CN109923111A - 抗生素化合物 - Google Patents
抗生素化合物 Download PDFInfo
- Publication number
- CN109923111A CN109923111A CN201780063473.8A CN201780063473A CN109923111A CN 109923111 A CN109923111 A CN 109923111A CN 201780063473 A CN201780063473 A CN 201780063473A CN 109923111 A CN109923111 A CN 109923111A
- Authority
- CN
- China
- Prior art keywords
- oxazole
- base
- benzo
- amine
- oxadiazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1614314.1A GB201614314D0 (en) | 2016-08-22 | 2016-08-22 | Antibiotic compounds |
| GB1614314.1 | 2016-08-22 | ||
| PCT/GB2017/052478 WO2018037223A1 (en) | 2016-08-22 | 2017-08-22 | Antibiotic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109923111A true CN109923111A (zh) | 2019-06-21 |
Family
ID=57045563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780063473.8A Pending CN109923111A (zh) | 2016-08-22 | 2017-08-22 | 抗生素化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20190194179A1 (https=) |
| EP (1) | EP3500567A1 (https=) |
| JP (1) | JP2019528291A (https=) |
| KR (1) | KR20190046894A (https=) |
| CN (1) | CN109923111A (https=) |
| AU (1) | AU2017316742A1 (https=) |
| BR (1) | BR112019003427A2 (https=) |
| CA (1) | CA3034000A1 (https=) |
| CO (1) | CO2019002624A2 (https=) |
| EA (1) | EA201990551A1 (https=) |
| GB (1) | GB201614314D0 (https=) |
| MX (1) | MX2019001978A (https=) |
| PH (1) | PH12019500360A1 (https=) |
| SG (1) | SG11201901374WA (https=) |
| WO (1) | WO2018037223A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117003710A (zh) * | 2023-07-19 | 2023-11-07 | 镇江先锋植保科技有限公司 | 一种2-巯基-6-氯苯并恶唑的制备方法 |
| CN117043141A (zh) * | 2021-05-31 | 2023-11-10 | 江苏亚虹医药科技股份有限公司 | 7-硝基-8-羟基喹啉衍生物、其制备方法及其医药用途 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3636645A1 (de) | 2018-10-11 | 2020-04-15 | Bayer Aktiengesellschaft | Verfahren zur herstellung schwefel-substituierter pyridinderivate |
| KR102793543B1 (ko) | 2018-10-11 | 2025-04-11 | 바이엘 악티엔게젤샤프트 | 이미다졸 유도체의 제조 방법 |
| TWI841671B (zh) | 2019-01-24 | 2024-05-11 | 日商第一三共股份有限公司 | 具有取代基之脲化合物 |
| AU2020225301A1 (en) | 2019-02-22 | 2021-08-26 | Anifera Limited | Compositions providing enhanced antibacterial activity against gram-positive bacteria and use thereof |
| CN111808093B (zh) * | 2019-04-12 | 2023-05-16 | 中国医学科学院医药生物技术研究所 | 一种新德里金属-β-内酰胺酶-1抑制剂 |
| IL287183B2 (en) | 2019-04-12 | 2025-01-01 | Mitobridge Inc | Inductors 1 HMOX |
| US12528798B2 (en) | 2019-10-29 | 2026-01-20 | Lg Chem, Ltd. | Compound for crop protectant |
| CN116528873B (zh) * | 2020-11-19 | 2025-08-22 | A&J科学有限公司 | 新型化合物、其制造方法及包含其的抗生素组合物 |
| CN113185475A (zh) * | 2021-04-29 | 2021-07-30 | 江苏永凯化学有限公司 | 一种高效低污染的精恶唑禾草灵生产工艺 |
| KR102754999B1 (ko) * | 2022-01-06 | 2025-01-21 | 충남대학교산학협력단 | 신규한 화합물 및 이를 포함하는 결핵균 또는 비결핵항산균 감염질환 치료용 약제학적 조성물 |
