CN111991524A - Traditional Chinese medicine composition for convalescent period of neocoronary pneumonia infection and preparation method thereof - Google Patents
Traditional Chinese medicine composition for convalescent period of neocoronary pneumonia infection and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides a traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection, which is prepared from the following raw materials in parts by weight: 0.5-5 parts of ginseng, 1-30 parts of Chinese yam, 2-15 parts of rhizoma polygonati, 1-15 parts of gordon euryale seed, 2-30 parts of coix seed, 3-10 parts of dried orange peel, 1-18 parts of emblic leafflower fruit, 1-15 parts of silk reeling flower and 1-10 parts of black tea. And a preparation method of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection is provided. The research result of the formula component-target point-pharmacological action mechanism network of the traditional Chinese medicine composition for the convalescent period of the new coronary pneumonia infection is consistent with the link of the main treatment disease, and the modern precise medical principle is met. Meanwhile, the product has low cost and meets the requirement of industrialized production.
Description
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a traditional Chinese medicine composition for treating neocoronary pneumonia in a recovery period and a preparation method thereof.
Background
The novel Coronavirus pneumonia (COVID-19, New CoV pneumonia) is an Acute infectious disease caused by a newly discovered Coronavirus (Severe Acute Respiratory Syndrome-Coronavir-2, SARS-CoV-2) infection. The disease is taken as an acute respiratory infectious disease and is incorporated into a B infectious disease specified in the infection prevention and treatment law of the people's republic of China, and is managed according to the A infectious disease. By adopting a series of preventive control and medical treatment measures, the rising momentum of the epidemic situation in China is restrained. With the deepening of clinical manifestation and pathological understanding of the disease and the accumulation of diagnosis and treatment experiences, new technologies and new methods for prevention, detection and treatment are urgently needed to be developed and applied in order to further strengthen early diagnosis and early treatment of the disease, improve the cure rate and reduce the death rate.
Although the patients who are discharged have reached the discharge standard with improvement of inflammation and disappearance of infectivity as main indicators, a considerable part of the patients still have clinical discomfort. After statistics, a research team in Dongzhou university of traditional Chinese medicine hospital discovers that 67% of patients who are discharged from the hospital and have at least 1 respiratory system discomfort symptom such as mild dry cough and short breath. With the adoption of scientific prevention and control measures in China and the combined efforts of all epidemic prevention personnel, the epidemic situation is effectively controlled, most of cases are cured and discharged, and the rehabilitation treatment of patients in the convalescent period is expected to gradually become a new treatment requirement.
In the latest version of diagnosis and treatment scheme of Xinguan pneumonia, the recommended prescription for convalescent patients is 9 g of rhizoma pinellinae praeparata, 10g of dried orange peel, 15g of radix codonopsitis, 30g of radix astragali preparata, 10g of fried rhizoma atractylodis macrocephalae, 15g of poria cocos, 10g of wrinkled gianthyssop herb, 6g of fructus amomi (added later) and 6g of liquorice. The study of Chinese medicine prescription in convalescent period released by health administration before 3/5/2020 for prevention and treatment of new coronary pneumonia by scholars mainly comprises deficiency tonifying medicine, heat clearing medicine and dampness eliminating medicine, and the first 5 high-frequency medicines are Glycyrrhrizae radix, Poria, pericarpium Citri Tangerinae, radix Ophiopogonis and radix astragali respectively. However, the new coronary pneumonia has a long course of disease and is easy to consume healthy qi, the recovery period has the characteristics of weak healthy qi and incomplete remaining pathogens, and the common clinical manifestations include short breath, lassitude, hypodynamia, poor appetite, nausea, fullness, weakness of stool, loose stool, pale and fat tongue, white and greasy tongue coating and the like. Therefore, improvement of subsequent treatment of patients in convalescent stage of new coronary pneumonia is of considerable importance.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection and a preparation method thereof.
The invention provides a traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection, which is prepared from the following raw materials in parts by weight:
0.5 to 5 parts of ginseng,
1-30 parts of Chinese yam,
2-15 parts of rhizoma polygonati,
1-15 parts of gordon euryale seed,
2-30 parts of coix seed,
3-10 parts of dried orange peel,
1-18 parts of emblic leafflower fruit,
1-15 parts of silk reeling flower,
1-10 parts of black tea.
