CN104116028A - Oligopeptide immune-enhancing enteral nutrition emulsion and preparation method thereof - Google Patents

Oligopeptide immune-enhancing enteral nutrition emulsion and preparation method thereof Download PDF

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CN104116028A
CN104116028A CN201410351455.8A CN201410351455A CN104116028A CN 104116028 A CN104116028 A CN 104116028A CN 201410351455 A CN201410351455 A CN 201410351455A CN 104116028 A CN104116028 A CN 104116028A
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parts
vitamin
extract
cobastab
tpf
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CN104116028B (en
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周甄鸿
田晓丽
高永清
胡晨旭
梁玲玲
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CANGZHOU ENJI BIOLOGICAL PRODUCTS Co Ltd
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CANGZHOU ENJI BIOLOGICAL PRODUCTS Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides an oligopeptide immune-enhancing enteral nutrition emulsion and a preparation method thereof. The oligopeptide immune-enhancing enteral nutrition emulsion is prepared from maltodextrin, whey protein isolate, colza oil, high oleic acid sunflower seed oil, a ziziphus jujube extractive, a Chinese wolfberry fruit extractive, a pawpaw extractive, a kudzuvine root extractive, a poria cocos extractive, a mulberry extractive, a dandelion extractive, dietary fibers, mineral substances, vitamins, L-carnitine and taurine, an emulgator, citric acid fatty glyceride, and purified water through a mixing and concentrating method. The oligopeptide immune-enhancing enteral nutrition emulsion is capable of effectively improving the immunologic function of an organism through the combined action and synergistic interaction of high-content high-quality protein peptide and bioactive ingredients in medical and edible food materials, and can serve as a nutrition support for a cancer patient. The preparation method is simple, and can meet the requirement of large-scale industrialized production.

Description

A kind of small peptide immunity enhancement type TPF and preparation method thereof
Technical field
The present invention relates to a kind of TPF and preparation method thereof, especially a kind of small peptide immunity enhancement type TPF and preparation method thereof.
Background technology
, even there is dyscrasia in nearly 70% the malignant tumor patient malnutrition that usually occurrence degree does not wait in the evolution of the state of an illness.Malnutrition often causes again the hypofunction of each system organ of human body, comprises going down of immunologic function.And because most tumors patient is subject to the impact of side effect undergoing surgery, after radiation and chemotherapy, patient reduces nutritional labeling ability to accept, poor the weakening of the effective absorbability of body.
Nutritional labeling in short peptide type enteral nutrition preparation is through hydrolysis process predigestion type nutritional preparation, the lactalbumin hydrolysate (small peptide) of take is main nitrogen, and be furnished with appropriate vitamin, mineral matter, without digest and decompose, can directly by enterocyte, be absorbed, be easy to digesting and assimilating of tumor patient.
Small peptide immunity enhancement type clinical nutrition emulsion is a kind of emulsification system of oil-in-water type, its composition comprises that protein, fat, carbohydrate, mineral matter, vitamin etc. and processing technology all can impact the emulsification system stability of oil-in-water type, and therefore obtaining stable small peptide immunity enhancement type clinical nutrition emulsion will have very important social value.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of small peptide immunity enhancement type TPF.
Another technical problem to be solved by this invention is to provide above-mentioned immunity to strengthen the preparation method of short peptide type TPF.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, by its parts by weight maltodextrin 10-15 part, sepg whey albumen powder 9-12 part, rapeseed oil 5-7 part, high oleic sunflower oil 2-5 part, golden jujube extract 2-4 part, Fructus lycii P.E 1-3 part, papaya extractives 1-2 part, kudzu root extract 1-2 part, tuckahoe extracts 3-4 part, mulberries extract 0.5-1.5 part, dandelion extract 4-5 part, dietary fiber 1-3 part, mineral matter 0.2-0.8 part, vitamin 0.1-0.3 part, VBT 0.05-0.08 part and taurine 0.02-0.07 part, emulsifying agent citric acid fatty glyceride 0.1-0.4 part, pure water 50-80 part.
