CN103005467B - Liver-protecting nutritional composition and liver-protecting nutritional food therefrom - Google Patents

Liver-protecting nutritional composition and liver-protecting nutritional food therefrom Download PDF

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CN103005467B
CN103005467B CN201310024664.7A CN201310024664A CN103005467B CN 103005467 B CN103005467 B CN 103005467B CN 201310024664 A CN201310024664 A CN 201310024664A CN 103005467 B CN103005467 B CN 103005467B
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liver
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ultramicro
powder
powders
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CN103005467A (en
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易龙
糜漫天
王建
朱俊东
陈春烨
常微
唐勇
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Third Military Medical University TMMU
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Abstract

The invention discloses liver-protecting nutritional composition which comprises, by weight, 18-22 parts of pawpaw superfine powder, 8-12 parts of giant knot weed superfine powder, 8-12 parts of jujube superfine powder, 7-12 parts of hawthorn superfine power, 5-15 parts of tuchahoe powder, and 3-8 parts of Tengcha superfine powder. Formulation of the liver-protecting nutritional composition is reasonable. As being made of superfine powders, the liver-protecting nutritional composition has greatly reserved biological activity. Human bioavailability is improved. Since the liver-protecting nutritional composition is utilized for preparing the liver-protecting national food, hepatocyte function of patients with liver disease can be conditioned effectively, catabolism of fat granule is improved, liver microenvironment is improved remarkably, necrotic tissue regeneration is improved, catabolism load of the liver is released, and rehabilitation is improved after the patients with liver diseases eat the liver-protecting national food.

