CN104116028B - A kind of small peptide immunity enhancement type TPF and preparation method thereof - Google Patents

A kind of small peptide immunity enhancement type TPF and preparation method thereof Download PDF

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Publication number
CN104116028B
CN104116028B CN201410351455.8A CN201410351455A CN104116028B CN 104116028 B CN104116028 B CN 104116028B CN 201410351455 A CN201410351455 A CN 201410351455A CN 104116028 B CN104116028 B CN 104116028B
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parts
extract
vitamin
tpf
cobastab
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CN104116028A (en
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刘国洪
田晓丽
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CANGZHOU ENJI BIOLOGICAL PRODUCTS Co Ltd
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CANGZHOU ENJI BIOLOGICAL PRODUCTS Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention provides a kind of small peptide immunity enhancement type TPF and preparation method thereof, described emulsion is by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water obtain by mixing method for concentration, this emulsion is by the acting in conjunction of the bioactive ingredients in high-quality protein peptide and the each food materials of integration of drinking and medicinal herbs of high-load, Synergistic, can effectively improve the immunologic function of body, for tumor patient provides nutritional support, its preparation method is simple, is applicable to the needs that large-scale industrial is produced.

Description

A kind of small peptide immunity enhancement type TPF and preparation method thereof
Technical field
The present invention relates to a kind of TPF and preparation method thereof, especially a kind of small peptide is exempted fromEpidemic disease enhancement mode TPF and preparation method thereof.
Background technology
Usually occurrence degree is not etc. in the evolution of the state of an illness for nearly 70% malignant tumor patientMalnutrition, even there is dyscrasia. Malnutrition often causes again the each system organ of human bodyHypofunction, comprises going down of immunologic function. And due to most tumors patient undergoing surgery,After radiation and chemotherapy, be subject to the impact of side effect, patient reduces nutritional labeling ability to accept, machinePoor the weakening of the effective absorbability of body.
Nutritional labeling in short peptide type enteral nutrition preparation is to seek through hydrolysis process predigestion typeSupport preparation, taking lactalbumin hydrolysate (small peptide) as main nitrogen, and be furnished with appropriate dimensionRaw element, mineral matter, can directly be absorbed by enterocyte without digest and decompose, is easy toDigesting and assimilating of tumor patient.
Small peptide immunity enhancement type clinical nutrition emulsion is a kind of emulsification system of oil-in-water type, its one-tenthDivide and comprise protein, fat, carbohydrate, mineral matter, vitamin etc. and processing technologyCapital impacts the emulsification system stability of oil-in-water type, therefore obtains stable small peptide and exempts fromEpidemic disease enhancement mode clinical nutrition emulsion will have very important social value.
Summary of the invention
Technical problem to be solved by this invention is to provide in a kind of small peptide immunity enhancement type intestinesNutrition emulsion.
Another technical problem to be solved by this invention is to provide above-mentioned immunity to strengthen short peptide typeThe preparation method of TPF.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumenPowder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, woodMelon extract, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract,Dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid aliphatic acidGlyceride and pure water composition, by its parts by weight maltodextrin 10-15 part, sepg wheyAlbumen powder 9-12 part, rapeseed oil 5-7 part, high oleic sunflower oil 2-5 part, golden jujube are carriedGet thing 2-4 part, Fructus lycii P.E 1-3 part, papaya extractives 1-2 part, kudzu root extract1-2 part, tuckahoe extracts 3-4 part, mulberries extract 0.5-1.5 part, dandelion extract 4-5Part, dietary fiber 1-3 part, mineral matter 0.2-0.8 part, vitamin 0.1-0.3 part, VBT0.05-0.08 part and taurine 0.02-0.07 part, emulsifying agent citric acid fatty glyceride0.1-0.4 part, pure water 50-80 part.