Preferably, above-mentioned small peptide immunity enhancement type TPF, by 12.8 parts of its parts by weight maltodextrins, 10.3 parts of sepg whey albumen powders, 6.5 parts of rapeseed oils, 3.4 parts of high oleic sunflower oils, 2.47 parts of golden jujube extracts, 2.07 parts of Fructus lycii P.Es, 1 part of papaya extractives, 1.5 parts of kudzu root extracts, 4 parts of tuckahoe extracts, 1 part of mulberries extract, 4.5 parts of dandelion extracts, 1.5 parts of dietary fibers, 0.5 part, mineral matter, 0.2 part of vitamin, 0.05 part of 0.07 part of VBT and taurine, 0.21 part of emulsifying agent citric acid fatty glyceride, 60 parts of pure water.
Preferably, above-mentioned small peptide immunity enhancement type TPF, in described golden jujube extract, the concentration of CAMP (cAMP) is that every 100g is greater than 12mg.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described mineral matter is a kind of, several or all mixing in calcium, phosphorus, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, molybdenum, selenium, iodine, chromium; Described vitamin is vitamin A, vitamin D, vitamin E, vitamin K 1, Cobastab 1, Cobastab 2, Cobastab 6, Cobastab 12, a kind of, several in nicotinic acid, folic acid, choline, biotin or all mix.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described mineral matter is for counting by weight the mixture of 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine.
Preferably, above-mentioned small peptide immunity enhancement type TPF, described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 2850 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, and concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 45-55 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 45-55 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
5-10min sterilization at 80-125 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 40-45 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 60-70 ℃ is mixed with oil plant, is homogeneous under 10-20MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 60-80 ℃ of condition;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is EAT 150-170 ℃, and logistics flow velocity is 1.25-1.40L/h, obtains.
The invention has the beneficial effects as follows:
Above-mentioned small peptide immunity enhancement type TPF, the acting in conjunction of high-quality protein peptide and the bioactive ingredients in each food materials of integration of drinking and medicinal herbs by high-load, Synergistic, can effectively improve the immunologic function of body, for tumor patient provides nutritional support; Its preparation method is simple, is applicable to the needs that large-scale industrial is produced.
Accompanying drawing explanation
Fig. 1 is nutrition biochemical indicator level view;
Fig. 2 is immunizing antigen index level figure.
The specific embodiment
Embodiment 1
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, wherein, maltodextrin 12.8kg, sepg whey albumen powder 10.3kg, rapeseed oil 6.5kg, high oleic sunflower oil 3.4kg, golden jujube extract 2.47kg, Fructus lycii P.E 2.07kg, papaya extractives 1kg, kudzu root extract 1.5kg, tuckahoe extracts 4kg, mulberries extract 1kg, dandelion extract 4.5kg, dietary fiber 1.5kg, mineral matter 0.5kg, vitamin 0.2kg, VBT 0.07kg and taurine 0.05kg, emulsifying agent citric acid fatty glyceride 0.21kg, pure water 60kg, described mineral matter is for to count the mixture of 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine by weight, and described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 2850 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, and concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 50 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 50 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
8min sterilization at 115 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 42 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 65 ℃ is mixed with oil plant, is homogeneous under 17MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 75 ℃ of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 165 ℃ of EATs, and logistics flow velocity is 1.35L/h, obtains;
(6) filling
Heavy metal sampling inspection after powder is sieved, carries out preserving after sterile filling, sealed cans, packing.
Embodiment 2
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, wherein, maltodextrin 15kg, sepg whey albumen powder 9kg, rapeseed oil 7kg, high oleic sunflower oil 5kg, golden jujube extract 2kg, Fructus lycii P.E 3kg, papaya extractives 1kg, kudzu root extract 1kg, tuckahoe extracts 4kg, mulberries extract 1.5kg, dandelion extract 4kg, dietary fiber 1kg, mineral matter 0.8kg, vitamin 0.3kg, VBT 0.05kg and taurine 0.02kg, emulsifying agent citric acid fatty glyceride 0.1kg, pure water 50kg, described mineral matter is for to count the mixture of 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine by weight, and described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 180 parts, folic acid, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, and concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 55 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 45 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
5min sterilization at 125 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 45 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 70 ℃ is mixed with oil plant, is homogeneous under 10MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 60 ℃ of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 170 ℃ of EATs, and logistics flow velocity is 1.40L/h, obtains.
