CN111991524A - Traditional Chinese medicine composition for convalescent period of neocoronary pneumonia infection and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection. servings, 2-30 servings of Yiren, 3-10 servings of dried tangerine peel, 1-18 servings of Emblica, 1-15 servings of silk reeling, and 1-10 servings of black tea. And, a preparation method of the traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection is provided. The results of the network research on the formulation components-target-pharmacological action mechanism of the traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection are consistent with the main disease, and are in line with the principles of modern precision medicine. At the same time, the cost of this product is low, which meets the needs of industrialized production.

Description

A kind of traditional Chinese medicine composition for convalescent period of new coronary pneumonia infection and preparation method thereof

technical field

The invention belongs to the technical field of health care products, and in particular relates to a traditional Chinese medicine composition used for the recovery period of new coronary pneumonia infection and a preparation method thereof.

Background technique

Novel coronavirus pneumonia (COVID-19, new coronary pneumonia) is an acute infectious disease caused by a newly discovered coronavirus (SevereAcute Respiratory Syndrome-Coronavirus-2, SARS-CoV-2). As an acute respiratory infectious disease, the disease has been included in the Class B infectious disease stipulated in the Law of the People's Republic of China on the Prevention and Control of Infections, and is managed as a Class A infectious disease. Through the adoption of a series of preventive control and medical treatment measures, the upward trend of the epidemic situation in my country has been contained. With the deepening of the clinical manifestations and pathological understanding of the disease and the accumulation of diagnosis and treatment experience, in order to further strengthen the early diagnosis and early treatment of the disease, improve the cure rate, and reduce the mortality rate, related prevention, detection and treatment of new technologies, new The method urgently needs to be developed and applied.

Although all discharged patients have reached the discharge standard with improvement of inflammation and disappearance of infectivity as the main indicators, a considerable number of patients still have clinical discomfort. After statistics, the research team of Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine found that nearly 67% of discharged patients had at least one symptom of respiratory discomfort such as mild dry cough and shortness of breath. With the adoption of scientific prevention and control measures in China and the joint efforts of all anti-epidemic personnel, the epidemic has been effectively controlled, and most of the cases have been cured and discharged. It is expected that the rehabilitation treatment of patients in the convalescent period will gradually become a new treatment demand.

In the latest version of the new coronary pneumonia diagnosis and treatment plan, the recommended prescriptions for convalescent patients are 9 g of Pinellia Fructus, 10 g of dried tangerine peel, 15 g of Codonopsis pilosula, 30 g of Zhi Astragalus, 10 g of Fried Atractylodes, 15 g of Poria, 10 g of Huoxiang, and 6 g of Amomum radix (later). bottom), licorice 6g. Some scholars have counted the Chinese medicine prescriptions for the recovery period in the new coronary pneumonia prevention and treatment plan issued by the health authorities before March 5, 2020. The medicines are mainly tonic, heat-clearing and damp-removing medicines. The top 5 high-frequency medicines They are Licorice, Poria, Chenpi, Ophiopogon japonicus and Astragalus. However, the course of COVID-19 is long, and it is easy to damage the righteousness. During the recovery period, the righteousness is weak and the remaining evils are not exhausted. Common clinical manifestations include shortness of breath, fatigue, anorexia, nausea, fullness, weak stools, and unpleasant stools. , Tongue fat, greasy coating and so on. Therefore, it is very important to improve the follow-up treatment of patients in the convalescent period of new coronary pneumonia.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to overcome the defects of the prior art, and to provide a traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection and a preparation method thereof.

The present invention provides a kind of traditional Chinese medicine composition for new coronary pneumonia infection recovery period, and it is prepared from the following raw materials by weight:

0.5 to 5 servings of ginseng,

1 to 30 portions of Huaishan,

2 to 15 servings of Huang Jing,

Gorgon 1 to 15 servings,

Yi Ren 2 to 30 servings,

3-10 servings of dried tangerine peel,

1-18 servings of Embergia,

1-15 servings of silk reeling flowers,

1-10 servings of black tea.