Preferably, above-mentioned small peptide immunity enhancement type TPF, by its parts by weight wheat12.8 parts, bud dextrin, 10.3 parts of sepg whey albumen powders, 6.5 parts of rapeseed oils, high oleic acid sunflower3.4 parts of seed oil, 2.47 parts of golden jujube extracts, 2.07 parts of Fructus lycii P.Es, pawpaw are carriedGet 1 part of thing, 1.5 parts of kudzu root extracts, 4 parts of tuckahoe extracts, 1 part of mulberries extract,4.5 parts of dandelion extracts, 1.5 parts of dietary fibers, 0.5 part, mineral matter, 0.2 part of vitamin,0.07 part of VBT and 0.05 part of taurine, 0.21 part of emulsifying agent citric acid fatty glyceride,60 parts of pure water.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described golden jujube extractsThe concentration of CAMP in thing (cAMP) is that every 100g is greater than 12mg.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described mineral matter be calcium,One in phosphorus, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, molybdenum, selenium, iodine, chromium,Several or all mix; Described vitamin is vitamin A, vitamin D, vitamin E, dimensionRaw plain K1, Cobastab1, Cobastab2, Cobastab6, Cobastab12, nicotinic acid, folic acid,One in choline, biotin, several or all mixing.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described mineral matter is heavy for pressing400 parts of amount umber meter calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, iron8.5 parts, the mixture of 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described vitamin is heavy for pressing480 parts of amount umber meter vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitaminK155 parts, Cobastab1350 parts, Cobastab2850 parts, Cobastab6480 parts, dimensionRaw plain B121.7 parts, 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotinsMixture.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, concrete preparation process asUnder:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract,Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract,Dandelion extract in major ingredient cylinder with 45-55 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively littleExpect in cylinder with 45-55 DEG C of pure water stirring and dissolving;
Oil plant: rapeseed oil, high oleic sunflower oil are added to emulsification in carburetion cylinder by formula ratioAgent citric acid fatty glyceride dissolves;
(2) pasteurize
5-10min sterilization at 80-125 DEG C in pasteurization machine after major ingredient is mixed with small powder,Kill pathogenic bacteria and most of microorganism, be cooled to 40-45 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 60-70 DEG C is mixed with oil plant, is 10-20MPa at homogenizer pressureHomogeneous under condition; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and is dissolved, add in the material after homogeneous,Mixture is warming up to concentration and evaporation under 60-80 DEG C of condition;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is EAT 150-170 DEG C,Logistics flow velocity is 1.25-1.40L/h, to obtain final product.
The invention has the beneficial effects as follows:
Above-mentioned small peptide immunity enhancement type TPF, the high-quality protein peptide by high-load withAnd the acting in conjunction of bioactive ingredients in the each food materials of integration of drinking and medicinal herbs, Synergistic, can be effectiveImprove the immunologic function of body, for tumor patient provides nutritional support; Its preparation method is simple,Be applicable to the needs that large-scale industrial is produced.
Brief description of the drawings
Fig. 1 is nutrition biochemical indicator level view;
Fig. 2 is immunizing antigen index level figure.
Detailed description of the invention
Embodiment 1
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumenPowder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, woodMelon extract, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract,Dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid aliphatic acidGlyceride and pure water composition, wherein, maltodextrin 12.8kg, sepg whey albumen powder 10.3kg,Rapeseed oil 6.5kg, high oleic sunflower oil 3.4kg, golden jujube extract 2.47kg, matrimony vineSeed extract 2.07kg, papaya extractives 1kg, kudzu root extract 1.5kg, tuckahoe extracts 4kg,Mulberries extract 1kg, dandelion extract 4.5kg, dietary fiber 1.5kg, mineral matter 0.5kg,Vitamin 0.2kg, VBT 0.07kg and taurine 0.05kg, emulsifying agent citric acid aliphatic acid are sweetGrease 0.21kg, pure water 60kg; Described mineral matter is for counting by weight 400 parts of calcium, phosphorus250 parts, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, copper 450The mixture of part, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine, described vitamin is for by weight480 parts of vitamin As of number meter, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K155Part, Cobastab1350 parts, Cobastab2850 parts, Cobastab6480 parts, vitaminB121.7 parts, 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins mixedCompound.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, concrete preparation process asUnder:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract,Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract,Dandelion extract in major ingredient cylinder with 50 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively littleExpect in cylinder with 50 DEG C of pure water stirring and dissolving;
Oil plant: rapeseed oil, high oleic sunflower oil are added to emulsification in carburetion cylinder by formula ratioAgent citric acid fatty glyceride dissolves;
(2) pasteurize
After major ingredient is mixed with small powder, 8min sterilization at 115 DEG C in pasteurization machine, kills diseaseFormer bacterium and most of microorganism, be cooled to 42 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 65 DEG C is mixed with oil plant, is 17MPa condition at homogenizer pressureLower homogeneous; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and is dissolved, add in the material after homogeneous,Mixture is warming up to concentration and evaporation under 75 DEG C of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 165 DEG C of EATs, logisticsFlow velocity is 1.35L/h, to obtain final product;
(6) filling
Heavy metal sampling inspection after powder is sieved, carries out storing after sterile filling, sealed cans, packagingHide.