Embodiment 3
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, wherein, maltodextrin 10kg, sepg whey albumen powder 12kg, rapeseed oil 5kg, high oleic sunflower oil 2kg, golden jujube extract 4kg, Fructus lycii P.E 1kg, papaya extractives 2kg, kudzu root extract 2kg, tuckahoe extracts 3kg, mulberries extract 0.5kg, dandelion extract 5kg, dietary fiber 3kg, mineral matter 0.2kg, vitamin 0.1kg, VBT 0.08kg and taurine 0.07kg, emulsifying agent citric acid fatty glyceride 0.4kg, pure water 80kg, described mineral matter is for to count the mixture of 380 parts of calcium, 240 parts, phosphorus, 630 parts, potassium, 255 parts, sodium, 430 parts of chlorine, 9.5 parts of iron, 6.0 parts, zinc, 453 parts of copper, 19 parts, manganese, 18 parts, selenium, 47 parts of iodine by weight, and described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 2850 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 320 parts, nicotinic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, and concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 45 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 55 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
10min sterilization at 80 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 40 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 60-70 ℃ is mixed with oil plant, is homogeneous under 20MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 80 ℃ of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 150 ℃ of EATs, and logistics flow velocity is 1.25L/h, obtains;
(6) filling
Heavy metal sampling inspection after powder is sieved, carries out preserving after sterile filling, sealed cans, packing.
Embodiment 4
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, wherein, maltodextrin 12kg, sepg whey albumen powder 11kg, rapeseed oil 5.5kg, high oleic sunflower oil 4kg, golden jujube extract 2.5kg, Fructus lycii P.E 1.5kg, papaya extractives 2kg, kudzu root extract 1.5kg, tuckahoe extracts 3kg, mulberries extract 1.0kg, dandelion extract 5kg, dietary fiber 2kg, mineral matter 0.5kg, vitamin 0.2kg, VBT 0.06kg and taurine 0.05kg, emulsifying agent citric acid fatty glyceride 0.3kg, pure water 70kg, described mineral matter is for to count the mixture of 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine by weight, and described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 2850 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, and concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 47 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 47 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
8min sterilization at 100 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 42 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 65 ℃ is mixed with oil plant, is homogeneous under 15MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 70 ℃ of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 155 ℃ of EATs, and logistics flow velocity is 1.30L/h, obtains.
Embodiment 5
A kind of small peptide immunity enhancement type TPF, by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, wherein, maltodextrin 11kg, sepg whey albumen powder 11kg, rapeseed oil 6kg, high oleic sunflower oil 3kg, golden jujube extract 3kg, Fructus lycii P.E 2kg, papaya extractives 2kg, kudzu root extract 2kg, tuckahoe extracts 3.5kg, mulberries extract 0.5kg, dandelion extract 5kg, dietary fiber 2kg, mineral matter 0.7kg, vitamin 0.1kg, VBT 0.07kg and taurine 0.04kg, emulsifying agent citric acid fatty glyceride 0.4kg, pure water 65kg, described mineral matter is for to count the mixture of 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine by weight, and described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 2850 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
Above-mentioned immunity strengthens the preparation method of short peptide type TPF, and concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 50 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 50 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
10min sterilization at 110 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 45 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 65 ℃ is mixed with oil plant, is homogeneous under 20MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 75 ℃ of conditions;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is 165 ℃ of EATs, and logistics flow velocity is 1.30L/h, obtains;
(6) filling
Heavy metal sampling inspection after powder is sieved, carries out preserving after sterile filling, sealed cans, packing.
In above-described embodiment 1-5, each component is commercially available prod, wherein, described golden jujube extract (concentration of its CAMP is that every 100g is greater than 12mg), Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract are the extract that water-bath extraction obtains.
