CN110013455A - It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition - Google Patents
It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition Download PDFInfo
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- CN110013455A CN110013455A CN201910198548.4A CN201910198548A CN110013455A CN 110013455 A CN110013455 A CN 110013455A CN 201910198548 A CN201910198548 A CN 201910198548A CN 110013455 A CN110013455 A CN 110013455A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Abstract
A kind of composition having antipruritic, oil-control, strong hair, Anti-hair loss effect, including following components: at least one of ginseng extract, anemarrhena asphodefoides extract, safflower extract or kylin draconis extract；At least one of -1 copper of palmityl tripeptides -1, myristoyl pentapeptide -4 or tripeptides.The composition further includes Angelica roots, Cacumen Platycladi extract, fleece-flower root root extract, ginger-root extract.Referring now to the prior art, composition of the present invention has anti-inflammatory, antibacterial, antipruritic, oil-control, strong hair, Anti-hair loss effect, and safety is without side-effects.Composition of the present invention has the characteristics that in terms of Anti-hair loss quick than traditional plant extract, has better Anti-hair loss effect than pure polypeptide composition, and the effect in terms of the auxiliaring effects such as anti-inflammatory, antibacterial, antipruritic, oil-control becomes apparent from.In addition, the preparation process of composition of the present invention is simple, manufacturing cost is cheap, is suitble to industry mass production.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of composition for having antipruritic, oil-control, strong hair, Anti-hair loss effect.
Background technique
In China's Adult Groups, alopecia disease incidence is up to 30%, and alopecia becomes the second great society after obesity
Disease.Alopecia not only affects the appearance of people, more affects the confidence of people.
There are many cause of disease of alopecia, such as because exogenous bacterium infection and secondary inflammatory infiltration break hair follicle stem cells
Badly alopecia；The inactive missing for leading to hair root nutrients of scalp microfilament blood vessel and alopecia；The exception of dihydrotestosterone point in organism
Secreting causes growth cycle of hair to shorten, even atrophy and the alopecia of hair follicle microminiaturization；Scald harm of the dye to scalp；Familial inheritance disease
Cause；Vivo immunization power decline etc..One of the most common alopecia type is alopecia seborrheica and nervous baldness.
Alopecia seborrheica is also known as male sex hormone alopecia, and the induction of male sex hormone alopecia may be since male sex hormone alopecia is suffered from
II type 5α-reductase activity is stronger in person, causes internal DHT (i.e. dihydrotestosterone) horizontal higher, due to DHT and male sex hormone by
The affinity of body is five times of testosterone, and after DHT is combined with androgen receptor, stimulation sebaceous glands is activated, and promotes sebum secretion,
Metabolic disorder is accelerated, so that growth cycle of hair shortens extremely, newborn hair development is inadequate, and the hair in growth period is gradually
Attenuate, the even atrophy of hair follicle microminiaturization, and then there is alopecia.
Nervous baldness is also known as alopecia areata or alopecia cicatrisata, be one group centered on hair follicle, by inflammatory destruction and forever
The alopecia disease of long property feature.The induction of alopecia cicatrisata may be infection and inflammation due to scalp by extraneous bacterium
Immunity degradation caused by infiltrating, so that the apoptosis of hair follicle stem cells and follicle keratinocytes, and then lead to hair follicle regresses,
There is alopecia result there is no new hair growth.
The growth cycle of hair is divided into growth period (about 2-6), stand-down (about 2-3 weeks) and catagen (the about 2-3 month), day
Medically it is considered as normal alopecia amount within alopecia amount 100, same day alopecia amount, which is greater than 100, is then considered having alopecia puzzlement.
It is in the prior art Western medicine, Chinese herbal medicine effective substance or active peptides class product for the preparation main component of hair growth.
It is clinically used for Western medicine such as the horse forefront limb, minoxidil of hair growth, can promote the growth of eyelashes, inhibits 5 α-also
Original enzyme activity inhibits the excessive secretion of sebaceous glands and plays the role of Anti-hair loss；Herbal composite passes through blood-nourishing profit hair, wind-dispelling
Promoting blood circulation, clearing away heat and eliminating dampeness, unobstructed obstruction hair follicle, antimicrobial antiphlogistic, inhibits the method for sebaceous glands excessive secretion to carry out anti-anti-avulsion at activation hair follicle
Hair；Polypeptides matter passes through the activation hair growth factor, promotion hair follicle stem cells differentiation, healing of wound, antibacterial, anti-inflammatory method
Achieve the purpose that promote hair growth, delay trichomadesis.Pass through the catagen in contract short-haired growth period and extension hair
It controls opposite alopecia amount, reaches the visual effect of anticreep.
Being excessively used for horse forefront limb will cause optic nerve injury, may cause visual impairment and even blinds, additionally may be used
It can cause the adverse consequences such as retina swelling and inflammatory eye.The side effect of minoxidil also results in scalp irritation and face
Hair increases.
Trichogenous polypeptides matter (such as CN105106028A) and trichogenous Chinese herbal medicine group
Close object (such as CN104383114B, CN103768577B) though etc. patents to show that polypeptides matter and herbal composite have anti-
The effect of de- strong hair, but cut both ways.The simple process of herbal composite, low manufacture cost have auxiliary synergy effect,
But Anti-hair loss is ineffective, and takes effect slowly；Polypeptides matter synthesis is difficult, condition of storage requires high, manufacturing cost height, and
Often only there is Anti-hair loss effect, and acted on without auxiliary synergy, it is rapid-action although active peptides class product is single-minded for target spot,
But the not multi-faceted auxiliary synergy effect of Chinese medical extract.