Embodiment 2
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumenPowder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, woodMelon extract, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract,Dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid aliphatic acidGlyceride and pure water composition, wherein, maltodextrin 15kg, sepg whey albumen powder 9kg,Rapeseed oil 7kg, high oleic sunflower oil 5kg, golden jujube extract 2kg, the fruit of Chinese wolfberry extractThing 3kg, papaya extractives 1kg, kudzu root extract 1kg, tuckahoe extracts 4kg, mulberries are carriedGet thing 1.5kg, dandelion extract 4kg, dietary fiber 1kg, mineral matter 0.8kg, vitamin0.3kg, VBT 0.05kg and taurine 0.02kg, emulsifying agent citric acid fatty glyceride0.1kg, pure water 50kg; Described mineral matter for count by weight 400 parts of calcium, 250 parts, phosphorus,600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, manganese17 parts, the mixture of 15 parts, selenium, 45 parts of iodine, described vitamin is supported one's family for meter by weightElement A480 part, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K155 parts, support one's familyElement B1350 parts, Cobastab6480 parts, Cobastab121.7 parts, 180 parts, folic acid, biologyThe mixture that element is 18 parts.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, concrete preparation process asUnder:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract,Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract,Dandelion extract in major ingredient cylinder with 55 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively littleExpect in cylinder with 45 DEG C of pure water stirring and dissolving;
Oil plant: rapeseed oil, high oleic sunflower oil are added to emulsification in carburetion cylinder by formula ratioAgent citric acid fatty glyceride dissolves;
(2) pasteurize
After major ingredient is mixed with small powder, 5min sterilization at 125 DEG C in pasteurization machine, kills diseaseFormer bacterium and most of microorganism, be cooled to 45 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 70 DEG C is mixed with oil plant, is 10MPa condition at homogenizer pressureLower homogeneous; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and is dissolved, add in the material after homogeneous,Mixture is warming up to concentration and evaporation under 60 DEG C of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 170 DEG C of EATs, logisticsFlow velocity is 1.40L/h, to obtain final product.
Embodiment 3
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumenPowder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, woodMelon extract, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract,Dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid aliphatic acidGlyceride and pure water composition, wherein, maltodextrin 10kg, sepg whey albumen powder 12kg,Rapeseed oil 5kg, high oleic sunflower oil 2kg, golden jujube extract 4kg, the fruit of Chinese wolfberry extractThing 1kg, papaya extractives 2kg, kudzu root extract 2kg, tuckahoe extracts 3kg, mulberries are carriedGet thing 0.5kg, dandelion extract 5kg, dietary fiber 3kg, mineral matter 0.2kg, vitamin0.1kg, VBT 0.08kg and taurine 0.07kg, emulsifying agent citric acid fatty glyceride0.4kg, pure water 80kg; Described mineral matter for count by weight 380 parts of calcium, 240 parts, phosphorus,630 parts, potassium, 255 parts, sodium, 430 parts of chlorine, 9.5 parts of iron, 6.0 parts, zinc, 453 parts of copper, manganese19 parts, the mixture of 18 parts, selenium, 47 parts of iodine, described vitamin is supported one's family for meter by weightElement A480 part, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K155 parts, support one's familyElement B1350 parts, Cobastab2850 parts, Cobastab6480 parts, Cobastab121.7 parts,The mixture of 320 parts, nicotinic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, concrete preparation process asUnder:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract,Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract,Dandelion extract in major ingredient cylinder with 45 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively littleExpect in cylinder with 55 DEG C of pure water stirring and dissolving;
Oil plant: rapeseed oil, high oleic sunflower oil are added to emulsification in carburetion cylinder by formula ratioAgent citric acid fatty glyceride dissolves;
(2) pasteurize
After major ingredient is mixed with small powder, 10min sterilization at 80 DEG C in pasteurization machine, kills diseaseFormer bacterium and most of microorganism, be cooled to 40 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 60-70 DEG C is mixed with oil plant, is 20MPa bar at homogenizer pressureHomogeneous under part; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and is dissolved, add in the material after homogeneous,Mixture is warming up to concentration and evaporation under 80 DEG C of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 150 DEG C of EATs, logisticsFlow velocity is 1.25L/h, to obtain final product;
(6) filling
Heavy metal sampling inspection after powder is sieved, carries out storing after sterile filling, sealed cans, packagingHide.
