CA2913338C - Hydrophobic tissue adhesives - Google Patents

Hydrophobic tissue adhesives Download PDF

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Publication number
CA2913338C
CA2913338C CA2913338A CA2913338A CA2913338C CA 2913338 C CA2913338 C CA 2913338C CA 2913338 A CA2913338 A CA 2913338A CA 2913338 A CA2913338 A CA 2913338A CA 2913338 C CA2913338 C CA 2913338C
Authority
CA
Canada
Prior art keywords
polymer
tissue
groups
patch
surgical glue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2913338A
Other languages
English (en)
French (fr)
Other versions
CA2913338A1 (en
Inventor
Jeffrey M. Karp
Pedro Del Nido
Nora LANG
Robert S. Langer
Maria Jose M.N. Pereira
Yuhan Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The Brigham and Women's Hospital Inc
Boston Children's Hospital
Massachusetts Institute of Technology
Original Assignee
The Brigham and Women's Hospital Inc
Boston Children's Hospital
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Brigham and Women's Hospital Inc, Boston Children's Hospital, Massachusetts Institute of Technology filed Critical The Brigham and Women's Hospital Inc
Publication of CA2913338A1 publication Critical patent/CA2913338A1/en
Application granted granted Critical
Publication of CA2913338C publication Critical patent/CA2913338C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/46—Polyesters chemically modified by esterification
    • C08G63/47—Polyesters chemically modified by esterification by unsaturated monocarboxylic acids or unsaturated monohydric alcohols or reactive derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/106—Esters of polycondensation macromers
    • C08F222/1061—Esters of polycondensation macromers of alcohol terminated polyesters or polycarbonates, e.g. polyester (meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Biological Depolymerization Polymers (AREA)
CA2913338A 2013-05-24 2014-05-23 Hydrophobic tissue adhesives Active CA2913338C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361827240P 2013-05-24 2013-05-24
US61/827,240 2013-05-24
US201461924864P 2014-01-08 2014-01-08
US61/924,864 2014-01-08
PCT/US2014/039417 WO2014190302A1 (en) 2013-05-24 2014-05-23 Hydrophobic tissue adhesives

Publications (2)

Publication Number Publication Date
CA2913338A1 CA2913338A1 (en) 2014-11-27
CA2913338C true CA2913338C (en) 2018-05-01

Family

ID=50983193

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2913338A Active CA2913338C (en) 2013-05-24 2014-05-23 Hydrophobic tissue adhesives

Country Status (8)

Country Link
US (1) US9724447B2 (enExample)
EP (2) EP3004221B1 (enExample)
JP (2) JP6678101B2 (enExample)
CN (2) CN110051876B (enExample)
BR (1) BR112015029078B1 (enExample)
CA (1) CA2913338C (enExample)
ES (2) ES2899023T3 (enExample)
WO (1) WO2014190302A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12472069B2 (en) * 2010-07-27 2025-11-18 Tenon Medical, Inc. Methods for sacroiliac joint stabilization
US12409039B2 (en) * 2010-07-27 2025-09-09 Tenon Medical, Inc. Systems for sacroiliac joint stabilization
US12465491B2 (en) * 2010-07-27 2025-11-11 Tenon Medical, Inc. Methods for sacroiliac joint stabilization
EP3004221B1 (en) * 2013-05-24 2021-10-27 Massachusetts Institute of Technology Hydrophobic tissue adhesives
JP2018507013A (ja) 2015-02-02 2018-03-15 コロプラスト アクティーゼルスカブ オストミー器具
HUE044528T2 (hu) 2015-04-10 2019-10-28 Coloplast As Osztómiás készülék
AU2016277799A1 (en) * 2015-06-18 2018-01-18 Gecko Biomedical Adhesive composition
US11898005B2 (en) * 2015-06-18 2024-02-13 Tissium Sa Sealant composition
KR102593373B1 (ko) 2015-06-18 2023-10-23 티시움 에스에이 실런트 조성물
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN107063873A (zh) * 2016-12-02 2017-08-18 杭州亚慧生物科技有限公司 一种外科手术封合剂恒温胀破强度检测装置
CN106769502A (zh) * 2016-12-02 2017-05-31 杭州亚慧生物科技有限公司 一种外科手术封合剂胀破强度检测装置
WO2018175619A1 (en) 2017-03-22 2018-09-27 Edwards Lifesciences Corporation System and method for implanting and securing a bioprosthetic device to wet tissue
JP7293132B2 (ja) 2017-05-25 2023-06-19 テルモ株式会社 接着閉塞システム
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
WO2019079252A1 (en) 2017-10-20 2019-04-25 Edwards Lifesciences Corporation LOCALIZED FUSION OF NATIVE VALVES USING AN ACTIVE ADHESIVE
EP3560427A1 (en) * 2018-04-24 2019-10-30 Gecko Biomedical Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
JP2021006140A (ja) * 2019-06-28 2021-01-21 三洋化成工業株式会社 医療用接着剤
JP7260655B2 (ja) * 2019-09-27 2023-04-18 富士フイルム株式会社 ポリマー、硬化性組成物、硬化物
CA3155938A1 (en) 2019-10-25 2021-04-29 Tissium Sa Composition comprising activated and functionalized prepolymer
CN114980815A (zh) * 2019-12-20 2022-08-30 爱德华兹生命科学创新(以色列)有限公司 植入物附着技术
KR20230133313A (ko) 2021-01-18 2023-09-19 티시움 에스에이 수술 재료
KR20230150830A (ko) 2021-02-24 2023-10-31 티시움 에스에이 활성화 및 작용화된 예비중합체를 포함하는 조성물
CN115501381B (zh) * 2022-09-23 2023-10-03 北京大学 替代可吸收缝合线的脂肪组织粘合剂、制备方法及其应用
EP4744896A1 (en) 2024-11-15 2026-05-20 Tissium SA COMPOSITION INCLUDING A PREPOLYMER
EP4745175A1 (en) 2024-11-15 2026-05-20 Tissium SA COMPOSITION COMPRISING A PREPOLYMER WITH IMPROVED MECHANICAL PROPERTIES
WO2026104576A1 (en) 2024-11-15 2026-05-21 Tissium Sa Composition comprising pre-polymer with improved mechanical properties

