CN102228181B - Composition eaten by cancer patients and containing oligopeptide and chitosan oligosaccharide - Google Patents
Composition eaten by cancer patients and containing oligopeptide and chitosan oligosaccharide Download PDFInfo
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- CN102228181B CN102228181B CN2011102156203A CN201110215620A CN102228181B CN 102228181 B CN102228181 B CN 102228181B CN 2011102156203 A CN2011102156203 A CN 2011102156203A CN 201110215620 A CN201110215620 A CN 201110215620A CN 102228181 B CN102228181 B CN 102228181B
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Abstract
The invention discloses a composition eaten by cancer patients and containing oligopeptide and chitosan oligosaccharide. The composition comprises the oligopeptide, the chitosan oligosaccharide and a Chinese medicine extract, wherein the oligopeptide is a mixture of ocean collagen peptide, lactalbumin and ovalbumin; and the Chinese medicine extract is extracts of Indian Iphigenia bulb, shiitake, dandelion and kudzuvine root. The composition can maintain the nutrient balance of the cancer patients, and can also achieve a remarkable cancer-inhibiting or anticancer treatment effect.
Description
Technical field
The present invention relates to a kind of food formula, relate in particular to the edible composition that contains oligopeptide and chitosan oligosaccharide of a kind of cancer patient of confession, belong to the health care of food technical field.
Background technology
Cancer is a common frdquently encountered disease, and the people's life and healthy in serious harm, because the position of pathogenesis of cancer is different, various cancer can be arranged, like non-small cell lung cancer, cancer of the stomach, lung cancer, osteocarcinoma, cutaneum carcinoma, intestinal cancer, liver cancer etc.
Cancer cell is different with normal tissues and cell, not according to Normocellular metabolic rule growth, thereby becomes unfettered and control, and is irregular ramp, so that can destroy the structure of normal tissues organ and influence its function.The love cell is compared with normal cell, and the unusual of structure, function and metabolism arranged, and they have paranormal hyperplasia ability, and this hyperplasia and body are not in tune.Pernicious cancer cell can soak into towards periphery and spread, even diffusion transfer continues to increase exponentially to other organ, causes human body or life are endangered greatly.
Because the cancer factor and endocrine variation; The cancer patient usually has appetite decline, the sense of taste changes; The metabolic mechanism of each big nutriment of body interior all changes; Occur body weight thereupon and descend and nutrient depletion, and nutrition depletion is patient's the basic cause of death down to the cachexia that cancer property occurs.That adopts at present in addition, is various to the treatment for cancer means, like radiotherapy, chemotherapy, operation etc.; Be another test,, might cause strong digestive tract reaction such as chemotherapy to cancer patient's sick body; Patient is perplexed by serious nauseating, vomiting in the phase in chemotherapy, almost can not take food.Even some embolic chemotherapy can cause directly that nutriment runs off at kidney and enteron aisle, causes patient's nutrition famine.Show that according to foreign data accept the patient of radiotherapy, chemotherapy in hospital, nearly 20%-40% dies from severe malnutrition.This shows that the cancer patient is crucial in the nutritional support of radiotherapy or chemotherapeutic period.
Nitrogen balance is need in chemotherapy, the radiotherapy group nutritional support to accept the content of emphasis consideration.There is negative nitrogen balance in the cancer patient that the overwhelming majority accepts chemotherapy, radiotherapy, and the negative nitrogen balance of continuation can further increase the weight of the side reaction of medicine, reduces immunity of organisms, causes vicious circle like this, has a strong impact on cancer patient's survival rate.Zoopery proves that also body protein consumption can increase the toxicity and the lethal of chemotherapeutics, and the animal that increases dietary protein is compared the animal of routine or low protein diet, and the side effect of its chemotherapeutics reduces.Yet both at home and abroad research shows, even a lot of chemotherapy, radiotherapy patient have been accepted the diet of high protein, high heat, during treating, still has tangible body weight to reduce and malnutritive, this often with diet in the absorption rate of protein low relevant.Therefore, exploration more is prone to digest and assimilate, and the albumen supplementary that bioavailability is high is of great practical significance.
