1A 2013-05-24 2014-05-23 疏水性组织粘着剂 Active CN110051876B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361827240P 2013-05-24 2013-05-24
US61/827,240 2013-05-24
US201461924864P 2014-01-08 2014-01-08
US61/924,864 2014-01-08
CN201480030016.5A CN105377963B (zh) 2013-05-24 2014-05-23 疏水性组织粘着剂
PCT/US2014/039417 WO2014190302A1 (en) 2013-05-24 2014-05-23 Hydrophobic tissue adhesives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480030016.5A Division CN105377963B (zh) 2013-05-24 2014-05-23 疏水性组织粘着剂

Publications (2)

Publication Number Publication Date
CN110051876A CN110051876A (zh) 2019-07-26
CN110051876B true CN110051876B (zh) 2022-05-31

Family

ID=50983193

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201811299270.1A Active CN110051876B (zh) 2013-05-24 2014-05-23 疏水性组织粘着剂
CN201480030016.5A Active CN105377963B (zh) 2013-05-24 2014-05-23 疏水性组织粘着剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480030016.5A Active CN105377963B (zh) 2013-05-24 2014-05-23 疏水性组织粘着剂

Country Status (8)

Country Link
US (1) US9724447B2 (enExample)
EP (2) EP3004221B1 (enExample)
JP (2) JP6678101B2 (enExample)
CN (2) CN110051876B (enExample)
BR (1) BR112015029078B1 (enExample)
CA (1) CA2913338C (enExample)
ES (2) ES2899023T3 (enExample)
WO (1) WO2014190302A1 (enExample)

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US12472069B2 (en) * 2010-07-27 2025-11-18 Tenon Medical, Inc. Methods for sacroiliac joint stabilization
US12409039B2 (en) * 2010-07-27 2025-09-09 Tenon Medical, Inc. Systems for sacroiliac joint stabilization
US12465491B2 (en) * 2010-07-27 2025-11-11 Tenon Medical, Inc. Methods for sacroiliac joint stabilization
EP3004221B1 (en) * 2013-05-24 2021-10-27 Massachusetts Institute of Technology Hydrophobic tissue adhesives
JP2018507013A (ja) 2015-02-02 2018-03-15 コロプラスト アクティーゼルスカブ オストミー器具
HUE044528T2 (hu) 2015-04-10 2019-10-28 Coloplast As Osztómiás készülék
AU2016277799A1 (en) * 2015-06-18 2018-01-18 Gecko Biomedical Adhesive composition
US11898005B2 (en) * 2015-06-18 2024-02-13 Tissium Sa Sealant composition
KR102593373B1 (ko) 2015-06-18 2023-10-23 티시움 에스에이 실런트 조성물
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN107063873A (zh) * 2016-12-02 2017-08-18 杭州亚慧生物科技有限公司 一种外科手术封合剂恒温胀破强度检测装置
CN106769502A (zh) * 2016-12-02 2017-05-31 杭州亚慧生物科技有限公司 一种外科手术封合剂胀破强度检测装置
WO2018175619A1 (en) 2017-03-22 2018-09-27 Edwards Lifesciences Corporation System and method for implanting and securing a bioprosthetic device to wet tissue
JP7293132B2 (ja) 2017-05-25 2023-06-19 テルモ株式会社 接着閉塞システム
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
WO2019079252A1 (en) 2017-10-20 2019-04-25 Edwards Lifesciences Corporation LOCALIZED FUSION OF NATIVE VALVES USING AN ACTIVE ADHESIVE
EP3560427A1 (en) * 2018-04-24 2019-10-30 Gecko Biomedical Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
JP2021006140A (ja) * 2019-06-28 2021-01-21 三洋化成工業株式会社 医療用接着剤
JP7260655B2 (ja) * 2019-09-27 2023-04-18 富士フイルム株式会社 ポリマー、硬化性組成物、硬化物
CA3155938A1 (en) 2019-10-25 2021-04-29 Tissium Sa Composition comprising activated and functionalized prepolymer
CN114980815A (zh) * 2019-12-20 2022-08-30 爱德华兹生命科学创新(以色列)有限公司 植入物附着技术
KR20230133313A (ko) 2021-01-18 2023-09-19 티시움 에스에이 수술 재료
KR20230150830A (ko) 2021-02-24 2023-10-31 티시움 에스에이 활성화 및 작용화된 예비중합체를 포함하는 조성물
CN115501381B (zh) * 2022-09-23 2023-10-03 北京大学 替代可吸收缝合线的脂肪组织粘合剂、制备方法及其应用
EP4744896A1 (en) 2024-11-15 2026-05-20 Tissium SA COMPOSITION INCLUDING A PREPOLYMER
EP4745175A1 (en) 2024-11-15 2026-05-20 Tissium SA COMPOSITION COMPRISING A PREPOLYMER WITH IMPROVED MECHANICAL PROPERTIES
WO2026104576A1 (en) 2024-11-15 2026-05-21 Tissium Sa Composition comprising pre-polymer with improved mechanical properties

