CN110038092A - A kind of Chinese herbal medicine granule and preparation method thereof treating and preventing children's cold - Google Patents
A kind of Chinese herbal medicine granule and preparation method thereof treating and preventing children's cold Download PDFInfo
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- CN110038092A CN110038092A CN201910422564.7A CN201910422564A CN110038092A CN 110038092 A CN110038092 A CN 110038092A CN 201910422564 A CN201910422564 A CN 201910422564A CN 110038092 A CN110038092 A CN 110038092A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention discloses a kind of Chinese herbal medicine granule and preparation method thereof for treating and preventing children's cold, belongs to food processing technology field.The Chinese herbal medicine granule of the treatment and prevention children's cold includes following raw material: honeysuckle, mulberry leaf, chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn, oligofructose, xylitol and maltodextrin.Preparation method includes weighing, extract, be concentrated, stir, pelletize, dry and packing.The Chinese herbal medicine granule of the treatment and prevention children's cold of the method for the present invention preparation has the immune system of enhancing human body itself, raw material uses Chinese herbal medicine, safe without toxic side effect, achieve the purpose that prevent and treat flu, especially to vulnerable children, achieve the purpose that effective, side effect will not be generated.
Description
Technical field
The present invention relates to health food processing technique fields, and in particular to a kind of Chinese herbal medicine for treating and preventing children's cold
Electuary and preparation method thereof.
Background technique
Flu is a kind of common disease, is divided into common cold and influenza.Common cold is drawn by various respiratory road virus
Rise, clinical symptoms to have a stuffy nose, runny nose, cough, headache and aversion to cold, whole year can fall ill, and be mainly in early winter and early spring.No
It is not just the same with Causative virus caused by season.Influenza is the acute respiration road transmission as caused by influenza virus
Disease.Virus is present in the respiratory tract of patient, gives others through droplet infection in patient's cough, sneezing.Flu is a kind of pole
For common and extremely harmful disease.Ache, weakness of limbs, the patient having a high fever are properly termed as heavy cold from head to foot.
Children are especially vulnerable to the influence of Changes in weather due to its own weaker resistance, do not pay attention to slightly to cause
Virus flu, children's cold fever is the most anxious thing of every parent, once cat fever, parent is just thrown into a panic, and fears
Be afraid of firing pneumonia, jeopardize brain.Solution is usually that garter is beaten by hospital, but taking for children's cold is treated in Hospitals at Present
With fairly expensive, and a large amount of antibiotic are often used, has biggish side effect, the physical and mental health of children is caused more serious
Damage.The Chinese patent drug of traditional treatment flu, because of the variation of environment and weather, unsatisfactory curative effect, be badly in need of it is a kind of it is without side-effects,
And has effects that the Chinese herbal medicine granule treated and prevented.
Summary of the invention
The purpose of the invention is to overcome the deficiencies of existing technologies, a kind of medium-height grass for treating and preventing children's cold is provided
Medicine electuary and preparation method thereof, the Chinese herbal medicine granule that the application treats and prevents children's cold have enhancing child resistant, especially
It is the effect for assisting in the treatment of children's cold.Purpose to realize the present invention, used technical solution are as follows:
A kind of Chinese herbal medicine granule treating and preventing children's cold, including following raw material: honeysuckle, mulberry leaf, chrysanthemum, cape jasmine, fresh
Rhizoma imperatae, fresh Rhizoma Phragmitis, hawthorn, oligofructose, xylitol and maltodextrin.
Preferably, the honeysuckle, mulberry leaf, chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn are dual-purpose of drug and food extraction
Object.
Preferably, including following parts by weight raw material: 20-40 parts of honeysuckle, 15-23 parts of mulberry leaf, 10-19 parts of chrysanthemum, Cape jasmine
5-13 parts sub-, 3-8 parts of fresh Rhizoma Imperatae, 30-45 parts of fresh Rhizoma Phragmitis, 20-30 parts of hawthorn, 1-5 parts of oligofructose, xylitol 0.3-0.9
Part and maltodextrin 0.1-0.3 parts.
