CN110025743A - A kind of Chinese herbal medicine granule and preparation method thereof adjusting children's stomach - Google Patents
A kind of Chinese herbal medicine granule and preparation method thereof adjusting children's stomach Download PDFInfo
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- CN110025743A CN110025743A CN201910422503.0A CN201910422503A CN110025743A CN 110025743 A CN110025743 A CN 110025743A CN 201910422503 A CN201910422503 A CN 201910422503A CN 110025743 A CN110025743 A CN 110025743A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention discloses a kind of Chinese herbal medicine granule and preparation method thereof for adjusting children's stomach, belongs to food processing technology field.The Chinese herbal medicine granule of the adjusting stomach includes following raw material: malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube, oligofructose, xylitol and maltodextrin.Preparation method includes weighing, extract, be concentrated, stir, pelletize, dry and packing.The Chinese herbal medicine granule of adjusting children's stomach of the method for the present invention preparation has the gastrointestinal system of conditioning children, and raw material uses Chinese herbal medicine, safe without toxic side effect, achieve the purpose that treat anorexia, children especially vulnerable to stomach, have achieved the purpose that effective, will not generate side effect.
Description
Technical field
The present invention relates to health food processing technique fields, and in particular to it is a kind of adjust children's stomach Chinese herbal medicine granule and
Preparation method.
Background technique
Childhood is in the stage of growth and development, its growth factor is highly prone to the shadow of interior external environment in the period
Ring, each organ of body is in fast-developing period in this period, slightly not note that will cause resistance decline or
It is damaged.If children's stomach is due to not yet developing completely, is influenced and drawn by the factors such as external environment variation, improper diet
Play the phenomenon that digestive discomfort, having indigestion and digestion power reduce.Digestive discomfort is being one of child growth common disease, is influenced
The feed of children and stomach absorb, healthy growth to children bad so as to cause the nutrient absorption of children and calcium absorption etc.
It impacts.
Currently, there is a variety of coordinating intestines and stomach products in the market, but there are not easy for human absorption, conditioning intestines for such product
Stomach, treatment anti-constipation effect are poor, at the same by existing coordinating intestines and stomach form Chinese herbal medicine thick taste, mouthfeel is not easy to connect for people
By, and the product of such coordinating intestines and stomach, spininess are designed the stomach of adult's maturation, easily make to the delicate stomach of children
At damage.Therefore it provides making a kind of conditioning children stomach Chinese herbal medicine granule, not only children are growing with the intestines of stage of development
Stomach situation, and convenient for absorption, coordinating intestines and stomach and constipation, good mouthfeel can be treated, it is current problem to be solved.
Summary of the invention
The purpose of the invention is to overcome the deficiencies of existing technologies, provide it is a kind of adjust stomach Chinese herbal medicine granule and its
Preparation method, the Chinese herbal medicine granule that the application adjusts stomach, which has, adjusts children's stomach, especially assists in the treatment of the effect of anorexia.
Purpose to realize the present invention, used technical solution are as follows:
A kind of Chinese herbal medicine granule adjusting stomach, including following raw material: malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube, low
Fructooligosaccharides, xylitol and maltodextrin.
Preferably, including following parts by weight raw material: the malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube are medicine
Eat dual-purpose extract.
Preferably, including following parts by weight raw material: 30-50 parts of malt, 20-30 parts of endothelium corneum gigeriae galli, 35-45 parts of Chinese yam, Fu
15-23 parts of Siberian cocklebur, 23-35 parts of hawthorn, 20-30 parts of jujube, 2-6 parts of oligofructose, 0.8-3 parts of xylitol and maltodextrin 0.2-
0.6 part.
Preferably, including following parts by weight raw material: 35-45 parts of malt, 22-28 parts of endothelium corneum gigeriae galli, 38-43 parts of Chinese yam, Fu
17-22 parts of Siberian cocklebur, 25-30 parts of hawthorn, 23-28 parts of jujube, 3-5 parts of oligofructose, 1-2 parts of xylitol and maltodextrin 0.3-0.5
Part.