Therefore it provides a kind of not only have good Anti-hair loss effect, and also other hair care hair care effects, and preparation process
Simply, the cheap Anti-hair loss substance of cost of manufacture very it is necessary to.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of composition for having antipruritic, oil-control, strong hair, Anti-hair loss effect.
In addition, the present invention also provides the preparation methods for having antipruritic, oil-control, being good for hair, the composition that Anti-hair loss acts on.Combination of the present invention
Object has anti-inflammatory, antibacterial, strong hair, Anti-hair loss effect, and the composition preparation process is simple, and manufacturing cost is low, is suitble to industry
Mass production.
A kind of composition having antipruritic, oil-control, strong hair, Anti-hair loss effect, including following components: ginseng extract, rhizoma anemarrhenae
At least one of extract, safflower extract or kylin draconis extract；Palmityl tripeptides -1, myristoyl pentapeptide -4 or three
At least one of -1 copper of peptide.
Preferably, a kind of composition having antipruritic, oil-control, strong hair, Anti-hair loss effect, including following components: ginseng mentions
Take at least one of object, rhizoma anemarrhenae root extract, safflower extract or kylin draconis extract；Palmityl tripeptides -1, myristoyl
At least one of -1 copper of pentapeptide -4 or tripeptides.
Preferably, a kind of composition having antipruritic, oil-control, strong hair, Anti-hair loss effect, further includes Angelica roots, side
CedarLeaves extract, fleece-flower root root extract, ginger-root extract.
It is further preferred that it is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight,
Including following components: ginseng root extract is 0.1-60 parts (preferably 0.1-50 parts), rhizoma anemarrhenae root extract be 0.1-60 parts (preferably
0.1-50 parts), safflower extract be 0.1-60 parts (preferably 0.1-50 parts), kylin draconis extract is 0.1-60 parts of (preferably 0.1-
50 parts), palmityl tripeptides -1 be 0.01-8 parts (preferably 0.1-5 parts), myristoyl pentapeptide -4 is 0.01-8 parts of (preferably 0.1-5
Part), in -1 copper of tripeptides be 0.01-8 parts (preferably 0.1-5 parts), Angelica roots are 0.1-50 parts, Cacumen Platycladi extract is
0.1-50 parts, fleece-flower root root extract be 0.1-50 parts, ginger-root extract is 0.1-50 parts.
It is furthermore preferred that it is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including
Following components: ginseng root extract is 0.1-15 parts, rhizoma anemarrhenae root extract is 0.1-15 parts, safflower extract is 0.1-15 parts,
Kylin draconis extract is 0.1-15 parts, palmityl tripeptides -1 are 0.1-1 parts, myristoyl pentapeptide -4 is 0.1-1 parts, -1 copper of tripeptides
In be 0.1-1 parts, Angelica roots are 0.1-7 parts, Cacumen Platycladi extract is 0.1-7 parts, fleece-flower root root extract is 0.1-7
Part, ginger-root extract are 0.1-7 parts.
It is furthermore preferred that it is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including
Following components: ginseng root extract is 0.1-4 parts, rhizoma anemarrhenae root extract is 0.1-4 parts, safflower extract is 0.1-4 parts, kylin
Draconis extract is 0.1-4 parts, palmityl tripeptides -1 are 0.1 part, myristoyl pentapeptide -4 is 0.1 part, in -1 copper of tripeptides is 0.1
Part, Angelica roots are 0.3-2 parts, Cacumen Platycladi extract is 0.3-2 parts, fleece-flower root root extract is 0.3-2 parts, race mentions
Taking object is 0.3-2 parts.
Preferably, a kind of composition with antipruritic, oil-control, strong hair, Anti-hair loss effect further includes according to parts by weight
0.1-1.5 parts of 30-300 parts of water (preferably 50-150 parts), 0.1-2 parts of preservative (preferably 0.5-1 parts) and sodium chloride (preferably 0.5-
0.9 part).
Preferably, the water is deionized water, and the preservative is Phenoxyethanol.
Ginseng root extract, ginseng be Araliaceae ginseng dry root, can " tonifying five zang organs, soothe the nerves ", recuperating depleted yang.Ginseng
In ginsenoside dosage be greater than 12.5 μ g/ml can promote hair follicle stem cells Proliferation, Differentiation, inhibit platelet aggregation
(IC50Value is 0.197g/L, wherein IC50Meaning be exactly the drug when inhibiting rate reaches 50% concentration, such as when inhibit blood
When the effect of platelet aggregation reaches 50%, the concentration of ginsenoside is needed, and there is dose-dependent).It is big in dosage
Arachidonic acid can be inhibited to induce the release of inflammatory factor when 50 μm of ol/L, can be destroyed carefully when dosage is greater than 10 μ g/ml
The cyto-architectural effect of bacterium, play promote hair follicle differentiation, promoting blood circulation, anti-inflammatory and antibacterial effect, contract short-haired growth period and
Extend the catagen of hair.