Preferably, including following parts by weight raw material: 25-35 parts of honeysuckle, 18-20 parts of mulberry leaf, 13-17 parts of chrysanthemum, Cape jasmine
7-12 parts sub-, 4-7 parts of fresh Rhizoma Imperatae, 35-40 parts of fresh Rhizoma Phragmitis, 22-28 parts of hawthorn, 2-4 parts of oligofructose, xylitol 0.5-0.8
Part and maltodextrin 0.2-0.3 parts.
The present invention also provides a kind of preparation method of Chinese herbal medicine granule for treating and preventing children's cold as previously discussed, tools
Preparation step is as follows:
1) it weighs: weighing honeysuckle, mulberry leaf, chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn respectively, and each raw material is crushed
At 50-80 mesh powder;
2) it extracts: each raw material is placed in supercritical CO2It carries out extracting its extract in extraction equipment;
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into;
4) it stirs: oligofructose, xylitol and maltodextrin is added in the material of concentrate and is placed on high-speed stirred in blender;
5) it pelletizes: the material after stirring being pelletized again;
6) dry: the particle pelletized to be placed in vacuum environment again 3-5 hours dry;
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Preferably, the supercritical CO2The temperature of extraction is 36-38 DEG C.
Preferably, the concentration uses vacuum degree for 50-70kPa, and temperature is that 40-50 DEG C of condition is concentrated.
Preferably, the temperature of the drying is 75-85 DEG C.
Beneficial effects of the present invention:
(1) present invention first extracts the effective component of honeysuckle, mulberry leaf, chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn
Come, then oligofructose, xylitol and maltodextrin are combined and stirred, is uniformly mixed it, effective component can enhance human body
The immune system of itself, raw material use Chinese herbal medicine, and safe without toxic side effect achievees the purpose that prevent and treat flu, especially right
Vulnerable children, have achieved the purpose that effective, will not generate side effect.
(2) processing method of the present invention uses supercritical CO2Abstraction technique can effectively extract the effective component of each raw material,
The oxidation and loss of heat-sensitive substance are effectively prevented, and does not increase the pollution of organic solvent, reduces extraction process to human body
The presence of nuisance is the pollution to environment.
(3) by vacuum concentration, chemical change will not occur in the process, reduce side effects of pharmaceutical drugs, and it is effectively
The effectively intact reservation of ingredient.
Specific embodiment
The present invention program is described in further detail below with reference to embodiment, following the description is merely to explain this hair
It is bright, its content is not defined.
Embodiment 1
A kind of Chinese herbal medicine granule treating and preventing children's cold, it is specific the preparation method is as follows:
1) it weighs: weighing honeysuckle 20kg, mulberry leaf 15kg, chrysanthemum 10kg, cape jasmine 5kg, fresh Rhizoma Imperatae 3kg, fresh Rhizoma Phragmitis respectively
30kg, hawthorn 20kg, and each raw material is ground into 80 mesh powder;
2) it extracts: each raw material is placed in the supercritical CO that temperature is 36 DEG C2It carries out extracting its extract in extraction equipment;
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 70kPa, temperature
Condition for 40 DEG C is concentrated;
4) it stirs: 1kg oligofructose, 0.3kg xylitol and 0.1kg maltodextrin is added in the material of concentrate and is placed on stirring
High-speed stirred in machine;
5) it pelletizes: the material after stirring being pelletized again;
6) dry: to be again placed in the particle pelletized 5 hours dry in the vacuum environment that temperature is 75 DEG C;
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Embodiment 2
1) it weighs: weighing honeysuckle 40kg, mulberry leaf 23kg, chrysanthemum 19kg, cape jasmine 13kg, fresh Rhizoma Imperatae 8kg, fresh Rhizoma Phragmitis respectively
45kg, hawthorn 30kg, and each raw material is ground into 50 mesh powder;