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE13023C (de) J. JAEGLE in Mülhausen i. E. Regulator für selbstwirkende Feinspinnmaschinen. !
JPH0681782B2 (ja) * 1985-07-19 1994-10-19 東亞合成化学工業株式会社 ポリエステルポリ（メタ）アクリレートの製造法
JP3560096B2 (ja) * 1996-02-02 2004-09-02 日本ゼオン株式会社 重合性不飽和化合物及びそれを含む硬化性樹脂組成物並びに成形体
CN1225014A (zh) * 1996-07-11 1999-08-04 生命医学科学公司 减少或消除术后粘着形成的方法和组合物
AU2022599A (en) * 1997-12-31 1999-07-19 Kimberly-Clark Worldwide, Inc. Method of reducing molecular weights and polydispersity indices of polymers of ethylene oxide
RU2320677C2 (ru) * 2002-06-11 2008-03-27 Басф Акциенгезелльшафт Сложный (мет)акриловый эфир полиалкоксилированного триметилолпропана (варианты) и его применение для получения абсорбирующих водосодержащие жидкости полимеров
US20040120981A1 (en) * 2002-12-20 2004-06-24 Aruna Nathan Crosslinked alkyd polyesters for medical applications
EP1706440A1 (en) * 2004-01-14 2006-10-04 Cytec Surface Specialties, S.A. Adhesives
DE102004049544A1 (de) * 2004-10-12 2006-04-13 Degussa Ag Strahlungshärtbar modifizierte, ungesättigte, amorphe Polyester
JP5175041B2 (ja) * 2005-09-21 2013-04-03 コスメディ製薬株式会社 親水性粘着剤、それを用いた親水性皮膚外用粘着剤組成物および親水性貼付剤
EP1973493A2 (en) * 2006-01-12 2008-10-01 Massachusetts Institute of Technology Biodegradable elastomers
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EP3004221B1 (en) * 2013-05-24 2021-10-27 Massachusetts Institute of Technology Hydrophobic tissue adhesives

Also Published As

Publication number Publication date
JP2016526078A (ja) 2016-09-01
CN110051876A (zh) 2019-07-26
BR112015029078A8 (pt) 2020-03-17
CN105377963A (zh) 2016-03-02
EP3950018A1 (en) 2022-02-09
EP3004221A1 (en) 2016-04-13
BR112015029078A2 (pt) 2017-08-22
JP2019081906A (ja) 2019-05-30
ES3055201T3 (en) 2026-02-10
US9724447B2 (en) 2017-08-08
HK1221238A1 (zh) 2017-05-26
CN105377963B (zh) 2018-11-27
ES2899023T3 (es) 2022-03-09
EP3004221B1 (en) 2021-10-27
WO2014190302A1 (en) 2014-11-27
JP6678101B2 (ja) 2020-04-08
BR112015029078B1 (pt) 2020-12-08
CN110051876B (zh) 2022-05-31
US20140348896A1 (en) 2014-11-27
EP3950018B1 (en) 2025-10-15
CA2913338A1 (en) 2014-11-27

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