CN100515230C - New medicinal use of eupatorium lindleyanun - Google Patents
New medicinal use of eupatorium lindleyanun Download PDFInfo
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- CN100515230C CN100515230C CNB2006100009181A CN200610000918A CN100515230C CN 100515230 C CN100515230 C CN 100515230C CN B2006100009181 A CNB2006100009181 A CN B2006100009181A CN 200610000918 A CN200610000918 A CN 200610000918A CN 100515230 C CN100515230 C CN 100515230C
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Abstract
An application of lindly eupatorium in preparing the functional food or medicine for preventing and treating hyperlipemia is disclosed.
Description
Technical field
The present invention relates to a kind of new purposes that is used for plant, particularly the new purposes of a kind of eupatorium lindleynun var. trifoliolatum.
Background technology
Eupatorium lindleynun var. trifoliolatum (yemazhui) is the composite family feverwort, two blade tip eupatoriums (Eupatoriumlindleyanum DC.Var.trifoliatum Makino), and perennial herb is with all herbal medicine.Contained chemical composition mainly contains flavonoids, alkaloids, volatile oil and coumarin etc.Its bitter, property are flat, have clearing lung-heat, cough-relieving, relieving asthma and effect such as antibiotic, antiviral, and potential applicability in clinical practice is extensive.This product is abounded with in mountain areas, ground such as Jiangsu, Anhui, and also there is distribution other each province, and the medicine source is abundant, and can introduce a fine variety the wild family's kind that is.Clinically be used for cough-relieving, relieving asthma, respond well.Extensive by its Chasing Wildhorse syrup of making in clinical practice, general cough is had obvious result of treatment, especially to the children cough patient, adult or senile chronic bronchitis patient are also more suitable.Eupatorium lindleynun var. trifoliolatum is to be extracted by Chinese herbal medicine, does not see the bibliographical information about its pharmacological action and toxic action so far as yet.
Summary of the invention
One object of the present invention is to disclose the new purposes of a kind of eupatorium lindleynun var. trifoliolatum.
The present invention realizes by the preventive and therapeutic effect research of eupatorium lindleynun var. trifoliolatum to big hyperlipemia mice.
Material and method: animal: 60 of healthy qualified one-level Wistar rats, male and female half and half, body weight 220～280g; 60 of healthy qualified one-level Kunming mouses, male and female half and half, body weight 18～22g provides by Medical University Of Chongqing's Experimental Animal Center.Medicine, reagent: Herba Eupatorii Lindleyani extract, brownish black liquid, bitter and puckery flavor.Airtightly deposit in 4 ℃ of refrigerators.The Atorvastatin calcium tablet, Hong Hui bio-pharmaceuticals limited company provides by Beijing, 10mg/ sheet, lot number: the accurate word X19990258 of traditional Chinese medicines.Methylthiouracil is produced lot number: the accurate word H31021082 of traditional Chinese medicines by Shanghai Fosun Zhaohui Pharmaceutical Co., Ltd..Cholesterol, import reagent is by the packing of Yue Nanization glass Co., Ltd.The cholesterin detection reagent box, high and low density lipoprotein cholesterol (Cholesterol HDL Cholesterol LDL) detection kit, serum triglyceride (Triglycerides) all build up bio-engineering research institute available from Nanjing.Method: each 60 of rat and mouse are divided into large and small mouse hyperlipidemia model group, the large, medium and small dosage group of eupatorium lindleynun var. trifoliolatum and positive drug and blank group respectively at random.Rat is except that the blank group, and all the other each groups are all fed high lipid food and corresponding medicine, successive administration 30 days; Each group of mouse is given corresponding thing medicine and normal diet, successive administration 30 days.Survey blood cholesterol, triglycerides height, high low-density lipoprotein.The result: experimental result shows that Herba Eupatorii Lindleyani extract can obviously reduce experimental high cholesterol, triglycerides and LDL-C.Conclusion: eupatorium lindleynun var. trifoliolatum has obvious preventive and therapeutic effect to experimental large and small mouse hyperlipidemia.