Rhizoma anemarrhenae root extract, rhizoma anemarrhenae are the dry rhizome of liliaceae plant, also known as " rabbit oil grass, garlic clove grass "
Deng for conventional Chinese medicine.Anemarrhena saponin AIII in rhizoma anemarrhenae, which has, inhibits platelet aggregation (IC50Value is 26.35 ± 4.75 μ g/ml),
Inhibit the abnormal secretion (IC of sebaceous glands50Peanut four can be inhibited for 0.81mmol/L), when dosage is greater than 40mg/ (kgd)
Olefin(e) acid induces the release of inflammatory factor, plays promoting blood circulation, inhibits sebaceous glands excessive secretion and anti-inflammatory effect, extends the degeneration of hair
Phase.
Safflower extract, safflower are the dry flower of compositae plant safflower.Summer flower from yellow to red when pick, dry in the shade or shine
It is dry.With blood circulation, the effect of removing blood stasis and acesodyne.Carthamus tinctorius yellow colour A in safflower, which has, inhibits platelet aggregation (IC50For
17.5 μm of ol/L), safflower extract in vitro dosage be greater than 0.5g/L when just can inhibit the abnormal secretion of sebaceous glands, can inhibit Huang
Purine oxidase and the small precursor reactant (IC of inflammation50For 40.04 μm of ol/L), plays promoting blood circulation, inhibits sebaceous glands excessive secretion and anti-inflammatory
Effect, extend the catagen of hair.
Kylin draconis extract, dracaena set height up to more than 10 meters, trunk is sturdy, usually up to 1 in liliaceous arbor
Rice or so.Blade long ribbon shape, apex are sharp.After its injury, a kind of resin of aubergine can be also flowed out, injured areas is contaminated
Necrosis wood red, that this block is contaminated, in Chinese medicine also referred to as " dragon's blood " or " Sanguis Draxonis ".Its main active is dracorhodin and blood
Red pigment is exhausted, dracorhodin (concentration 50mg/Kg) can significantly inhibit platelet aggregation.Dracoalban is 20- in concentration
80 μ g/ml can inhibit the synthesis of cicatricial fibroblastic formation and inhibition Collagen of Fibroblasts, play anti-proliferate
The effect of scar.Play the role of promoting blood circulation, environment alopecia cicatrisata.
Palmityl tripeptides -1 have activation keratin gene, promote its expression, promote the proliferation point of epidermal keratinocytes
Change, makes hair growth.
Myristoyl pentapeptide -4 is similar with palmityl tripeptides -1, plays the work for promoting epidermal keratinocytes Proliferation, Differentiation
With making hair growth.
- 1 copper of tripeptides is also known as copper peptide, copper peptide can promote HDP (i.e. human dermis' papilla) cell Proliferation and natural on-off cycles of hair growth because
Son, hepatocyte growth factor HGF, insulin-like growth factor I GF, keratinocyte growth factor KGF, vascular endothelial growth factor
The expression of sub- VEGF delays the growth period of hair follicle, promotes papilla collagen to generate, consolidates hair strong.
Ginger-root extract, ginger are the rhizomes of Zingiber zingiber herbaceos perennial ginger, are common Chinese medicines, are medicine foods two
Use plant.Gingerol in ginger, which has, to be inhibited platelet aggregation, inhibits the release of arachidonic acid induction inflammatory factor, destruction thin
The cyto-architectural effect of bacterium plays promoting blood circulation, anti-inflammatory and antibacterial effect, extends the catagen of hair, is the auxiliary in composition
Synergy functional component.
Angelica roots, when the root for being classified as umbelliferae angelica, the main active of Radix Angelicae Sinensis is Flavonoid substances,
Angelica extract has the function of anti-inflammatory, antibacterial, promoting blood circulation as ginger-root extract, be composition in auxiliary synergy effect at
Point.
Cacumen Platycladi extract, cacumen biotae are the browse of cupressaceae plant, are in flakey, quality is crisp, gas micro-perfume, bitter
It is puckery.Active constituent in cacumen biotae is polyphenol and Flavonoid substances, Cacumen Platycladi extract have as ginger-root extract promoting blood circulation,
Anti-inflammatory and antibacterial effect is the auxiliary element in composition.
Fleece-flower root root extract, it is tonic medicine that the fleece-flower root, which is polygonaceae arsesmart its stem tuber,.Hexichol second in the fleece-flower root
The ingredients such as alkene glycosides, Anthraquinones, phospholipid have the function of it is antibacterial and anti-inflammatory, be composition in auxiliary element.
A kind of preparation method for having antipruritic, oil-control, being good for hair, the composition that Anti-hair loss acts on, comprising the following steps:
(1) each component is weighed by formula ratio, added water in pot, stirred, be warming up to 70 DEG C -90 DEG C (preferably 80 DEG C -85
DEG C), 20-40 minutes (preferably 30 minutes) are kept the temperature, it is spare；
(2) step (1) described pot temperature is then down to 40 DEG C -45 DEG C, remaining component is put into pot and stirs evenly 15-
20 minutes, the composition is made.
The normal saline solution that composition of the present invention can be configured to 1%-50% be applied directly to scalp surface into
It exercises and uses, can also be applied in cosmetics, mass percent of the composition in cosmetics is 1-15% (preferably 1-
10%).