2) it extracts: each raw material is placed in the supercritical CO that temperature is 38 DEG C2It carries out extracting its extract in extraction equipment;
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 50kPa, temperature
Condition for 50 DEG C is concentrated;
4) it stirs: 5kg oligofructose, 0.9kg xylitol and 0.3kg maltodextrin is added in the material of concentrate and is placed on stirring
High-speed stirred in machine;
5) it pelletizes: the material after stirring being pelletized again;
6) dry: to be again placed in the particle pelletized 3 hours dry in the vacuum environment that temperature is 85 DEG C;
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Embodiment 3
A kind of Chinese herbal medicine granule treating and preventing children's cold, it is specific the preparation method is as follows:
1) it weighs: weighing honeysuckle 25kg, mulberry leaf 18kg, chrysanthemum 13kg, cape jasmine 7kg, fresh Rhizoma Imperatae 4kg, fresh Rhizoma Phragmitis respectively
35kg, hawthorn 22kg, and each raw material is ground into 60 mesh powder;
2) it extracts: each raw material is placed in the supercritical CO that temperature is 37 DEG C2It carries out extracting its extract in extraction equipment;
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into, uses vacuum degree for 60kPa, temperature
Condition for 45 DEG C is concentrated;
4) it stirs: 2kg oligofructose, 0.5kg xylitol and 0.2kg maltodextrin is added in the material of concentrate and is placed on stirring
High-speed stirred in machine;
5) it pelletizes: the material after stirring being pelletized again;
6) dry: to be again placed in the particle pelletized 4 hours dry in the vacuum environment that temperature is 80 DEG C;
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Embodiment 4
A kind of Chinese herbal medicine granule treating and preventing children's cold, it is specific the preparation method is as follows:
1) it weighs: weighing honeysuckle 35kg, mulberry leaf 20kg, chrysanthemum 17kg, cape jasmine 12kg, fresh Rhizoma Imperatae 7kg, fresh Rhizoma Phragmitis respectively
40kg, hawthorn 28kg, and each raw material is ground into 70 mesh powder;
2) it extracts: each raw material is placed in the supercritical CO that temperature is 37 DEG C2It carries out extracting its extract in extraction equipment;
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, after being condensed into concentrate, uses vacuum degree for 55kPa, temperature
Degree is concentrated for 43 DEG C of condition;
4) it stirs: 4kg oligofructose, 0.8kg xylitol and 0.1kg maltodextrin is added in the material of concentrate and is placed on stirring
High-speed stirred in machine;
5) it pelletizes: the material after stirring being pelletized again;
6) dry: to be again placed in the particle pelletized 4 hours dry in the vacuum environment that temperature is 80 DEG C;
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
Testing experiment: for the clinical efficacy for further investigating Chinese herbal medicine granule of the present invention, selection flu children are to the present invention
Chinese herbal medicine granule carry out clinical observation, by Chinese herbal medicine granule made from embodiment 1-4 give 120 flu children takings, every group 30
A children, an edible packet electuary, every electuary 5g daily three times after taking 3, carry out the respiratory tract of children every time
Observation, it is effective: without nasal obstruction, runny nose;It is effective: a small amount of runny nose;Invalid: cold symptoms aggravate, and control group is not edible infusion, knot
Fruit is as shown in table 1.
1 therapeutic effect of table label
Group | Number of cases | It is effective | Effectively | In vain | Gross efficiency |
Example 1 group | 30 | 25 | 5 | 0 | 100% |
2 groups of embodiment | 30 | 26 | 4 | 0 | 100% |
3 groups of embodiment | 30 | 26 | 4 | 0 | 100% |
4 groups of embodiment | 30 | 27 | 3 | 0 | 100% |
Control group | 30 | 0 | 0 | 30 | 0% |
As shown in Table 1, that takes electuary of the present invention can treat flu purpose, and can reach the mesh for the treatment of after taking 3 days
, find no abnormal conditions appearance.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.It is done within the spirit and principles of the present invention any to repair
Change, equivalent replacement, improvement etc., should be included within scope of the invention.