Description

A kind ofly protect the liver alimentation composition and protect the liver nutraceutical
Technical field
The present invention relates to field of food, particularly a kind of alimentation composition that protects the liver, also relates to and contains the nutraceutical that protects the liver that protects the liver alimentation composition.
Background technology
Most of fatty livers, cirrhosis and serious hepatitis patient must give suitable nutrition treatment in drug therapy clinically, to regulate liver metabolism, alleviate liver load, improve liver microenvironment, to promote prognosis of disease.But it is supplementary that clinical conventional nutritional preparation product only considers to give the conventional nutrient of patient at present, meets body basic nutrition needs, and there is no to consider that the mode by nutrition treatment regulates hepatocyte function, promotes disease recovery.Studies confirm that, nutrition treatment plays a crucial role in various diseases treatment and promotion prognosis of disease.
The conventional hepatopathy nutritional preparation of existing market is as the branched-amino acid type enteral nutrition preparation of vertical suitable Kanggong department, and its main component is branched-chain amino acid, collagen hydrolysate, dietary fiber and micronutrient thereof etc.This product can supplement human body basic nutritional need, and performance branched-chain amino acid alleviate the effect of liver metabolism load, there is certain nutrition treatment effect.The composition of other hepatopathy nutraceutical is also comparatively similar both at home and abroad.But these protect the liver nutraceutical and all can not regulate hepatocyte function, to advancing of disease with lapse to and can not play certain containment effect.In addition, the enteral nutrition preparation in Chinese market more than 90% is foreign brand name at present, and independent brand product is very few, and particularly the independent brand of hepatopathy nutraceutical is almost blank.On the contrary, the long traditional medicine of China has confirmed that by a large amount of practices some natural plants have definite liver protecting effect already, therefore adopt advanced food processing technology, extract wherein effective function factor, develop the novel nutraceutical that protects the liver with Chinese characteristics and will there is important application prospect.
Summary of the invention
One of object of the present invention is to provide a kind of alimentation composition that protects the liver, and rationally, raw material is easy to get its formula, and each raw material is Ultramicro-powder, has at utmost retained BA, can improve the bioavilability of human body.
For achieving the above object, technical scheme is:
An alimentation composition, comprises following component by weight:
Pawpaw Ultramicro-powder 18-22 part;
Giant knotweed Ultramicro-powder 8-12 part;
Date Ultramicro-powder 8-12 part;
Hawthorn Ultramicro-powder 7-12 part;
Poria cocos powder 5-15 part;
Vine tea Ultramicro-powder 3-8 part.
Preferably, comprise by weight following component:
20 parts of pawpaw Ultramicro-powders;
10 parts of giant knotweed Ultramicro-powders;
10 parts of date Ultramicro-powders;
10 parts of hawthorn Ultramicro-powders;
10 parts of Poria cocos powders;
5 parts of vine tea Ultramicro-powders.
Preferably, also comprise by weight following component:
Valine 1.5-2.5 part;
L-Leu 1.5-2.5 part;
ILE 1.5-2.5 part;
Water-soluble dietary fiber 4-8 part.
Preferred, also comprise by weight following component:
2.1 parts of Valines;
2.7 parts of L-Leus;
1.7 parts of ILEs;
6 parts of water-soluble dietary fibers.
Preferred, comprise by weight following component: 20 parts of pawpaw Ultramicro-powders, 10 parts, 10 parts of giant knotweed Ultramicro-powders, 10 parts of date Ultramicro-powders, 10 parts of hawthorn Ultramicro-powders, 10 parts of Poria cocos powders, 5 parts of vine tea Ultramicro-powders, 2.1 parts of Valines, 2.7 parts of L-Leus, 1.7 parts of ILEs, 6 parts of water-soluble dietary fibers, 1.5 parts of L-arginines, 0.7 part of Pidolidone, 0.7 part of L-ASPARTIC ACID, 3 parts, Fructus Hordei Germinatus and carbohydrate.
In the present invention, the particle diameter of pawpaw Ultramicro-powder, giant knotweed Ultramicro-powder, date Ultramicro-powder, hawthorn Ultramicro-powder and vine tea Ultramicro-powder is 2-3 micron.
Two of object of the present invention is to provide and contains the nutraceutical that protects the liver that protects the liver alimentation composition, and technical scheme is:
Described in containing, protect the liver the nutraceutical that protects the liver of alimentation composition.