Prescription analysis:
Golden jujube extract contains extremely abundant nutritional labeling, and exist multiple bioactive ingredients, comprise polysaccharide, phenols, saponin(e, CAMP (cAMP), alkaloid, essence wet goods, have and strengthen immunologic function, anti-oxidant, anti-inflammatory, improve the effects such as stomach environment and protection liver; The LBP-X of Fructus lycii P.E has expression and the signal conduction that strengthens humoral immunity, cellular immunity, promotion cell factor, improves animal cell immunity power, suppresses the effect of pathogen infection; Papaya extractives has the effect of good inhibition tumour; Kudzu root extract has good antiinflammatory action, can improve cytophagous picked-up ability simultaneously, strengthens immunity of organisms, has two-way immunoregulation effect; Tuckahoe extracts has the effect of eliminating dampness and diuresis, the peaceful heart of invigorating the spleen, and the Multiple components such as Poria cocos triterpene, pachymaran have the immunologic function of adjusting, suppress many-sided pharmacological actions such as tumour, anti-inflammatory; That mulberries extract has is anti-oxidant, anti-inflammatory, the biological effect such as antitumor; Dandelion extract nutritive value is abundant, is rich in various vitamin and mineral matter, and the various active compositions such as its polysaccharide containing, flavones, organic acid, triterpene, phytosterol all have the effect of antitumor raising immunity; Sepg whey albumen powder is that main nitrogen is the sepg whey albumen of high bioactivity, has the characteristics such as anti-oxidant, antiviral, and can be absorbed by enterocyte without digest and decompose; Each component Synergistic, strengthen aspect patient's autoimmunity remarkably productive, especially can improve tumor patient immunity, nutritional support is provided, be embodied in following test experiments:
Test case:
40 routine patients with gastric cancer are divided into two groups at random, and grouping situation is in Table 1.Within postoperative the 1st, 2 days, give conventional parenteral nutrition support, within postoperative 48 hours, start EA support.Small peptide immunity enhancement type TPF described in experimental group Application Example 1, the conventional TPF of the control group.All patient's feeder pathways are through jejunostomy tube.Using dosage is 500g/ days, continues to feed 7 days.Deng heat, etc. the nutritional support of nitrogen amount, postoperative input 20% human serum albumin injection, is 50ml/ days.
Table 1 experimenter ordinary circumstance
Subject age, sex, neoplasm staging are all without significant difference (P>0.05).
Statistical method: each variable with represent.Adopt t check, P value is less than or equal to 0.05 has statistical significance by being considered to checked difference.
1, nutrition biochemical indicator: the white egg of serum (ALB), prealbumin (PAB), transferrins (TF).Record each monitoring index first day, the dynamic change of postoperative the 10th day after surgery.As shown in Figure 1, and compare * P<0.05 before nutritional support; Compare P<0.05 with control group.
2, immunizing antigen index: radio-immunity typing monitoring Immunoglobulin IgM, IgA, IgG, record the dynamic change of the 1st day after surgery, postoperative the 10th day of each monitoring index.As shown in Figure 2, and compare * P<0.05 before nutritional support; Compare with control group, Δp<0.05.
3, postoperative patient infects complication situation
Whether the infection of postoperative patient has much relations with nutrition, immune state, the results are shown in Table 2.The first, protein, energy shortage can produce harmful effect.The healing of post-surgical trauma, needs fibroblast to utilize amino acid to synthesize collagen, and nutrition supply is not enough, and spy is protein, shortage of heat, wound healing easily occurs and postpone or infect.The second, the decline of immunologic function is one of reason causing infection.The existence of postoperative immunosuppression, has weakened immunologic function, is unfavorable for postoperative anti-infective.Small peptide immunity enhancement type TPF of the present invention can provide the nutrient of high-load, high absorption rate, and postoperative function of intestinal canal is recovered early, reduces the occurrence probability of wound infection and other infection.
The situation of table 2 POI complication
4, the reaction in enteral Nutrition Support for Postoperative nursing process, the results are shown in Table 3.
Clinical effectiveness shows, adopts short peptide type TPF experimental group experimenter intestines and stomach tolerance apparently higher than control group, has a good application prospect.