And, a kind of above-mentioned preparation method of the traditional Chinese medicine composition for new coronary pneumonia infection convalescence, it comprises the steps:

The raw materials are weighed according to the weight parts of the above-mentioned traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection, and the Chinese yam, Polygonatum chinensis, Gorgon, yiren, dried tangerine peel, Emblica, silk reeling flower and black tea are mixed, and 5 to 20 times the mass of water is added. Soak for 15-60 minutes, heat and reflux for extraction for 0.5-2 hours, and filter with 80-200 mesh to obtain the first extract;

Add 5～20 times mass parts of water to the medicinal residues for reflux extraction for 0.5～2 hours, and filter with 80～200 meshes to obtain the second extract;

The first extraction solution and the second extraction solution are mixed and concentrated, and ginseng is added to obtain the described traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection.

The traditional Chinese medicine composition used in the recovery period of new coronary pneumonia infection of the present invention is composed of ginseng and yam, rhizoma rhizoma, gorgonian, yiren, tangerine peel, emblica, silk reeling flower, and black tea extracts, which together play the role of invigorating qi and nourishing yin, strengthening the spleen and benefiting the lungs. It is used for the treatment of new coronary pneumonia patients with lung and spleen deficiency during the recovery period. It has the characteristics of reasonable formulation, significant effect, clear active ingredients, clear target and pharmacological effect, wide range of raw materials, low cost, excellent preparation, and convenient administration. Nourishes qi, nourishes the lungs and strengthens the spleen, and relieves clinical symptoms.

Description of drawings

Fig. 1 is the traditional Chinese medicine raw material-active ingredient-action target correlation network diagram of the traditional Chinese medicine composition for new coronary pneumonia infection convalescence provided by the embodiment of the present invention.

Detailed ways

In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

The embodiment of the present invention provides a kind of traditional Chinese medicine composition for new coronary pneumonia infection recovery period, and it is prepared from the following raw materials by weight:

0.5 to 5 servings of ginseng,

1 to 30 portions of Huaishan,

2 to 15 servings of Huang Jing,

Gorgon 1 to 15 servings,

Yi Ren 2 to 30 servings,

3-10 servings of dried tangerine peel,

1-18 servings of Embergia,

1-15 servings of silk reeling flowers,

1-10 servings of black tea.

Preferably, the raw materials for the preparation of the traditional Chinese medicine composition for the recovery period of the new coronary pneumonia infection further include 1-6 parts of Chlorella pyrenoidosa, 1-6 parts of trehalose, and 1-3 parts of mannose. Mannose oligosaccharides can directly enter the large intestine and be utilized by bifidobacteria, promoting the proliferation of bifidobacteria and producing a variety of organic acids at the same time. Reduce intestinal pH, inhibit the growth of harmful bacteria, and make probiotics proliferate in the intestinal tract, thereby regulating intestinal function. More preferably, 6 parts of Chlorella pyrenoidosa, 6 parts of trehalose, and 1.5 parts of mannose.

More preferably, the traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection is prepared from the following raw materials by weight: 2 to 4 parts of ginseng, 8 to 10 parts of yam, 8 to 10 parts of Polygonatum chinensis, and 8 to 10 parts of Gorgon. , 8 to 12 parts of Yi Ren, 8 to 10 parts of dried tangerine peel, 8 to 10 parts of Emblica, 8 to 10 parts of reeling flower, and 4 to 6 parts of black tea. More specifically, the traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection is prepared from the following raw materials by weight: 3 parts of ginseng, 9 parts of yam, 9 parts of Polygonatum chinensis, 9 parts of Gorgon, 10 parts of Yiren, and 9 parts of dried tangerine peel. , 9 parts of Embergia, 9 parts of silk reeling, 5 parts of black tea.