At present, have on the market and utilize food source property small peptide to carry out the food that protein replenishes, the Chinese medicine preparation of treatment cancer is also arranged.In addition; Chinese patent CN101496579A discloses a kind of edible prescription that contains the food for special foods of small peptide of tumor patient that supplies; This food is primary raw material with food source property small peptide; Add medicine-food two-purpose Chinese herbal medicine extracts such as mushroom, dried orange peel, matrimony vine, Chinese yam, Poria cocos, sealwort, be aided with functional oligose, vitamin and mineral matter again and form compound prescription.This food formula replenishes the multivitamin and the mineral matter of needed by human through for body provides nitrogenous source, reaches the negative nitrogen balance of correcting tumor patient, improves the purpose of tumor patient nutrition condition.Yet the edible food formula of special diet that contains small peptide of this confession tumor patient is pressing down the not outstanding especially action effect of cancer or anticancer aspect.
Summary of the invention
The present invention is directed to the deficiency of prior art, a kind of cancer patient of confession is provided the edible composition that contains oligopeptide and chitosan oligosaccharide.Said composition not only can be kept cancer patient's nutrient balance, and can reach highly significant press down cancer or anticancer therapy effect.
The bright purpose of this law is achieved in that
A kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies; Comprise oligopeptide, chitosan oligosaccharide and Chinese medical extract; Described oligopeptide is the mixture of marine collagen peptide, lactalbumin and ovalbumin, and described Chinese medical extract is the extract of edible tulip, mushroom, dandelion and the root of kudzu vine.
Described a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies except that containing oligopeptide, chitosan oligosaccharide and traditional Chinese medicine extraction beyond the region of objective existence, also contains B B-complex, and described B B-complex is selected from following one or more: vitamin C, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12, biotin and folic acid.
Described a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies; Remove and contain oligopeptide, chitosan oligosaccharide and traditional Chinese medicine extraction beyond the region of objective existence; Also contain composite mineral matter, described composite mineral matter is selected from following one or more: calcium monohydrogen phosphate, magnesia, zinc sulfate, ferrous fumarate, copper sulphate and manganese sulfate.
Preferably; Described a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies; Form by oligopeptide, chitosan oligosaccharide, Chinese medical extract, B B-complex and composite mineral matter; Described oligopeptide is the mixture of marine collagen peptide, lactalbumin and ovalbumin, and described Chinese medical extract is the extract of edible tulip, mushroom, dandelion and the root of kudzu vine, and described B B-complex is selected from following one or more: vitamin C, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12, biotin and folic acid, described composite mineral matter is selected from following one or more: calcium monohydrogen phosphate, magnesia, zinc sulfate, ferrous fumarate, copper sulphate and manganese sulfate.
Further preferably; Described a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies, each component is formed by following weight portion: marine collagen peptide 2g, lactalbumin 2g, ovalbumin 1g, chitosan oligosaccharide 2.5g, Chinese medical extract 4g, vitamin C 25mg, Cobastab
10.6mg, Cobastab
20.5mg, Cobastab
30.4mg, Cobastab
50.8mg, Cobastab
60.5mg, Cobastab
120.4mg, biotin 1.5mg, folic acid 0.2mg, calcium monohydrogen phosphate 0.5g, magnesia 0.15g, zinc sulfate 12mg, ferrous fumarate 15mg, manganese sulfate 2mg;
Wherein, described Chinese medical extract is prepared from the Chinese medicine of edible tulip 100-120 part, mushroom 300-350 part, dandelion 250-300 part and root of kudzu vine 100-110 part.
Further preferably, described a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies, it is powdery or granule state food.
Marine collagen peptide of the present invention is that the fish-skin with deep-sea fish (salmon) is a raw material, utilizes biological enzymolysis technology to extract the low molecular weight protein of preparation, and its mean molecule quantity is lower than 1000 dalton.
Lactalbumin of the present invention is that the lactalbumin with cow's milk is a raw material, utilizes biological enzymolysis technology to extract the low molecular weight protein of preparation, and its mean molecule quantity is lower than 1000 dalton.
Ovalbumin of the present invention is to be raw material with the hen egg, utilizes biological enzymolysis technology to extract the low molecular weight protein of preparation, and its mean molecule quantity is lower than 1000 dalton.
Chitosan oligosaccharide of the present invention (Chitosan oligosaccharide); Also claim chitin oligo saccharide; Formal name used at school is β-1, and 4-oligomerization-gucosamine is to be raw material with the shitosan; Through the low molecular weight product that good water solubility, function are big, biologically active is high that the biotechnology degraded forms, molecular weight is lower than 2000.