The present invention also provides a kind of preparation method of Chinese herbal medicine granule for adjusting stomach as previously discussed, specific preparation steps
It is as follows:
1) it weighs: weighing malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube respectively, and each raw material is ground into 50-80 mesh powder
End；
2) it extracts: each raw material is placed in supercritical CO2It carries out extracting its extract in extraction equipment；
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into；
4) it stirs: oligofructose, xylitol and maltodextrin is added in the material of concentrate and is placed on high-speed stirred in blender；
5) it pelletizes: the material after stirring being pelletized again；
6) dry: the particle pelletized to be placed in vacuum environment again 3-5 hours dry
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Preferably, the supercritical CO2The temperature of extraction is 36-38 DEG C.
Preferably, the concentrate drying uses vacuum degree for 50-70kPa, and temperature is that 40-50 DEG C of condition is concentrated.
Preferably, the temperature of the drying is 75-85 DEG C.
Beneficial effects of the present invention:
(1) present invention first extracts the effective component of malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube, then by oligomeric fruit
Sugar, xylitol and maltodextrin combine stirring, are uniformly mixed it, and effective component can improve the gastrointestinal system of human body, former
Material use Chinese herbal medicine, safe without toxic side effect, achieve the purpose that treat anorexia, children especially vulnerable to stomach, and
Pharmacological property is mild, will not children's stomach to growth stage generate ill effect, achieved the purpose that it is effective, it is without side-effects.
(2) processing method of the present invention uses supercritical CO2Abstraction technique can effectively extract the effective component of each raw material,
The oxidation and loss of heat-sensitive substance are effectively prevented, and does not increase the pollution of organic solvent, reduces extraction process to human body
The presence of nuisance is the pollution to environment.
(3) by vacuum concentration, chemical change will not occur in the process, reduce side effects of pharmaceutical drugs, and it is effectively
The effectively intact reservation of ingredient.
Specific embodiment
The present invention program is described in further detail below with reference to embodiment, following the description is merely to explain this hair
It is bright, its content is not defined.
Embodiment 1
A kind of Chinese herbal medicine granule adjusting children's stomach, it is specific the preparation method is as follows:
1) it weighs: weighing malt 30kg, endothelium corneum gigeriae galli 20kg, Chinese yam 35kg, Poria cocos 15kg, hawthorn 23kg, jujube 20kg respectively, and
Each raw material is ground into 80 mesh powder；
2) it extracts: each raw material is placed in the supercritical CO that temperature is 36 DEG C2It carries out extracting its extract in extraction equipment；
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 70kPa, temperature
Condition for 40 DEG C is concentrated；
4) it stirs: 2kg oligofructose, 0.8kg xylitol and 0.2kg maltodextrin is added in the material of concentrate and is placed on stirring
High-speed stirred in machine；
5) it pelletizes: the material after stirring being pelletized again；
6) dry: to be again placed in the particle pelletized 5 hours dry in the vacuum environment that temperature is 75 DEG C；
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Embodiment 2
A kind of Chinese herbal medicine granule adjusting children's stomach, it is specific the preparation method is as follows:
1) it weighs: weighing malt 50kg, endothelium corneum gigeriae galli 30kg, Chinese yam 45kg, Poria cocos 23kg, hawthorn 35kg, jujube 30kg respectively, and
Each raw material is ground into 50 mesh powder；
2) it extracts: each raw material is placed in the supercritical CO that temperature is 38 DEG C2It carries out extracting its extract in extraction equipment；
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 50kPa, temperature
Condition for 50 DEG C is concentrated；
4) it stirs: 6kg oligofructose, 3kg xylitol and 0.6kg maltodextrin is added in the material of concentrate and is placed on blender
Interior high-speed stirred；
5) it pelletizes: the material after stirring being pelletized again；
6) dry: to be again placed in the particle pelletized 3 hours dry in the vacuum environment that temperature is 85 DEG C；