The composition is applied in cosmetics or curable product, and the preparation type of the cosmetics or curable product includes
But it is not limited to Essence, shampoo, lotion, creme, washing lotion, spray, gel, ointment, solid and liposome.
Composition of the present invention has anti-inflammatory, antibacterial, strong hair, Anti-hair loss effect, not only without side-effects, the Er Qiezao of safety
Valence is cheap, it is rapid-action, have good improvement to the various symptoms for inducing alopecia.
Plant extracts and peptide material in the composition have the effect of coordinating synergy, effectively play and invigorate blood circulation, is anti-
Effect that is scorching, antibacterial, inhibiting sebaceous glands excessive secretion, promote hair follicle stem cells Proliferation, Differentiation reaches antipruritic, oil-control, strong hair, prevents
The effect of alopecia.
Composition of the present invention, can be applied to may generate hair reduce and/or there are the trouble of hair reduction
Person, is applied at scalp or hair reduces region.
Composition of the present invention is in terms of promoting hair growth, hence it is evident that is better than pure Chinese medicine formula；Phase is formulated with pure polypeptide
Than, better effect, and pure polypeptide formula is substantially better than in terms of other auxiliary effects such as antipruritic, oil-control.It can be seen that of the present invention
Plant extracts and peptide material in composition have the effect of coordinating synergy.
Compared with the existing technology, beneficial effects of the present invention are as follows:
(1) composition of the present invention has anti-inflammatory, antibacterial, antipruritic, oil-control, strong hair, Anti-hair loss effect, and safety is without pair
Effect.
(2) composition of the present invention has the characteristics that in terms of Anti-hair loss quick than traditional plant extract, than pure
Peptide composition has better Anti-hair loss effect, and the effect in terms of the auxiliaring effects such as anti-inflammatory, antibacterial, antipruritic, oil-control is brighter
It is aobvious.
(3) preparation process of composition of the present invention is simple, and manufacturing cost is cheap, is suitble to industry mass production.
Specific embodiment
In order to allow those skilled in the art's more clearly technical solution of the present invention, following embodiment progress is now enumerated
Explanation, it is pointed out that following embodiment to the present invention claims protection scope do not constitute a limitation effect.
Embodiment 1
It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including following components:
3 parts of ginseng root extract, 2 parts of rhizoma anemarrhenae root extract, 3 parts of safflower extract, 3 parts of kylin draconis extract, palmityl tripeptides -1
0.05 part, -4 0.03 parts of myristoyl pentapeptide, 0.05 part of -1 copper of tripeptides, 1 part of Angelica roots, 1 part of Cacumen Platycladi extract,
1 part of fleece-flower root root extract, 1 part of ginger-root extract, 0.9 part of sodium chloride, 0.6 part of Phenoxyethanol, 50 parts of deionized water.
Embodiment 2
It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including following components:
4 parts of safflower extract, 4 parts of kylin draconis extract, 0.1 part of palmityl tripeptides -1,0.5 part of Angelica roots, cacumen biotae are extracted
0.5 part of object, 1 part of fleece-flower root root extract, 2 parts of ginger-root extract, 0.9 part of sodium chloride, 0.6 part of Phenoxyethanol, deionized water 100
Part.
Embodiment 3
It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including following components:
3 parts of ginseng root extract, 2 parts of rhizoma anemarrhenae root extract, 0.03 part of palmityl tripeptides -1, -4 0.02 parts of myristoyl pentapeptide, when
Return 0.5 part of root extract, 0.6 part of Cacumen Platycladi extract, 0.6 part of fleece-flower root root extract, 2 parts of ginger-root extract, sodium chloride 0.9
Part, 0.6 part of Phenoxyethanol, 90 parts of deionization.
Embodiment 4
It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including following components:
Ginseng root extract is 50 parts, rhizoma anemarrhenae root extract is 50 parts, 50 parts of safflower extract, 50 parts of kylin draconis extract, palmityl
8 parts of tripeptides -1, -4 7 parts of myristoyl pentapeptide, 8 parts of -1 copper of tripeptides, Angelica roots are 40 parts, Cacumen Platycladi extract 30
Part, 40 parts of fleece-flower root root extract, ginger-root extract is 30 parts, 250 parts of water, 0.5 part of Phenoxyethanol and 1.1 parts of sodium chloride.
Embodiment 5
It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition, according to parts by weight, including following components:
4 parts of ginseng root extract, 3 parts of rhizoma anemarrhenae root extract, 4 parts of safflower extract, 4 parts of kylin draconis extract, palmityl tripeptides -1
0.1 part, -4 0.1 parts of myristoyl pentapeptide, 0.1 part of -1 copper of tripeptides, 2 parts of Angelica roots, 2 parts of Cacumen Platycladi extract, He Shou
Black root extract is 2 parts, ginger-root extract is 2 parts, 150 parts of water, 1 part of Phenoxyethanol and 0.6 part of sodium chloride.
Comparative example 1
A kind of composition without polypeptide, according to parts by weight, including following components: ginseng root extract is 3%, rhizoma anemarrhenae
3 parts of root extract, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2 parts of Angelica roots, 2 parts of Cacumen Platycladi extract, what
2 parts of tuber of multiflower knotweed root extract, 2 parts of ginger-root extract, 0.9 part of sodium chloride, 0.6 part of Phenoxyethanol, 100 parts of deionization.