Beneficial effect of the present invention: the alimentation composition that protects the liver disclosed by the invention, the Ultramicro-powder of pawpaw, giant knotweed, date, hawthorn and vine tea of the natural plants with remarkable liver protection function of take is raw material, contains multiple phytochemical hepatocyte function to effective regulating action in composition; Ultramicro-powder adopts air-flow superfine communication technique, is conducive to absorption of human body and biological utilisation after ultramicro grinding, and biological effectiveness is remarkable; In composition, add natural plant extracts Poria cocos powder simultaneously, in Poria cocos, contained pachymaran, a series of triterpene compound, more than 20 kind trace elements, had obvious enhancing human immunological competence, antitumor and liver-protecting efficacy.Protect the liver the nutrition treatment that alimentation composition can be used for fatty liver, cirrhosis and patients with severe hepatitis in various degree, performance liver protecting effect, because the product composition in composition is all from natural food or medicine-food two-purpose natural plants, without drug ingedient, therefore long-term edible without any side effects.In the present invention, the preparation of Ultramicro-powder utilizes the technique that the air-flow crushing machinery of flash distillation and many times of velocities of sound (over 3.08 Mach) combines, to after flash-evaporation dehydration, pulverize as particle, fully make plant cell wall breaking, nutritive effect composition wherein can freely discharge at human body alimentary canal, do not need through traditional making beating filter residue or enzymolysis and extraction juice, keep original nutritional labeling and functional components, and all dietary fibers of fruit and the refining losses of antioxidant content minimum degree have been retained, this technique can reduce the particle diameter of Ultramicro-powder greatly, and minimum grain size reaches 2 microns; In addition, Ultramicro-powder prepared by this technique is different from traditional extraction drying powder of spraying, and process procedure is few, little to antioxidant composition heat loss, retains whole active matter components, active high, need not add any processing aid.
The specific embodiment
In order to make the object, technical solutions and advantages of the present invention clearer, below the preferred embodiments of the present invention are described in detail.
Raw material is processed:
The preparation of pawpaw Ultramicro-powder: pawpaw is made to pulp with beater, fast flash distillation to water content lower than 8%, then be crushed to the granularity of particle for being less than 3mm, again pawpaw particle is pulverized by airslide disintegrating mill under lower than-140 ℃ of conditions in temperature, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, be crushed to granularity for being less than 3 microns, obtain pawpaw Ultramicro-powder.
The preparation of giant knotweed Ultramicro-powder: by giant knotweed beater homogenate, fast flash distillation to water content lower than 8%, then be crushed to the granularity of particle for being less than 3mm, again giant knotweed particle is pulverized by airslide disintegrating mill under lower than-140 ℃ of conditions in temperature, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, be crushed to granularity for being less than 3 microns, obtain giant knotweed Ultramicro-powder.
The preparation of date Ultramicro-powder: will make pulp with beater after Removing Kernel for Date, fast flash distillation to water content lower than 8%, then be crushed to the granularity of particle for being less than 3mm, again large jujube granule is pulverized by airslide disintegrating mill under lower than-140 ℃ of conditions in temperature, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, be crushed to granularity for being less than 3 microns, obtain date Ultramicro-powder.
The preparation of hawthorn Ultramicro-powder: will make pulp with beater after hawthorn stoning, flash distillation, to water content lower than 8%, is then crushed to the granularity of particle for being less than 3mm fast; Haw thorn granule is pulverized by airslide disintegrating mill under lower than-140 ℃ of conditions in temperature, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, is crushed to granularity for being less than 3 microns, obtains hawthorn Ultramicro-powder again.
The preparation of vine tea Ultramicro-powder: by vine tea beater homogenate, flash distillation, to water content lower than 8%, is then crushed to the granularity of particle for being less than 3mm fast; Vine tea particle is pulverized by airslide disintegrating mill under lower than-140 ℃ of conditions in temperature, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, is crushed to granularity for being less than 3 microns, obtains vine tea Ultramicro-powder again.
In the present invention, except using above-mentioned method to prepare Ultramicro-powder, can, with the additive method of preparing Ultramicro-powder, as long as meet granularity, be also that 2-3 micron all can be realized goal of the invention.
embodiment 1
An alimentation composition, comprises by weight:
20 parts of pawpaw Ultramicro-powders;
10 parts of giant knotweed Ultramicro-powders;
10 parts of date Ultramicro-powders;
10 parts of hawthorn Ultramicro-powders;
10 parts of Poria cocos powders;
5 parts of vine tea Ultramicro-powders.
Said components is mixed in proportion, and to add general food filler ad pond om be 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contains pawpaw Ultramicro-powder 2g, giant knotweed Ultramicro-powder 1g, date Ultramicro-powder 1g, hawthorn Ultramicro-powder 1g, Poria cocos powder 1g and vine tea Ultramicro-powder 0.5g.
embodiment 2
An alimentation composition, comprises by weight:
18 parts of pawpaw Ultramicro-powders;
8 parts of giant knotweed Ultramicro-powders;
12 parts of date Ultramicro-powders;