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Embodiment 3
A kind of Chinese herbal medicine granule adjusting children's stomach, it is specific the preparation method is as follows:
1) it weighs: weighing malt 35kg, endothelium corneum gigeriae galli 22kg, Chinese yam 38kg, Poria cocos 17kg, hawthorn 25kg, jujube 23kg respectively, and
Each raw material is ground into 60 mesh powder；
2) it extracts: each raw material is placed in the supercritical CO that temperature is 37 DEG C2It carries out extracting its extract in extraction equipment；
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 70kPa, temperature
Condition for 40 DEG C is concentrated；
4) it stirs: 3kg oligofructose, 1kg xylitol and 0.3kg maltodextrin is added in the material of concentrate and is placed on blender
Interior high-speed stirred；
5) it pelletizes: the material after stirring being pelletized again；
6) dry: to be again placed in the particle pelletized 4 hours dry in the vacuum environment that temperature is 80 DEG C；
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Embodiment 4
A kind of Chinese herbal medicine granule adjusting children's stomach, it is specific the preparation method is as follows:
1) it weighs: weighing malt 45kg, endothelium corneum gigeriae galli 28kg, Chinese yam 43kg, Poria cocos 22kg, hawthorn 30kg, jujube 28kg respectively, and
Each raw material is ground into 70 mesh powder；
2) it extracts: each raw material is placed in the supercritical CO that temperature is 37 DEG C2It carries out extracting its extract in extraction equipment；
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 60kPa, temperature
Condition for 45 DEG C is concentrated；
4) it stirs: 5kg oligofructose, 2kg xylitol and 0.5kg maltodextrin is added in the material of concentrate and is placed on blender
Interior high-speed stirred；
5) it pelletizes: the material after stirring being pelletized again；
6) dry: to be again placed in the particle pelletized 5 hours dry in the vacuum environment that temperature is 80 DEG C；
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Testing experiment: for the clinical efficacy for further investigating Chinese herbal medicine granule of the present invention, the children couple of digestive discomfort are selected
Chinese herbal medicine granule of the present invention carries out clinical observation, gives Chinese herbal medicine granule made from embodiment 1-4 to 200 digestive discomfort children's dress
With every group of 40 stomach viruses, edible one steeps electuary, every bubble electuary 5g, daily three times, after taking 10, to intestines every time
Stomach is detected, effective: rehabilitation；It is effective: to alleviate；Invalid: significant change, control group are not take electuary, result such as 1 institute of table
Show.
1 therapeutic effect of table label
| Group | Number of cases | It is effective | Effectively | In vain | Gross efficiency |
| Example 1 group | 40 | 28 | 11 | 1 | 96% |
| 2 groups of embodiment | 40 | 27 | 12 | 1 | 96% |
| 3 groups of embodiment | 40 | 26 | 12 | 2 | 93% |
| 4 groups of embodiment | 40 | 29 | 10 | 1 | 96% |
| Control group | 40 | 0 | 0 | 40 | 0% |
As shown in Table 1, take electuary of the present invention can coordinating intestines and stomach, and can reach the purpose for the treatment of after taking 10 days,
Find no abnormal conditions appearance.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.It is done within the spirit and principles of the present invention any to repair
Change, equivalent replacement, improvement etc., should be included within scope of the invention.
Claims (8)
1. it is a kind of adjust children's stomach Chinese herbal medicine granule, which is characterized in that including following raw material: malt, endothelium corneum gigeriae galli, Chinese yam,
Poria cocos, hawthorn, jujube, oligofructose, xylitol and maltodextrin.
2. the Chinese herbal medicine granule according to claim 1 for adjusting children's stomach, which is characterized in that including following parts by weight
Raw material: the malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube are dual-purpose of drug and food extract.
3. the Chinese herbal medicine granule according to claim 1 for adjusting children's stomach, which is characterized in that including following parts by weight
Raw material: 30-50 parts of malt, 20-30 parts of endothelium corneum gigeriae galli, 35-45 parts of Chinese yam, 15-23 parts of Poria cocos, 23-35 parts of hawthorn, jujube 20-30
Part, 2-6 parts of oligofructose, 0.8-3 parts of xylitol and 0.2-0.6 parts of maltodextrin.