Reaction in table 3 EA nursing process
Above-mentioned detailed description of this kind of small peptide immunity enhancement type TPF and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (7)

1. a small peptide immunity enhancement type TPF, is characterized in that: by maltodextrin, sepg whey albumen powder, rapeseed oil, high oleic sunflower oil, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract, dietary fiber, mineral matter, vitamin, VBT and taurine, emulsifying agent citric acid fatty glyceride and pure water form, by its parts by weight maltodextrin 10-15 part, sepg whey albumen powder 9-12 part, rapeseed oil 5-7 part, high oleic sunflower oil 2-5 part, golden jujube extract 2-4 part, Fructus lycii P.E 1-3 part, papaya extractives 1-2 part, kudzu root extract 1-2 part, tuckahoe extracts 3-4 part, mulberries extract 0.5-1.5 part, dandelion extract 4-5 part, dietary fiber 1-3 part, mineral matter 0.2-0.8 part, vitamin 0.1-0.3 part, VBT 0.05-0.08 part and taurine 0.02-0.07 part, emulsifying agent citric acid fatty glyceride 0.1-0.4 part, pure water 50-80 part.
2. small peptide immunity enhancement type TPF according to claim 1, it is characterized in that: by 12.8 parts of its parts by weight maltodextrins, 10.3 parts of sepg whey albumen powders, 6.5 parts of rapeseed oils, 3.4 parts of high oleic sunflower oils, 2.47 parts of golden jujube extracts, 2.07 parts of Fructus lycii P.Es, 1 part of papaya extractives, 1.5 parts of kudzu root extracts, 4 parts of tuckahoe extracts, 1 part of mulberries extract, 4.5 parts of dandelion extracts, 1.5 parts of dietary fibers, 0.5 part, mineral matter, 0.2 part of vitamin, 0.05 part of 0.07 part of VBT and taurine, 0.21 part of emulsifying agent citric acid fatty glyceride, 60 parts of pure water.
3. small peptide immunity enhancement type TPF according to claim 2, is characterized in that: in described golden jujube extract, the concentration of CAMP is that every 100g is greater than 12mg.
4. small peptide immunity enhancement type TPF according to claim 1 and 2, is characterized in that: described mineral matter is a kind of, several or all mixing in calcium, phosphorus, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, molybdenum, selenium, iodine, chromium; Described vitamin is vitamin A, vitamin D, vitamin E, vitamin K 1, Cobastab 1, Cobastab 2, Cobastab 6, Cobastab 12, a kind of, several in nicotinic acid, folic acid, choline, biotin or all mix.
5. small peptide immunity enhancement type TPF according to claim 4, is characterized in that: described mineral matter is for counting by weight the mixture of 400 parts of calcium, 250 parts, phosphorus, 600 parts, potassium, 250 parts, sodium, 450 parts of chlorine, 8.5 parts of iron, 6.2 parts, zinc, 450 parts of copper, 17 parts, manganese, 15 parts, selenium, 45 parts of iodine.
6. small peptide immunity enhancement type TPF according to claim 4, is characterized in that: described vitamin is for counting by weight 480 parts of vitamin As, 8 parts of vitamin Ds, 8 parts of vitamin Es, vitamin K 155 parts, Cobastab 1350 parts, Cobastab 2850 parts, Cobastab 6480 parts, Cobastab 121.7 parts, the mixture of 320 parts, nicotinic acid, 180 parts, folic acid, 50 parts, choline, 18 parts of biotins.
