KR20070067256A - Composition for growing hair and preventing fall-out of hair - Google Patents

Abstract

A composition for growing hair and preventing falling-out of the hair is provided to prevent loss of hair and dandruff, keep scalp clean and healthy, improve the blood circulation of hair root cell to make the hair generation cycle smooth, thereby promoting nutrition supply to damaged hair and growing hair at the hair fallen-out portion. The composition for growing hair and preventing falling-out of the hair comprises 25 wt.% of an extract of Tribulus terrestris, 25 wt.% of an extract of Indian gooseberry, 18 wt.% of an extract of green tea, 15 wt.% of an extract of betaine, 4 wt.% of an extract of Capsicum, 4 wt.% of an extract of peppermint, 4 wt.% of an extract of Urtica dioica L. Nettle, 2 wt.% of an extract of Equisetum arvense, 2 wt.% of an extract of Lavandula officinalis and 1 wt.% of an extract of Humulus lupulus.

Description

COMPOSITION FOR GROWING HAIR AND PREVENTING FALL-OUT OF HAIR}

1 is an experimental third final result, Figure 1a is a control, Figure 1b Mynoxyl (Minoxidil 3), Figure 1c is a composite composition of the present invention (low concentration group), Figure 1d is a composite composition of the present invention (high concentration group) The degree of hair growth when administered is shown.

The present invention relates to a natural complex composition for preventing hair loss and promoting wool, more specifically, Tribulus terrestris, Indian gooseberry, Green tea extract, Green tea, Betaine, Capsicum, Peppermint extract, Wedge Extract (Urtica dioica.L. Nettle), Horsetail Extract (Equisetum arvense, Horsetail) Lavender Extract (Lavandula officinalis, Lavender) and Hop Extract (Humulus lupulus, Hop) It relates to a natural complex composition for preventing hair loss and promoting wool.

On average, the number of human hair is about 100,000 to 120,000. Hair has a life cycle of development, growth, degeneration and rest periods, and it is normal for hair to enter the resting phase of 50-100 drops per day. The hair falls out after a certain period of time and new hair develops. Unlike nails and toenails, they have a cycle of 'growing-resting-falling'. In the case of molting animals, the hairs of all the hairs are the same, so the hairs fall out at the same time, and so-called molting. However, since human hair has its own hair cycle, it always maintains a constant hair count without molting.

In the case of human hair, after three years of growth, the hair falls out, and after three months, new hair is formed. There are about 80,000 hairs, of which 70 are lost a day, and about 70 hairs that were missing three months ago are newly growing, and the hair is always 80,000.

But today's busy people are vulnerable to stress. These stresses and the effects of aging work the most closely on hair loss. In the past, hair loss was recognized as genetic, but hair loss in recent years is a phenomenon of aging and a major problem is that the timing is accelerated by changes in living environment.

Alopecia is known to occur mainly because of the function of producing hair energy, that is, the hair energy cycle does not work normally, resulting in energy shortage in the hair roots.

Testosteron, a type of androgen known to hinder the growth and development of energy needed for hair growth, is the activity of 5 alpha-reductases distributed around the hair follicles. ). Activated DHT shortens hair growth by binding to androgen receptors, shrinks hair follicles, thins hair gradually and eventually causes hair loss.

As hair loss progresses, the hair papilla present in the hair root becomes smaller, the thickness of the hair becomes thinner, and at the same time the hair cycle becomes shorter. In other words, after three years of hair growth to fall out after one year of hair growth is calculated to be about 210 dogs a day. If hair loss continues, the hair turns to fluffy and the hair cycle becomes shorter, and after a little overgrowing, the hair becomes thinner and not longer.

Therefore, under the assumption that applying a factor that regulates male hormones, hair loss will be prevented, and the medical community has been conducting a number of studies to develop new drugs effective for hair loss. Propecia, a male hormone inhibitor approved by the FDA in 1997, and Duta, a prostatic hypertrophy and effective hair loss prevention, and external treatment and antihypertensive minoxidil, are the most representative hair loss prevention and hair growth agents.

However, when applying such a hair loss prevention agent or a hair regrowth agent, various side effects are observed due to the imbalance of homeostasis in the body, and typically, various unexpected side effects such as decreased sexual function, allergy, depression, and local inflammation occur.

In addition, since hair loss occurs due to a complex system, there is a problem that narrow treatment such as hormone inhibition limited to 5-alpha-reductase is only myopic prescription.

Henna, also known as botanical name 'Lawsonia uremis', is a plant native to hot regions of North Africa, India, Iran, Pakistan, and West Asia, and has been used for thousands of years to prevent skin diseases, hemostasis, bruises, burns, and preservatives. It has been widely used as a drug for dermatitis. Today, it is a trend that is widely used as a hair dye to replace the existing chemical dye, and is also recently used as a tattoo among young people.