Comparative example 2
A kind of peptide composition, according to parts by weight, including following components: 0.1 part of palmityl tripeptides -1, myristoyl
- 40.1 parts of pentapeptide, 0.1 part of -1 copper of tripeptides, 0.9 part of sodium chloride, 0.6 part of Phenoxyethanol, 100 parts of deionized water.
Embodiment 6
Formula described in embodiment 1-5 and comparative example 1-2 is followed the steps below into preparation, obtains correspondent composition:
(1) it adds water in pot, stirs, be warming up to 80 DEG C, keep the temperature 30 minutes, it is spare；
(2) step (1) described pot temperature is then down to 40 DEG C -45 DEG C, it is equal that remaining component is then put into stirring in pot
It is even, the composition is made.
Product measure of merit
Embodiment 7
The few hair of screening and the serious volunteer of alopecia 210, stochastic averagina is divided into 7 groups.Under identical use condition respectively
(after daily cleaning hair washing, sample on probation being taken to be applied to scalp or be applied at exiguous human hair) embodiment 1-5 and comparative example 1-2 on probation
The composition.Related questionnaire survey is carried out at 29 days (to mitigate every group of volunteer from greasy feeling, itch mitigates, alopecia subtracts
Gently, tiny hair increases by four angles to count the ratio that volunteer's number accounts for every group of total number of persons), thus to of the present invention group
The anticreep and other performances for closing object are assessed, and the results are shown in Table 1.
Table 1:
As it can be seen from table 1 composition is using after 29 days, 80% or more volunteer thinks the composition energy of embodiment 1-5
Alleviate itching of the scalp and greasy feeling to mitigate, about 90% or more volunteer think the composition of embodiment 1-5 can prevent hair loss and
Tiny hair increases obviously, but thinks that can not mitigate greasy feeling eases up using most of volunteer of the composition of comparative example 2
Solve itching of the scalp；Think that alopecia can not be significantly reduced using most of volunteer of the composition of comparative example 1, tiny hair increases
Add also unobvious.In general, the corresponding composition of embodiment 1-5 of the present invention is in antipruritic, oil resistant, Anti-hair loss and hair
Effect is significantly better than composition described in comparative example 1-2 in terms of hyperplasia.
In addition, using the volunteer of composition described in embodiment 1-5 scalp detector test root of hair and grease to change
Amount, behind composition 29 days described in embodiment 1-5, hair becomes more sturdy health and person of outstanding talent's hair is increased, the position of alopecia
Whole effect of covering become apparent, realize the purpose of strong hair, Anti-hair loss.It can also can effectively reduce alopecia amount, promote tiny hair
The multinomial effects such as hair growth, and be used for a long time, better effect.
Embodiment 8
A kind of Anti-hair loss scalp Essence, by mass percentage, including following components: composition 5% of the present invention,
Full gear alcohol 30%, menthol 0.1%, peppermint leaf oil 0.15%, butanediol 18%, parahydroxyacet-ophenone 0.5%, 1,2- penta 2
Alcohol 1.8%, deionized water surplus.
Wherein composition of the present invention, according to parts by weight, including 2.4 parts of ginseng root extract, rhizoma anemarrhenae root extract
3.2 parts, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2.4 parts of ginger-root extract, 0.52 part of Angelica roots, cacumen biotae
0.52 part of extract, 0.52 part of fleece-flower root root extract, 0.003 part of palmityl tripeptides -1, myristoyl pentapeptide -4 0.011
Part, 0.05 part of -1 copper of tripeptides.
Embodiment 9
A kind of Anti-hair loss scalp Essence, by mass percentage, including following components: composition 8% of the present invention,
Full gear alcohol 32%, menthol 0.15%, peppermint leaf oil 0.2%, butanediol 15%, parahydroxyacet-ophenone 0.5%, 1,2- penta 2
Alcohol 1.8%, deionized water surplus.
Wherein composition of the present invention, according to parts by weight, including 2.4 parts of ginseng root extract, rhizoma anemarrhenae root mention
Take 3.2 parts of object, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2.4 parts of ginger-root extract, 0.52 part of Angelica roots, side
0.52 part of CedarLeaves extract, 0.52 part of fleece-flower root root extract, 0.003 part of palmityl tripeptides -1, myristoyl pentapeptide -4
0.011 part, 0.05 part of -1 copper of tripeptides.
Embodiment 10
A kind of Anti-hair loss scalp Essence, by mass percentage, including following components: composition of the present invention
10%, full gear alcohol 30%, menthol 0.1%, peppermint leaf oil 0.1%, butanediol 18%, parahydroxyacet-ophenone 0.6%, 1,2-
Pentanediol 1.8%, deionized water surplus.
Wherein composition of the present invention, according to parts by weight, including 2.4 parts of ginseng root extract, rhizoma anemarrhenae root mention
Take 3.2 parts of object, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2.4 parts of ginger-root extract, 0.52 part of Angelica roots, side
0.52 part of CedarLeaves extract, 0.52 part of fleece-flower root root extract, 0.003 part of palmityl tripeptides -1, myristoyl pentapeptide -4
0.011 part, 0.05 part of -1 copper of tripeptides.