Chinese medical extract of the present invention prepares according to following method: get edible tulip, mushroom, dandelion and root of kudzu vine four traditional Chinese medicine material and mixing, boiling twice adds 8 times of amounts that water is medicinal material weight for the first time; Decoct 1h; Add for the second time 6 times of amounts that water is medicinal material weight, decoct 1h, collecting decoction; Filter, filtrating is concentrated into relative density 1.10 (65 ℃).Add an amount of ethanol and make and contain alcohol amount (volume fraction) and reach 65%, stir, left standstill 24 hours; Filter, filtrate recycling ethanol also is concentrated into the medicinal extract of relative density 1.20 (65 ℃), and spray-dried (condition is that EAT is 100 ℃; Leaving air temp is 80 ℃; Temperature of charge is 70 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), be ground into dry extract, get Chinese medical extract.
See that from theory of traditional Chinese medical science four used flavor Chinese medicines of the present invention have following biologically active:
Edible tulip: clearing heat and detoxicating, reducing phlegm and resolving masses.Be used for the swollen serious case of furuncle of carbuncle, scrofula subcutaneous nodule, scrofula, snake bite and insect sting.The bright described edible tulip of this law is the dry pseudobulb of Yunnan pleione bulbocodioides P. yunnansis Rolfe.Summer, Qiu Erji excavate, and remove aerial part and silt, and separately size puts that boiling is to passing through the heart in the boiling water pot, and drying promptly gets.
The root of kudzu vine induces sweat and brings down a fever, and promotes the production of body fluid, and promoting eruption rises positive antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, have loose bowels.Compendium of Material Medica is carried: the root of kudzu vine, cool in nature, gas is flat, flavor is sweet, the tool heat-clearing, falls fire, all effects of toxin expelling.Modern medicine study shows that the isoflavonoid Puerarin in the root of kudzu vine has certain curative effect to hypertension, high fat of blood, hyperglycaemia and cardiovascular and cerebrovascular disease.The bright described root of kudzu vine of this law is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi, i.e. elegant jessamine.
Mushroom has benefiting qi and nourishing blood, appetizing helps food, function such as antitumor, is applicable to anaemia, stomachache, rickets, poor appetite, cirrhosis, tumour, hyperlipidemia, children's measles, functional uterine bleeding, cervix cancer and cancer postoperation radiotherapy, chemotherapy etc.
Dandelion cures mainly the infection of the upper respiratory tract, eye conjunctivitis, and mumps, hyperglycaemia, acute mastitis swells and ache, gastritis; Dysentery, hepatitis, courage is assisted inflammation, acute appendicitis, urinary infection, pelvic infecton; Carbuncle furuncle furunculosis, pharyngitis is controlled acute mastitis, adenolymphitis, scrofula; The malignant boil carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infections.The bright described dandelion of this law is the dry herb of feverfew dandelion Toraxacum mongolicum Hand. Mazz. or alkali ground dandelion Toraxacum borealisinense Kitam..
The edible composition that contains oligopeptide and chitosan oligosaccharide of confession tumor patient of the present invention can become granule according to following prepared: the components such as oligopeptide, chitosan oligosaccharide and Chinese medical extract that take by weighing recipe quantity; Add wherein one or more auxiliary materials such as suitable dextrin, soluble starch and sucrose again, wetting with an amount of 80% ethanol, the system softwood; Crossing 14 mesh sieves granulates; 50-80 ℃ of drying, the whole grain of 60 orders gets granule.The granule of the present invention's preparation can adopt boiling water to take after mixing it with water.
Compared with prior art, the bright a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies that relates to of this law has following advantage and obvious improvement:
(1) can find out (referring to table 1) with the chitosan oligosaccharide composition to the inhibitory action result of the test of Mouse Liver growth of cancer cells through embodiment 4 oligopeptides that contain of the present invention: test I group (endoxan+nutriment of the present invention) is compared aspect the tumour inhibiting rate with the endoxan group has significant difference; And 3 of the dead mouses of endoxan group chemotherapy group; The nutriment that this explanation the present invention contains oligopeptide and chitosan oligosaccharide can reach significant Synergistic anti-cancer result of treatment by the combined with chemotherapy medicine, and can reduce the death rate of mice with tumor.
