KR102083003B1 - Composition having improvement activity of scalp and hair using compound extract - Google Patents

Abstract

The present invention relates to a composition having an effect of improving scalp and hair conditions. The composition comprises, as an active ingredient, 0.15 to 5.00 wt% of a complex extract in which a Hydrangea serrata leaf extract, Arnica montana flower extract, Foeniculum vulgare extract, Scutellaria baicalensis extract, Matricaria chamomilla flower extract, Paeonia suffruticosa root extract, salvia extract, and Calendula officinalis flower extract are mixed, based on a total weight of a formulation for scalp and hair. The composition has a hair moisturizing effect, anti-splitting effect and softening effect, suppresses the excessive production of sebum associated with alopecia, has an anti-hair loss effect, a hair growth effect, and a strong antibacterial action against dandruff bacteria, and has a hair growth effect of making new hair grow well and a hair restoration effect of making thin and weak hair thick and strong.

Description

Composition having improvement activity of scalp and hair using compound extract}

The present invention using the hydrangea leaf extract, Arnica montana flower extract, fennel extract, golden extract, Matricaria flower extract, peony root extract, salvia extract, pot marigold flower extract, hair moisturizing effect and cracking prevention effect, supple Effects, inhibits overproduction of sebum associated with alopecia, prevents hair loss and hair growth, has strong antibacterial effects against dandruff, and hair growth to make young hair grow well and wool to make thin and strong hair thick and strong. It relates to a composition having ameliorative activity of the scalp and hair having a.

Human hair is about 100,000 to 150,000 pieces, each hair has a different cycle and grow, drop out through the growth phase, the degenerative phase, the resting phase. This cycle is repeated over three to six years, with the result that on average 60 to 100 hairs fall out normally. In general, alopecia refers to a shortening of hair growth rate in the growth phase and more hair in the degenerative or resting phase due to abnormal hair loss.

In addition to the scalp, it can also be seen on the beard, armpits, eyebrows, pubic hair, etc. In severe cases, hair loss may occur all over the body.

The causes of hair loss have been discussed such as poor blood circulation, excessive male hormone action, excessive sebum secretion, scalp hypofunction caused by dandruff and other bacteria, genetic factors, aging, stress. However, there is no clear cause for hair loss, and in recent years, more and more people are suffering from hair loss due to changes in diet and stress due to social conditions, and their age is also decreasing. The trend is.

Among the causes of alopecia, the most common type of alopecia, which is directly related to male hormone oversecretion, is masculine alopecia, which is more precise and scientific name called androgenetic alopecia. In the case of androgenetic alopecia, healthy hair becomes thinner and shorter, and the hair is weak and easily broken. This phenomenon is called miniaturization.

Hair follicles, which shrink, eventually become thin and invisible, turning into short hairs, which leads to hair loss.

Accordingly, many studies have recently been reported for the prevention and treatment of hair loss through inhibition of male hormone activity.

Briefly explain the mechanism of hair loss on male hormones are as follows.

Testosterone, one of the male hormones, is converted to the active male hormone dihydrotestosterone by an enzyme called 5-alpha-reductase, and the activated hormone is a constant receptor. In combination with and induces a protein that causes hair loss will proceed hair loss.

In addition, this mechanism may cause excessive production of sebum, which may cause acne or seborrheic dermatitis, and as a result, scalp may occur with inflammation.

As a result, androgenetic alopecia suggests that inhibiting the activity of 5 alpha-reductase can effectively prevent and treat masculine alopecia.

Accordingly, the present inventors have studied and experimented with several herbal extracts as active ingredients for improving the scalp and hair, and as a result, the complex extracts have a moisturizing effect of hair, prevention of hair splitting, softening effect, and strong antibacterial activity against dandruff. It has been found to have the effect of improving the scalp and hair by inhibiting the excessive production of sebum, preventing hair loss and hair growth, hair growth effect for growing young hair, and wool effect for thick and strong hair.

Therefore, an object of the present invention is an active ingredient for improving the scalp and hair, as a hydrangea leaf extract, arnica montana flower extract, fennel extract, golden extract, matricaria flower extract, peony root extract, salvia extract, port marigold flower extract By using to provide a composition having the effect of improving the scalp and hair.

The composition having the improvement effect of the scalp and hair of the present invention is an active ingredient as a hydrangea leaf extract, arnica montana flower extract, fennel extract, golden extract, matrikaria flower extract, peony root extract, salvia extract, pot marigold flower It is characterized in that the extract contains a mixed extract of 0.15 to 5.00% by weight based on the total weight of the scalp and hair formulation.