The main ingredient called "LAWSONIA" of henna leaves acts on the keratin (protein) component of the hair to heal, dye and shine, and heal the hair. , Itching, dandruff, etc.) is known to have an effect of improving the use of a hair loss agent and a wool agent.

However, it has been reported that the henna component also includes a metal component, so that when it comes into contact with the skin for a long time, sensitization reaction and contact dermatitis may be continuously performed.

Therefore, the present inventors have found a complex natural products without fear of side effects such as henna which can prevent hair loss and maximize the wool effect of hair, and in order to set their optimum composition ratio, it is an effective composition for preventing hair loss and wool after many trials and errors. And these composition ratios were obtained.

In order to solve the above problems, the present invention is a complex prescription, such as cleanliness of the scalp and hair health, energy supply to the hair root cells, protection of hair root cells due to smooth blood circulation, excellent safety and natural except for henna It is to provide a natural composite composition for preventing hair loss and promoting wool including plant components and their optimum composition ratio.

In order to solve the above problems, the present invention is a tribulus extract (Tribulus terrestris), Indian gooseberry (Indian gooseberry), green tea extract (Green tea), betaine (Betaine), pepper extract (Capsicum), peppermint extract (Peppermint) Natural complex composition for hair loss prevention and wool promotion, including Wedge extract (Urtica dioica. To provide.

Hereinafter, the components contained in the composition of the present invention will be described in detail.

Indian gooseberry extract (Emblica officinalis), a blood circulation improving component for cell activation of hair follicle cells, is known as Amla as a traditional plant of India. In India, the fruit of this plant has traditionally been used to purify blood and improve blood flow, and in Western countries, many of these fruits are sold. This fruit is rich in vitamin C and contains natural vitamin C, equivalent to 100 mg of synthetic vitamins.

In addition, the tribula (Pinus, Whitetail, Tribulus terrestris L.) grows mostly on sandy beaches and in dry land. 1 ~ 2 years early, stem is divided into many branches and grows on the ground. Its length is 1m, and it has hairs along with flowers and leaf axes. The main component of the tribulus is saponin, which is widely used in foreign countries such as ginseng in Korea. It is mainly used for improving blood, nourishing tonic, and strengthening male muscle. It is one of the traditional plants of India.

Indian gooseberry extract and tribulus facilitate the blood circulation of the hair root cells, thereby promoting the hair cycle.

Red pepper extract, peppermint extract, horsetail extract, lavender extract, etc., cleans the scalp and inhibits dandruff and clogging of hair follicles.

Betaine and hop extracts not only repair damaged hair, but also moisturize and convert it into shiny and elastic hair. In addition, it gives a sense of volume of the hair shows an improved effect on the aesthetic effect of the hair dropout or dropout.

Green tea extract and dill grass extract act on the activity of 5-alpha-reductase to reduce the concentration of DHT (dihydroxytestosterone), which causes hair loss, to prevent underlying hair loss. Reduction of DHT reduces the binding frequency of androgen receptors, leading to normalization of hair growth. In addition, DHT inhibits the birth of hair due to atrophy of hair follicle size, and green tea extract and wedge extract inhibit the action and promote the appearance of durable new hair.

In order to prepare the composition of the present invention, the raw material was pulverized well and obtained through a method of hot water extraction, alcohol extraction, propylene glycol extraction, acetone extraction, and the like under reduced pressure, and the liquid phase was used as it was through a powder process.

Carriers that can be used for the formulation of the present invention are conventional in the pharmaceutical art, and include, for example, suspending agents, disintegrating agents, excipients, solubilizers, stabilizers, suspending agents, pigments, flavoring agents, and the like. The natural complex composition for preventing hair loss and promoting wool is preferably formulated with topical preparations such as ointments, lotions and sprays to act directly on the hair loss site. In addition, various formulations such as shampoos, hair conditioners, hair lotions, liquid tonic forms, soaps, and creams are also possible.

The composition of the present invention may be applied to the hair promoting composition commonly used as needed, such as hinokithiol, tocopherol acetate, salicylic acid, menthol and the like, and also includes one or more additional natural ingredients that can enhance the wool effect. can do. Ingredients that can be included for this purpose include black soybean extract, black sesame extract, nasturtium extract, goji berry extract, red ginseng extract, dermis extract. Where such additional compositions are included, their content is preferably within 1-10% based on the total weight of the composition of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms or words used in the specification and claims should not be construed as having a conventional or dictionary meaning, and the inventors should properly explain the concept of terms in order to best explain their own invention. Based on the principle that can be defined, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention.

Therefore, the embodiments described in the specification and the drawings shown in the drawings are only the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various equivalents that may be substituted for them at the time of the present application It should be understood that there may be water and variations.

(Example)

The raw materials of the composition ratio as shown in Table 1 was well pulverized and hot water extracted to obtain a liquid composition. The composition ratio of the composition regarding the conventional hair loss prevention and wool of this invention is shown in Table 1.