(2) can find out (referring to table 1) with the chitosan oligosaccharide composition to the inhibitory action result of the test of Mouse Liver growth of cancer cells through embodiment 4 oligopeptides that contain of the present invention: test I group (endoxan+nutriment of the present invention) is compared aspect the tumour inhibiting rate with test II group (endoxan+CN101496579A nutriment) has significant difference; And 1 of the dead mouse of test II group, the nutriment that this explanation the present invention contains oligopeptide and chitosan oligosaccharide is pressing down cancer or anticancer and keep aspect the survival rate of mice with tumor significantly owing to prior art.This shows that nutriment of the present invention is when keeping the mice with tumor nutrient balance, what can also reach highly significant presses down cancer or anticancer therapy effect, has obtained unforeseeable technique effect.
The specific embodiment
Below through the embodiment form foregoing of the present invention is remake further detailed description; But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1 contains the preparation of oligopeptide and chitosan oligosaccharide granule
Get edible tulip 100g, mushroom 350g, dandelion 250g and root of kudzu vine 100g medicinal material and mixing, boiling twice adds 8 times of amounts that water is medicinal material weight for the first time; Decoct 1h; Add for the second time 6 times of amounts that water is medicinal material weight, decoct 1h, collecting decoction; Filter, filtrating is concentrated into relative density 1.10 (65 ℃).Add an amount of ethanol and make and contain alcohol amount (volume fraction) and reach 65%, stir, left standstill 24 hours; Filter, filtrate recycling ethanol also is concentrated into the medicinal extract of relative density 1.20 (65 ℃), and spray-dried (condition is that EAT is 100 ℃; Leaving air temp is 80 ℃; Temperature of charge is 70 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), be ground into dry extract, get Chinese medical extract.
Prepare granule of the present invention by following prescription:
| Marine collagen peptide | 2g |
| Lactalbumin | 2g |
| Ovalbumin | 1g |
| Chitosan oligosaccharide | 2.5g |
| Chinese medical extract | 4g |
Preparation technology: take by weighing said components, add wherein one or more auxiliary materials such as an amount of dextrin, soluble starch and sucrose again, wetting with an amount of 80% ethanol, the system softwood is crossed 14 mesh sieves and is granulated, 50-80 ℃ of drying, and the whole grain of 60 orders gets granule.
Embodiment 2 contains the preparation of oligopeptide and chitosan oligosaccharide granule
Get the Chinese medical extract of embodiment 1 preparation, prepare granule of the present invention by following prescription:
| Marine collagen peptide | 4g |
| Lactalbumin | 1g |
| Ovalbumin | 1g |
| Chitosan oligosaccharide | 1g |
| Chinese medical extract | 5g |
Preparation technology: take by weighing said components, add wherein one or more auxiliary materials such as suitable dextrin, soluble starch and sucrose again, wetting with an amount of 80% ethanol, the system softwood is crossed 14 mesh sieves and is granulated, 50-80 ℃ of drying, and the whole grain of 60 orders gets granule.
Embodiment 3 contains the preparation of oligopeptide and chitosan oligosaccharide pulvis
Get edible tulip 120g, mushroom 300g, dandelion 300g and root of kudzu vine 110g medicinal material and mixing, boiling twice adds 8 times of amounts that water is medicinal material weight for the first time; Decoct 1h; Add for the second time 6 times of amounts that water is medicinal material weight, decoct 1h, collecting decoction; Filter, filtrating is concentrated into relative density 1.10 (65 ℃).Add an amount of ethanol and make and contain alcohol amount (volume fraction) and reach 65%, stir, left standstill 24 hours; Filter, filtrate recycling ethanol also is concentrated into the medicinal extract of relative density 1.20 (65 ℃), and spray-dried (condition is that EAT is 100 ℃; Leaving air temp is 80 ℃; Temperature of charge is 70 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), be ground into dry extract, get Chinese medical extract.
Prepare pulvis of the present invention by following prescription:
Marine collagen peptide 2g, lactalbumin 2g, ovalbumin 1g, chitosan oligosaccharide 2.5g, Chinese medical extract 4g, vitamin C 25mg, Cobastab
10.6mg, Cobastab
20.5mg, Cobastab
30.4mg, Cobastab
50.8mg, Cobastab
60.5mg, Cobastab
120.4mg, biotin 1.5mg, folic acid 0.2mg, calcium monohydrogen phosphate 0.5g, magnesia 0.15g, zinc sulfate 12mg, ferrous fumarate 15mg, manganese sulfate 2mg.
Preparation technology: take by weighing said components and mix, stir,, process powdered food through super-dry.