In addition, the present invention is a tyrosinase activator, penetration promoter, blood flow promoter, follicle activator or 5α-reductase inhibitor, scalp nutrient, itch inhibitor, dissolution aid, solvent, surfactant, humectant, thickener, preservative, antioxidant, metal It is characterized in that it further comprises an ion blocking agent, anti-inflammatory agent, antimicrobial agent, surfactant, fungicide, colorant, flavoring agent.

The composition having the improvement effect of the scalp and hair containing the complex extract of the present invention has dandruff, anti-itch and healing effect, hair moisturizing effect and cracking effect, softening effect, wool effect, hair growth effect, sebum overproduction suppression There is an effect of showing the activity on the effect, hair loss prevention and hair growth effect, hair growth promoting effect.

Hereinafter, with reference to the accompanying drawings will be described an embodiment of the present invention.

The composition having the improvement effect of the scalp and hair of the present invention includes a wild hydrangea leaf extract, arnica montana flower extract, fennel extract, golden extract, matricaria flower extract, peony root extract, salvia extract, port marigold flower extract do.

In the composite extract composition of the present invention, it is preferable that the hydrangea leaf extract, arnica montana flower extract, fennel extract, golden extract, matricaria flower extract, peony root extract, salvia extract and pot marigold flower extract are mixed in the same amount. .

In addition, the condition improvement of hair and scalp according to the present invention is to prevent dandruff and treatment effect of the scalp, moisturizing effect of hair, hair splitting effect, softening effect, wool effect, hair growth effect, hair loss prevention and hair growth effect, sebum excess It means production inhibition effect and hair growth promotion effect.

As used herein, the term "extract" includes all substances obtained by extracting the components of natural products, regardless of the extraction method, the extraction solvent, the extracted components or the form of the extract, and after extracting the substances obtained by extracting the components of natural products, It is a broad concept that includes all of the materials that can be obtained by processing or processing in a method. For example, washing the raw material of each component, and extracting the washed raw material by mixing with a solvent selected from the group consisting of water, alcohol or a mixture of water and alcohol, and sterilizing and filtering the mixture to separate the filtrate Steps; The separated filtrate is sterilized to yield an extract. In this case, the extraction mixed with the solvent may be used in the form of a freeze-dried by extracting the extract extracted in this way at about 45 degrees after freeze-drying concentrated.

In addition, the composition having the improving effect of the scalp and hair of the present invention is not limited as long as it is an agent that can be directly applied to the local surface of the scalp and hair as an auxiliary component having the improving effect of the scalp and hair. That is, the other composition which can be contained in this composition can confirm the effect of the objective of this invention to a scalp and hair, and can also mix | blend two or more types, although it can mix | blend with one type in this composition. For example, tyrosinase activators, penetration promoters and blood flow promoters, follicle inactivators, 5α-reductase inhibitors, scalp nutrients, anti-itch agents, and the like can be used as components of the composite extract composition. And the contents of the examples of the components contained in the composition.

Tyrosinase activator may be an extract of green tea, green tea extract, and the like. The tyrosinase activator is preferably added in an amount of 0.1 to 0.2% by weight based on the total weight of the composite extract composition.

Penetrant accelerators and blood flow promoters may be used iris extracts, Angelica extracts, witch hazel extracts, lichen herb extracts, cheongung extracts, chamomile extracts, red ginseng extracts, sugar extracts. Penetration accelerator and blood flow promoter is preferably added in a 0.1 to 0.5 weight ratio based on the total weight of the composite extract composition.

The follicle rejuvenating agent may be a sulfur extract, red ginseng extract, acid extract, sugar extract, and the like. It is preferable that a blanket activator is added in 0.1 to 0.5 weight ratio with respect to the total weight of the composite extract composition.

As a 5α-reductase inhibitor, licorice extract, marigold extract, aloe extract, red ginseng extract, cheongung extract, yolk extract, sugar extract, and the like can be used. The 5α-reductase inhibitor is preferably added at a ratio of 0.1 to 0.5% by weight based on the total weight of the composite extract composition.