Claims (8)
1. it is a kind of treat and prevent children's cold Chinese herbal medicine granule, which is characterized in that including following raw material: honeysuckle, mulberry leaf,
Chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn, oligofructose, xylitol and maltodextrin.
2. the Chinese herbal medicine granule according to claim 1 for treating and preventing children's cold, which is characterized in that the gold and silver
Flower, mulberry leaf, chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn are dual-purpose of drug and food extract.
3. the Chinese herbal medicine granule according to claim 1 for treating and preventing children's cold, which is characterized in that including following heavy
Measure number raw material: 20-40 parts of honeysuckle, 15-23 parts of mulberry leaf, 10-19 parts of chrysanthemum, 5-13 parts of cape jasmine, 3-8 parts of fresh Rhizoma Imperatae, fresh
30-45 parts of reed root, 20-30 parts of hawthorn, 1-5 parts of oligofructose, 0.3-0.9 parts of xylitol and 0.1-0.3 parts of maltodextrin.
4. the Chinese herbal medicine granule according to claim 3 for treating and preventing children's cold, which is characterized in that including following heavy
Measure number raw material: 25-35 parts of honeysuckle, 18-20 parts of mulberry leaf, 13-17 parts of chrysanthemum, 7-12 parts of cape jasmine, 4-7 parts of fresh Rhizoma Imperatae, fresh
35-40 parts of reed root, 22-28 parts of hawthorn, 2-4 parts of oligofructose, 0.5-0.8 parts of xylitol and 0.2-0.3 parts of maltodextrin.
5. a kind of preparation method for the Chinese herbal medicine granule that children's cold is treated and prevented as described in claim 1-4 any one,
It is characterized in that, specific preparation process is as follows:
1) it weighs: weighing honeysuckle, mulberry leaf, chrysanthemum, cape jasmine, fresh Rhizoma Imperatae, fresh Rhizoma Phragmitis, hawthorn respectively, and each raw material is crushed
At 50-80 mesh powder;
2) it extracts: each raw material is placed in supercritical CO2It carries out extracting its extract in extraction equipment;
3) it is concentrated: the merging of each extract being placed in vacuum concentration pot, concentrate is condensed into;
4) it stirs: oligofructose, xylitol and maltodextrin is added in the material of concentrate and is placed on high-speed stirred in blender;
5) it pelletizes: the material after stirring being pelletized again;
6) dry: the particle pelletized to be placed in vacuum environment again 3-5 hours dry;
7) it packs: the particle after drying is packed into the packaging bag sterilized in advance, i.e. finished product.
6. treating and preventing the preparation method of the Chinese herbal medicine granule of children's cold according to claim 5, which is characterized in that institute
State supercritical CO2The temperature of extraction is 36-38 DEG C.
7. treating and preventing the preparation method of the Chinese herbal medicine granule of children's cold according to claim 5, which is characterized in that institute
Stating concentration uses vacuum degree for 50-70kPa, and temperature is that 40-50 DEG C of condition is concentrated.
8. treating and preventing the preparation method of the Chinese herbal medicine granule of children's cold according to claim 5, which is characterized in that institute
The temperature for the drying stated is 75-85 DEG C.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110663952A (en) * | 2019-10-29 | 2020-01-10 | 海宁纪亨保健食品有限公司 | Production process of mulberry leaf chrysanthemum crystal |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110663952A (en) * | 2019-10-29 | 2020-01-10 | 海宁纪亨保健食品有限公司 | Production process of mulberry leaf chrysanthemum crystal |
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Application publication date: 20190723 |