7 parts of hawthorn Ultramicro-powders;
5 parts of Poria cocos powders;
3 parts of vine tea Ultramicro-powders.
Said components is mixed in proportion, and to add general food filler ad pond om be 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contains pawpaw Ultramicro-powder 1.8g, giant knotweed Ultramicro-powder 0.8g, date Ultramicro-powder 1.2g, hawthorn Ultramicro-powder 0.7g, Poria cocos powder 0.5g and vine tea Ultramicro-powder 0.3g.
embodiment 3
An alimentation composition, comprises by weight:
22 parts of pawpaw Ultramicro-powders;
12 parts of giant knotweed Ultramicro-powders;
12 parts of date Ultramicro-powders;
7 parts of hawthorn Ultramicro-powders;
5 parts of Poria cocos powders;
8 parts of vine tea Ultramicro-powders.
Said components is mixed in proportion, and to add general food filler ad pond om be 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contains pawpaw Ultramicro-powder 2.2g, giant knotweed Ultramicro-powder 1.2g, date Ultramicro-powder 1.2g, hawthorn Ultramicro-powder 0.7g, Poria cocos powder 0.5g and vine tea Ultramicro-powder 0.8g.
embodiment 4
An alimentation composition, comprises by weight:
20 parts of pawpaw Ultramicro-powders;
10 parts of giant knotweed Ultramicro-powders;
10 parts of date Ultramicro-powders;
10 parts of hawthorn Ultramicro-powders;
15 parts of Poria cocos powders;
5 parts of vine tea Ultramicro-powders;
2.1 parts of Valines;
2.7 parts of L-Leus;
1.7 parts of ILEs;
6 parts of water-soluble dietary fibers.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contains pawpaw Ultramicro-powder 2g, giant knotweed Ultramicro-powder 1g, date Ultramicro-powder 1g, hawthorn Ultramicro-powder 1g, Poria cocos powder 1.5g, vine tea Ultramicro-powder 0.5g, Valine 210mg, L-Leu 270mg, ILE 170mg and water-soluble dietary fiber 600mg.
embodiment 5
An alimentation composition, comprises by weight:
22 parts of pawpaw Ultramicro-powders;
8 parts of giant knotweed Ultramicro-powders;
12 parts of date Ultramicro-powders;
7 parts of hawthorn Ultramicro-powders;
5 parts of Poria cocos powders;
3 parts of vine tea Ultramicro-powders;
1.5 parts of Valines;
2.0 parts of L-Leus;
1.5 parts of ILEs;
4 parts of water-soluble dietary fibers.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contain pawpaw Ultramicro-powder 2.2g, giant knotweed Ultramicro-powder 0.8g, date Ultramicro-powder 1.2g, hawthorn Ultramicro-powder 0.7g, Poria cocos powder 0.5g, vine tea Ultramicro-powder 0.3g, Valine 150mg, L-Leu 200mg, ILE 150mg and water-soluble dietary fiber 400mg.
embodiment 6
An alimentation composition, comprises by weight:
22 parts of pawpaw Ultramicro-powders;
12 parts of giant knotweed Ultramicro-powders;
12 parts of date Ultramicro-powders;
12 parts of hawthorn Ultramicro-powders;
5 parts of Poria cocos powders;
3 parts of vine tea Ultramicro-powders;
2.5 parts of Valines;
3.0 parts of L-Leus;
2.5 parts of ILEs;
8 parts of water-soluble dietary fibers.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contains pawpaw Ultramicro-powder 2.2g, giant knotweed Ultramicro-powder 1.2g, date Ultramicro-powder 1.2g, hawthorn Ultramicro-powder 1.2g, Poria cocos powder 0.5g, vine tea Ultramicro-powder 0.3g, Valine 250mg, L-Leu 300mg, ILE 250mg and water-soluble dietary fiber 800mg
embodiment 7
An alimentation composition, comprises by weight:
20 parts of pawpaw Ultramicro-powders, 10 parts, 10 parts of giant knotweed Ultramicro-powders, 10 parts of date Ultramicro-powders, 10 parts of hawthorn Ultramicro-powders, 10 parts of Poria cocos powders, 5 parts of vine tea Ultramicro-powders, 2.1 parts of Valines, 2.7 parts of L-Leus, 1.7 parts of ILEs, 6 parts of water-soluble dietary fibers, 1.5 parts of L-arginines, 0.7 part of Pidolidone, 0.7 part of L-ASPARTIC ACID, 3 parts, Fructus Hordei Germinatus and carbohydrate.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, must protect the liver nutraceutical.The every 10g of gained protects the liver in nutraceutical, contains pawpaw Ultramicro-powder 2g, giant knotweed Ultramicro-powder 1g, date Ultramicro-powder 1g, hawthorn Ultramicro-powder 1g, Poria cocos powder 1g, vine tea Ultramicro-powder 0.5g, Valine 210mg, L-Leu 270mg, ILE 170mg, water-soluble dietary fiber 600mg, L-arginine 150mg, Pidolidone 70mg, L-ASPARTIC ACID 70mg, Fructus Hordei Germinatus 300mg and carbohydrate 1g.
embodiment 8
A kind of alimentation composition that protects the liver, in 10g composition, contain pawpaw Ultramicro-powder 2g, giant knotweed Ultramicro-powder 1g, date Ultramicro-powder 1g, hawthorn Ultramicro-powder 1g, Poria cocos powder 1g, vine tea Ultramicro-powder 0.5g, Valine 210mg, L-Leu 270mg, ILE 170mg, water-soluble dietary fiber 600mg, L-arginine 150mg, Pidolidone 70mg, L-ASPARTIC ACID 70mg, Fructus Hordei Germinatus 300mg, carbohydrate 1g, vitamin B1 40 μ g, vitamin B2 40 μ g, pyridoxamine 30 μ g, vitamin C 700 μ g, pantothenic acid 100 μ g, nicotinic acid 150 μ g, biotin 2.5 μ g, sodium 4.5 mg, potassium 1.6 mg, calcium 7 mg, phosphorus 8 mg, chlorine 24 mg, iron 0.13 mg and zinc 0.5 mg, surplus is conventional food filler.
In the present invention, conventional food filler can be starch, and animal protein or vegetable protein can be also antioxidant conventional in food or fumet.