Scalp nutrients include one or more vitamins or vitamin precursors consisting of iron, calcium, manganese, essential amino acids, pyridoxine hydrochloride, biotin, vitamin B1, vitamin B2, vitamin B6, vitamin D, and folic acid, menthol di-panthenol, polyquaternium- 7, tricetylmonium chloride, dimethicone / isolaures-6, complex extract (yeast, gold, propolis, ginseng, machi, clove, sewage), cetyltrimethylammonium chloride, cetearyl alcohol, keratinamino acid, Various minerals other than cyclopentasiloxane / dimethicone, dimethicone / isolaureth-6, etc. can be used. The scalp nutrient is preferably added in a weight ratio of 0.1 to 0.3 based on the total weight of the composite extract composition.

Itching inhibitors can be used extracts, gourd extract, panchae extract, peppermint and mixtures thereof. Itch suppressant is preferably added in a 0.1 to 0.2 weight ratio based on the total weight of the composite extract composition.

In addition, the present invention is used to maintain the quality as long as the general base ingredient or the active ingredient that can be blended in the external composition (hair composition) does not impair the desired effect in the formulation or form of the specific composition according to the formulation or form of the specific composition. Can be combined. Specifically, the solubilizer, solvent, surfactant, moisturizer, thickener, preservative, antioxidant, metal ion sequestrant, anti-inflammatory agent, antimicrobial agent, bactericide, colorant, flavoring agent, etc. are appropriately selected according to the formulation or form for the purpose. Can be blended.

As the dissolution aid, isopropyl myristate, polyethylene glycol, medium chain fatty acid triglycerides, hydrocarbons, glycols and the like can be used. Dissolving aid is preferably added in a 0.1 to 0.2 weight ratio based on the total weight of the composite extract composition.

As the solvent, ethanol, purified water, Tween 20, cyclomethicone, mineral oil, dimethicone and the like can be used. The solvent is preferably added in a 0.5 to 0.8 weight ratio based on the total weight of the composite extract composition.

Surfactant can use any of anionic surfactant, nonionic surfactant, and cationic surfactant. The surfactant is preferably added in a ratio of 1 to 50% by weight based on the total weight of the composite extract composition.

As the moisturizing agent, for example, glycerin, propylene glycol, 1, 3-butylene glycol, dipropylene glycol, sorbitol and the like can be used. Moisturizing agent is preferably added in a 0.1 to 0.5 weight ratio based on the total weight of the composite extract composition.

As the thickener, for example, methyl cellulose, hydroxyethyl cellulose, carrageenan, carboxymethyl cellulose, polyquaternium-10, sodium chloride, hydroxymethyl cellulose and the like are used, and citric acid, sodium hydroxide, triethanolamine, sodium citrate, Phosphoric acid, sodium phosphate, lactic acid and the like can be used. The thickener is preferably added in a 0.1 to 0.5 weight ratio based on the total weight of the composite extract composition.

As the preservative, for example, a mixture of benzoic acid, paraoxybenzoic acid ester, methylchloroisothiazolinone, phenoxyethanol, DMDM hydantoin and the like can be used. Preservatives are preferably added in a 0.1 to 0.3 weight ratio based on the total weight of the composite extract composition.

As the antioxidant, for example, dibutyl hydroxytoluene, ascorbic acid and the like can be used. Antioxidant is preferably added in a 0.1 to 0.2 weight ratio based on the total weight of the composite extract composition.

As the metal ion blocking agent, for example, ethylenediaminetetraacetate acetate, ethylenediaminetetraacetate tetrasodium and the like can be used. The metal ion sequestrant is preferably added in an amount of 0.01 to 0.1 weight based on the total weight of the composite extract composition.

As the anti-inflammatory agent, for example, those selected from monoammonium glycyrrhinate, dipotassium glycyrizine, stearyl glycyrizinate, chamomile, alpha bisabolol, allantoin, mixtures thereof, and the like can be used. Anti-inflammatory agent is preferably added in a 0.1 to 0.2 weight ratio based on the total weight of the composite extract composition.

As antimicrobial agents, for example, phenoxyethanol, chlorhexidine, chlorhexidine gluconate, pyroxtonolamine, ketoconazole arnica extract, iodopropynylbutylcarbamate, benzalkonium chloride, benzenetonium chloride, benzoic acid and its salts, benzyl alcohol lavender, rosemary, Salicylic acid, triclocarban, zinc pyrithione suspensions, mixtures thereof and the like can be used. The antimicrobial agent is preferably added in a 0.1 to 0.2 weight ratio based on the total weight of the composite extract composition.