Anti-hair loss scalp Essence described in embodiment 8-10 the preparation method comprises the following steps: (1) by deionized water, butanediol put into
In ingredients pot, stirring is warming up to 80 DEG C -85 DEG C, keeps the temperature 30 minutes；(2) parahydroxyacet-ophenone is put into ingredients pot, stirring is equal
Ingredient pot temperature is down to 40 DEG C -45 DEG C after even；(3) present composition, pentanediol, be added ingredients pot in, stir evenly；
(4) by full gear alcohol, menthol, peppermint leaf oil elder generation's stirring and dissolving to transparent clarification without putting into ingredients pot after particle, stirring is equal
Discharging, is made the Anti-hair loss scalp Essence after even.
The volunteer of 100 exiguous human hairs using Anti-hair loss scalp Essence described in embodiment 8-10, as a result 85% with
On volunteer think that the Anti-hair loss scalp Essence has oil-control, antipruritic effect, 95% volunteer thinks to have obvious
Anti-hair loss effect.
Embodiment 11
A kind of Anti-hair loss leaves shampoo, by mass percentage, including following components: composition 5% of the present invention, laurel
Alcohol polyethers sulfuric ester ammonium 8%, laurel alcohol sulfuric ester ammonium 2%, lauroylamidopropyl betaine 2%, essence 0.3%, ethylene glycol two
Stearate 0.5%, cetostearyl alcohol 0.3%, hexamidine two (isethionic acid) salt 0.05%, Polyquaternium-10
0.25%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.3%, piroctone olamine salt 0.3%,
Dimethiconol 1%, sodium benzoate 0.2%, Phenoxyethanol 0.9%, sodium chloride 0.5%, deionized water surplus.
Wherein composition of the present invention, according to parts by weight, including 2 parts of ginseng root extract, rhizoma anemarrhenae root extract
3 parts of object, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2 parts of ginger-root extract, 0.45 part of Angelica roots, cacumen biotae mention
Take 0.45 part of object, 0.45 part of fleece-flower root root extract, 0.002 part of palmityl tripeptides -1, -4 0.005 parts of myristoyl pentapeptide,
0.001 part of -1 copper of tripeptides.
Embodiment 12
A kind of Anti-hair loss leaves shampoo, by mass percentage, including following components: composition 7% of the present invention, laurel
Alcohol polyethers sulfuric ester ammonium 7%, laurel alcohol sulfuric ester ammonium 2.5%, lauroylamidopropyl betaine 2%, essence 0.3%, ethylene glycol
Distearate 1.0%, cetostearyl alcohol 0.2%, hexamidine two (isethionic acid) salt 0.03%, Polyquaternium-10
0.5%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.5%, piroctone olamine salt 0.3%, poly-
Dimethyl silica alkanol 2%, sodium benzoate 0.2%, Phenoxyethanol 0.9%, sodium chloride 0.5%, deionized water surplus.
Wherein composition of the present invention, according to parts by weight, including 2 parts of ginseng root extract, rhizoma anemarrhenae root extract
3 parts of object, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2 parts of ginger-root extract, 0.45 part of Angelica roots, cacumen biotae mention
Take 0.45 part of object, 0.45 part of fleece-flower root root extract, 0.002 part of palmityl tripeptides -1, -4 0.005 parts of myristoyl pentapeptide,
0.001 part of -1 copper of tripeptides.
Embodiment 13
A kind of Anti-hair loss leaves shampoo, by mass percentage, including following components: composition 8% of the present invention, laurel
Alcohol polyethers sulfuric ester ammonium 7%, laurel alcohol sulfuric ester ammonium 2%, lauroylamidopropyl betaine 2%, essence 0.3%, ethylene glycol two
Stearate 0.5%, cetostearyl alcohol 0.2%, hexamidine two (isethionic acid) salt 0.05%, Polyquaternium-10 0.5%,
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.5%, piroctone olamine salt 0.3%, poly dimethyl
Siloxanes alcohol 1.5%, sodium benzoate 0.4%, Phenoxyethanol 0.7%, sodium chloride 0.8%, deionized water surplus.
Wherein composition of the present invention, according to parts by weight, including 2 parts of ginseng root extract, rhizoma anemarrhenae root extract
3 parts of object, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2 parts of ginger-root extract, 0.45 part of Angelica roots, cacumen biotae mention
Take 0.45 part of object, 0.45 part of fleece-flower root root extract, 0.002 part of palmityl tripeptides -1, -4 0.005 parts of myristoyl pentapeptide,
0.001 part of -1 copper of tripeptides.
A kind of Anti-hair loss leaves shampoo described in embodiment 11-13 the preparation method comprises the following steps: (1) by acrylic acid (ester) class/C10-
30 alkylol acrylamide acid esters cross-linked polymers are added in agitated kettle, sufficiently impregnate and are uniformly dispersed；(2) laureth sulfuric ester is added
Ammonium, laurel alcohol sulfuric ester ammonium, glycol distearate, cetostearyl alcohol, hexamidine two (isethionic acid) salt, polyquaternary amine
Salt -10, after homogeneous 8 minutes, stirring is warming up to 80-85 DEG C, keeps the temperature 40 minutes, opens cooling device；(3) temperature is down to 50-55
DEG C, after mixing by piroctone olamine salt, lauroylamidopropyl betaine in advance, puts into agitated kettle, is sufficiently stirred,
It is uniformly dissolved；(4) it is cooled to 40-45 DEG C, dimethiconol, composition of the present invention, sodium benzoate, benzene oxygen is added
Ethyl alcohol, essence, are sufficiently stirred, and are uniformly dissolved；(5) viscosity is adjusted with remaining ingredient, the Anti-hair loss leaves shampoo is made in discharging.