The pawpaw protecting the liver in alimentation composition of embodiment 1-3 contains pawpaw polyphenol, oleanolic acid, organic acid and flavone compound, be called as " hundred benefits are fruit ", " emperor of fruit ", " ten thousand longevity melons ", have the effect of reinforcing spleen to promote digestion, anti-epidemic disease desinsection, removing heat to expel wind, liver protecting.In date, be rich in jujube polysaccharide, jujube CAMP, jujube triterpenic acid, dietary fiber, can improve liver metabolism and digestive function, enhance strong immunity, improve endocrine, antifatigue, Traditional Chinese medical theory thinks that date can tonifying middle-Jiao and Qi, nourishing blood and tranquilization, few for insufficiency of the spleen food, weak loose stool.Hawthorn active component mainly comprises flavanols, daucosterol, ursolic acid, cupreol and dietary fiber, tool be significantly improved intestines and stomach, protect the liver, anti-oxidant, antitumor and cardiovascular protection effect.Giant knotweed is as important Chinese medicine food materials; contain abundant polyphenolic plant chemicals-resveratrol; resveratrol has multiple significant biological effectiveness; comprise antitumor, cardiovascular protection, anti-ageing, balance the body substance metabolism functions; multiplely take dietary supplements or the nutraceutical that resveratrol is main component and go on the market in the U.S., its nutrition is claimed and is comprised anti-ageing, prevention coronary heart disease etc.
Protecting the liver of embodiment 4-6 added branched-chain amino acid Valine, L-Leu and ILE in alimentation composition, this three seed amino acid all belongs to essential amino acid, mainly at muscle metabolism, account for the essential amino acid 35% of skeletal muscle protein, with skeletal muscle synthetic, have close relationship.And the metabolism of branched-chain amino acid (BCAA) can be carried out in skeletal muscle, liver, kidney, brain, the mainly amino acid of metabolism outside liver of a unique part, the concentration of the required enzyme of its metabolism in skeletal muscle be liver 3-10 doubly, so skeletal muscle is the most active metabolism of BCAA place.Therefore give liver diseases patient branched-chain amino acid and can alleviate liver metabolism load, at cirrhosis, serious hepatitis, particularly important in the treatment of hepatic encephalopathy.
Utilize BABL/c mouse to carry out zoopery to the nutraceutical that protects the liver of embodiment 1 preparation, the mouse that will suffer from fatty liver is divided into 5 groups, 8 every group.Experiment grouping: this product intervention group of various dose (100mg/ days, 200mg/ days, 400mg/ days), blank group, Models of Fatty Liver group, feed after 30 days, take out liver organization, measure T-CHOL (TC) and total triglycerides (TG) level, result is as shown in table 1.
Table 1 murine liver tissue T-CHOL (TC), total triglycerides (TG) level
Group Dosage (mg/ days) TC(mmol/L) TG
Blank group / 1.89±0.45 0.99±0.12
Models of Fatty Liver group / 2.57±0.56 ## 1.32±0.11 ##
Low dose group 100 2.42±0.89 * 1.28±0.09 *
Middle dosage group 200 2.21±0.33 ** 1.21±0.11 **
High dose group 400 2.01±0.12 ** 1.14±0.12 **
Note: ##p<0.01, with the comparison of blank group; *p<0.05, *p<0.01, with model group comparison (Mean ± S.E. M., n=8).
As shown in Table 1, with control group comparison, prepared by the present invention that feeds protects the liver after nutraceutical, and TC and TG level significantly decline, and result has statistical significance (P<0.05).Result shows, the alimentation composition that protects the liver disclosed by the invention has restitution to fatty liver.
In sum, the nutraceutical that protects the liver prepared by the present invention can be used in hepatopath, has hepatoprotective effect.Oral and tube feed all can, while taking, every 10g protects the liver nutraceutical and adds warm water 200mL, stirring and dissolving.Slight and moderate Patients with Fatty Liver suggestion consumption is each 10g, twice on the one.Severe fatty liver, cirrhosis and patients with severe hepatitis suggestion consumption are each 10g, three times on the one.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by with reference to the preferred embodiments of the present invention, invention has been described, but those of ordinary skill in the art is to be understood that, can to it, make various changes in the form and details, and not depart from the spirit and scope of the present invention that appended claims limits.

Claims (2)

1. protect the liver an alimentation composition, it is characterized in that, by following component, formed by weight:
20 parts of pawpaw Ultramicro-powders;
10 parts of giant knotweed Ultramicro-powders;
10 parts of date Ultramicro-powders;
10 parts of hawthorn Ultramicro-powders;
10 parts of Poria cocos powders;
5 parts of vine tea Ultramicro-powders.
2. contain the nutraceutical that protects the liver that protects the liver alimentation composition described in claim 1.
CN201310024664.7A 2013-01-23 2013-01-23 Liver-protecting nutritional composition and liver-protecting nutritional food therefrom Active CN103005467B (en)

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CN104705643A (en) * 2015-01-19 2015-06-17 訾璐 Fatty liver conditioning dietotherapy recipe
CN111602817A (en) * 2020-05-19 2020-09-01 西安交通大学医学院第一附属医院 Dietary composition for preventing and treating hepatic sarcopenia and preparation method thereof

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