As the bactericide, for example, chlorhexidine gluconate, quaternary ammonium salt, pyrotonolamine, zinc pyrithione suspension, iodopropynyl butyl carbamate, salicylic acid and the like can be used. The fungicide is preferably added in an amount of 0.01 to 0.1 weight based on the total weight of the composite extract composition.

The complex extract composition of the present invention is one of the product form selected from the form of all formulations that can be applied to the normal scalp and hair, such as hair tonic, hair pack, shampoo, shampoo and rinse mixture, the composition is generally scalp or hair Used by hair or transdermal administration, such as direct application or spraying on. In addition, the amount of the composition to be used should be appropriately determined according to individual differences, dosage forms, and forms such as age and degree of lesion. As described above, the present composition can be suitably used in various fields such as pharmaceuticals, quasi-drugs, or cosmetics as various hair treatment agents. The composite extract composition of the present invention is applied differently depending on the composition form within the range of 0.15 to 5.00% of the total weight of the scalp and hair formulation.

Hereinafter, a preferred embodiment of the composition having a composition having the effect of improving the scalp and hair using the complex extract of the present invention will be described in detail.

However, the technical range of this invention is not limited by these, and the compounding quantity in the preparation example of these Examples, etc. is the weight% with respect to the whole system to which the component is mix | blended unless it is specifically determined.

Preparation of Complex Extract Mixture

A total of 1 kg of each of the raw materials of the hydrangea leaf, arnica montana flower, fennel, golden, matricaria flower, peony root, salvia, and port marigold flower were washed with purified water. Then, the washed raw material was extracted by refluxing three times for 24 hours with a 70% ethanol aqueous solution, and then cooled, and then mixed with Whatman # 5 filter paper to prepare a composite extract.

<Production of Hair Tonic Containing Complex Extract Composition>

Each of the raw materials were weighed by three formulations shown in Table 1, stirred at 500 rpm for 5 minutes, and filtered to prepare hair tonics of Examples 1, 2, and 3. In addition, the hair tonic of Comparative Examples 1, 2, and 3 was prepared in the formulation without the composite extract composition.

Purpose of Mixing
Raw material name Quantity (g) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 solvent Purified water Quantity Quantity Quantity Quantity Quantity Quantity Moisturizer 1,3-butylene glycol 2.00 2.00 2.00 2.00 2.00 2.00 Scalp Nutritional Supplements Biotin 0.02 0.02 0.02 0.02 0.02 0.02 Metal Ion Blocker Ethylenediaminetetradiacetic acid sodium 0.03 0.03 0.03 0.03 0.03 0.03 Anti-inflammatory Allantoin 0.10 0.10 0.10 0.10 0.10 0.10 solvent ethanol 30.00 30.00 30.00 30.00 30.00 30.00 Scalp Nutritional Supplements menthol 0.02 0.02 0.02 0.02 0.02 0.02 Flavor Spices Quantity Quantity Quantity Quantity Quantity Quantity antiseptic DMH Hidantoin 0.10 0.10 0.10 0.10 0.10 0.10 Complex extract 1.00 2.00 5.00 pH adjuster Citric acid 0.10 0.10 0.10 0.10 0.10 0.10 disinfectant Salicylic acid 0.10 0.20 0.30 0.10 0.10 0.10 solvent Twin 20 0.10 0.10 0.10 0.10 0.10 0.10 antiseptic Paraoxybenzoic Acid Methyl 0.10 0.10 0.10 0.10 0.10 0.10 Anti-inflammatory Dipotassium glycyrrhinate 0.02 0.02 0.02 0.02 0.02 0.02 Itching Inhibitor Peppermint 0.10 0.10 0.10 0.10 0.10 0.10

<Production of Shampoo Containing Complex Extract Composition>

The three formulations shown in Table 2 were mixed with each other except the fragrance and purified water, and then heated to 80 ° C. to complete dissolution while stirring. The shampoo of Example 4, 5, 6 was prepared by terminating the same. In addition, the extract of Comparative Example 4, 5, 6 was prepared in a formulation without the composite extract composition.