4. the Chinese herbal medicine granule according to claim 2 for adjusting children's stomach, which is characterized in that including following parts by weight
Raw material: 35-45 parts of malt, 22-28 parts of endothelium corneum gigeriae galli, 38-43 parts of Chinese yam, 17-22 parts of Poria cocos, 25-30 parts of hawthorn, jujube 23-28
Part, 3-5 parts of oligofructose, 1-2 parts of xylitol and 0.3-0.5 parts of maltodextrin.
5. a kind of preparation method for the Chinese herbal medicine granule for adjusting children's stomach as described in claim 1-4 any one, feature
It is, specific preparation process is as follows:
1) it weighs: weighing malt, endothelium corneum gigeriae galli, Chinese yam, Poria cocos, hawthorn, jujube respectively, and each raw material is ground into 50-80 mesh powder
End；
2) it extracts: each raw material is placed in supercritical CO2It carries out extracting its extract in extraction equipment；
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into；
4) it stirs: oligofructose, xylitol and maltodextrin is added in the material of concentrate and is placed on high-speed stirred in blender；
5) it pelletizes: the material after stirring being pelletized again；
6) dry: the particle pelletized to be placed in vacuum environment again 3-5 hours dry
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
6. adjusting the preparation method of the Chinese herbal medicine granule of children's stomach according to claim 5, which is characterized in that described super to face
Boundary CO2The temperature of extraction is 36-38 DEG C.
7. adjusting the preparation method of the Chinese herbal medicine granule of children's stomach according to claim 5, which is characterized in that the concentration
Drying uses vacuum degree for 50-70kPa, and temperature is that 40-50 DEG C of condition is concentrated.
8. adjusting the preparation method of the Chinese herbal medicine granule of children's stomach according to claim 5, which is characterized in that described is dry
Dry temperature is 75-85 DEG C.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111227155A (en) * | 2020-03-31 | 2020-06-05 | 清远创春园食品生产有限公司 | Wild jujube seed and chrysanthemum solid beverage and preparation method thereof |
| CN112544969A (en) * | 2020-12-10 | 2021-03-26 | 广东生和堂健康食品股份有限公司 | Digestion-aiding tortoise jelly and formula and preparation method thereof |
| CN113729222A (en) * | 2020-05-29 | 2021-12-03 | 李永川 | A food or health food containing endothelium corneum Gigeriae Galli for children and its preparation method |
| CN115444133A (en) * | 2022-09-27 | 2022-12-09 | 河南君和堂健康管理有限公司 | Medicine-food homologous powder for regulating spleen and stomach and preparation method thereof |
| CN117044853A (en) * | 2023-07-06 | 2023-11-14 | 合肥友极健康科技有限公司 | Herbal liquid calcium preparation and preparation method thereof |
| CN117481345A (en) * | 2024-01-03 | 2024-02-02 | 四川如源科技有限公司 | Chitosan oligosaccharide composition with gastrointestinal regulating function and functional sugar |
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2019
- 2019-05-21 CN CN201910422503.0A patent/CN110025743A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111227155A (en) * | 2020-03-31 | 2020-06-05 | 清远创春园食品生产有限公司 | Wild jujube seed and chrysanthemum solid beverage and preparation method thereof |
| CN113729222A (en) * | 2020-05-29 | 2021-12-03 | 李永川 | A food or health food containing endothelium corneum Gigeriae Galli for children and its preparation method |
| CN112544969A (en) * | 2020-12-10 | 2021-03-26 | 广东生和堂健康食品股份有限公司 | Digestion-aiding tortoise jelly and formula and preparation method thereof |
| CN115444133A (en) * | 2022-09-27 | 2022-12-09 | 河南君和堂健康管理有限公司 | Medicine-food homologous powder for regulating spleen and stomach and preparation method thereof |
| CN117044853A (en) * | 2023-07-06 | 2023-11-14 | 合肥友极健康科技有限公司 | Herbal liquid calcium preparation and preparation method thereof |
| CN117481345A (en) * | 2024-01-03 | 2024-02-02 | 四川如源科技有限公司 | Chitosan oligosaccharide composition with gastrointestinal regulating function and functional sugar |
| CN117481345B (en) * | 2024-01-03 | 2024-04-05 | 四川如源科技有限公司 | Chitosan oligosaccharide composition with gastrointestinal regulating function and functional sugar |
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