The traditional Chinese medicine composition used for the recovery period of new coronary pneumonia infection is composed of ginseng, yam, Polygonatum chinensis, Gorgon, Yiren, dried tangerine peel, Emblica, reeling flower, black tea, Chlorella pyrenoidosa, trehalose, oligosaccharide, clinical Mainly used for the recovery period of new coronary pneumonia (lung and spleen deficiency), mild cough, shortness of breath, tiredness and tiredness of limbs, juice out when moving, lack of appetite, pale tongue with white fur, slow and weak pulse. A total of 102 potential active ingredients were screened in the network pharmacology study, mainly including ginsenosides (3R)-Protopanaxadiol, (20S)-Protopanaxadiol, (20R)-Protopanaxadiol, ginsenoside rh2, ginsenoside rf, Ginsenoside Rg1, Ginsenoside Rb1, Ginsenoside-Rd , GinsenosideRe; Adenosine (adenosine), diosgenin (diosgenin), Garcinone B (forsunin alcohol B), hancinone C (behenone C), piperlonguminine (longunning amide), Uracil (uracil); caprylic acid (caprylic acid), ergosterol (ergosterol), linolenic acid (linolenic acid), chebulic acid (keric acid), ellagic acid (ellagic acid), Epigallocatechin gallate (epigallocatechin gallate), Gallic acid ( gallic acid), alpha-amyrin (alpha-amyrin); hesperidin (hesperidin), naringenin (naringin); Caffeine (caffeine), Epigallocatechin (gallocatechin), catechin gallate (catechin gallate) Ester), Epigallocatechin gallate (gallocatechin gallate); euscaphic acid (spicy acid), protocatechuic acid (protocatechuic acid), Myricetin (myricetin), Succinic acid (succinic acid), Citric Acid (lemon acid) acid), malic acid (malic acid), gallic acid (gallic acid), caffeic acid (caffeic acid), ursolic acid (ursolic acid). Target prediction of active ingredients, a total of 264 targets were screened, mainly including AR, PTGS2, ESR1, DPP4, NOS2, CDK2, CA2, PRSS1, PTPN1, PTGS1, PIM1, F2, PPARG, ESR2, CCNA2, NCOA2, GSK3B, NOS3, ACHE, MAPK14, etc. The results of a large number of pharmacological studies have shown that the components of the traditional Chinese medicine composition used in the recovery period of new coronary pneumonia infection have pharmacological functions such as improving lung function, anti-virus, enhancing immunity, promoting digestion and absorption, and improving negative nitrogen balance, thereby promoting the recovery period of patients with new coronary pneumonia. early recovery. Table 1 systematically discloses the pharmacodynamic and active substance basis and its target and molecular mechanism of traditional Chinese medicine composition to promote the recovery of patients with new coronary pneumonia.

The specific functions of each component are shown in Table 1:

Table 1

Qi deficiency is the core pathogenesis of COVID-19 in the recovery period. This point of view is put forward in both the "New Coronary Virus Pneumonia Diagnosis and Treatment Program (Trial Version 7)" and the "New Coronary Virus Pneumonia Recovery Period TCM Rehabilitation Guidance Suggestions (Trial Version)". Most patients with COVID-19 recovering from qi deficiency are characterized by cough, shortness of breath, fatigue when moving, abdominal distension and anorexia. The main principle of convalescent treatment is to make up for the deficiency. The pathogenesis and evolution of new coronary pneumonia is as follows: Epidemic Qi is an evil that combines wind, cold and dampness. It is endowed with wind and has the ability to quickly contaminate and change. Although it is cold and damp, its nature is surly. Jiao, like a canopy, is warmed by the fire of the heart, absorbs the qi of the camp and guards, and has the ability to control the festival, and can transmit the qi and blood. Cold-dampness enters the lung, directly injuring the lung-yang, dyspnea and shortness of breath, abnormal distribution of qi, blood and body fluids, stagnation in the lung, and phlegm and blood stasis. , when the evil is prosperous, the righteous and evil are fighting in the lungs and have high fever, and when the yang qi is deficient, there is no heat or only hot flashes in the afternoon, and the lungs are cold and damp for a long time. It can be stagnant and turn into heat, or it can go down to the spleen and stomach along the three energizers, or go straight to the middle energizer, so it is uncomfortable to see abdominal distension and loose stools. It can be cured; in the recovery period, symptoms of deficiency of the lung and spleen are more common, and the treatment should be based on tonifying qi and strengthening the spleen.

The traditional Chinese medicine composition for the recovery period of the new coronary pneumonia infection provided by the present invention is mainly based on ginseng, which is rich in vitality, plus spleen and phlegm, and stomach digestion drugs, and restores the functions of various zang-fu organs by adjusting the "acquired foundation". Nourishes Lung Qi, effectively improves symptoms of shortness of breath, fatigue, anorexia, nausea, bloating, weak stool, loose stools, pale tongue, greasy coating and other symptoms caused by Qi deficiency. Contribute to the overall recovery of the patient. The effective components of the traditional Chinese medicine composition are clear, the network of action targets is clear, and the physiological/pathological processes involved in the action are clear. As shown in Figure 1, the results of the network research on the composition-target-pharmacological action mechanism of the formula and the needs of patients in the convalescent period of infection match.