Citations (6)

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CN1225014A (zh) * 1996-07-11 1999-08-04 生命医学科学公司 减少或消除术后粘着形成的方法和组合物
CN1524903A (zh) * 2002-12-20 2004-09-01 伊西康公司 用于医学用途的交联醇酸聚酯
JP2005532430A (ja) * 2002-06-11 2005-10-27 ビーエーエスエフ アクチェンゲゼルシャフト ポリアルコキシル化されたトリメチロールプロパンの（メタ）アクリルエステル
CN1910215A (zh) * 2004-01-14 2007-02-07 氰特表面技术有限公司 粘合剂
JP2007112991A (ja) * 2005-09-21 2007-05-10 Kosumedei Seiyaku Kk 親水性粘着剤、それを用いた親水性皮膚外用粘着剤組成物および親水性貼付剤
JP5131945B2 (ja) * 2011-03-24 2013-01-30 三洋化成工業株式会社 水性液体吸収性樹脂、水性液体吸収性組成物並びにこれらを用いた吸収体及び吸収性物品

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EP3004221B1 (en) * 2013-05-24 2021-10-27 Massachusetts Institute of Technology Hydrophobic tissue adhesives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1225014A (zh) * 1996-07-11 1999-08-04 生命医学科学公司 减少或消除术后粘着形成的方法和组合物
JP2005532430A (ja) * 2002-06-11 2005-10-27 ビーエーエスエフ アクチェンゲゼルシャフト ポリアルコキシル化されたトリメチロールプロパンの（メタ）アクリルエステル
CN1524903A (zh) * 2002-12-20 2004-09-01 伊西康公司 用于医学用途的交联醇酸聚酯
CN1910215A (zh) * 2004-01-14 2007-02-07 氰特表面技术有限公司 粘合剂
JP2007112991A (ja) * 2005-09-21 2007-05-10 Kosumedei Seiyaku Kk 親水性粘着剤、それを用いた親水性皮膚外用粘着剤組成物および親水性貼付剤
JP5131945B2 (ja) * 2011-03-24 2013-01-30 三洋化成工業株式会社 水性液体吸収性樹脂、水性液体吸収性組成物並びにこれらを用いた吸収体及び吸収性物品

Also Published As

Publication number Publication date
JP2016526078A (ja) 2016-09-01
CN110051876A (zh) 2019-07-26
BR112015029078A8 (pt) 2020-03-17
CN105377963A (zh) 2016-03-02
EP3950018A1 (en) 2022-02-09
EP3004221A1 (en) 2016-04-13
BR112015029078A2 (pt) 2017-08-22
JP2019081906A (ja) 2019-05-30
ES3055201T3 (en) 2026-02-10
CA2913338C (en) 2018-05-01
US9724447B2 (en) 2017-08-08
HK1221238A1 (zh) 2017-05-26
CN105377963B (zh) 2018-11-27
ES2899023T3 (es) 2022-03-09
EP3004221B1 (en) 2021-10-27
WO2014190302A1 (en) 2014-11-27
JP6678101B2 (ja) 2020-04-08
BR112015029078B1 (pt) 2020-12-08
US20140348896A1 (en) 2014-11-27
EP3950018B1 (en) 2025-10-15
CA2913338A1 (en) 2014-11-27

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