Embodiment 4
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumenPowder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, woodMelon extract, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract,Dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid aliphatic acidGlyceride and pure water composition, wherein, maltodextrin 12kg, sepg whey albumen powder 11kg,Rapeseed oil 5.5kg, high oleic sunflower oil 4kg, golden jujube extract 2.5kg, the fruit of Chinese wolfberryExtract 1.5kg, papaya extractives 2kg, kudzu root extract 1.5kg, tuckahoe extracts 3kg,Mulberries extract 1.0kg, dandelion extract 5kg, dietary fiber 2kg, mineral matter 0.5kg,Vitamin 0.2kg, VBT 0.06kg and taurine 0.05kg, emulsifying agent citric acid aliphatic acid are sweetGrease 0.3kg, pure water 70kg; Described mineral matter is for counting by weight 400 parts of calcium, phosphorus250 parts, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, copper 450The mixture of part, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine, described vitamin is for by weight480 parts of vitamin As of number meter, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K155Part, Cobastab1350 parts, Cobastab2850 parts, Cobastab6480 parts, vitaminB121.7 parts, 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins mixedCompound.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, concrete preparation process asUnder:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract,Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract,Dandelion extract in major ingredient cylinder with 47 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively littleExpect in cylinder with 47 DEG C of pure water stirring and dissolving;
Oil plant: rapeseed oil, high oleic sunflower oil are added to emulsification in carburetion cylinder by formula ratioAgent citric acid fatty glyceride dissolves;
(2) pasteurize
After major ingredient is mixed with small powder, 8min sterilization at 100 DEG C in pasteurization machine, kills diseaseFormer bacterium and most of microorganism, be cooled to 42 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 65 DEG C is mixed with oil plant, is 15MPa condition at homogenizer pressureLower homogeneous; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and is dissolved, add in the material after homogeneous,Mixture is warming up to concentration and evaporation under 70 DEG C of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 155 DEG C of EATs, logisticsFlow velocity is 1.30L/h, to obtain final product.
Embodiment 5
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumenPowder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, woodMelon extract, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract,Dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid aliphatic acidGlyceride and pure water composition, wherein, maltodextrin 11kg, sepg whey albumen powder 11kg,Rapeseed oil 6kg, high oleic sunflower oil 3kg, golden jujube extract 3kg, the fruit of Chinese wolfberry extractThing 2kg, papaya extractives 2kg, kudzu root extract 2kg, tuckahoe extracts 3.5kg, mulberriesExtract 0.5kg, dandelion extract 5kg, dietary fiber 2kg, mineral matter 0.7kg, support one's familyElement 0.1kg, VBT 0.07kg and taurine 0.04kg, emulsifying agent citric acid fatty glyceride0.4kg, pure water 65kg; Described mineral matter for count by weight 400 parts of calcium, 250 parts, phosphorus,600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, manganese17 parts, the mixture of 15 parts, selenium, 45 parts of iodine, described vitamin is supported one's family for meter by weightElement A480 part, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K155 parts, support one's familyElement B1350 parts, Cobastab2850 parts, Cobastab6480 parts, Cobastab121.7 parts,The mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, concrete preparation process asUnder:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract,Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract,Dandelion extract in major ingredient cylinder with 50 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively littleExpect in cylinder with 50 DEG C of pure water stirring and dissolving;
Oil plant: rapeseed oil, high oleic sunflower oil are added to emulsification in carburetion cylinder by formula ratioAgent citric acid fatty glyceride dissolves;
(2) pasteurize
After major ingredient is mixed with small powder, 10min sterilization at 110 DEG C in pasteurization machine, killsPathogen and most of microorganism, be cooled to 45 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 65 DEG C is mixed with oil plant, is 20MPa condition at homogenizer pressureLower homogeneous; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and is dissolved, add in the material after homogeneous,Mixture is warming up to concentration and evaporation under 75 DEG C of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 165 DEG C of EATs, logisticsFlow velocity is 1.30L/h, to obtain final product;
(6) filling
Heavy metal sampling inspection after powder is sieved, carries out storing after sterile filling, sealed cans, packagingHide.