The embodiment of the present invention also provides the above-mentioned preparation method of the traditional Chinese medicine composition for new coronary pneumonia infection recovery period, and it comprises the steps:

The raw materials are weighed according to the weight parts of the above-mentioned traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection, and the Chinese yam, Polygonatum chinensis, Gorgon, yiren, dried tangerine peel, Emblica, silk reeling flower and black tea are mixed, and 5 to 20 times the mass of water is added. Soak for 15 to 60 minutes, heat and reflux for extraction for 0.5 to 2 hours, and filter with 100 meshes to obtain the first extract;

Add 5～20 times mass parts of water to the medicinal residues for reflux extraction for 0.5～2 hours, filter with 100 meshes to obtain the second extract;

The first extraction solution and the second extraction solution are mixed and concentrated, and ginseng is added to obtain the described traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection.

Preferably, Chinese yam, Polygonatum chinensis, Gorgon, yiren, dried tangerine peel, emblica, reeling flower and black tea are mixed, and 8 to 15 times by mass of water is added to soak for 20 to 40 minutes, heated and refluxed for extraction for 0.5 to 2 hours, and filtered with 100 meshes. get the first extract;

Add 8 to 15 times by mass of water to the medicinal residue, heat under reflux for extraction for 0.5 to 2 hours, and filter with 100 mesh to obtain a second extract.

Preferably, the ginseng is used after ultrafine pulverization.

Specifically, the first extraction solution and the second extraction solution were combined, concentrated under reduced pressure at 70° C. to a relative density of about 1.08 to obtain a concentrated solution, added maltodextrin to the concentrated solution, stirred evenly, spray-dried (nozzle inlet air temperature Set to 150 degrees, the air outlet temperature is 80 degrees) to obtain the extract powder. Add ginseng ultrafine powder, Chlorella pyrenoidosa, trehalose, and oligomannose to the extract powder, and mix evenly; pack in 10 g/bag to obtain a solid beverage.

In addition, take the above extract powder, add ginseng ultrafine powder, Chlorella pyrenoidosa, trehalose, oligomannose, mix well, add 85% ethanol to granulate, dry at 70°C, granulate, and perform tablet compression; or use Suitable excipients such as maltodextrin, corn starch, wheat flour, protein powder, etc. can also be made into suitable tablet form by dry granulation or direct powder compression.

The final form of the product can be various, including powder, granule, tablet, honeydew, cream, oral liquid, syrup, etc. In the preparation process, the drying method can be spray drying, vacuum drying, freeze drying, etc.; the granulation method can be dry granulation, wet granulation, one-step granulation, etc. Preferably, the concentrated solution is dried under reduced pressure, spray drying, and powder is rapidly dried to reduce damage to various components and provide support for the effectiveness of the product.

The traditional Chinese medicine components of the above-mentioned traditional Chinese medicine composition for the recovery period of new coronary pneumonia infection can be extracted, concentrated, dried or pulverized by methods acceptable to relevant laws and regulations on pharmacy, food, health products, etc., and further processed into products, retaining the compound formula. The active ingredients are made into suitable administration forms (including dosage forms such as granules, powders, oral liquids, tablets, etc.) or food forms such as tablet candies, meal powders, solid beverages, etc., to meet the market demand for related products, All belong to the protection scope of the present invention.

The above-mentioned traditional Chinese medicine composition and its preparation method for the recovery period of new coronary pneumonia infection are described below by the embodiment of specific formula and preparation process.

