CN106421508A - Traditional Chinese medicine composition for treating heat-type asthma - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating heat-type asthma, prepared from, by weight, 15-25 parts of Herba Ephedrae, 12-16 parts of mulberry leaf, 10-15 parts of Fructus Trichosanthis, 10-15 parts of Fructus Perillae, 10-15 parts of Flos Inulae, 10-15 parts of Radix Ephedrae, 10-15 parts of Radix Scutellariae, 8-13 parts of Cortex Mori, 8-12 parts of Flos Farfarae, 8-12 parts of Rhizoma Anemarrhenae, 8-12 parts of Herba Andrographis, 7-11 parts of Herba Houttuyniae, 7-11 parts of Semen Ginkgo, 6-10 parts of Radix Ophiopogonis, 5-10 parts of Fructus Arctii, 5-10 parts of Fructus Aristolochiae, 5-10 parts of Rhizoma Phragmitis, 3-9 parts of Radix Trichosanthis, 4-8 parts of Pumex, 5-10 parts of Rhizoma Cynanchi Stauntonii, 4-8 parts of Semen Lepidii seu Descurainiae, and 4-8 parts of Radix Asparagi. The traditional Chinese medicine composition jointly serves for clearing heat and freeing lung, reducing phlegm and lowering adverse qi, and relieving cough and stopping asthma, and is clinically verified to provide a cure rate of 92% for heat-type asthma.

Description

A kind of Chinese medicine composition for treating asthma of heat type type asthma

Technical field

The present invention relates to a kind of Chinese medicine composition for treating asthma of heat type type asthma.

Background technology

Asthma of heat type type asthma is one kind of asthma, and asthma of heat type type asthma syndrome is as follows：Dyspnea, paroxysm of cough and choke, roar in larynx Ring, chest expansion and distending of the hypchondrium, restlessness with opprssive feeling and worry, sweating, thirst and liking drink, flushed complexion bitter taste, expectoration yellow skin or color are white, glutinous turbid stiff, difficulty in expectorating, Red tongue, yellow and greasy fur, slippery and rapid pulse or stringy and rolling pulse.

Treatment current for the asthma of cold syndrome it has been reported that a kind of such as Chinese medicine for treating asthma of heat type type bronchial asthma, Which is removed and states the primary raw material of weight proportion and be prepared from：12 parts of Caulis et Folium Argyreia eacutae, 10 parts of FRUCTUS CITRI AURANTII AMARAE, the province of the Yuan Dynasty grass 18 parts, Canis familiaris L. tassel 10 parts of son, 10 parts of Folium Eriobotryae, 15 parts of Herba Murdanniae Divergentiss, 5 parts of Gecko, 15 parts of Herba Moghaniae fruticulosa, 15 parts of Flos Sauropi changiani leaf, the rabbit ears or side handles of a utensil are careless 12 parts, black 12 parts of Herba Saxifragae, 12 parts of bead Rhizoma panacis majoris, 15 parts of Dischidia minor (Vahl) Merr, 10 parts of Flos Inulae helianthus-aquaticae, 6 parts of Radix Glycyrrhizae, 30 parts of Cortex celtis bungeanae (Cortex seu Caulis Celtis Bungeane), Herba Lespedezae Cuneatae 20 Part, 15 parts of Radix Berberidis soulieanae, 12 parts of Herba Gynostemmatiss, 15 parts of Herba Emiliae, 30 parts of Herba platantherae minoris.One kind disclosed in CN 201610464026.0 is controlled The Chinese medicinal granule of accumulation of phlegm and heat in type asthma is treated, is made up of the raw material of Chinese medicine of following composition by weight：Great Ye Rhizoma Curculiginises 9-15 part, Stachys geobombycis C. Y. Wu 6-12 part, Rhizoma Polygonati Odorati 10-15 part, Fructus Phyllanthi 5-10 part, Herba Leibnitziae 6-12 part, Cortex Lycii 15-60 part, pears 5-15 part, upper tree Trionyx sinensis Wiegmann 4.5-9 part, Fructus Aristolochiae 5-15 part, Bulbus Lilii 2-5 part, Herba Taraxaci 5-15 part, vinegar 100-200 part, the effect of prior art can not make People is satisfied with, and doctor trained in Western medicine easily causes great burden to the body of patient generally using the method for the treatment such as western medicine, suction sputum, And costly, it is big that sufferer bears pain.

Content of the invention

The technical problem to be solved is to provide a kind of Chinese medicine composition for treating asthma of heat type type asthma.