And a preparation method of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection, which comprises the following steps:
weighing the raw materials according to the weight parts of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection, mixing Chinese yam, rhizoma polygonati, gordon euryale seed, coix seed, dried orange peel, emblic leafflower fruit, filature flower and black tea, adding 5-20 parts by mass of water to soak for 15-60 minutes, heating and reflux extracting for 0.5-2 hours, and filtering with 80-200 meshes to obtain a first extract;
adding 5-20 times of water by mass into the medicine residues, performing reflux extraction for 0.5-2 hours, and filtering by 80-200 meshes to obtain a second extracting solution;
mixing the first extract and the second extract, concentrating, and adding Ginseng radix to obtain the Chinese medicinal composition for treating convalescent stage of neocoronary pneumonia infection.
The traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection consists of ginseng, Chinese yam, rhizoma polygonati, gorgon fruit, coix seed, dried orange peel, emblic leafflower fruit, filature flower and black tea extracts, has the effects of tonifying qi and yin, strengthening spleen and tonifying lung, and is used for treating the convalescent period of a patient with the neocoronary pneumonia due to lung-spleen qi deficiency. The traditional Chinese medicine composition has the characteristics of reasonable formula, remarkable effect, definite active ingredients, clear action target and pharmacological effect, wide raw materials, low cost, excellent preparation, convenient taking and the like, is suitable for patients with new coronary pneumonia with lung and spleen qi deficiency in convalescent period, has the effects of tonifying qi and nourishing body fluid, tonifying lung and spleen, and relieves clinical discomfort symptoms.
Drawings
Fig. 1 is a network diagram of the association between the traditional Chinese medicine raw materials, active ingredients and action targets of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection provided by the embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention provides a traditional Chinese medicine composition for a convalescent period of neocoronary pneumonia infection, which is prepared from the following raw materials in parts by weight:
0.5 to 5 parts of ginseng,
1-30 parts of Chinese yam,
2-15 parts of rhizoma polygonati,
1-15 parts of gordon euryale seed,
2-30 parts of coix seed,
3-10 parts of dried orange peel,
1-18 parts of emblic leafflower fruit,
1-15 parts of silk reeling flower,
1-10 parts of black tea.
Preferably, the preparation raw materials of the traditional Chinese medicine composition for the convalescent period of the new coronary pneumonia infection also comprise 1-6 parts of chlorella pyrenoidosa, 1-6 parts of trehalose and 1-3 parts of mannose oligomer. The low-polymannan mannose can directly enter into large intestine to be utilized by Bacillus bifidus, and can promote proliferation of Bacillus bifidus and simultaneously produce various organic acids. The pH value of the intestinal tract is reduced, the growth of harmful bacteria is inhibited, and the probiotics are greatly proliferated in the intestinal tract, so that the intestinal function is adjusted. More preferably, the chlorella pyrenoidosa is 6 parts, the trehalose is 6 parts, and the mannose oligomer is 1.5 parts.
More preferably, the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection is prepared from the following raw materials in parts by weight: 2-4 parts of ginseng, 8-10 parts of Chinese yam, 8-10 parts of rhizoma polygonati, 8-10 parts of gordon euryale seed, 8-12 parts of coix seed, 8-10 parts of dried orange peel, 8-10 parts of emblic leafflower fruit, 8-10 parts of silk reeling flower and 4-6 parts of black tea. More specifically, the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection is prepared from the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of Chinese yam, 9 parts of rhizoma polygonati, 9 parts of gordon euryale seed, 10 parts of coix seed, 9 parts of dried orange peel, 9 parts of emblic leafflower fruit, 9 parts of silk reeling flower and 5 parts of black tea.