7. immunity claimed in claim 1 strengthens the preparation method of short peptide type TPF, it is characterized in that: concrete preparation process is as follows:
(1) mixing of materials
Major ingredient: press formula ratio by maltodextrin, sepg whey albumen powder, golden jujube extract, Fructus lycii P.E, papaya extractives, kudzu root extract, tuckahoe extracts, mulberries extract, dandelion extract in major ingredient cylinder with 45-55 ℃ of purified water stirring and dissolving;
Small powder: press formula ratio by dietary fiber, mineral matter, VBT, taurine respectively in small powder cylinder with 45-55 ℃ of pure water stirring and dissolving;
Oil plant: add emulsifying agent citric acid fatty glyceride to dissolve in carburetion cylinder rapeseed oil, high oleic sunflower oil by formula ratio;
(2) pasteurize
5-10min sterilization at 80-125 ℃ in pasteurization machine after major ingredient is mixed with small powder, kill pathogenic bacteria and most of microorganism, be cooled to 40-45 ℃ immediately;
(3) homogeneous
The raw material that is preheated to 60-70 ℃ is mixed with oil plant, is homogeneous under 10-20MPa condition at homogenizer pressure; Cool to 10 ℃ of following keeping in;
(4) Vacuum Concentration
The vitamin of formula ratio is added in purified water and dissolved, add in the material after homogeneous, mixture is warming up to concentration and evaporation under 60-80 ℃ of condition;
(5) spraying is dry
After concentrating, material is sprayed and is dried, and drying condition is EAT 150-170 ℃, and logistics flow velocity is 1.25-1.40L/h, obtains.
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104886602A (en) * 2015-05-18 2015-09-09 安徽省虹升生物科技有限公司 Life-preserving vitamin oil prepared by mixing volvaria volvacea with walnuts and preparation method of life-preserving vitamin oil
CN104886600A (en) * 2015-05-18 2015-09-09 安徽省虹升生物科技有限公司 Life-preserving vitamin oil prepared by mixing mushrooms with bean curds and preparation method of life-preserving vitamin oil
CN104905273A (en) * 2015-05-18 2015-09-16 安徽省虹升生物科技有限公司 Health maintaining vitamin oil mixed by coprinus comatus and lean pork and preparation method thereof
CN104905253A (en) * 2015-05-18 2015-09-16 安徽省虹升生物科技有限公司 A health maintaining vitamin oil mixed by mushroom dictyophora indusiata and pisum sativum and a preparation method thereof
CN104921144A (en) * 2015-05-18 2015-09-23 安徽省虹升生物科技有限公司 Vitamin oil capable of preserving health prepared by mixing quail and bamboo fungus and preparation method thereof
CN106377756A (en) * 2015-08-03 2017-02-08 安徽华明制药有限公司 Enteral nutrition emulsion for patients with severe cerebral infarction
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CN107712907A (en) * 2017-09-18 2018-02-23 诺和生物技术（天津）有限公司 Composition that a kind of suitable fat and fat reducing operation crowd eats and preparation method thereof
CN108703376A (en) * 2018-05-25 2018-10-26 上海市浦东医院 A kind of short peptide type many polymerizers of the EA
CN109588697A (en) * 2017-09-30 2019-04-09 江苏正大丰海制药有限公司 A kind of oral complete nutritional composition
CN110179039A (en) * 2019-06-20 2019-08-30 江苏科技大学 A method of improving oil-in-water emulsion oxidation stability
CN111184220A (en) * 2020-01-15 2020-05-22 山东省农业科学院农产品研究所 Special plant-based emulsion for gastrointestinal tract patients after operation and preparation method thereof
US11278037B2 (en) 2017-09-22 2022-03-22 Conopco Inc. Composition comprising vegetable oil and apple cider vinegar
CN116920075A (en) * 2023-09-15 2023-10-24 潍坊格菲特生物科技有限公司 Enteral nutrient solution and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1660406A (en) * 2004-12-16 2005-08-31 广东省农业科学院农业生物技术研究所 Short peptide type nutriend emulsion inside bowel and producing method
CN101278736A (en) * 2008-03-28 2008-10-08 西安力邦制药有限公司 Balanced enteral total nutrient preparation suitable for nutrition support of Asian population
