CN109880803B - 嵌合蛋白、表达嵌合蛋白的免疫效应细胞及其应用 - Google Patents
嵌合蛋白、表达嵌合蛋白的免疫效应细胞及其应用 Download PDFInfo
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KR20210025525A (ko) | 2018-06-22 | 2021-03-09 | 카이트 파마 인코포레이티드 | 키메라 막횡단 단백질 및 그의 용도 |
BR112021025735A2 (pt) * | 2019-06-21 | 2022-03-08 | Kite Pharma Inc | Receptores de tgf-ss e métodos de uso |
CN114929863A (zh) * | 2019-08-09 | 2022-08-19 | 克莱格医学有限公司 | 共表达趋化因子受体的免疫效应细胞 |
CN112390892B (zh) * | 2019-08-14 | 2024-01-12 | 博源润生医药(杭州)有限公司 | 一种嵌合抗原受体以及表达该嵌抗原受体的免疫效应细胞 |
CN110564695A (zh) * | 2019-09-23 | 2019-12-13 | 华东师范大学 | 靶向前列腺癌的增强型car-t细胞及其制备方法和药物 |
JP7488337B2 (ja) * | 2019-11-27 | 2024-05-21 | ジーアイ・セル・インコーポレイテッド | Il-2タンパク質及びcd80タンパク質を含む融合タンパク質及びnk細胞を含む抗癌治療用組成物 |
CN111171160B (zh) * | 2020-02-14 | 2022-05-17 | 四川大学华西医院 | 基于TGF-β改造的嵌合抗原受体及其修饰的免疫细胞 |
CN111218426A (zh) * | 2020-02-26 | 2020-06-02 | 华东师范大学 | 一种克服肿瘤微环境car-t细胞的制备及其用途 |
CN111269326A (zh) * | 2020-02-28 | 2020-06-12 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
CN111690070A (zh) * | 2020-05-13 | 2020-09-22 | 深圳市众循精准医学研究院 | 一种sPD-1-Fc-sTGFβRII融合蛋白及其应用 |
CN115698038A (zh) * | 2020-06-01 | 2023-02-03 | 上海君赛生物科技有限公司 | 信号转换受体及其用途 |
CN112210543B (zh) * | 2020-07-30 | 2023-01-03 | 山东省成体细胞产业技术研究院有限公司 | 一种针对实体瘤克服TGF-β免疫抑制的CAR-T细胞 |
CN116194125A (zh) | 2020-08-07 | 2023-05-30 | 克莱格医学有限公司 | 工程化改造的细胞以及工程化改造细胞的方法 |
CN111978412B (zh) * | 2020-08-13 | 2021-04-30 | 南京凯地生物科技有限公司 | 武装靶向TGF-β的特异性嵌合抗原受体细胞及其制备方法和应用 |
CN116390940A (zh) * | 2020-09-23 | 2023-07-04 | 海正生物制药有限公司 | Tgfbr2-ecd突变体及包含其的融合蛋白与应用 |
CN117545771A (zh) | 2021-04-08 | 2024-02-09 | 克莱格医学有限公司 | 细胞免疫治疗的应用 |
CN117460741A (zh) | 2021-06-29 | 2024-01-26 | 科济生物医药(上海)有限公司 | 调控细胞生理活动的嵌合多肽 |
TW202317602A (zh) * | 2021-07-15 | 2023-05-01 | 福瑞德哈金森腫瘤中心 | 嵌合多肽 |
CN115873802A (zh) * | 2021-09-29 | 2023-03-31 | 亘喜生物科技(上海)有限公司 | 嵌合抗原受体免疫细胞及其制法和应用 |
WO2024099990A1 (fr) * | 2022-11-07 | 2024-05-16 | Leibniz-Institut Für Immuntherapie (Lit) | Cellules car t de récepteur de commutateur tgf-ss |
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WO2016122738A1 (fr) * | 2015-01-31 | 2016-08-04 | The Trustees Of The University Of Pennsylvania | Compositions et procédés d'administration à des cellules t de molécules thérapeutiques |
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JP6578271B2 (ja) * | 2013-04-17 | 2019-09-18 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 免疫抑制TGF−βシグナルコンバーター |
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CN103582699A (zh) * | 2011-04-08 | 2014-02-12 | 贝勒医学院 | 使用嵌合细胞因子受体逆转肿瘤微环境的影响 |
WO2016061574A1 (fr) * | 2014-10-17 | 2016-04-21 | Baylor College Of Medicine | Cellules immunitaires bipartites et tripartites de signalisation |
WO2016122738A1 (fr) * | 2015-01-31 | 2016-08-04 | The Trustees Of The University Of Pennsylvania | Compositions et procédés d'administration à des cellules t de molécules thérapeutiques |
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