The traditional Chinese medicine composition for the recovery period of the neocoronary pneumonia infection is composed of ginseng, Chinese yam, sealwort, gordon euryale seed, coix seed, dried orange peel, emblic leafflower fruit, filature flower, black tea, chlorella pyrenoidosa, trehalose and oligomannose, and is mainly used for patients with the recovery period of the neocoronary pneumonia (deficiency of lung and spleen qi), mild cough, short breath, mental fatigue, juicing when in movement, anorexia, pale tongue with white and moist fur and slow and weak pulse. 102 potential active ingredients are screened in the cyber pharmacological research, and mainly comprise Ginsenoside (3R) -Protopanaxadiol, (20S) -Protopanaxadiol, (20R) -Protopanaxadiol, Ginsenoside rh2, Ginsenoside rf, Ginsenoside Rg1, Ginsenoside Rb1, Ginsenoside-Rd and Ginsenoside Re; adenosine (Adenosine), diosgenin (diosgenin), Garcinone B (forrestinol B), hancinone C (piperitone C), piperlongumine (piperlongumine), Uracil (Uracil); caprylic acid (caprylic acid), ergosterol (ergosterol), linolenic acid (linolenic acid), chebulic acid (kojic acid), ellagic acid (ellagic acid), epigalloatechin gate (Epigallocatechin gallate), galilic acid (Gallic acid), alpha-amyrin (alpha-coumarol); heperidin (hesperidin), naringenin (naringin); caffeine, Epigallocatechin, catechin gate (catechin gallate), Epigallocatechin gate (gallocatechin gallate); euscapic Acid (roxburgh Acid), protocathechuic Acid (protocatechuic Acid), Myricetin (Myricetin), succidic Acid (Succinic Acid), Citric Acid (Citric Acid), malic Acid (malic Acid), gallic Acid (gallic Acid), caffeic Acid (caffeic Acid), and ursolic Acid. The target prediction is carried out on the active ingredients, 264 targets are screened together, and the active ingredients mainly comprise AR, PTGS2, ESR1, DPP4, NOS2, CDK2, CA2, PRSS1, PTPN1, PTGS1, PIM1, F2, PPARG, ESR2, CCNA2, NCOA2, GSK3B, NOS3, ACHE, MAPK14 and the like. A large number of pharmacological research results show that the traditional Chinese medicine composition for the convalescent period of the new coronary pneumonia has the pharmacological functions of improving the lung function, resisting viruses, enhancing the immunity, promoting the digestion and absorption, improving the negative nitrogen balance and the like, so that the early rehabilitation of patients in the convalescent period of the new coronary pneumonia is promoted. The system in table 1 reveals the pharmacodynamic active substance basis, action target and molecular mechanism of the traditional Chinese medicine composition for promoting the rehabilitation of patients in the convalescent period of new coronary pneumonia.
The specific functions of the components are shown in the table 1:
TABLE 1
Qi deficiency is the core pathogenesis of the convalescent stage of new coronary pneumonia, and the diagnosis and treatment scheme (trial seventh edition) of novel coronavirus pneumonia and the Chinese medical rehabilitation guidance suggestion (trial) of the convalescent stage of novel coronavirus pneumonia both propose the point. The qi deficiency of most patients in the convalescent period of the new coronary pneumonia is manifested by cough, shortness of breath, hypodynamia, abdominal distension, anorexia, and the like. Tonifying when deficiency occurs is the main principle of convalescent treatment. The pathogenesis evolution process of the new coronary pneumonia is as follows: epidemic qi is pathogenic factors of both wind-cold-dampness, and has rapid and easy-to-infect ability due to natural wind, although it is cold-dampness nature and good in nature crime, and it enters the lung from the upper jiao; the lung is in the upper energizer, such as Huagai, and is warmed by heart fire and receives the qi of ying-wei to control and distribute qi and blood. Cold-dampness entering lung directly impairs lung yang, and is indicated for dyspnea and dyspnea due to abnormal qi, blood and body fluids distribution, and accumulation in lung to form phlegm and blood stasis; when yang qi is exuberant, or cold-dampness of lung is directly relieved for curing, when yang qi is exuberant, healthy qi and pathogenic qi struggle with lung and high fever, and when yang qi is deficient, lung cold-dampness is hard to relieve for a long time or after noon hot flash occurs; yang qi resisting pathogen gradually releases cold pathogen, dampness is sticky and can stagnate to transform into heat, or descend to the spleen and stomach of middle energizer along the triple energizer, or to the middle energizer directly, so it is uncomfortable to have abdominal distension and loose stool; the soil is the mother-of-jin, the child-organ comes from the evil, the disease is gradually weakened, and the disease can be cured by the strong spleen and stomach; during the convalescent period, the symptoms of qi deficiency of lung and spleen are common, and the treatment is mainly to tonify qi and strengthen spleen.
The traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection provided by the invention takes ginseng which can tonify primordial qi as a main material, and is added with spleen-invigorating, phlegm-resolving, stomach-harmonizing and digestion-promoting medicines, recovers the functions of various viscera by adjusting the acquired basis, and can tonify lung qi, effectively improves the symptoms of short breath, fatigue and hypodynamia, poor appetite and nausea, fullness, no strength of stool, loose stool, pale and fat tongue, white and greasy tongue coating and the like caused by qi deficiency, is suitable for treating the patient with the convalescent period of the neocoronary pneumonia, and is beneficial to the comprehensive rehabilitation of the patient. The traditional Chinese medicine composition has clear effective components, clear action target network and clear participating physiological/pathological process, and as shown in figure 1, the research result of the component-target-pharmacological action mechanism network of the formula conforms to the requirements of patients in the infection recovery period.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection, which comprises the following steps:
weighing the raw materials according to the weight parts of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection, mixing Chinese yam, rhizoma polygonati, gordon euryale seed, coix seed, dried orange peel, emblic leafflower fruit, filature flower and black tea, adding 5-20 parts by mass of water to soak for 15-60 minutes, heating and reflux extracting for 0.5-2 hours, and filtering with 100 meshes to obtain a first extracting solution;
adding 5-20 times of water by mass into the medicine residues, performing reflux extraction for 0.5-2 hours, and filtering by a 100-mesh sieve to obtain a second extracting solution;
mixing the first extract and the second extract, concentrating, and adding Ginseng radix to obtain the Chinese medicinal composition for treating convalescent stage of neocoronary pneumonia infection.
Preferably, the Chinese yam, the sealwort, the gorgon fruit, the coix seed, the dried orange peel, the emblic leafflower fruit, the filature flower and the black tea are mixed, added with 8-15 times of water by mass for soaking for 20-40 minutes, heated and refluxed for extraction for 0.5-2 hours, and filtered by a sieve of 100 meshes to obtain a first extracting solution;
adding 8-15 times of water by mass into the medicine residues, heating, refluxing and extracting for 0.5-2 hours, and filtering by a 100-mesh sieve to obtain a second extracting solution.
Preferably, the ginseng is used after being subjected to superfine grinding.
Specifically, the first extract and the second extract are combined, concentrated at 70 ℃ under reduced pressure until the relative density is about 1.08 to obtain a concentrated solution, maltodextrin is added into the concentrated solution, stirred uniformly, and spray-dried (the air inlet temperature of a nozzle is set to be 150 ℃, and the air outlet temperature is 80 ℃) to obtain extract powder. Adding Ginseng radix micropowder, Chlorella pyrenoidosa, trehalose, and mannose oligomer into the extract powder, and mixing; subpackaging with 10g per bag to obtain the solid beverage.
In addition, mixing the above extract powder with Ginseng radix micropowder, Chlorella pyrenoidosa, trehalose, and mannose oligomer, adding 85% ethanol, granulating, drying at 70 deg.C, grading, and tabletting; or adopting appropriate adjuvants such as maltodextrin, corn starch, wheat flour, and protein powder, performing dry granulation or directly tabletting, and making into appropriate tablet.
The final form of the product can be various, including powder, granule, tablet, honeyed pill, soft extract, oral liquid, syrup, etc. In the preparation process, the drying mode can be spray drying, vacuum drying, freeze drying and the like; the granulation method can be dry granulation, wet granulation, one-step granulation and the like. Preferably, the concentrated solution is dried under reduced pressure, dried by spraying, and quickly dried to obtain powder, so that damage to various components is reduced, and support is provided for effectiveness of the product.
By adopting the method acceptable by relevant laws and regulations of pharmacy, food, health care products and the like, the traditional Chinese medicine components of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection can be extracted, concentrated, dried or crushed, further processed into products, the effective components of the compound are reserved, and the products are prepared into suitable administration forms (including dosage forms such as granules, powder, oral liquid, tablets and the like) or food forms such as tabletting candies, meal powder, solid beverages and the like, so that the requirements of the market on relevant products are met, and the invention belongs to the protection scope.
The following describes the above-mentioned traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection and the preparation method thereof by means of specific formulation and preparation process examples.