| JP2025522339A (ja) * | 2022-06-01 | 2025-07-15 | クダ セラピューティクス インコーポレイテッド | イミダゾピリジン及びオキサゾロピリジン誘導体及びその類似体、その調製方法、ＨＩＦ－１／２ａ経路阻害の方法、並びに、フェロトーシスの誘導 |
| WO2024130173A1 (en) * | 2022-12-16 | 2024-06-20 | Immvention Therapeutix | Benzimidazole derivatives |
| KR102840252B1 (ko) * | 2023-04-27 | 2025-07-30 | 한국화학연구원 | 시아노벤즈이미다졸 유도체, 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| AU2024331213A1 (en) * | 2023-09-01 | 2026-04-16 | Immvention Therapeutix, Inc. | Substituted benzoxazolylamino benzoxazoles |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8604217B2 (en) * | 2009-11-12 | 2013-12-10 | Selvita S.A. | Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| JP5786402B2 (ja) * | 2011-03-29 | 2015-09-30 | コニカミノルタ株式会社 | 光学フィルム、及びそれを用いた偏光板、液晶表示装置 |
| WO2016039939A1 (en) * | 2014-09-09 | 2016-03-17 | Ptc Therapeutics, Inc. | Bicyclic and tricyclic substituted 2-pyridinone antibacterial compounds |
-
2016
- 2016-08-22 GB GBGB1614314.1A patent/GB201614314D0/en not_active Ceased
-
2017
- 2017-08-22 US US16/327,286 patent/US20190194179A1/en not_active Abandoned
- 2017-08-22 SG SG11201901374WA patent/SG11201901374WA/en unknown
- 2017-08-22 AU AU2017316742A patent/AU2017316742A1/en not_active Withdrawn
- 2017-08-22 BR BR112019003427-7A patent/BR112019003427A2/pt not_active Application Discontinuation
- 2017-08-22 MX MX2019001978A patent/MX2019001978A/es unknown
- 2017-08-22 EA EA201990551A patent/EA201990551A1/ru unknown
- 2017-08-22 JP JP2019510688A patent/JP2019528291A/ja not_active Withdrawn
- 2017-08-22 EP EP17761308.0A patent/EP3500567A1/en not_active Withdrawn
- 2017-08-22 CA CA3034000A patent/CA3034000A1/en not_active Abandoned
- 2017-08-22 KR KR1020197008269A patent/KR20190046894A/ko not_active Withdrawn
- 2017-08-22 WO PCT/GB2017/052478 patent/WO2018037223A1/en not_active Ceased
- 2017-08-22 CN CN201780063473.8A patent/CN109923111A/zh active Pending
-
2019
- 2019-02-20 PH PH12019500360A patent/PH12019500360A1/en unknown
- 2019-03-21 CO CONC2019/0002624A patent/CO2019002624A2/es unknown
Non-Patent Citations (9)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117043141A (zh) * | 2021-05-31 | 2023-11-10 | 江苏亚虹医药科技股份有限公司 | 7-硝基-8-羟基喹啉衍生物、其制备方法及其医药用途 |
| CN117003710A (zh) * | 2023-07-19 | 2023-11-07 | 镇江先锋植保科技有限公司 | 一种2-巯基-6-氯苯并恶唑的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018037223A1 (en) | 2018-03-01 |
| MX2019001978A (es) | 2019-08-01 |
| US20190194179A1 (en) | 2019-06-27 |
| AU2017316742A1 (en) | 2019-04-11 |
| KR20190046894A (ko) | 2019-05-07 |
| EA201990551A1 (ru) | 2019-12-30 |
| EP3500567A1 (en) | 2019-06-26 |
| BR112019003427A2 (pt) | 2019-05-21 |
| SG11201901374WA (en) | 2019-03-28 |
| PH12019500360A1 (en) | 2019-11-11 |
| CA3034000A1 (en) | 2018-03-01 |
| JP2019528291A (ja) | 2019-10-10 |
| CO2019002624A2 (es) | 2019-05-31 |
| GB201614314D0 (en) | 2016-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190621 |