Purpose of Mixing
Raw material name Quantity (g) Example 4 Example 5 Example 6 Comparative Example 4 Comparative Example 5 Comparative Example 6 solvent Purified water Quantity Quantity Quantity Quantity Quantity Quantity Metal Ion Blocker Ethylenediaminetetradiacetic acid sodium 0.01 0.01 0.01 0.01 0.01 0.01 Scalp Nutritional Supplements Diel-Pantenol 0.20 0.20 0.20 0.20 0.20 0.20 Moisturizer Propylene glycol 0.50 0.50 0.50 0.50 0.50 0.50 Thickener Polyquaternium-10 0.35 0.35 0.35 0.35 0.35 0.35 Surfactants Ammonium Laureth-3 Sulfate 15.00 15.00 15.00 15.00 15.00 15.00 Surfactants Sodium Laureth-3 Sulfate 40.00 40.00 40.00 40.00 40.00 40.00 Surfactants Kokamido Profile 8.00 8.00 8.00 8.00 8.00 8.00 Scalp Nutritional Supplements Polyquaternium-7 2.50 2.50 2.50 2.50 2.50 2.50 pH regulator Sodium phosphate Quantity Quantity Quantity Quantity Quantity Quantity Surfactants Glycol distearate 2.00 2.00 2.00 2.00 2.00 2.00 Surfactants Cocamide MEI 1.80 1.80 1.80 1.80 1.80 1.80 Surfactants Potassium cocoyl glutamate 2.00 2.00 2.00 2.00 2.00 2.00 Thickener Sodium chloride 0.80 0.80 0.80 0.80 0.80 0.80 Scalp Nutritional Supplements Tricetylmonium chloride 0.50 0.50 0.50 0.50 0.50 0.50 disinfectant Salicylic acid 0.10 0.10 0.10 0.10 0.10 0.10 disinfectant Urethral propynylbutyl carbamate 0.10 0.10 0.10 0.10 0.10 0.10 Scalp Nutritional Supplements Dimethicone / isolauresu-6 3.20 3.20 3.20 3.20 3.20 3.20 antiseptic Methylchloroisothiazolinone /
Methylchlorothiazolinone 0.05 0.05 0.05 0.05 0.05 0.05 Complex extract 0.30 1.00 2.00 Bulking agent Bentonite 0.05 0.05 0.05 0.05 0.05 0.05 Surfactants Potassium Coyl Glycinate 2.00 2.00 2.00 2.00 2.00 2.00 coloring agent Pigment Quantity Quantity Quantity Quantity Quantity Quantity Flavor Spices Quantity Quantity Quantity Quantity Quantity Quantity

<Production of Hair Treatment Containing Complex Extract Composition>

In each of the three raw materials shown in Table 3, raw materials 1 to 5 were weighed and heated to 80 ° C (1). Thereafter, raw materials 6 to 13 were weighed and heated to 80 ° C (2). After confirming the temperature and the dissolved state of (1) (2), (2) is added to (1) to emulsify. After stirring for 3 minutes at Homo Mixer 2500 rpm and 25 rpm Disper Mixer, cooling starts. The raw materials 14-20 were added at 40 degreeC, and it stirred and cooled, and terminated at 30 degreeC, and the hair treatment of Examples 7, 8, and 9 was produced. In addition, the hair extract of Comparative Example 7, 8, 9 was prepared in a formulation in which the composite extract composition was not added.

Purpose of Mixing
Raw material name Quantity (g) Example 7 Example 8 Example 9 Comparative Example 7 Comparative Example 8 Comparative Example 9 solvent Purified water Quantity Quantity Quantity Quantity Quantity Quantity Thickener Guar hydroxypropyl trimonium chloride 0.50 0.50 0.50 0.50 0.50 0.50 Moisturizer Propylene glycol 2.00 2.00 2.00 2.00 2.00 2.00 Scalp Nutritional Supplements Cetyltrimethylammonium chloride 1.00 1.00 1.00 1.00 1.00 1.00 antiseptic Methylparaben 0.10 0.10 0.10 0.10 0.10 0.10 Surfactants Steartrimonium chloride 4.00 4.00 4.00 4.00 4.00 4.00 Surfactants Glyceryl Stearate 2.50 2.50 2.50 2.50 2.50 2.50 Scalp Nutritional Supplements Cetearyl Alcohol 6.00 6.00 6.00 6.00 6.00 6.00 antiseptic Profile paraben 0.10 0.10 0.10 0.10 0.10 0.10 solvent Cyclomethicone 2.00 2.00 2.00 2.00 2.00 2.00 solvent Mineral oil 5.00 5.00 5.00 5.00 5.00 5.00 Scalp Nutritional Supplements Cyclopentasiloxane / dimethicone 3.00 3.00 3.00 3.00 3.00 3.00 solvent Dimethicone 0.50 0.50 0.50 0.50 0.50 0.50 coloring agent Pigment Quantity Quantity Quantity Quantity Quantity Quantity Scalp Nutritional Supplements Dimethicone / isolauresu-6 3, 00 3, 00 3, 00 3, 00 3, 00 3, 00 Scalp Nutritional Supplements Complex extract 015 1.50 3.00 Scalp Nutritional Supplements Keratinamino acids 0.20 0.20 0.20 0.20 0.20 0.20 disinfectant Pyrotonolamine 0.02 0.02 0.02 0.02 0.02 0.02 solvent ethanol 0.15 0.15 0.15 0.15 0.15 0.15 Complex extract 1.00 3.00 5.00 Flavor Spices Quantity Quantity Quantity Quantity Quantity Quantity