Example 1:
weighing 9kg of Chinese yam, 9kg of rhizoma polygonati, 9kg of gordon euryale seed, 10kg of coix seed, 9kg of dried orange peel, 9kg of emblic leafflower fruit, 9kg of filature flower and 5kg of black tea according to the weight parts of the traditional Chinese medicine composition for the recovery period of the neocoronary pneumonia infection, mixing, adding 720L of water for soaking for 30 minutes, heating, refluxing and extracting for 1 hour, and filtering by 100 meshes to obtain a first extracting solution;
adding 720L water into the residue, reflux extracting for 1 hr, and filtering with 100 mesh filter to obtain second extractive solution;
mixing the first extractive solution and the second extractive solution, concentrating at 70 deg.C under reduced pressure to relative density of about 1.08 to obtain concentrated solution, adding maltodextrin, stirring, spray drying (nozzle air inlet temperature is 150 deg.C, air outlet temperature is 80 deg.C) to obtain extract powder, adding Ginseng radix 3kg, Chlorella pyrenoidosa 6kg, trehalose 6kg, and oligomannose 1.5kg into the extract powder, and mixing; subpackaging with 10 g/bag to obtain solid beverage powder.
Example 2:
10 patients in the convalescent period of the new coronary pneumonia infection are selected to take the solid beverage powder prepared in the example 1 every day, and after continuous taking for two weeks, no adverse reaction exists, and 7 patients have remarkable relief of uncomfortable symptoms.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection is characterized by being prepared from the following raw materials in parts by weight:
0.5 to 5 parts of ginseng,
1-30 parts of Chinese yam,
2-15 parts of rhizoma polygonati,
1-15 parts of gordon euryale seed,
2-30 parts of coix seed,
3-10 parts of dried orange peel,
1-18 parts of emblic leafflower fruit,
1-15 parts of silk reeling flower,
1-10 parts of black tea.
2. The traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection of claim 1, which is prepared from the following raw materials in parts by weight:
2-4 parts of ginseng,
8-10 parts of Chinese yam,
8-10 parts of rhizoma polygonati,
8-10 parts of gordon euryale seed,
8-12 parts of coix seeds, namely,
8-10 parts of dried orange peel,
8-10 parts of emblic leafflower fruit,
8-10 parts of silk reeling flowers,
4-6 parts of black tea.
3. The traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection of claim 2, which is prepared from the following raw materials in parts by weight:
3 parts of ginseng, namely ginseng root,
9 parts of Chinese yam, namely,
9 parts of sealwort, 9 parts of,
9 parts of gorgon fruit, namely,
10 parts of coix seed, namely 10 parts of coix seed,
9 parts of dried orange peel, namely dried orange peel,
9 parts of emblic leafflower fruit, namely,
9 parts of silk reeling flower,
5 parts of black tea.
4. The traditional Chinese medicine composition for the convalescent period of the new coronary pneumonia infection of claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition further comprise chlorella pyrenoidosa, trehalose and oligomannose.
5. A preparation method of a traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection is characterized by comprising the following steps:
weighing the raw materials according to the weight parts of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection according to any one of claims 1 to 3, mixing Chinese yam, rhizoma polygonati, gorgon fruit, coix seed, dried orange peel, emblic leafflower fruit, filature flower and black tea, adding 5-20 times of water by mass, soaking for 15-60 minutes, heating, refluxing and extracting for 0.5-2 hours, and filtering with 80-200 meshes to obtain a first extracting solution;
adding 5-20 times of water by mass into the medicine residues, performing reflux extraction for 0.5-2 hours, and filtering by 80-200 meshes to obtain a second extracting solution;
mixing the first extract and the second extract, concentrating, and adding Ginseng radix to obtain the Chinese medicinal composition for treating convalescent stage of neocoronary pneumonia infection.
6. The method for preparing a Chinese medicinal composition for the convalescent period of neocoronary pneumonia infection as claimed in claim 5, wherein rhizoma Dioscoreae, rhizoma Polygonati, semen euryales, semen Coicis, pericarpium Citri Reticulatae, fructus Phyllanthi, filature flower and black tea are mixed, and soaked in 8-15 times of water for 20-40 min.
7. The preparation method of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection, which is disclosed by claim 5, is characterized in that 8-15 times of water in parts by mass of medicine residues is added.
8. The method of claim 5, wherein the addition of the ginseng is followed by the addition of chlorella pyrenoidosa, trehalose, and oligomannose.
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