In above-described embodiment 1-5, each component is commercially available prod, and wherein, described golden jujube is carriedGet thing (concentration of its CAMP is that every 100g is greater than 12mg), Fructus lycii P.E,Papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extractBe the extract that water-bath extraction obtains.
Prescription analysis:
Golden jujube extract contains extremely abundant nutritional labeling, and exists multiple biological livingProperty composition, comprises polysaccharide, phenols, saponin(e, CAMP (cAMP), alkaloid, perfume (or spice)Essential oils etc., have the immunologic function of enhancing, anti-oxidant, anti-inflammatory, improve stomach environment and protectionThe effects such as liver; The LBP-X of Fructus lycii P.E have the humoral immunity, cellular immunity of enhancing,Promote expression and the signal conduction of cell factor, improve animal cell immunity power, suppress cause of disease senseThe effect of dying; Papaya extractives has the effect of good inhibition tumour; Kudzu root extract hasWell antiinflammatory action, can improve cytophagous picked-up ability simultaneously, strengthens immunity of organismPower, has two-way immunoregulation effect; Tuckahoe extracts have eliminating dampness and diuresis, the peaceful heart of invigorating the spleen itEffect, the Multiple components such as Poria cocos triterpene, pachymaran have regulate immunologic function, suppress tumour,Many-sided pharmacological action such as anti-inflammatory; Anti-oxidant, anti-inflammatory, antitumor that mulberries extract hasDeng biological effect; Dandelion extract nutritive value is abundant, is rich in various vitamin and mineralMatter, the various active compositions such as its polysaccharide containing, flavones, organic acid, triterpene, phytosterolAll there is the effect of antitumor raising immunity; Sepg whey albumen powder is that main nitrogen is Gao ShengThe sepg whey albumen of thing activity, has the characteristics such as anti-oxidant, antiviral, and without digestion pointSolution can be absorbed by enterocyte; Each component Synergistic, exempts from enhancing patient selfEpidemic disease power aspect is remarkably productive, especially can improve tumor patient immunity, nutritional support is provided,Be embodied in following test experiments:
Test case:
40 routine patients with gastric cancer are divided into two groups at random, and grouping situation is in table 1. Postoperative the 1st, 2 daysGive conventional parenteral nutrition support, within postoperative 48 hours, start EA support. Experimental group shouldWith small peptide immunity enhancement type TPF described in embodiment 1, in the conventional intestines of the control groupNutrition emulsion. All patient's feeder pathways are through jejunostomy tube. Using dosage is 500g/ days,Continue to feed 7 days. Deng heat, etc. the nutritional support of nitrogen amount, postoperative input 20% human serum albuminParenteral solution, is 50ml/ days.
Table 1 experimenter ordinary circumstance
Subject age, sex, neoplasm staging are all without significant difference (P > 0.05).
Statistical method: each variable withRepresent. Adopt t inspection, P value is less than or equal to 0.05There is statistical significance by being considered to checked difference.
1, nutrition biochemical indicator: the white egg of serum (ALB), prealbumin (PAB), turn iron egg(TF) in vain. Record first day, the dynamic change of postoperative the 10th day after surgery of each monitoring index.As shown in Figure 1, compared with before nutritional support, * P < 0.05; Compared with control group, P < 0.05.
2, immunizing antigen index: radio-immunity typing monitoring Immunoglobulin IgM, IgA,IgG, records the dynamic change of the 1st day after surgery, postoperative the 10th day of each monitoring index. As figureShown in 2, compared with before nutritional support, * P < 0.05; Compared with control group,ΔP<0.05。
3, postoperative patient infects complication situation
Whether the infection of postoperative patient has much relations with nutrition, immune state, the results are shown in Table 2.The first, protein, energy shortage can produce harmful effect. The healing of post-surgical trauma, needs intoFibrocyte utilizes amino acid to synthesize collagen, nutrition supply deficiency, spy be protein,, easily there is wound healing and postpone or infect in shortage of heat. The second, the decline of immunologic function isCause one of reason of infection. The existence of postoperative immunosuppression, has weakened immunologic function, unfavorableIn postoperative anti-infective. Small peptide immunity enhancement type TPF of the present invention can provide height to containThe nutrient of amount, high absorption rate, recovers postoperative function of intestinal canal early, reduces wound senseDye the occurrence probability with other infection.