For solving the above problems, the technical solution used in the present invention is：

A kind of Chinese medicine composition for treating asthma of heat type type asthma, its key technology is, which is made up of following parts by weight of component：Herba Ephedrae 15-25 part, Folium Mori 12-16 part, Fructus Trichosanthis 10-15 part, Fructus Perillae 10-15 part, Flos Inulae 10-15 part, Radix Ephedrae 10-15 part, Radix Scutellariae 10-15 part, Cortex Mori 8-13 part, Flos Farfarae 8-12 part, Rhizoma Anemarrhenae 8-12 part, Herba Andrographis 8-12 part, Herba Houttuyniae 7-11 part, Semen Ginkgo 7- 11 parts, 6-10 part Radix Ophiopogonis, Fructus Arctii 5-10 part, Semen Oroxyli 5-10 part, Rhizoma Phragmitiss 5-10 part, Radix Trichosanthis 3-9 part, Pumex 4-8 part, white Front 5-10 part, Semen Lepidii (Semen Descurainiae) 4-8 part and horse Radix Asparagi 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment asthma of heat type type asthma, which is made up of following parts by weight of component：Herba Ephedrae 20 Part, 14 parts of Folium Mori, 13 parts of Fructus Trichosanthis, 13 parts of Fructus Perillae, 12 parts of Flos Inulae, 12 parts of Radix Ephedrae, 12 parts of Radix Scutellariae, 10 parts of Cortex Mori, coltsfoot Spend 10 parts, 10 parts of the Rhizoma Anemarrhenae, 10 parts of Herba Andrographis, 9 parts of Herba Houttuyniae, 9 parts of Semen Ginkgo, 8 parts of Radix Ophiopogonis, 7 parts of Fructus Arctii, 7 parts of Semen Oroxyli, Rhizoma Phragmitiss 7 Part, 6 parts of Radix Trichosanthis, 6 parts of Pumex, 7 parts of Rhizoma Cynanchi Stauntonii, 6 parts of Semen Lepidii (Semen Descurainiae) and 5 parts of horse Radix Asparagi.

Further improve as the present invention, the pharmaceutical formulation of above-mentioned treatment asthma is powder.

Further improve as the present invention, the preparation method of above-mentioned powder is as follows：

Weigh above component by weight, total medical material 6-10 times amount water is added, first time decoction is carried out, at a simmer front using frying by intense fire Boil, with 1-2 hour is cooked by slow fire after boiling, filter；Filtering residue adds 3-5 times amount water, decocts 1-2 hour, filters；Merging filtrate, concentrates, Dry, packaging, obtain final product.

In the formula of the present invention：

Herba Ephedrae is Ephedraceae plant Ephedra sinica Ephedra sinica Stapf, epheday intermedia Ephedra intermedia Schrenk et C. A. Mey. or ephedra equisetina Ephedra equisetina Bge. dries herb stem.Indication Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.

Folium Mori are the dried leaves of moraceae plants mulberry Morus alba L..Indication dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing Improving eyesight.

Fructus Trichosanthis are cucurbitaceous plant Fructus Trichosanthiss Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harmses The dry mature fruit of Trichosan-thes rosthornii Harms.Indication clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize Laxation.

Fructus Perillae is the fruit of labiate common perilla.The indication therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, wide intestinal.Control cough with dyspnea, phlegm dyspnea, gas Stagnant constipation.

Flos Inulae is feverfew Flos Inulae Inula japonica Thunb. or Inula britannica Inula The dry capitulum of britannica L..Indication sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.

Radix Ephedrae is Ephedraceae plant Ephedra sinica Ephedra sinica Stapf or epheday intermedia Ephedra Intermedia Schrenk et C. A. Mey. dries root and rhizome.Indication hidroschesis.

Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Indication is clear Hot dampness, eliminating fire and detoxication, hemostasis, antiabortive.

Cortex Mori is the dry root skin of moraceae plants mulberry Morus alba L..Indication eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.

Flos Farfarae is the dry flower of feverfew coltsfoot Tussilago farfara L..Indication nourishing the lung to keep the adverse QI downward, Relieving cough and resolving phlegm.

The Rhizoma Anemarrhenae is the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge..Function master Control clearing away heat-fire, fluid dryness.

Herba Andrographis are acanthaceous plant Herba Andrographis（Circular cone must medicinal herbs）Andrographis paniculata （Burm. f. ）The dry aerial parts of Nees.Indication heat-clearing and toxic substances removing, removing heat from blood, detumescence.