Experimental example 1 eupatorium lindleynun var. trifoliolatum is to the influence of the high fat high cholesterol of egg-nog induced mice
Choose 60 of qualified mouse, be divided into 6 groups at random, hyperlipidemia model group, the large, medium and small dosage group of eupatorium lindleynun var. trifoliolatum and positive drug group and blank group, 10 every group.The large, medium and small dosage group of eupatorium lindleynun var. trifoliolatum is pressed 45.12g (crude drug)/kg respectively, 22.56g (crude drug)/kg, and 11.28g (crude drug)/kg gavages the eupatorium lindleynun var. trifoliolatum extract; Atorvastatin calcium tablet group (positive controls) gavages the Atorvastatin calcium tablet by 2.2mg/kg; Blank group and model group such as gavage respectively at the 1%CMC of capacity, and 1 time/day, each treated animal gavages capacity and is 0.5ml/10g, continuous 30 days.2h after last gavages medicine, each test group animal is lumbar injection 75% egg-nog 0.5ml/ (except the blank group) respectively.Behind the 20h,, use the serum cholesterol kit through the eye socket blood sampling, the serum triglyceride kit, high and low density lipoprotein cholesterol reagent box is measured the serum cholesterol of each treated animal, triglycerides and high and low density lipoprotein cholesterol level.The result is shown in table 1,2.
Table 1 eupatorium lindleynun var. trifoliolatum is to the egg-nog induced mice
The influence of serum high cholesterol and triglycerides (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with model group
Table 2 eupatorium lindleynun var. trifoliolatum is to the egg-nog induced mice
The influence of the high LDL-C of serum (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with model group
Shown in table 1-2. eupatorium lindleynun var. trifoliolatum can obviously reduce mouse cholesterol, triglycerides, the low-density lipoprotein rising effect due to the egg-nog, and the while is increasing high density lipoprotein content obviously.And there were significant differences between model group (P＜0.05 or 0.01).
Experimental example 2 eupatorium lindleynun var. trifoliolatums are to the influence of experimental hyperlipemia in rats
Rat high lipid food prescription: in basal feed, add cholesterol 2%, yolk powder 5%, lard 10%, methylthiouracil 0.2% is made into high lipid food.
Method and result: choose 60 of qualified rats, divide 6 to be group, 10 every group at random.The blank group is fed normal diet, feeds high lipid food for all the other 5 groups, is subjected to the reagent thing when feeding high lipid food.The large, medium and small dosage group of eupatorium lindleynun var. trifoliolatum is pressed 22g/kg respectively, 11g/kg, and 6g/kg gavages, and Atorvastatin calcium tablet group gavages by 1.1mg/kg; Blank group and model group such as gavage at the 1%CMC of capacity, and each treated animal administration capacity is 0.5ml/100g, continuous 30 days.Fasting 24h takes a blood sample through eye socket after last gavages medicine, use the serum cholesterol kit, the serum triglyceride kit, high and low density lipoprotein cholesterol reagent box is measured the serum cholesterol of each treated animal, triglycerides and high and low density lipoprotein cholesterol level.The results are shown in Table 3,4.
Table 3 eupatorium lindleynun var. trifoliolatum is to the experimental hyperlipidemia rat
The influence of serum high cholesterol and triglycerides (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with model group
Table 4 eupatorium lindleynun var. trifoliolatum is to the experimental hyperlipidemia rat
The influence of the high low-density lipoprotein of serum (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with model group
By table 3-4 finding, eupatorium lindleynun var. trifoliolatum can obviously reduce experimental hyperlipemia rat serum cholesterol, triglycerides, LDL-C, and the while is the increasing high density lipoprotein cholesterol level obviously, and there were significant differences between model group (P＜0.01).
The contained chemical composition of eupatorium lindleynun var. trifoliolatum herb mainly contains flavonoids, alkaloids, volatile oil and coumarin etc.Various compositions all have its unique pharmacological action, but various composition also may exist collaborative mutually and produce its distinctive pharmacological action.Originally discover in the eupatorium lindleynun var. trifoliolatum chronic toxicity test is observed, take eupatorium lindleynun var. trifoliolatum treated animal cholesterolemia glyceride and be starkly lower than other groups, inquire into eupatorium lindleynun var. trifoliolatum for this reason and reduce blood fat and cholesterol effect.Experimental result shows: eupatorium lindleynun var. trifoliolatum has tangible reduction because of egg-nog and the caused animal high cholesterol of high lipid food, high triglyceride and low-density lipoprotein effect, and obviously can increasing high density lipoprotein.Prompting, eupatorium lindleynun var. trifoliolatum simple possess so good lipopenicillinase and cholesterol effect, and dosage are arranged according to relation, and the lipopenicillinase of heavy dose of group, norcholesterol effect are strong than Atorvastatin calcium tablet group.