The volunteer of 100 exiguous human hairs is using Anti-hair loss leaves shampoo described in embodiment 11-13, and as a result 86% or more
Volunteer thinks that the Anti-hair loss leaves shampoo has oil-control, antipruritic effect, and 85% volunteer thinks there is apparent Anti-hair loss
Effect.
Embodiment 14
A kind of anticreep hair essence, by mass percentage, including following components: composition 5% of the present invention, laurel
Acylsarcosine sodium 4%, sodium cocoyl glycinate 2.5%, cocamidopropyl propyl amide hydroxyl sulfo betaine 6%, menthol 0.12%,
Peppermint leaf oil 0.08%, hydroxypropyl guar hydroxypropyltrimonium chloride 0.11%, allantoin 0.2%, dipotassium glycyrrhizinate
1%, PEG-7 glyceryl cocoate 0.5%, trimethylpentanediol/adipic acid/glycerin crosspolymers 1.0%, PPG-3 octyl
Ether 0.5%, nonyl phenol polyethers -14 0.5%, DMDM hydantoin 0.3%, Phenoxyethanol 0.5%, sodium chloride 0.8%, go from
Sub- water surplus.Wherein composition of the present invention, according to parts by weight, including 2 parts of ginseng root extract, rhizoma anemarrhenae root extract 3
Part, safflower extract 3 parts, 3 parts of kylin draconis extract, 2 parts of ginger-root extract, 0.45 part of Angelica roots, Cacumen Platycladi extract
0.45 part, 0.45 part of fleece-flower root root extract, 0.002 part of palmityl tripeptides -1, -4 0.005 parts of myristoyl pentapeptide, tripeptides -
1 0.001 part of bronze medal.
Embodiment 15
A kind of anticreep hair essence, by mass percentage, including following components: composition 8% of the present invention, laurel
It is acylsarcosine sodium 3%, sodium cocoyl glycinate 3%, cocamidopropyl propyl amide hydroxyl sulfo betaine 5%, menthol 0.2%, thin
Lotus leaf oil 0.06%, hydroxypropyl guar hydroxypropyltrimonium chloride 0.12%, allantoin 0.3%, dipotassium glycyrrhizinate
0.9%, PEG-7 glyceryl cocoate 1%, trimethylpentanediol/adipic acid/glycerin crosspolymers 1.2%, PPG-3 octyl
Ether 0.3%, nonyl phenol polyethers -14 0.5%, DMDM hydantoin 0.3%, Phenoxyethanol 0.5%, sodium chloride 0.8%, go from
Sub- water surplus.Wherein composition of the present invention, according to parts by weight, including 2 parts of ginseng root extract, rhizoma anemarrhenae root extract 3
Part, 3 parts of safflower extract, 3 parts of kylin draconis extract, 2 parts of ginger-root extract, 0.45 part of Angelica roots, cacumen biotae are extracted
0.45 part of object, 0.45 part of fleece-flower root root extract, 0.002 part of palmityl tripeptides -1, -4 0.005 parts of myristoyl pentapeptide, three
0.001 part of -1 copper of peptide.
Embodiment 16
A kind of anticreep hair essence, by mass percentage, including following components: composition 10% of the present invention, the moon
Osmanthus acylsarcosine sodium 4%, sodium cocoyl glycinate 3%, cocamidopropyl propyl amide hydroxyl sulfo betaine 6%, menthol 0.1%,
Peppermint leaf oil 0.05%, hydroxypropyl guar hydroxypropyltrimonium chloride 0.1%, allantoin 0.2%, dipotassium glycyrrhizinate
0.8%, PEG-7 glyceryl cocoate 0.8%, trimethylpentanediol/adipic acid/glycerin crosspolymers 1.5%, PPG-3 are pungent
Base ether 0.4%, nonyl phenol polyethers -14 0.5%, DMDM hydantoin 0.3%, Phenoxyethanol 0.5%, deionized water surplus.Its
In composition of the present invention, according to parts by weight, including 2 parts of ginseng root extract, 3 parts of rhizoma anemarrhenae root extract, safflower extract
3 parts of object, 3 parts of kylin draconis extract, 2 parts of ginger-root extract, 0.45 part of Angelica roots, 0.45 part of Cacumen Platycladi extract, what
0.45 part of tuber of multiflower knotweed root extract, 0.002 part of palmityl tripeptides -1, -4 0.005 parts of myristoyl pentapeptide, -1 copper 0.001 of tripeptides
Part.
Anticreep hair essence described in embodiment 14-16 the preparation method comprises the following steps: (1) by hydroxypropyl melon rubber hydroxypropyl trimethylammonium
Ammonium chloride, allantoin, sodium lauroyl sarcosine, sodium cocoyl glycinate, cocamidopropyl propyl amide hydroxyl sulfo betaine investment
In agitated kettle, deionized water, stirring is warming up to 80-85 DEG C, keeps the temperature 30 minutes, opens cooling device；(3) temperature is down to 50-55
DEG C, investment PPG-3 Octyl Ether, dipotassium glycyrrhizinate, PEG-7 glyceryl cocoate cool down while stirring；(3) temperature is down to 40-45
DEG C, put into trimethylpentanediol/adipic acid/glycerin crosspolymers, DMDM hydantoin, Phenoxyethanol, of the present invention group
Object is closed, stirs evenly (4) for menthol, peppermint leaf oil, nonyl phenol polyethers elder generation stirring and dissolving to transparent clarification without putting into after particle
It in ingredients pot, discharges after mixing evenly, the anticreep hair essence is made.