Herba Houttuyniae is the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Function Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.

Radix Ophiopogonis is liliaceous plant Radix Ophiopogonis（Dwarf lilyturf）Ophiopogon japonicus （Thunb.）Ker-Gawl. Dried root.Indication YIN nourishing and the production of body fluid promoting, moistening lung clears away heart-fire.

Fructus Arctii is the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..Indication dispelling wind and heat pathogens, Lung qi dispersing rash, resolving toxin and disinhibiting the throat.

Fructus Aristolochiae is aristolochiaceae plant Aristolochia contorta Aristolochia contorta Bge. or Fructus Aristolochiae The dry mature fruit of Aristolochia debilis Sieb. et Zucc..Indication lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, Bowel relieving disappears hemorrhoid.

Rhizoma Phragmitiss are the fresh or dry rhizome of grass phragmites communiss Phragmites communis Trin..Function master Control clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.

Radix Trichosanthis are cucurbitaceous plant Fructus Trichosanthiss Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harmses The dry root of Trichosan-thes rosthornii Herms.Indication clearing away heat and promoting production of body fluid, detumescence and apocenosis.

The stone that the magma that Pumex is gone out by volcanic eruption is formed；Indication removing heat from the lung and dissipating phlegm, hard masses softening and resolving.

Rhizoma Cynanchi Stauntonii is the root and rhizome of trailing plants section plant rhizoma et radix cynanchi stauntoni or leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii.Eliminating the pathogens from the lung sending down the abnormal ascending QI, lower expectorant antitussive.

Semen Lepidii (Semen Descurainiae) is crucifer Lepidium sativum L. Lepidium apetalum Willd. or descurainia sophia (l.) webb ex prantl Descurainia sophia （L.）The dry mature seed of Webb ex prantl.Indication eliminating pathogen from the lung for relieving asthma, row water disappears Swollen.

Radix Asparagi is liliaceous plant Radix Asparagi Asparagus cochinchinensis（Lour.）Merr. dried pieces Root.Indication nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.

It is using the beneficial effect produced by technique scheme：

Prescription provided by the present invention, theoretical as instructing with Chinese medicine and pharmacy, Syndrome Differentiation of Chinese Medicine disease with debate treating under disease guidance, strictly Defer to Chinese medicine seven emotions compatibility, each prescription of scientific allocation, each prescription is shared, and effect is complemented each other, Herba Ephedrae depressed lung-energy dispersing；Fructus Arctii and Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness；The Rhizoma Anemarrhenae, Rhizoma Phragmitiss and Radix Trichosanthis clearing away heat and promoting production of body fluid；Flos Inulae, Pumex, Rhizoma Cynanchi Stauntonii and Fructus Trichosanthis lung heat clearing Sending down the abnormal ascending QI, Cortex Mori, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Fructus Aristolochiae and Flos Farfarae clearing away lung-heat to relieve cough resolving sputum；Semen Ginkgo, Radix Asparagi and astringing lung QI for relieving asthma Radix Ophiopogonis； Radix Ephedrae hidroschesis is consolidated；Radix Scutellariae, Herba Andrographis and Herba Houttuyniae clearing away heat-fire, we share altogether and beat reducing heat and dispersing lung-QI, eliminating phlegm and lowering adverse QI, cough-relieving The effect of Dingchuan, according to clinical verification, the cure rate to asthma of heat type type asthma is 92%.

Specific embodiment

For making the object, technical solutions and advantages of the present invention clearer, with reference to specific embodiment, invention is carried out Clear, complete description.

Embodiment 1

The Chinese medicine composition for the treatment of asthma of heat type type asthma, which is grouped into by following group：Herba Ephedrae 20g, Folium Mori 14g, Fructus Trichosanthis 13g, Fructus Perillae 13g, Flos Inulae 12g, Radix Ephedrae 12g, Radix Scutellariae 12g, Cortex Mori 10g, Flos Farfarae 10g, Rhizoma Anemarrhenae 10g, Herba Andrographis 10g, Herba Houttuyniae 9g, Semen Ginkgo 9g, 8g Radix Ophiopogonis, Fructus Arctii 7g, Semen Oroxyli 7g, Rhizoma Phragmitiss 7g, Radix Trichosanthis 6g, Pumex 6g, Rhizoma Cynanchi Stauntonii 7g, Semen Lepidii (Semen Descurainiae) 6g and horse Radix Asparagi 5g.