The present invention's experiment is all adopted the concentrate of eupatorium lindleynun var. trifoliolatum herb with the method gained of conventional poach alcohol precipitation with the Herba Eupatorii Lindleyani extract experiment, experiment has comprehensively kept the composition of the former grass of eupatorium lindleynun var. trifoliolatum, the basic research of the new purposes of the former grass of eupatorium lindleynun var. trifoliolatum of the present invention with Herba Eupatorii Lindleyani extract.Eupatorium lindleynun var. trifoliolatum can be made various functional food or medicines with effect for reducing blood fat.
Embodiment 1:
10 kilograms of eupatorium lindleynun var. trifoliolatums, adding is that water 4-8 doubly decocts 2-3 time, merges each extract, concentrates back 75%-90% precipitation with alcohol, receives alcohol, gets concentrate; Make syrup, the oral hyperlipidemia of preventing and treating.
Embodiment 2:
20 kilograms of eupatorium lindleynun var. trifoliolatums, adding is 6 times of decoctions of water 2 times, merges each extract, concentrates back 75% precipitation with alcohol, receives alcohol, gets concentrate, drying; Make granule, the oral hyperlipidemia of preventing and treating.
Embodiment 3:
20 kilograms of eupatorium lindleynun var. trifoliolatums, adding is that water decocts 3 times for 8 times, merges each extract, concentrates back 85% precipitation with alcohol, receives alcohol, is concentrated into thick paste; Make soft capsule, the oral hyperlipidemia of preventing and treating.
Embodiment 4:
10 kilograms of eupatorium lindleynun var. trifoliolatums, adding is 7 times of decoctions of water 2 times, merges each extract, concentrates back 75%-90% precipitation with alcohol, receives alcohol, gets concentrate, spray-drying; Make tablet, the oral hyperlipidemia of preventing and treating.
Claims (10)
1, eupatorium lindleynun var. trifoliolatum has the functional food of effect for reducing blood fat or the application in the medicine in preparation.
2, application as claimed in claim 1, wherein effect for reducing blood fat is meant the reduction serum cholesterol.
3, application as claimed in claim 1, wherein effect for reducing blood fat is meant the reduction triglycerides.
4, application as claimed in claim 1, wherein effect for reducing blood fat is meant the reduction LDL-C.
5, application as claimed in claim 1, wherein effect for reducing blood fat is meant the increasing high density lipoprotein cholesterol level.
6, eupatorium lindleynun var. trifoliolatum prevents and treats the functional food of hyperlipidemia or the application in the medicine in preparation.
7, application as claimed in claim 6 wherein prevents and treats hyperlipidemia and is meant the reduction serum cholesterol.
8, application as claimed in claim 6 wherein prevents and treats hyperlipidemia and is meant the reduction triglycerides.
9, application as claimed in claim 6 wherein prevents and treats hyperlipidemia and is meant the reduction LDL-C.
10, application as claimed in claim 6 wherein prevents and treats hyperlipidemia and is meant the increasing high density lipoprotein cholesterol level.
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| CNB2006100009181A CN100515230C (en) | 2006-01-12 | 2006-01-12 | New medicinal use of eupatorium lindleyanun |
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| CNB2006100009181A CN100515230C (en) | 2006-01-12 | 2006-01-12 | New medicinal use of eupatorium lindleyanun |
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| CN100515230C true CN100515230C (en) | 2009-07-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069145A (en) * | 2014-06-04 | 2014-10-01 | 苏州大学 | Application of lindley eupatorium herb in preparing anti-hepatitis B virus medicaments |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101933919B (en) * | 2010-07-01 | 2012-04-18 | 北京世纪博康医药科技有限公司 | Application of brown cyanidin |
| CN112772799B (en) * | 2020-12-29 | 2023-06-02 | 海南自贸区沃佳实业有限公司 | Preparation method of old salt lemon sea grape beverage |
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2006
- 2006-01-12 CN CNB2006100009181A patent/CN100515230C/en active Active
Non-Patent Citations (4)
| Title |
|---|
| 中药大辞典. 江苏新医学院，2130，上海科学技术出版社. 1977 |
| 中药大辞典. 江苏新医学院，2130，上海科学技术出版社. 1977 * |
| 野马追一般药理作用实验研究. 周远大，陈康，何海霞，江舟，曾敏莉，杨辉.中国药房，第16卷第2期. 2005 |
| 野马追一般药理作用实验研究. 周远大，陈康，何海霞，江舟，曾敏莉，杨辉.中国药房，第16卷第2期. 2005 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069145A (en) * | 2014-06-04 | 2014-10-01 | 苏州大学 | Application of lindley eupatorium herb in preparing anti-hepatitis B virus medicaments |
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