The situation of table 2 POI complication
4, the reaction in enteral Nutrition Support for Postoperative nursing process, the results are shown in Table 3.
Clinical effectiveness shows, adopts short peptide type TPF experimental group experimenter intestines and stomach resistance toBeing subject to property, apparently higher than control group, has a good application prospect.
Reaction in table 3 EA nursing process
Above-mentioned with reference to embodiment to this one small peptide immunity enhancement type TPF and system thereofThe detailed description that Preparation Method carries out, is illustrative instead of determinate, can according to limitScope lists several embodiment, therefore do not depart from variation under general plotting of the present invention andAmendment, within should belonging to protection scope of the present invention.

Claims (7)

1. a small peptide immunity enhancement type TPF, is characterized in that: by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water composition, by its parts by weight maltodextrin 10-15 part, sepg whey albumen powder 9-12 part, rapeseed oil 5-7 part, high oleic sunflower oil 2-5 part, golden jujube extract 2-4 part, Fructus lycii P.E 1-3 part, papaya extractives 1-2 part, kudzu root extract 1-2 part, tuckahoe extracts 3-4 part, mulberries extract 0.5-1.5 part, dandelion extract 4-5 part, dietary fiber 1-3 part, mineral matter 0.2-0.8 part, vitamin 0.1-0.3 part, VBT 0.05-0.08 part and taurine 0.02-0.07 part, emulsifying agent citric acid fatty glyceride 0.1-0.4 part, pure water 50-80 part.
2. small peptide immunity enhancement type TPF according to claim 1, it is characterized in that: by 12.8 parts of its parts by weight maltodextrins, 10.3 parts of sepg whey albumen powders, 6.5 parts of rapeseed oils, 3.4 parts of high oleic sunflower oils, 2.47 parts of golden jujube extracts, 2.07 parts of Fructus lycii P.Es, 1 part of papaya extractives, 1.5 parts of kudzu root extracts, 4 parts of tuckahoe extracts, 1 part of mulberries extract, 4.5 parts of dandelion extracts, 1.5 parts of dietary fibers, 0.5 part, mineral matter, 0.2 part of vitamin, 0.05 part of 0.07 part of VBT and taurine, 0.21 part of emulsifying agent citric acid fatty glyceride, 60 parts of pure water.
3. small peptide immunity enhancement type TPF according to claim 2, is characterized in that: in described golden jujube extract, the concentration of CAMP is that every 100g is greater than 12mg.
4. small peptide immunity enhancement type TPF according to claim 1 and 2, is characterized in that: described mineral matter is the one in calcium, phosphorus, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, molybdenum, selenium, iodine, chromium, several or all mixing; Described vitamin is vitamin A, vitamin D, vitamin E, vitamin K1, Cobastab1, Cobastab2, Cobastab6, Cobastab12, one in nicotinic acid, folic acid, choline, biotin, several or all mix.
5. small peptide immunity enhancement type TPF according to claim 4, is characterized in that: described mineral matter is the mixture of counting by weight 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine.
6. small peptide immunity enhancement type TPF according to claim 4, is characterized in that: described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K155 parts, Cobastab1350 parts, Cobastab2850 parts, Cobastab6480 parts, Cobastab121.7 parts, the mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
7. the preparation method of small peptide immunity enhancement type TPF claimed in claim 1, is characterized in that: concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 45-55 DEG C of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 45-55 DEG C of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
5-10min sterilization at 80-125 DEG C in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 40-45 DEG C immediately;
(3) homogeneous
The raw material that is preheated to 60-70 DEG C is mixed with oil plant, is homogeneous under 10-20MPa condition at homogenizer pressure; Cool to 10 DEG C of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 60-80 DEG C of condition;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is EAT 150-170 DEG C, and logistics flow velocity is 1.25-1.40L/h, to obtain final product.
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