Example 1:

The raw materials were weighed according to the parts by weight of the traditional Chinese medicine composition used for the recovery period of new coronary pneumonia infection, 9kg of Chinese yam, 9kg of Polygonatum chinensis, 9kg of Gorgon, 10kg of Yiren, 9kg of dried tangerine peel, 9kg of Emblica, 9kg of silk reeling, 5kg of black tea and mixed with 720L of water. Soak for 30 minutes, heat under reflux for 1 hour, and filter with 100 meshes to obtain the first extract;

Add 720L of water to the medicinal residues for reflux extraction for 1 hour, and filter with 100 meshes to obtain the second extract;

The first extraction solution and the second extraction solution were mixed and concentrated, concentrated under reduced pressure at 70°C to a relative density of about 1.08 to obtain a concentrated solution, added maltodextrin, stirred evenly, and spray-dried (the inlet air temperature of the nozzle was set to 150 degrees, and the The tuyere temperature is 80 degrees) to obtain the extract powder, add 3kg of ginseng, 6kg of Chlorella pyrenoidosa, 6kg of trehalose, 1.5kg of mannose oligosaccharide to the extract powder, and mix well; Obtain solid beverage powder.

Example 2:

10 patients in the recovery period of new coronary pneumonia infection were selected to take the solid beverage powder prepared in Example 1 every day for two weeks without any adverse reaction, and the discomfort symptoms of 7 people were significantly relieved.

The above descriptions are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included in the protection of the present invention. within the range.

Claims (8)

1. A traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection is characterized by being prepared from the following raw materials in parts by weight:

0.5 to 5 parts of ginseng,

1-30 parts of Chinese yam,

2-15 parts of rhizoma polygonati,

1-15 parts of gordon euryale seed,

2-30 parts of coix seed,

3-10 parts of dried orange peel,

1-18 parts of emblic leafflower fruit,

1-15 parts of silk reeling flower,

1-10 parts of black tea.

2. The traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection of claim 1, which is prepared from the following raw materials in parts by weight:

2-4 parts of ginseng,

8-10 parts of Chinese yam,

8-10 parts of rhizoma polygonati,

8-10 parts of gordon euryale seed,

8-12 parts of coix seeds, namely,

8-10 parts of dried orange peel,

8-10 parts of emblic leafflower fruit,

8-10 parts of silk reeling flowers,

4-6 parts of black tea.

3. The traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection of claim 2, which is prepared from the following raw materials in parts by weight:

3 parts of ginseng, namely ginseng root,

9 parts of Chinese yam, namely,

9 parts of sealwort, 9 parts of,

9 parts of gorgon fruit, namely,

10 parts of coix seed, namely 10 parts of coix seed,

9 parts of dried orange peel, namely dried orange peel,

9 parts of emblic leafflower fruit, namely,

9 parts of silk reeling flower,

5 parts of black tea.

4. The traditional Chinese medicine composition for the convalescent period of the new coronary pneumonia infection of claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition further comprise chlorella pyrenoidosa, trehalose and oligomannose.

5. A preparation method of a traditional Chinese medicine composition for the convalescent period of neocoronary pneumonia infection is characterized by comprising the following steps:

weighing the raw materials according to the weight parts of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection according to any one of claims 1 to 3, mixing Chinese yam, rhizoma polygonati, gorgon fruit, coix seed, dried orange peel, emblic leafflower fruit, filature flower and black tea, adding 5-20 times of water by mass, soaking for 15-60 minutes, heating, refluxing and extracting for 0.5-2 hours, and filtering with 80-200 meshes to obtain a first extracting solution;

adding 5-20 times of water by mass into the medicine residues, performing reflux extraction for 0.5-2 hours, and filtering by 80-200 meshes to obtain a second extracting solution;

mixing the first extract and the second extract, concentrating, and adding Ginseng radix to obtain the Chinese medicinal composition for treating convalescent stage of neocoronary pneumonia infection.

6. The method for preparing a Chinese medicinal composition for the convalescent period of neocoronary pneumonia infection as claimed in claim 5, wherein rhizoma Dioscoreae, rhizoma Polygonati, semen euryales, semen Coicis, pericarpium Citri Reticulatae, fructus Phyllanthi, filature flower and black tea are mixed, and soaked in 8-15 times of water for 20-40 min.

7. The preparation method of the traditional Chinese medicine composition for the convalescent period of the neocoronary pneumonia infection, which is disclosed by claim 5, is characterized in that 8-15 times of water in parts by mass of medicine residues is added.

8. The method of claim 5, wherein the addition of the ginseng is followed by the addition of chlorella pyrenoidosa, trehalose, and oligomannose.

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