<Experimental evaluation with improving effect activity of scalp and hair of composition containing complex extract>

Experimental Example 1: Experimental evaluation on the effect of inhibiting hair loss, hair growth, wool, hair growth, sebum overproduction of the formulation containing the complex extract

〈Clinical Experiment Evaluation Subject〉

Model groups classified as shown in Table 4 were selected for clinical trial evaluation.

Model Group Hair condition 1st group  Hair loss is more than 50% in visual evaluation and 12 men in their 20s to 50s who are overly sebum produced. 2nd group  Hair loss is more than 50% in visual evaluation, and 10 men in their 20s to 50s have excessive sebum production. 3rd group  Although not hair loss, 14 men and 22 women in their 20's to 50's have a lot of hairs, and they fall out when they are visually evaluated. 4th group  20 males and 30 females from 18 to 50 years of age who look healthy hair but usually lose a lot of hair.

Clinical Trial Results

The hair tonic of Example 3, the shampoo of Example 6, and the treatment of Example 8 were used at least once or three times a day for an average of 4 months in the clinical trial evaluation model group of Table 4 to prevent hair loss, hair growth, and wool. The results of the experimental evaluation on the inhibitory effects of overgrowth of hair, hair growth and sebum are shown in Table 5. (The scores in the clinical trial evaluation show the improved effects of the models belonging to each group: 8 to 10 points. The results of averaging the scores of each model group were expressed as the effect on the composition.

Model Group Hair loss prevention effect Hair growth effect Hair growth effect Wool effect Sebum overproduction inhibitory effect 1st group 7.8 points 2.8 5.4 5.8 8.4 2nd group 8.3 points 3.9 6.1 5.7 8.4 3rd group 9.7 points 3.6 5.6 5.7 9.0 4th group 8.6 points - - - -

As shown in Table 5, it was evaluated that the skin condition was excellent in the improvement effect activity of the scalp and hair without finding any unusual skin irritation findings.

In addition, in the case of the average hair dropping cycle, the average daily dropping rate is about 60 to 100, but the dropout rate decreases to 90% to 40% in the number of dropouts in progress. Was rated very excellent.

In addition, the low score of the hair growth effect in the results of Table 5 is only a result of the evaluation during the experimental period, the score for the effect surface continues to increase for the model using the composition continuously.

Experimental Example 2: Antibacterial effect test on the dandruff bacteria of the complex extract

The antimicrobial activity test for the dandruff bacteria of the complex extract of the present invention was added to 0.5% concentration of the composite extract to pistrosporum ovale cultured in a liquid medium, or 0.3% concentration of the composite extract to dry dandruff cultured in anaerobic culture tank After that, the minimum inhibitory concentration (MIC) that inhibits the growth of each dandruff was confirmed.

As a result, the range of minimum inhibitory concentration of acetylsalicylic acid for each dandruff was estimated to be 10-100 ppm of oily dandruff and 7-100 ppm of dry dandruff.

Experimental Example 3: Antibacterial effect test on dandruff bacteria of the formulation containing the complex extract

〈Clinical Experiment Evaluation Subject〉

Model groups classified as shown in Table 6 were selected for clinical trial evaluation.

Model Group Hair condition 1st group Hair loss is more than 50% in visual evaluation and 15 males in their 20s to 60s with oily dandruff 2nd group Hair loss is more than 10% in visual evaluation and 15 men in their 20s to 60s with dry dandruff 3rd group 15 males and 20 females from 10s to 50s with oily dandruff with seborrheic dermatitis 4th group 20 males and 20 females from teenagers to 60s with other dandruff bacteria appearing as healthy hair when visual evaluation

<Clinical Trial Evaluation Results>

The hair tonic of Example 3, the shampoo of Example 6, and the treatment of Example 8 were continuously applied to the model group of Table 6, and used once every 7 days, for an average of 3 months. Table 7 shows the antimicrobial effect on the results of the clinical trials. Dividing by points and averaging the scores of each model group as the effect on the composition).