Embodiment 4 is of the present invention to contain oligopeptide and the chitosan oligosaccharide composition inhibitory action to the Mouse Liver growth of cancer cells
(1) preparation of transplanted hepatoma mouse model
48 of the healthy kunming mices of SPF level, male and female half and half, 6 age in week, heavily l8g-20g.Get exponential phase H22 (S type) HCC of in vitro culture, adjustment oncocyte concentration is 1 * 10
7/ mL.Under aseptic condition, it is subcutaneous that oncocyte is inoculated in the right armpit of mouse, and inoculum concentration is that only (cell number is 2 * 10 to 0.2ml/
6/ only).Whole seeded process must be carried out with sterile working in aseptic cover, accomplishes inoculation in the 1h.Treat that subcutaneous transplantation knurl volume reaches 60mm
3During the left and right sides (about lOd), model manufacturing success.
(2) grouping and administration
Test I group is tried thing: the powdered food that takes by weighing the embodiment of the invention 3 preparations.
Test II group is tried thing: the powdered food of pressing Chinese patent CN101496579A embodiment 1 preparation.
Be divided into following 4 groups by knurl volume and mice with tumor body weight homeostatic principle, 12 every group:
Model control group: the physiological saline of filling stomach equivalent 1 time/day, administration is 40 altogether;
The endoxan group: tail vein injection 25mg/kg endoxan, the next day administration 1 time, amount to 10 times;
Test I group: tail vein injection 25mg/kg endoxan, the next day administration 1 time, amount to 10 times; Irritate stomach simultaneously and give the thing that tried of above-mentioned preparation, dosage is 5g/kg, and 1 time/day, administration is 40 altogether;
Test II group: tail vein injection 25mg/kg endoxan, the next day administration 1 time, amount to 10 times; Irritate stomach simultaneously and give the thing that tried of above-mentioned preparation, dosage is 5g/kg, and 1 time/day, administration is 40 altogether;
Mouse is put to death in dislocation behind the last administration 48h, and the excision transplantable tumor takes by weighing knurl and weighs.Heavy inhibiting rate (%) IR of knurl=(1-administration group knurl weight-average value/model control group knurl weight-average value) * 100%.Relatively embody medicine to the liver cancer mouse model preventive and therapeutic effect through what knurl weighed.(x ± s) expression adopts SPSS15.0 software to carry out variance analysis to data with mean ± standard deviation.
(3) result and analysis
Result of the test shows (referring to table 1): compare with model control group, each treatment group to the preventive and therapeutic effect of rat liver cancer model all have utmost point significant difference (
P＜0.01), this explanation endoxan has extremely significant curative effect at the treatment liver cancer.
In addition; Test I group (endoxan+nutriment of the present invention) is compared aspect the tumour inhibiting rate with the endoxan group has significant difference; And 3 of the dead mouses of endoxan group chemotherapy group; The nutriment that this explanation the present invention contains oligopeptide and chitosan oligosaccharide can reach significant Synergistic anti-cancer result of treatment by the combined with chemotherapy medicine, and can reduce the death rate of mice with tumor.
The 3rd; Test I group (endoxan+nutriment of the present invention) is compared aspect the tumour inhibiting rate with test II group (endoxan+CN101496579A nutriment) has significant difference; And 1 of the dead mouse of test II group, the nutriment that this explanation the present invention contains oligopeptide and chitosan oligosaccharide is pressing down cancer or anticancer and keep aspect the survival rate of mice with tumor significantly owing to prior art.This shows that nutriment of the present invention is when keeping the mice with tumor nitrogen balance, what can also reach highly significant presses down cancer or anticancer therapy effect, has obtained unforeseeable technique effect.
Table 1 the present invention contains the preventive and therapeutic effect of the composition of oligopeptide and chitosan oligosaccharide to liver cancer mouse model
| Group | Sample size (beginning/end) | Knurl heavy (g) | Average tumour inhibiting rate (%) |
| Model control group | 12/12 | 2.89±0.55 | ? |
| The endoxan group | 12/9 | 1.64±0.71 ** | 43.3 |
| Test I group | 12/11 | 0.92±0.49 **￥# | 68.2 |
| Test II group | 12/12 | 1.57±0.46 ** | 45.7 |
Compare * * with model control group
P＜0.01;
Compare $ with the endoxan group
P＜0.05;
Compare # with test II group
P＜0.05.