The volunteer of 90 exiguous human hairs uses anticreep hair essence described in embodiment 14-16, as a result 83% or more will
Hope person thinks that the Anti-hair loss leaves shampoo has oil-control, antipruritic effect, and 90% volunteer thinks have apparent Anti-hair loss to imitate
Fruit.
Claims (10)
1. a kind of composition for having antipruritic, oil-control, strong hair, Anti-hair loss effect, which is characterized in that including following components: ginseng mentions
Take at least one of object, anemarrhena asphodefoides extract, safflower extract or kylin draconis extract；Palmityl tripeptides -1, myristoyl five
At least one of -1 copper of peptide -4 or tripeptides.
2. composition according to claim 1, which is characterized in that including following components: ginseng root extract, rhizoma anemarrhenae root mention
Take at least one of object, safflower extract or kylin draconis extract；Palmityl tripeptides -1, myristoyl pentapeptide -4 or tripeptides -1
At least one of copper.
3. composition according to claim 1 or 2, which is characterized in that further include Angelica roots, cacumen biotae extraction
Object, fleece-flower root root extract, ginger-root extract.
4. composition according to claim 1 or 2, which is characterized in that according to parts by weight, including following components: ginseng
Root extract is 0.1-60 parts, rhizoma anemarrhenae root extract is 0.1-60 parts, safflower extract is 0.1-60 parts, kylin draconis extract is
0.1-60 parts, palmityl tripeptides -1 be 0.01-8 parts, myristoyl pentapeptide -4 is 0.01-8 parts, in -1 copper of tripeptides is 0.01-8
Part, Angelica roots are 0.1-50 parts, Cacumen Platycladi extract is 0.1-50 parts, fleece-flower root root extract is 0.1-50 parts, ginger
Root extract is 0.1-50 parts.
5. composition according to claim 4, which is characterized in that according to parts by weight, including following components: ginseng mentions
Taking object is 0.1-15 parts, rhizoma anemarrhenae root extract is 0.1-15 parts, safflower extract is 0.1-15 parts, kylin draconis extract is 0.1-
15 parts, palmityl tripeptides -1 be 0.1-1 parts, myristoyl pentapeptide -4 is 0.1-1 parts, in -1 copper of tripeptides is 0.1-1 parts, angelica root
Extract is 0.1-7 parts, Cacumen Platycladi extract is 0.1-7 parts, fleece-flower root root extract is 0.1-7 parts, ginger-root extract is
0.1-7 parts.
6. composition according to claim 5, which is characterized in that according to parts by weight, including following components: ginseng mentions
Taking object is 0.1-4 parts, rhizoma anemarrhenae root extract is 0.1-4 parts, safflower extract is 0.1-4 parts, kylin draconis extract is 0.1-4
Part, palmityl tripeptides -1 be 0.1 part, myristoyl pentapeptide -4 is 0.1 part, in -1 copper of tripeptides be 0.1 part, Angelica roots are
0.3-2 parts, Cacumen Platycladi extract be 0.3-2 parts, fleece-flower root root extract is 0.3-2 parts, ginger-root extract is 0.3-2 parts.
7. composition according to claim 4, which is characterized in that further include 30-300 parts of water, anti-corrosion according to parts by weight
0.1-2 parts and sodium chloride 0.1-1.5 parts of agent.
8. composition according to claim 7, which is characterized in that the water is deionized water；The preservative is benzene oxygen
Ethyl alcohol.
9. the application of composition described in any one of -8 according to claim 1, which is characterized in that the composition is applied to makeup
The preparation of product or curable product.
10. application according to claim 9, which is characterized in that the preparation type of the cosmetics or curable product includes
But it is not limited to Essence, shampoo, lotion, creme, spray, gel.
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| CN201910198548.4A CN110013455A (en) | 2019-03-15 | 2019-03-15 | It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition |
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| CN201910198548.4A CN110013455A (en) | 2019-03-15 | 2019-03-15 | It is a kind of with antipruritic, oil-control, strong hair, Anti-hair loss effect composition |
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| CN112190510A (en) * | 2020-09-22 | 2021-01-08 | 广东嘉丹婷日用品有限公司 | Anti-hair loss composition and preparation method thereof |
| CN112274463A (en) * | 2020-09-22 | 2021-01-29 | 广东嘉丹婷日用品有限公司 | Anti-hair loss shampoo and preparation method thereof |
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| CN110613627A (en) * | 2019-10-25 | 2019-12-27 | 上海中医药大学 | Cosmetic and preparation method thereof |
| CN110946813A (en) * | 2019-11-12 | 2020-04-03 | 澳宝化妆品（惠州）有限公司 | Compound fermentation extract containing cubilose and preparation method and application thereof |
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| CN112107527A (en) * | 2020-09-22 | 2020-12-22 | 广东嘉丹婷日用品有限公司 | Anti-hair loss essence and preparation method thereof |
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Application publication date: 20190716 |