Weigh above component by weight, total 8 times amount water of medical material is added, first time decoction is carried out, at a simmer front employing intense fire Decoct, with being cooked by slow fire 1.5 hours after boiling, filter；Filtering residue adds 4 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentrates, Dry, packaging, obtain final product.

Embodiment 2

The Chinese medicine composition for the treatment of asthma of heat type type asthma, which is grouped into by following group：Herba Ephedrae 15g, Folium Mori 16g, Fructus Trichosanthis 10g, Fructus Perillae 15g, Flos Inulae 10g, Radix Ephedrae 15g, Radix Scutellariae 10g, Cortex Mori 13g, Flos Farfarae 8g, Rhizoma Anemarrhenae 12g, Herba Andrographis 8g, Herba Houttuyniae 11g, Semen Ginkgo 7g, 10g Radix Ophiopogonis, Fructus Arctii 5g, Semen Oroxyli 10g, Rhizoma Phragmitiss 5g, Radix Trichosanthis 9g, Pumex 4g, Rhizoma Cynanchi Stauntonii 10g, Semen Lepidii (Semen Descurainiae) 4g With horse Radix Asparagi 8g.

G by weight weighs above component, adds total 8 times amount water of medical material, carries out first time decoction, at a simmer front using frying by intense fire Boil, with being cooked by slow fire 1.5 hours after boiling, filter；Filtering residue adds 4 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentrates, and does Dry, packaging, obtain final product.

Embodiment 3

The Chinese medicine composition for the treatment of asthma of heat type type asthma, which is grouped into by following group：Herba Ephedrae 25g, Folium Mori 12g, Fructus Trichosanthis 15g, Fructus Perillae 10g, Flos Inulae 15g, Radix Ephedrae 10g, Radix Scutellariae 15g, Cortex Mori 8g, Flos Farfarae 12g, Rhizoma Anemarrhenae 8g, Herba Andrographis 12g, Herba Houttuyniae 7g, Semen Ginkgo 11g, 6g Radix Ophiopogonis, Fructus Arctii 10g, Semen Oroxyli 5g, Rhizoma Phragmitiss 10g, Radix Trichosanthis 3g, Pumex 8g, Rhizoma Cynanchi Stauntonii 5g, Semen Lepidii (Semen Descurainiae) 8g and horse Radix Asparagi 4g.

G by weight weighs above component, adds total 8 times amount water of medical material, carries out first time decoction, at a simmer front using frying by intense fire Boil, with being cooked by slow fire 1.5 hours after boiling, filter；Filtering residue adds 4 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentrates, and does Dry, packaging, obtain final product.

Clinical trial：

1 physical data

Enter to organize case:400 patients, wherein male 208 people, 192 people of women, the oldest 72 years old, minimum 7 years old.It is randomly divided into：Control Treat one group 200, treat two groups 200, treatment three groups 200, matched group 200.The data such as four groups of ages, sexes are no notable Sex differernce, with comparability.

2 diagnostic criterias

Through Chinese medical discrimination, patient has following symptom：Dyspnea, paroxysm of cough and choke, wheezing in larynx, chest expansion and distending of the hypchondrium, restlessness with opprssive feeling and worry, antiperspirant Go out, thirst and liking drink, flushed complexion bitter taste, expectoration yellow skin or color are white, stick turbid stiff, difficulty in expectorating, red tongue, yellow and greasy fur, slippery and rapid pulse or The patient of stringy and rolling pulse.

3 Therapeutic Method

Treat one group of powder for taking the embodiment of the present invention 1, twice daily, sooner or later each once, each 8g, with warm boiled water, 5 Day is a course for the treatment of, treats two courses for the treatment of.

Matched group takes DINGCHUAN TANG, twice daily, sooner or later respectively once, the course for the treatment of 10 days.

4 criterions of therapeutical effect：

The criterion reference of curative effect《Clinical disease diagnosis are according to healing improvement standard》With《Chinese medical disease Standardization of diagnosis and curative effect》 Formulate.

（1）, clinic control：Symptoms of asthma complete incidence graph, even if even have mild episode to alleviate by being not required to medication.FEV1 (or PEF) incrementss>FEV1 (PEF) >=80% predicted value after 35%, or treatment.PEF day and night fluctuation rate<20%；

（2）, effective：Asthma attack substantially mitigates before relatively treating, after FEV1 (or PEF) incrementss scope 25%～35%, or treatment FEV1 (PEF) reaches 60%～79%, the PEF day and night fluctuation rate of predicted value<20%, still need to glucocorticoid or bronchiectasis Agent；

（3）, take a turn for the better：Symptoms of asthma has mitigated, FEV1（Or PEF) incrementss 15%～24%, still need to glucocorticoid and (or) bronchodilator；

（4）, invalid：Clinical symptoms and FEV1 (or PEF) measured value no improve or increase on the contrary.