CN102370129A (en) * 2011-07-01 2012-03-14 中山大学附属第一医院 Enteral nutrient preparation with low gastrointestinal adverse reaction
CN102872452A (en) * 2012-09-21 2013-01-16 中国人民解放军第三军医大学第三附属医院 Low sodium and low potassium enteral total nutrient
EP2677884A1 (en) * 2011-02-24 2014-01-01 N.V. Nutricia Ketogenic diet composition for the treatment of chemo therapy and/or radiation therapy patients
JP2014024819A (en) * 2012-07-30 2014-02-06 Nof Corp Emulsified nutritive composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1660406A (en) * 2004-12-16 2005-08-31 广东省农业科学院农业生物技术研究所 Short peptide type nutriend emulsion inside bowel and producing method
CN101278736A (en) * 2008-03-28 2008-10-08 西安力邦制药有限公司 Balanced enteral total nutrient preparation suitable for nutrition support of Asian population
EP2677884A1 (en) * 2011-02-24 2014-01-01 N.V. Nutricia Ketogenic diet composition for the treatment of chemo therapy and/or radiation therapy patients
CN102370129A (en) * 2011-07-01 2012-03-14 中山大学附属第一医院 Enteral nutrient preparation with low gastrointestinal adverse reaction
JP2014024819A (en) * 2012-07-30 2014-02-06 Nof Corp Emulsified nutritive composition
CN102872452A (en) * 2012-09-21 2013-01-16 中国人民解放军第三军医大学第三附属医院 Low sodium and low potassium enteral total nutrient

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
于新等: "《药食同源物品使用手册：既是食品又是药品的物品》", 31 July 2012, article "药食同源物品使用手册：既是食品又是药品的物品" *
赵余庆等: "《食疗与保健食品原料功能因子手册》", 31 March 2013, article "食疗与保健食品原料功能因子手册" *

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Publication number Priority date Publication date Assignee Title
CN104886602A (en) * 2015-05-18 2015-09-09 安徽省虹升生物科技有限公司 Life-preserving vitamin oil prepared by mixing volvaria volvacea with walnuts and preparation method of life-preserving vitamin oil
CN104886600A (en) * 2015-05-18 2015-09-09 安徽省虹升生物科技有限公司 Life-preserving vitamin oil prepared by mixing mushrooms with bean curds and preparation method of life-preserving vitamin oil
CN104905273A (en) * 2015-05-18 2015-09-16 安徽省虹升生物科技有限公司 Health maintaining vitamin oil mixed by coprinus comatus and lean pork and preparation method thereof
CN104905253A (en) * 2015-05-18 2015-09-16 安徽省虹升生物科技有限公司 A health maintaining vitamin oil mixed by mushroom dictyophora indusiata and pisum sativum and a preparation method thereof
CN104921144A (en) * 2015-05-18 2015-09-23 安徽省虹升生物科技有限公司 Vitamin oil capable of preserving health prepared by mixing quail and bamboo fungus and preparation method thereof
CN106377756A (en) * 2015-08-03 2017-02-08 安徽华明制药有限公司 Enteral nutrition emulsion for patients with severe cerebral infarction
CN106689868A (en) * 2015-08-04 2017-05-24 安徽华明制药有限公司 Cough-relieving and vomit-stopping enteral nutritional emulsion and preparing method thereof
CN107712907A (en) * 2017-09-18 2018-02-23 诺和生物技术（天津）有限公司 Composition that a kind of suitable fat and fat reducing operation crowd eats and preparation method thereof
US11278037B2 (en) 2017-09-22 2022-03-22 Conopco Inc. Composition comprising vegetable oil and apple cider vinegar
US11910804B2 (en) 2017-09-22 2024-02-27 Conopco Inc. Composition comprising vegetable oil and apple cider vinegar
CN109588697A (en) * 2017-09-30 2019-04-09 江苏正大丰海制药有限公司 A kind of oral complete nutritional composition
CN108703376A (en) * 2018-05-25 2018-10-26 上海市浦东医院 A kind of short peptide type many polymerizers of the EA
CN110179039A (en) * 2019-06-20 2019-08-30 江苏科技大学 A method of improving oil-in-water emulsion oxidation stability
CN111184220A (en) * 2020-01-15 2020-05-22 山东省农业科学院农产品研究所 Special plant-based emulsion for gastrointestinal tract patients after operation and preparation method thereof
CN111184220B (en) * 2020-01-15 2023-01-24 山东省农业科学院 Special plant-based emulsion for gastrointestinal tract patients after operation and preparation method thereof
CN116920075A (en) * 2023-09-15 2023-10-24 潍坊格菲特生物科技有限公司 Enteral nutrient solution and preparation method thereof
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