Claims (6)
1. one kind supplies the edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient; It is characterized in that: comprise oligopeptide, chitosan oligosaccharide and Chinese medical extract; Described oligopeptide is the mixture of marine collagen peptide, lactalbumin and ovalbumin, and described Chinese medical extract is the extract of edible tulip, mushroom, dandelion and the root of kudzu vine.
2. a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies according to claim 1 is characterized in that: contain B B-complex, said B B-complex is selected from following one or more: vitamin C, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12, biotin and folic acid.
3. a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies according to claim 1; It is characterized in that: contain composite mineral matter, described composite mineral matter is selected from following one or more: calcium monohydrogen phosphate, magnesia, zinc sulfate, ferrous fumarate, copper sulphate and manganese sulfate.
4. a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies according to claim 1; It is characterized in that: be made up of oligopeptide, chitosan oligosaccharide, Chinese medical extract, B B-complex and composite mineral matter, described B B-complex is selected from following one or more: vitamin C, Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12, biotin and folic acid, described composite mineral matter is selected from following one or more: calcium monohydrogen phosphate, magnesia, zinc sulfate, ferrous fumarate, copper sulphate and manganese sulfate.
5. a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies according to claim 4, it is characterized in that: each component is formed by following weight portion: marine collagen peptide 2g, lactalbumin 2g, ovalbumin 1g, chitosan oligosaccharide 2.5g, Chinese medical extract 4g, vitamin C 25mg, Cobastab
10.6mg, Cobastab
20.5mg, Cobastab
30.4mg, Cobastab
50.8mg, Cobastab
60.5mg, Cobastab
120.4mg, biotin 1.5mg, folic acid 0.2mg, calcium monohydrogen phosphate 0.5g, magnesia 0.15g, zinc sulfate 12mg, ferrous fumarate 15mg, manganese sulfate 2mg;
Wherein, described Chinese medical extract is prepared from the Chinese medicine of edible tulip 100-120 part, mushroom 300-350 part, dandelion 250-300 part and root of kudzu vine 100-110 part.
6. according to each described a kind of edible composition that contains oligopeptide and chitosan oligosaccharide of tumor patient that supplies of claim 1-5, it is characterized in that: it is powdery or granule state food.
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|---|---|---|---|
| CN2011102156203A CN102228181B (en) | 2011-07-29 | 2011-07-29 | Composition eaten by cancer patients and containing oligopeptide and chitosan oligosaccharide |
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| CN2011102156203A CN102228181B (en) | 2011-07-29 | 2011-07-29 | Composition eaten by cancer patients and containing oligopeptide and chitosan oligosaccharide |
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| CN102228181B true CN102228181B (en) | 2012-06-27 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404765B (en) * | 2013-08-29 | 2015-01-14 | 青岛海百合生物技术有限公司 | Composite marine special dietary food for consumption of tumor patients |
| CN103461756B (en) * | 2013-08-29 | 2014-06-25 | 山东卫康生物医药科技有限公司 | Mixed grain rice total nutrient formula food for patient with cancer |
| CN115606810A (en) * | 2022-10-12 | 2023-01-17 | 美雅健康江苏有限公司 | Food with efficacy enhancing and toxicity reducing effects of radiotherapy and chemotherapy of tumor, preparation process and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496578A (en) * | 2008-01-28 | 2009-08-05 | 中国食品发酵工业研究院 | Special diet and foodstuffs formula containing small peptide for hepatopath |
| CN101548775A (en) * | 2009-04-21 | 2009-10-07 | 陆伟 | Nutrient-rich foodstuff containing spirulina powder, konjaku flour, sesame powder and plant composite powder |
-
2011
- 2011-07-29 CN CN2011102156203A patent/CN102228181B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496578A (en) * | 2008-01-28 | 2009-08-05 | 中国食品发酵工业研究院 | Special diet and foodstuffs formula containing small peptide for hepatopath |
| CN101548775A (en) * | 2009-04-21 | 2009-10-07 | 陆伟 | Nutrient-rich foodstuff containing spirulina powder, konjaku flour, sesame powder and plant composite powder |
Non-Patent Citations (2)
| Title |
|---|
| 方祥年等.壳聚糖、壳寡糖及壳聚糖酶的研究初探.《吉林农业大学学报》. * |
| 申杰等.壳寡糖对高脂血症小鼠降血脂及肝脏保护的作用.《西北农林科技大学学报(自然科学版)》.2007,(第09期), * |
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| CN102228181A (en) | 2011-11-02 |
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