5 results

	Recovery from illness	Effective	Take a turn for the better	Invalid	Cure rate	Total effective rate
							Treat one group	184	12	4	0	92%	100%
Matched group	82	41	44	33	41%	83.5%

Above total effective rate deducts inefficiency for 100% and obtains.

Clinical practice safety analysiss

In process of clinical application, we give much attention to the safety observations of inventive formulation, and the allergy of whole body does not all occur in patient The untoward reaction such as reaction, safe and reliable using clinical practice of the present invention for a long time.By literature search, other safeties are not found Problem.

Clinical practice analysis shows, this formula Clinical practice crowd is extensive, clinical efficacy is good, toxic and side effects do not occur, right The cure rate of bathomorphic treatment is more than 92%, and effective percentage is worthy of promotion and application up to 100%.

Finally it should be noted that：Above example only in order to technical scheme to be described, rather than a limitation；Although With reference to the foregoing embodiments the present invention is described in detail, it will be understood by those within the art that：Which still may be used To modify to the technical scheme described in previous embodiment, or equivalent is carried out to which part technical characteristic；And These modifications or replacement, do not make the essence of appropriate technical solution depart from spirit and the model of embodiment of the present invention technical scheme Enclose.

Claims (4)

1. a kind of Chinese medicine composition for treating asthma of heat type type asthma, it is characterised in which is made up of following parts by weight of component：Herba Ephedrae 15-25 part, Folium Mori 12-16 part, Fructus Trichosanthis 10-15 part, Fructus Perillae 10-15 part, Flos Inulae 10-15 part, Radix Ephedrae 10-15 part, Radix Scutellariae 10-15 part, Cortex Mori 8-13 part, Flos Farfarae 8-12 part, Rhizoma Anemarrhenae 8-12 part, Herba Andrographis 8-12 part, Herba Houttuyniae 7-11 part, Semen Ginkgo 7- 11 parts, 6-10 part Radix Ophiopogonis, Fructus Arctii 5-10 part, Semen Oroxyli 5-10 part, Rhizoma Phragmitiss 5-10 part, Radix Trichosanthis 3-9 part, Pumex 4-8 part, white Front 5-10 part, Semen Lepidii (Semen Descurainiae) 4-8 part and horse Radix Asparagi 4-8 part.

2. a kind of Chinese medicine composition for treating asthma of heat type type asthma according to claim 1, it is characterised in which is by weighing as follows Amount part group is grouped into：20 parts of Herba Ephedrae, 14 parts of Folium Mori, 13 parts of Fructus Trichosanthis, 13 parts of Fructus Perillae, 12 parts of Flos Inulae, 12 parts of Radix Ephedrae, Radix Scutellariae 12 Part, 10 parts of Cortex Mori, 10 parts of Flos Farfarae, 10 parts of the Rhizoma Anemarrhenae, 10 parts of Herba Andrographis, 9 parts of Herba Houttuyniae, 9 parts of Semen Ginkgo, 8 parts of Radix Ophiopogonis, Fructus Arctii 7 parts, 7 parts of Semen Oroxyli, 7 parts of Rhizoma Phragmitiss, 6 parts of Radix Trichosanthis, 6 parts of Pumex, 7 parts of Rhizoma Cynanchi Stauntonii, 6 parts of Semen Lepidii (Semen Descurainiae) and 5 parts of horse Radix Asparagi.

3. a kind of Chinese medicine composition for treating asthma of heat type type asthma according to claim 1, it is characterised in that the treatment is roared The pharmaceutical formulation that breathes heavily is powder.

4. a kind of Chinese medicine composition for treating asthma of heat type type asthma according to claim 1, it is characterised in that the powder Preparation method is as follows：

Weigh above component by weight, total medical material 6-10 times amount water is added, first time decoction is carried out, at a simmer front using frying by intense fire Boil, with 1-2 hour is cooked by slow fire after boiling, filter；Filtering residue adds 3-5 times amount water, decocts 1-2 hour, filters；Merging filtrate, concentrates, Dry, packaging, obtain final product.