TABLE 1

ingredient Compounding ratio (% by weight) TRIBLES EXTRACT 25 Indian Gooseberry Extract 25 Green Tea Extract 18 Betaine 15 Peppermint Extract 4 Wedge Grass Extract 4 Horsetail Extract 4 Hope Extract 2 Lavender Extract 2 Pepper tincture One synthesis 100%

Experimental Example 1 Final Results of Wool Functional Evaluation of the Composite Composition

1. Experimental method

 1-1 Experiment Animal

Fifty male C57BL / 6 males were divided into five groups of 10 animals each and 5 animals per cage.

1-2 Diet and Drinks

The diet provided free feed for Cheil Jedang, while the negative water changed the tab water daily for free feeding.

1-3 Experiment group separation and treatment method

TABLE 2

Experimental group Military treatment method No. Control - 10 Mynoxyl (Minoxidil 3%) Apply sample No. 14 to hair removal site once a day and massage for 1 minute with the same brush 10 Complex composition (low concentration group) 10 Complex composition (high concentration group) 10

* Concentration of the composite composition was used at a high concentration of 50% solids composition, the low concentration was used by diluting 1/2 (25% solids) of the high concentration composite composition.

1-4. How to epilate

After weakly anesthetizing the test animal with ether, remove the back part of the test animal in a certain direction with a mechanical cutter.

1-5 Results observation

Samples were treated once a day, and the hair growth was visually observed on the 10th, 20th, and 30th days, and the hair growth rate of each group was scored by a five-point evaluation method. To ensure that the evaluation is accurate so that no action is taken that could affect the dialogue and mutual scoring between the three persons when scoring.

(Evaluation Day 10)

+++++: Growing up to normal state (epilation)

++++: Growth to the extent that the skin is invisible throughout the depilation area (the length is short)

+++: Significant hair growth throughout hair removal site

++: Short hair growth seen throughout the tip area

+: Hair growth on the epilated area.

(If hair growth is seen unevenly, evaluate it one step lower.)

2. Experimental Results

2-1) 1st and 2nd evaluation synthesis

TABLE 3

Group Primary (10 day) 2nd (20 day) Remarks Control 0.87 ± 0.35 1.200 ± 0.25 Mynoxyl (Minoxidil 3%) 1.42 ± 0.29 1.92 ± 0.34 Complex composition (low concentration group) 1.23 ± 0.49 1.75 ± 0.28 Complex composition (high concentration group) 1.33 ± 0.43 1.80 ± 0.36

* 5-point scoring method

2-2) The third final result photograph is shown in FIG. On the other hand, the sum of the 3rd results is as follows.

TABLE 4

Group 3rd Control 2.22 ± 0.52 Mynoxyl (Minoxidil 3%) 3.24 ± 0.25 (significant difference) Complex composition (low concentration group) 3.21 ± 0.43 (significant difference) Complex composition (high concentration group) 3.96 ± 0.64 (significant difference)

3. Conclusion

Hair growth was slow until 10, 20 and 30 days, and treatment groups showed similar effects by orders. As a result, the composite composition (high concentration group) group showed the best effect, and the minoxyl group and the composite composition (low concentration group) showed similar effects. On the other hand, each group showed a significant difference in 95% reliability compared to the control.

The present invention relates to a composition related to hair loss prevention and wool, which focuses on various causes of hair loss, and is approaching a multifaceted system such as hair, hair root cells, hormones, blood circulation, and scalp. It has been proved through animal and clinical experiments that it is effective in preventing hair loss and shows excellent effects on wool.

In other words, the present invention is a complex composition of natural plants, compared to the therapeutic drugs sold as medicines, has little side effects and restores and nourishs damaged hair, activates hair root cells, improves blood circulation to hair root cells, and 5 alpha-reductase-related men. Hormonal control, scalp cleansing and bactericidal effect, normalization of autonomic nerve through hair root and scalp stimulation effect, it is effective in preventing hair loss and wool.

Claims (2)

Tribulus terrestris, Indian gooseberry, Green tea, Betaine, Capsicum, Peppermint, Peppermint extract (Urtica dioica. L Natural complex composition for preventing hair loss and promoting wool, including Nettle, Equisetum arvense, Horsetail Lavender extract (Lavandula officinalis, Lavender), and hop extract (Humulus lupulus, Hop). The method of claim 1, Content of the component is a natural complex composition for preventing hair loss and promoting wool, characterized in that as follows. ingredient Compounding ratio (% by weight) TRIBLES EXTRACT 25 Indian Gooseberry Extract 25 Green Tea Extract 18 Betaine 15 Peppermint Extract 4 Wedge Grass Extract 4 Horsetail Extract 4 Hope Extract 2 Lavender Extract 2 Pepper tincture One synthesis 100%

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