Model group 1st group 2nd group 3rd group 4th group Antimicrobial Effects on Dandruff 9.3 points 8.8 points 3.5 points 5.5 points

As shown in Table 7 and results, it was evaluated that the anti-microbial activity against dandruff was excellent without any unusual skin irritation findings during the clinical trial process using the hair tonic, shampoo and treatment containing the complex extract of the present invention.

In addition, in the antibacterial activity test against dandruff bacteria of the present composition, the limit of the concentration of the complex extract in the range that can maintain the formulation is limited to 0.15 ~ 5.00%, in particular antibacterial activity against oily and dry dandruff and other dandruff bacteria The effect was evaluated to be excellent.

In addition, the antimicrobial effect against dandruff which does not show side effects such as skin attack is considered to be excellent even after long-term use.

Experimental Example 4: Experimental evaluation of the softening, moisturizing, and hair splitting effect of the formulation containing the complex extract.

〈Clinical Experiment Evaluation Subject〉

Model groups classified as in Table 8 were selected for clinical trial evaluation.

Model Group Hair condition 1st group Hair split, stiff, sloppy, and inflexible (more than 30% in visual evaluation) 10 men in their 20s and 60s 2nd group Hair splitting, stiffness, slackness and inflexibility (more than 30% in visual evaluation) 5 males and 11 females in their 20s and 60s 3rd group Hair stiff, sloppy, and inflexible (more than 20% in visual evaluation) 5 men in their 20s and 60s and 15 women 4th group In the visual evaluation, 15 healthy men and 20 women in their 60s, healthy hair

<Clinical Trial Evaluation Results>

The hair tonic of Example 3, the shampoo of Example 6, and the treatment of Example 8 were continuously applied to the model groups of Table 8, once every 7 days for 2 months, and the hair of each group was The effects of softening, moisturizing, and hair splitting were confirmed and shown in Table 9. (Scores in the clinical trial evaluations indicate the improved effect states of the models belonging to each group. Lower: Divided by 0-4 points and averaged the scores of each model group as the effect on the composition).

Model Group Yeon Yeon Effect Moisturizing effect Garage prevention effect First group 8.7 points 7.9 points 8.0 points Second group 8.4 points 7.5 points 6.7 points Third group 8.8 points 7.0 points 6.8 points Fourth group 8.1 points 7.2 points 7.1 points

Table 9 shows the condition of the skin during the clinical experiment using the hair tonic, shampoo, and treatment containing the complex extract of the present invention, while no unusual skin irritation was found, the moisturizing effect of the scalp and hair, hair softness and cracking prevention. The effect was evaluated to be excellent.

In particular, it was evaluated that the recovery effect of hair damaged by the perm and the like is also very good.

In addition, in the experiment of the moisturizing effect of the scalp and hair of the present composition, the softening and cracking prevention effect of the hair, the content of the complex extract is limited to 0.15 to 5.00% in the range that can maintain the formulation, and the weight Even if it increased, the side effect such as skin attack did not appear at all, and the effect was evaluated as being excellent.

In addition, long-term use is believed to be excellent in moisturizing effect of the scalp and hair, hair softness and cracking prevention effect does not appear side effects such as skin attack.

Claims (5)

The total weight of the formulation for the scalp and hair is mixed with a wild hydrangea leaf extract, arnica montana flower extract, fennel extract, golden extract, matricaria flower extract, peony root extract, salvia extract, and port marigold flower extract. 0.15 to 5.00% by weight based on the composition having the effect of improving the scalp and hair. delete The method of claim 1, a tyrosinase activator, a penetration enhancer, a blood flow promoting agent, a blanket activator or a 5α-reductase inhibitor, a scalp nutrient, an itch inhibitor, a dissolution aid, a solvent, a surfactant, a humectant, a thickener, a preservative, an antioxidant, a metal A composition having an improving effect of the scalp and hair, characterized in that it comprises one or more of an ion blocker, an anti-inflammatory agent, an antimicrobial agent, a surfactant, a bactericide, a colorant, and a flavoring agent. delete delete